Absorption, Plasma Transport, and Cellular Retention of Cobalamin Analogues in the Rabbit: EVIDENCE FOR THE EXISTENCE OF MULTIPLE MECHANISMS THAT PREVENT THE ABSORPTION AND TISSUE DISSEMINATION OF NATURALLY OCCURRING COBALAMIN ANALOGUES

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Abstract

Analogues of cobalamin (Cbl; vitamin B12) are prevalent in nature as a result of bacterial synthesis, and are of additional interest because of their potential use as antimetabolites and chemotherapeutic agents. We have synthesized 14 Cbl analogues containing 57Co and have compared their gastrointestinal absorption, plasma transport, and cellular retention to that of [58Co]Cbl in rabbits.

Authors

J. Fred Kolhouse, Robert H. Allen