Induction of Allogeneic Unresponsiveness in Adult Dogs: ROLE OF NON-DLA HISTOCOMPATIBILITY VARIABLES IN CONDITIONING THE OUTCOME OF BONE MARROW, KIDNEY, AND SKIN TRANSPLANTATION IN RADIATION CHIMERAS
F. T. Rapaport, … , N. Mollen, J. W. Ferrebee
F. T. Rapaport, … , N. Mollen, J. W. Ferrebee
Published March 1, 1978
Citation Information: J Clin Invest. 1978;61(3):790-800. https://doi.org/10.1172/JCI108993.
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Induction of Allogeneic Unresponsiveness in Adult Dogs: ROLE OF NON-DLA HISTOCOMPATIBILITY VARIABLES IN CONDITIONING THE OUTCOME OF BONE MARROW, KIDNEY, AND SKIN TRANSPLANTATION IN RADIATION CHIMERAS

Abstract

Exposure to supralethal total body irradiation and transplantation of bone marrow from a DLA- and pedigree-identical donor have regularly produced successful engraftment and the establishment of stable long-term chimerism in beagles of the Cooperstown colony. Bone marrow allografts performed in pairs of dogs bearing identical DLA haplotypes derived from different pedigree origins (i.e., different classes of the same haplotype) yielded two different results. Depending upon the particular haplotype pedigree combination used, such transplants either led to long-term chimerism or to failures of engraftment, secondary disease, and death of the recipients (i.e., pedigree-incompatible combinations).

Authors

F. T. Rapaport, R. J. Bachvaroff, K. Watanabe, H. Hirasawa, N. Mollen, J. W. Ferrebee

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