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Citations to this article

Effects of Glyceraldehyde on the Structural and Functional Properties of Sickle Erythrocytes
Alan M. Nigen, James M. Manning
Alan M. Nigen, James M. Manning
Published January 1, 1978
Citation Information: J Clin Invest. 1978;61(1):11-19. https://doi.org/10.1172/JCI108909.
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Research Article

Effects of Glyceraldehyde on the Structural and Functional Properties of Sickle Erythrocytes

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Abstract

The d- and l-isomers of glyceraldehyde are equally effective in the inhibition of SS erythrocyte sickling in vitro. The following compounds at a concentration of 20 mM were ineffective in inhibiting sickling: glyceraldehyde-3-phosphate, d-erythrose, d-ribose, d-fructose, d-glucose, d-sucrose, dihydroxyacetone, and methylglyoxal. Glyceraldehyde does not reverse the sickling of cells in the deoxy state. The properties of purified hemoglobin after treatment with glyceraldehyde and of the hemoglobin isolated from treated cells are very similar; these results suggest that glyceraldehyde itself is the reactive species within the erythrocyte. Erythrocyte glutathione is decreased by treatment in vitro with the aldehyde.

Authors

Alan M. Nigen, James M. Manning

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Total citations by year

Year: 2006 2003 1991 1988 1986 1984 1983 1982 1981 1980 1978 Total
Citations: 1 1 1 1 2 4 2 1 1 4 3 21
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (21)

Title and authors Publication Year
Advances in Enzymology - and Related Areas of Molecular Biology
H Waelsch
Advances in Enzymology and Related Areas of Molecular Biology 2006
Triosidines: novel Maillard reaction products and cross-links from the reaction of triose sugars with lysine and arginine residues
FJ Tessier, VM Monnier, LM Sayre, JA Kornfield
Biochemical Journal 2003
Proteins
V Renugopalakrishnan, PR Carey, IC Smith, SG Huang, AC Storer
Proteins 1991
Cross-linking of proteins by aldotriose: reaction of the carbonyl function of the keto amines generated in situ with amino groups
AS Acharya, YJ Cho, BN Manjula
Biochemistry 1988
Enzymic cleavage of the blocked amino terminal residues of peptides
WM Jones, LR Manning, JM Manning
Biochemical and Biophysical Research Communications 1986
Covalent binding of glutathione to hemoglobin. I. Inhibition of hemoglobin S polymerization
MC Garel, C Domenget, J Caburi-Martin, C Prehu, F Galacteros, Y Beuzard
The Journal of biological chemistry 1986
Membrane protein changes induced by tert-butyl hydroperoxide in red blood cells
SG Sullivan, A Stern
Biochimica et Biophysica Acta (BBA) - Biomembranes 1984
The oxidation of oxyhaemoglobin by glyceraldehyde and other simple monosaccharides
PJ Thornalley, SP Wolff, MJ Crabbe, A Stern
Biochemical Journal 1984
Inhibition of deoxyhemoglobin S polymerization by glyceraldehyde
AS Acharya, LG Sussman, WM Jones, JM Manning
Analytical Biochemistry 1984
The effect of glyceraldehyde on red cells
PJ Thornalley, A Stern
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1984
Schiff base adducts of glyceraldehyde with hemoglobin. Differences in the Amadori rearrangement at the alpha-amino groups
AS Acharya, LG Sussman, JM Manning
The Journal of biological chemistry 1983
Reductive hydroxyethylation of hemoglobin A. Functional properties of hemoglobin A selectively hydroxyethylated or dihydroxypropylated at the alpha-amino groups
AS Acharya, LG Sussman
The Journal of biological chemistry 1983
Clinical Pharmacology for Pediatricians. II. Antisickling Agents, with Special Reference to New Vasoerythroactive Drugs
YW Cho, DM Aviado
The Journal of Clinical Pharmacology 1982
The Molecular Basis of Mutant Hemoglobin Dysfunction
DR Harkness
The Molecular Basis of Mutant Hemoglobin Dysfunction 1981
The molecular basis of antisickling agents
IM Franklin, ER Huehns
Transactions of the Royal Society of Tropical Medicine and Hygiene 1980
Pathogenese
H Cottier
1980
Reactivity of the amino groups of carbonmonoxyhemoglobin S with glyceraldehyde
AS Acharya, JM Manning
The Journal of biological chemistry 1980
Amadori rearrangement of glyceraldehyde-hemoglobin Schiff base adducts. A new procedure for the determination of ketoamine adducts in proteins
AS Acharya, JM Manning
The Journal of biological chemistry 1980
Inhibition of erythrocyte sickling in vitro by pyridoxal
JA Kark, MP Kale, PG Tarassoff, M Woods, LS Lessin
Journal of Clinical Investigation 1978
Sickle-Cell Anemia: Molecular and Cellular Bases of Therapeutic Approaches
J Dean, AN Schechter
New England Journal of Medicine 1978
Biochemical and Clinical Aspects of Hemoglobin Abnormalities
HS Ballard
Biochemical and Clinical Aspects of Hemoglobin Abnormalities 1978

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