Citation Information: J Clin Invest. 1978;61(3):790-800. https://doi.org/10.1172/JCI108993.
Abstract
Exposure to supralethal total body irradiation and transplantation of bone marrow from a DLA- and pedigree-identical donor have regularly produced successful engraftment and the establishment of stable long-term chimerism in beagles of the Cooperstown colony. Bone marrow allografts performed in pairs of dogs bearing identical DLA haplotypes derived from different pedigree origins (i.e., different classes of the same haplotype) yielded two different results. Depending upon the particular haplotype pedigree combination used, such transplants either led to long-term chimerism or to failures of engraftment, secondary disease, and death of the recipients (i.e., pedigree-incompatible combinations).
Authors
F. T. Rapaport, R. J. Bachvaroff, K. Watanabe, H. Hirasawa, N. Mollen, J. W. Ferrebee
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