The immunoreactive parathyroid hormone (iPTH) in the plasma of hyperparathyroid man consists largely of carboxyl (COOH)-terminal fragments of the hormone. Although these fragments have been thought to arise principally or solely from peripheral metabolism of intact human PTH {hPTH(1-84)} secreted from the parathyroid gland, there is disagreement about the source of iPTH fragments in vivo.
James A. Flueck, Francis P. Di Bella, Anthony J. Edis, Jean M. Kehrwald, Claude D. Arnaud
Title and authors | Publication | Year |
---|---|---|
Endocrinology: Adult and Pediatric
M Gurnell, TJ Visser, P Beck-Peccoz, VK Chatterjee |
Endocrinology: Adult and Pediatric | 2016 |
Endocrinology
C Napier, SH Pearce |
Endocrinology | 2016 |
Chronic Renal Disease
P Delanaye, AD Rule |
2015 | |
Parathyroid Hormone and Calcium Homeostasis
JT Potts, TJ Gardella |
Pediatric Bone | 2012 |
Pediatric Bone
M Bastepe, H Jüppner, RV Thakker |
Pediatric Bone | 2012 |
Vitamins & Hormones
KJ Hare, FK Knop |
Vitamins & Hormones | 2010 |
Physiologie des parathyroïdes
P Houillier |
EMC - Endocrinologie - Nutrition | 2008 |
Influence of the parathyroid glands on bone metabolism
HH Malluche, N Koszewski, MC Monier-Faugere, JP Williams, H Mawad |
European Journal of Clinical Investigation | 2006 |
PTH(1–84)/PTH(7–84): a balance of power
PA Friedman, WG Goodman |
American journal of physiology. Renal physiology | 2006 |
Parathyroid Hormone Secretion and Action: Evidence for Discrete Receptors for the Carboxyl-Terminal Region and Related Biological Actions of Carboxyl-Terminal Ligands
TM Murray, LG Rao, P Divieti, FR Bringhurst |
Endocrine reviews | 2004 |
Intraoperative Parathyroid Hormone Measurement: A Surgeon???s Perspective
A Stephen, R Hodin |
Point of Care The Journal of Near-Patient Testing & Technology | 2004 |
Improved assessment of bone turnover by the PTH-(1-84)/large C-PTH fragments ratio in ESRD patients
MC Monier-Faugere, Z Geng, H Mawad, RM Friedler, P Gao, TL Cantor, HH Malluche |
Kidney International | 2001 |
The Parathyroids
SJ Marx |
The Parathyroids | 2001 |
Metabolic Bone Disease and Clinically Related Disorders
FR Singer, SM Krane |
Metabolic Bone Disease and Clinically Related Disorders | 1998 |
Deficiency of a Parathyroid Hormone Fragment Containing the Midportion and 1,25-Dihydroxyvitamin D in Serum of Patients with Slipped Capital Femoral Epiphysis
S Jingushi, T Hara, Y Sugioka |
Journal of Pediatric Orthopaedics | 1997 |
Prospektive Evaluierung von Parathormongradienten (PTH-intakt) nach totaler Parathyreoidektomie und heterotoper Nebenschilddrüsenreplantation beim renalen Hyperparathyreoidismus
S Walgenbach, G Hommel, G Bernhard, T Junginger |
European Surgery | 1997 |
Osteoporosis
DL Glaser, FS Kaplan |
Spine | 1997 |
Isolation and characterization of the bioactive circulating human parathyroid hormone, hPTH-1-37
D Hock, M Mägerlein, G Heine, P P Ochlich, W G Forssmann |
FEBS Letters | 1997 |
Immunoheterogeneity of parathyroid hormone pre- and postoperatively in primary hyperparathyroidism
A Bergenfelz, S Valdermarsson, B Ahrn |
Langenbecks Archiv für Chirurgie | 1995 |
Enzymological and cellular mechanisms of parathyroid hormone degradation by the kidney
T Yamaguchi, M Fukase, T Sugimoto, K Chihara |
Journal of Bone and Mineral Metabolism | 1994 |
Immunoheterogeneity of parathyroid hormone after surgery for primary hyperparathyroidism
A Bergenfelz, S Valdermarsson, B Ahrén |
Clinica Chimica Acta | 1994 |
