The d- and l-isomers of glyceraldehyde are equally effective in the inhibition of SS erythrocyte sickling in vitro. The following compounds at a concentration of 20 mM were ineffective in inhibiting sickling: glyceraldehyde-3-phosphate, d-erythrose, d-ribose, d-fructose, d-glucose, d-sucrose, dihydroxyacetone, and methylglyoxal. Glyceraldehyde does not reverse the sickling of cells in the deoxy state. The properties of purified hemoglobin after treatment with glyceraldehyde and of the hemoglobin isolated from treated cells are very similar; these results suggest that glyceraldehyde itself is the reactive species within the erythrocyte. Erythrocyte glutathione is decreased by treatment in vitro with the aldehyde.
Alan M. Nigen, James M. Manning
Title and authors | Publication | Year |
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Advances in Enzymology - and Related Areas of Molecular Biology
H Waelsch |
Advances in Enzymology and Related Areas of Molecular Biology | 2006 |
Triosidines: novel Maillard reaction products and cross-links from the reaction of triose sugars with lysine and arginine residues
FJ Tessier, VM Monnier, LM Sayre, JA Kornfield |
Biochemical Journal | 2003 |
Proteins
V Renugopalakrishnan, PR Carey, IC Smith, SG Huang, AC Storer |
Proteins | 1991 |
Cross-linking of proteins by aldotriose: reaction of the carbonyl function of the keto amines generated in situ with amino groups
AS Acharya, YJ Cho, BN Manjula |
Biochemistry | 1988 |
Enzymic cleavage of the blocked amino terminal residues of peptides
WM Jones, LR Manning, JM Manning |
Biochemical and Biophysical Research Communications | 1986 |
Covalent binding of glutathione to hemoglobin. I. Inhibition of hemoglobin S polymerization
MC Garel, C Domenget, J Caburi-Martin, C Prehu, F Galacteros, Y Beuzard |
The Journal of biological chemistry | 1986 |
Membrane protein changes induced by tert-butyl hydroperoxide in red blood cells
SG Sullivan, A Stern |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 1984 |
The oxidation of oxyhaemoglobin by glyceraldehyde and other simple monosaccharides
PJ Thornalley, SP Wolff, MJ Crabbe, A Stern |
Biochemical Journal | 1984 |
Inhibition of deoxyhemoglobin S polymerization by glyceraldehyde
AS Acharya, LG Sussman, WM Jones, JM Manning |
Analytical Biochemistry | 1984 |
The effect of glyceraldehyde on red cells
PJ Thornalley, A Stern |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 1984 |
Schiff base adducts of glyceraldehyde with hemoglobin. Differences in the Amadori rearrangement at the alpha-amino groups
AS Acharya, LG Sussman, JM Manning |
The Journal of biological chemistry | 1983 |
Reductive hydroxyethylation of hemoglobin A. Functional properties of hemoglobin A selectively hydroxyethylated or dihydroxypropylated at the alpha-amino groups
AS Acharya, LG Sussman |
The Journal of biological chemistry | 1983 |
Clinical Pharmacology for Pediatricians. II. Antisickling Agents, with Special Reference to New Vasoerythroactive Drugs
YW Cho, DM Aviado |
The Journal of Clinical Pharmacology | 1982 |
The Molecular Basis of Mutant Hemoglobin Dysfunction
DR Harkness |
The Molecular Basis of Mutant Hemoglobin Dysfunction | 1981 |
The molecular basis of antisickling agents
IM Franklin, ER Huehns |
Transactions of the Royal Society of Tropical Medicine and Hygiene | 1980 |
Pathogenese
H Cottier |
1980 | |
Reactivity of the amino groups of carbonmonoxyhemoglobin S with glyceraldehyde
AS Acharya, JM Manning |
The Journal of biological chemistry | 1980 |
Amadori rearrangement of glyceraldehyde-hemoglobin Schiff base adducts. A new procedure for the determination of ketoamine adducts in proteins
AS Acharya, JM Manning |
The Journal of biological chemistry | 1980 |
Inhibition of erythrocyte sickling in vitro by pyridoxal
JA Kark, MP Kale, PG Tarassoff, M Woods, LS Lessin |
Journal of Clinical Investigation | 1978 |
Sickle-Cell Anemia: Molecular and Cellular Bases of Therapeutic Approaches
J Dean, AN Schechter |
New England Journal of Medicine | 1978 |
Biochemical and Clinical Aspects of Hemoglobin Abnormalities
HS Ballard |
Biochemical and Clinical Aspects of Hemoglobin Abnormalities | 1978 |