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Citations to this article

Degradation products of fibrinogen by elastase-like neutral protease from human granulocytes. Characterization and effects on blood coagulation in vitro.
M Gramse, … , R Egbring, K Havemann
M Gramse, … , R Egbring, K Havemann
Published April 1, 1978
Citation Information: J Clin Invest. 1978;61(4):1027-1033. https://doi.org/10.1172/JCI109001.
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Research Article

Degradation products of fibrinogen by elastase-like neutral protease from human granulocytes. Characterization and effects on blood coagulation in vitro.

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Abstract

We investigated the effect of elastase-like neutral protease isolated from human granolocytes on human fibrinogen. Dependent on enzyme concentration and time of incubation, the elastase-like protease induced a progressive degradation of fibrinogen. Analysis of the remaining polypeptide chains showed a high susceptibility of the Aalpha- and low susceptibility of the gamma-chain of fibrinogen towards the proteolytic action of the enzyme. The split products were characterized by polyacrylamide gel electrophoresis and two-dimensional immunoelectrophoresis. They showed antigenic determinants of fibrinogen and of plasmin-induced proteolysis products D and E. The cleavage fragments isolated by gel chromatography had distinct molecular weights. Coagulability of fibrinogen by thrombin was inhibited according to the concentration of the protease and the time of incubation. Split products of fibrinogen with higher molecular weight prolonged the coagulation time of native fibrinogen, whereas low molecular weight fragments were ineffective.

Authors

M Gramse, C Bingenheimer, W Schmidt, R Egbring, K Havemann

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Total citations by year

Year: 2014 2011 2010 2008 2005 2002 2000 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1980 1979 1978 Total
Citations: 2 2 1 1 1 2 1 1 1 1 2 3 1 1 4 6 1 1 1 7 3 1 4 2 3 3 2 58
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2010 (1)

Title and authors Publication Year
Effect of Urinary Trypsin Inhibitor on Preterm Labor with High Granulocyte Elastase Concentration in Cervical Secretions
M Hayashi, A Oya, H Miyake, A Nakai, T Takeshita
Journal of Nippon Medical School 2010

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