Parathyroid gland function in chronic renal failure
AJ Felsenfeld, F Llach |
Kidney International | 1993 |
Immunological evidences for post-translational control of the parathyroid function by ionized calcium in dogs
M Cloutier, L Rousseau, M Gascon-Barré, P D’Amour |
Bone and Mineral | 1993 |
Endocrine Disorders (Parathyroid Hormone)
MK Gupta, D Khoo |
Analytical Chemistry | 1993 |
Parathyroid glands in primary hyperparathyroidism: An ultrastructural morphometric study of 25 cases
S Cinti, A Sbarbati, M Morroni, V Carboni, C Zancanaro, VL Cascio, GR Dickersin |
The Journal of Pathology | 1992 |
Proteases
MA Phillips, RJ Fletterick |
Current Opinion in Structural Biology | 1992 |
Protein Pharmacokinetics and Metabolism
BL Ferraiolo, MA Mohler, CA Gloff |
1992 | |
Stimulation and suppression of intact parathyroid hormone (PTH1–84) in normal subjects and hyperparathyroid patients
P Lips, JC Netelenbos, L Doorn', WH Hackeng, CJ Llps |
Clinical Endocrinology | 1991 |
The metabolism and radioimmunoassay of parathyroid hormone
KJ Martin |
Journal of Bone and Mineral Metabolism | 1991 |
International Review of Cytology
RA Miller |
International Review of Cytology | 1991 |
Intact parathyroid hormone assay is superior to mid region assay in the EDTA-infusion test in hyperparathyroidism
A Bergenfelz, NE Nordén, B Ahrén |
Clinica Chimica Acta | 1991 |
Nephrology
M Hatano |
Nephrology | 1991 |
Metabolism of parathyroid hormone in isolated perfused rat kidney and liver combined
H Daugaard, M Egfjord, K Olgaard |
Kidney International | 1990 |
The measurement of circulating parathyroid hormone
JS Woodhead |
Clinical Biochemistry | 1990 |
New Techniques in Metabolic Bone Disease
R Lindsay |
New Techniques in Metabolic Bone Disease | 1990 |
Laboratory comparison of diagnostic specificity of intact hormone and region-specific immunoassays of parathyroid hormone
JP Aston, MH Wheeler, RC Brown, IR Curley, JS Woodhead |
World Journal of Surgery | 1990 |
Measurement of Parathyroid Hormone
DB Endres, R Villanueva, CF Sharp, FR Singer |
Endocrinology and metabolism clinics of North America | 1989 |
Parathyroid hormone degradation by chymotrypsin-like endopeptidase in the clonal osteogenic UMR-106 cell
T Yamaguchi, M Fukase, M Nishikawa, T Fujimi, T Fujita |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 1989 |
Immunoheterogeneity of parathyroid hormone in parathyroid cysts: diagnostic implications
J Birnbaum, AJ Herle |
Journal of Endocrinological Investigation | 1989 |
SECRETION OF INTACT PTH BY DISPERSED HUMAN HYPERPARATHYROID CELLS
JP Aston, RC Brown, I Curley, MH Wheeler, JS Woodhead |
Clinical Endocrinology | 1988 |
Hypercalcemia
JP Bilezikian |
Disease-a-Month | 1988 |
Peripheral metabolism of PTH: fate of biologically active amino terminus in vivo
FR Bringhurst, AM Stern, M Yotts, N Mizrahi, GV Segre, JT Potts |
American journal of physiology. Endocrinology and metabolism | 1988 |
Metabolism of intact parathyroid hormone in isolated perfused rat liver and kidney
H Daugaard, M Egfjord, K Olgaard |
American journal of physiology. Endocrinology and metabolism | 1988 |
Studies on in vivo and in vitro release of intact parathyroid hormone using a new two-site immunochemiluminometric assay
JP Aston, MH Wheeler, RC Brown, IR Curley, JS Woodhead |
World Journal of Surgery | 1988 |
Proceedings of the 1985 Laurentian Hormone Conference
RM Carey, S Sen |
Proceedings of the 1985 Laurentian Hormone Conference | 1986 |
