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Citations to this article

Effects of dihydroxy bile acids and hydroxy fatty acids on the absorption of oleic acid in the human jejunum.
R Wanitschke, H V Ammon
R Wanitschke, H V Ammon
Published January 1, 1978
Citation Information: J Clin Invest. 1978;61(1):178-186. https://doi.org/10.1172/JCI108916.
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Research Article

Effects of dihydroxy bile acids and hydroxy fatty acids on the absorption of oleic acid in the human jejunum.

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Abstract

Perfusion studies of the normal human jejunum were performed to test whether dihydroxy bile acids and hydroxy fatty acids inhibit the absorption of oleic acid, since previous reports documented their inhibitory effects on the absorption of several other organic solutes. 3 mM deoxycholate and 7 mM glycodeoxycholate inhibited the absorption of 3 mM oleic acid in isotonic micellar solutions while inducing net fluid secretion. Similarly, fractional absorption of oleic acid decreased in the presence of hydroxy fatty acids. However, only the changes induced by 2 mM ricinoleic acid could be distinguished from changes induced by an increase in total fatty acid concentration. Under all experimental conditions, close linear relationships existed between net water movement and fractional absorption of glucose, xylose, and fatty acids, as well as between the absorption rates of these solutes. In contrast, net fluid secretion induced by hypertonic D-mannitol (450 mosmol/liter) had no effect on solute absorption. Our data and observations in the literature do not allow formulation of a hypothesis which would adequately define all effects of dihydroxy bile acids and fatty acids on intestinal transport processes. The observations help explain the malabsorption of fat and other nutrients in patients with the blind loop syndrome.

Authors

R Wanitschke, H V Ammon

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Total citations by year

Year: 2025 2024 2023 2022 2021 2019 2017 2015 2014 2013 2010 2009 2007 2006 2005 2004 2003 1997 1985 1984 1983 1981 1980 1979 Total
Citations: 1 1 2 1 1 1 2 1 3 1 3 1 1 1 1 1 1 1 2 1 4 1 1 4 37
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Obesity surgery 2023
Gastrointestinal Dysfunction in Parkinson's Disease.
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Scandinavian Journal of Gastroenterology 1985
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The American Journal of the Medical Sciences 1985
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1984
Effects of lysophosphatidylcholine on jejunal water and solute transport in the rat in vivo
HV Ammon, RE Loeffler, LA Luedtke
Lipids 1983
Human Intestinal Microflora in Health and Disease
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Dünndarm A
F Bazzoli, R Böhmer, WF Caspary, H Dombrowski, B Eckhardt, B Elsenhans, A Encke, A Ferguson, W Forth, H Fromm, A Gangl, S Gutschmidt, U Hopfer, GJ Kreijs, B Lembcke, KH zum Büschenfelde, G Mödder, G Nell, HF Otto, H Peerenboom, G Rehner, G Rettenmaier, EO Riecken, JW Robinson, K Rommel, H Ruppin, J Seifert, KH Soergel, S Strobel, L Vollrath, R Wanitschke, HJ Weis
1983
Dünndarm B
W Bommer, WF Caspary, M Classen, R Dölp, R Ecknauer, J Erckenbrecht, GE Feurle, D Filler, A Gangl, KE Grund, K Gyr, F Hagenmüller, V Helmstädter, HW von Heyden, K Hübner, B Husemann, F Kümmerle, V Lenner, K Loeschke, H Lorenz-Meyer, H Malchow, EM Mathus-Vliegen, H Menge, H Mergerian, B Miller, U Rasenack, B Reichlin, EO Riecken, W Rösch, H Ruppin, A Schaudig, HW Schreiber, KH Soergel, GN Tytgat, M Wienbeck, K Winckler, R Winkler
1983
Effect of glucose on jejunal water and solute absorption in the presence of glycodeoxycholate and oleate in man
BD Brown, HV Ammon
Digestive Diseases and Sciences 1981
Intestinal filtration as a consequence of increased mucosal hydraulic permeability: A new concept for laxative action
R Wanitschke
Klinische Wochenschrift 1980
Effect of lecithin on jejunal absorption of micellar lipids in man and on their monomer activity in vitro
HV Ammon, PJ Thomas, SF Phillipis
Lipids 1979
Mechanism of inhibition of alanine absorption by Na ricinoleate
JJ Hajjar, DM Murphy, RL Scheig
American journal of physiology. Endocrinology and metabolism 1979
Small Intestine Bacterial Overgrowth
CE King, PP Toskes
Gastroenterology 1979
Colonic absorption of unconjugated bile acids: Perfusion studies in man
HS Mekhjian, SF Phillips, AF Hofmann
Digestive Diseases and Sciences 1979

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