Influence of serum Ca concentration on circulating molecular forms of PTH in three species
P D'Amour, F Labelle, L Lecavalier, V Plourde, D Harvey |
American journal of physiology. Endocrinology and metabolism | 1986 |
Clinical Endocrinology
A Labhart |
Clinical Endocrinology | 1986 |
Formation and secretion of fragments of parathormone. Identification of cleavage sites
RR MacGregor, RL Jilka, JW Hamilton |
The Journal of biological chemistry | 1986 |
A “Carboxyl Terminal” Clinical R Adioim Muno Assay for Parathyroid Hormone with Apparent Recognition Preference for the Intact Hormone
DA Hanley, PG Wallings |
Journal of Immunoassay | 1985 |
Contemporary Endocrinology
SH Ingbar |
1985 | |
Characterization of parathyroid hormone fragments produced by cathepsin D
JE Zull, J Chuang |
The Journal of biological chemistry | 1985 |
Nephrogenous cyclic AMP and plasma parathyroid hormone in hypercalcaemia: the influence of renal function
G Bill, AF Jacquet, P Burckhardt |
European Journal of Clinical Investigation | 1984 |
Parathyroid hormone and bone histology: Response to hypocalcemia in osteitis fibrosa
A Voigts, AJ Felsenfeld, D Andress, F Llach |
Kidney International | 1984 |
Renal and Hepatic Extraction of Carboxyl-terminal Immunoreactive Parathyrin in Normal Man
N Fogh-Andersen, J Ladefoged, J Møller-Petersen |
Clinical Chemistry and Laboratory Medicine | 1984 |
Lifelong food restriction prevents senile osteopenia and hyperparathyroidism in F344 rats
DN Kalu, RR Hardin, R Cockerham, BP Yu, BK Norling, JW Egan |
Mechanisms of Ageing and Development | 1984 |
Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors
GJ Strewler, RD Williams, RA Nissenson |
Journal of Clinical Investigation | 1983 |
Canine renal receptors for parathyroid hormone. Down-regulation in vivo by exogenous parathyroid hormone
CA Mahoney, RA Nissenson |
Journal of Clinical Investigation | 1983 |
Proceedings of the 1982 Laurentian Hormone Conference
L Sokoloff |
Proceedings of the 1982 Laurentian Hormone Conference | 1983 |
Extracellular calcium is not necessary for acute, low calcium- or dopamine-stimulated PTH secretion in dispersed bovine parathyroid cells
EM Brown, EJ Watson, R Leombruno, RH Underwood |
Metabolism | 1983 |
Assay of Calcium-regulating Hormones
DD Bikle |
1983 | |
Handbook of Renal Therapeutics
M Martínez-Maldonado |
1983 | |
Regulation of parathyroid hormone secretion in vitro and in vivo
JA Fischer, JW Blum, W Born, MA Dambacher, DW Dempster |
Calcified Tissue International | 1982 |
Parathyroid function in persistent hyperparathyroidism: Relationship to gland size
DA McCarron, RS Muther, B Lenfesty, WM Bennett |
Kidney International | 1982 |
PARATHYROID SUPPRESSIBILITY IN HYPERPARATHYROIDISM DUE TO CHRONIC RENAL FAILURE: STUDIES WITH AUTOTRANSPLANTED PARATHYROID TISSUE
W Born, MA Dambacher, A Meyrier, R Ardaillou, JA Fischer |
Clinical Endocrinology | 1982 |
Disorders of Mineral Metabolism
RK Rude, FR Singer |
Disorders of Mineral Metabolism | 1982 |
Effects of Hepatectomy, Nephrectomy, and Nephrectomy/Uremia on the Metabolism of Parathyroid Hormone in the Rat
GV Segre, P D'Amour, A Hultman, JT Potts |
Journal of Clinical Investigation | 1981 |
EFFECTS OF VALPROIC ACID, NALOXONE AND HYDROCORTISONE IN NELSON'S SYNDROME AND CUSHING'S DISEASE
AN Elias, G Gwinup, LJ Valenta |
Clinical Endocrinology | 1981 |
Recent advances in parathyroid hormone research
JF Habener |
Clinical Biochemistry | 1981 |
Abnormal calcium-regulated PTH release in normal parathyroid tissue from patients with adenoma
EM Brown, RE Wilson, JG Thatcher, SP Marynick |
The American Journal of Medicine | 1981 |
Parathyroid hormone: A Laboratory Test not Just for Endocrinologists
CD Hawker, FP Bella |
The International Journal of Artificial Organs | 1981 |
Specific cleavage of bovine parathyroid hormone catalyzed by an endopeptidase from bovine kidney
RE Botti, E Heath, AL Frelinger, J Chuang, BA Roos, JE Zull |
The Journal of biological chemistry | 1981 |
In vitro perifusion for the study of parathyroid hormone secretion: Effects of extracellular calcium concentration and beta-adrenergic regulation on bovine parathyroid hormone secretion in vitro
DA Hanley, K Takatsuki, ME Birnbaumer, AB Schneider, LM Sherwood |
Calcified Tissue International | 1980 |
STUDIES OF CIRCULATING PARATHYROID HORMONE IN MAN USING A HOMOLOGOUS AMINO-TERMINAL SPECIFIC IMMUNORADIOMETRIC ASSAY
SE Papapoulos, RM Manning, GN Hendy, IG Lewin, JL O'riordan |
Clinical Endocrinology | 1980 |
Human Parathyroid Hormone: Antibody Characterization
R Hehrmann, JP Nordmeyer, H Mohr, RD Hesch |
Journal of Immunoassay | 1980 |
Hormonal derangements in uremia
G Tolis, D Goltzman, H Guyda, T Mountokalakis, S Pritchard, D Hollomby, J Seely, N Sevastos, S Voudiklaris |
Journal of Endocrinological Investigation | 1980 |
Phosphate and Minerals in Health and Disease
SG Massry, E Ritz, H Jahn |
1980 | |
Klinische Osteologie · A
BA Ashton, HF DeLuca, HJ Dulce, IM Evans, PP Fietzek, HM Frost, LS Galante, JG Ghazarian, HG Haas, JF Habener, F Heuck, CJ Hillyard, H Höhling, KH Knese, J Knop, T Lauffenburger, C Lentner, I MacIntyre, R Montz, BE Nordin, AJ Olah, JA Parsons, G Pfleiderer, JT Potts, WG Robertson, RK Schenk, K Vanselow, K zum Winkel, JM Zanelli, F Kuhlencordt, H Bartelheimer |
1980 | |
Analysis of Parathyroid Hormone and Its Fragments in Rat Tissues CHEMICAL IDENTIFICATION AND MICROSCOPICAL LOCALIZATION
P D'Amour, GV Segre, SI Roth, JT Potts |
Journal of Clinical Investigation | 1979 |
Calcium-regulated parathyroid hormone release in primary hyperparathyroidism
EM Brown, DG Gardner, MF Brennan, SJ Marx, AM Spiegel, MF Attie, RW Downs, JL Doppman, GD Aurbach |
The American Journal of Medicine | 1979 |
The Peripheral Metabolism of Parathyroid Hormone
KJ Martin, KA Hruska, JJ Freitag, S Klahr, E Slatopolsky |
New England Journal of Medicine | 1979 |
Selective Uptake of the Synthetic Amino Terminal Fragment of Bovine Parathyroid Hormone by Isolated Perfused Bone
KJ Martin, JJ Freitag, MB Conrades, KA Hruska, S Klahr, E Slatopolsky |
Journal of Clinical Investigation | 1978 |
Responsiveness of neoplastic and hyperplastic parathyroid tissues to calcium in vitro
JF Habener |
Journal of Clinical Investigation | 1978 |
Direct release of parathyroid hormone fragments from functioning bovine parathyroid glands in vitro
DA Hanley, K Takatsuki, JM Sultan, AB Schneider, LM Sherwood |
Journal of Clinical Investigation | 1978 |
Internal medicine-epitomes of progress: clinically applicable radioimmunoassays of parathyroid hormone
CD Arnaud |
The Western journal of medicine | 1978 |
The heterogeneity of radioiod noted parathyroid hormone in rat plasma
PQ Barrett, AP Teitelbaum, WF Neuman |
Metabolic Bone Disease and Related Research | 1978 |
Secondary Hyperparathyroidism in Chronic Renal Failure: Pathophysiology and Treatment
DA Hanley, LM Sherwood |
Medical Clinics of North America | 1978 |