Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

The effects of gastrin, gastric inhibitory polypeptide, secretin, and the octapeptide of cholecystokinin upon immunoreactive somatostatin release by the perfused canine pancreas.
E Ipp, … , W Vale, R H Unger
E Ipp, … , W Vale, R H Unger
Published November 1, 1977
Citation Information: J Clin Invest. 1977;60(5):1216-1219. https://doi.org/10.1172/JCI108875.
View: Text | PDF
Research Article Article has an altmetric score of 3

The effects of gastrin, gastric inhibitory polypeptide, secretin, and the octapeptide of cholecystokinin upon immunoreactive somatostatin release by the perfused canine pancreas.

  • Text
  • PDF
Abstract

The effects of gastrin, gastric inhibitory polypeptide, secretin, and the octapeptide of pancreozymin-cholecystokinin on immunoreactive somatostatin release were studied in the isolated perfused dog pancreas. Gastrin at a concentration of 65 ng/ml and the octapeptide of pancreozymin-cholecystokinin at a concentration of 25 ng/ml produced a prompt, but transient statistically significant, twofold rise in mean somatostatin concentration. Secretion at a concentration of 0.3 U/ml and gastric inhibitory polypeptide concentration of 58 ng/ml produced a prompt two- to threefold rise in mean somatostatin release, which persisted throughout the perfusion period. With all four polypeptides the pattern of the somatostatin response resembled that of insulin. It appears that pancreatic somatostatin release is stimulated by gastrointestinal hormones that influence the secretion of insulin and glucagon.

Authors

E Ipp, R E Dobbs, V Harris, A Arimura, W Vale, R H Unger

×

Total citations by year

Year: 2017 2014 2012 2011 2010 2009 2008 2005 2003 1997 1996 1995 1994 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 1979 1978 1964 Total
Citations: 2 1 1 1 2 2 1 1 1 1 3 1 2 3 2 4 2 4 5 3 3 4 2 8 6 6 6 1 78
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (78)

Title and authors Publication Year
GIP(3–30)NH 2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release
AH Sparre-Ulrich, MN Gabe, LS Gasbjerg, CB Christiansen, B Svendsen, B Hartmann, JJ Holst, MM Rosenkilde
Biochemical Pharmacology 2017
Somatostatin: One of the Rare Multifunctional Inhibitors of Mammalian Species
J Morisset
Pancreas 2017
Comprehensive Physiology
SN Cheuvront, RW Kenefick
Comprehensive Physiology 2014
Physiology of the Gastrointestinal Tract, Two Volume Set
PR Kiela, JF Collins, FK Ghishan
Physiology of the Gastrointestinal Tract, Two Volume Set 2012
Sulfated gastrin stimulates ghrelin and growth hormone release but inhibits insulin secretion in cattle
H Zhao, S YanNaing, S ThanThan, H Kuwayama
Peptides 2011
Control of Somatostatin (SS) Secretion by CCK-1 and CCK-2 Receptors' Occupation in RIN-14B Cells, a Rat Pancreatic Islet Cell Line
K El-Kouhen, J Morisset
Pancreas 2010
Vitamins & Hormones
KJ Hare, FK Knop
Vitamins & Hormones 2010
Cholecystokinin and Somatostatin Negatively Affect Growth of the Somatostatin-RIN-14B Cells
K El-Kouhen, J Morisset
International Journal of Endocrinology 2009
Galanin potentiates supramaximal caerulein-stimulated pancreatic amylase secretion via its action on somatostatin secretion
SG Barreto, CJ Carati, AC Schloithe, J Toouli, GT Saccone
AJP Gastrointestinal and Liver Physiology 2009
Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas
J de Heer, C Rasmussen, DH Coy, JJ Holst
Diabetologia 2008
Association between Endocrine Pancreas and Ductal System. More than an Epiphenomenon of Endocrine Differentiation and Development?
E Bertelli, M Bendayan
Journal of Histochemistry & Cytochemistry 2005
Localization of cholecystokinin receptor subtypes in the endocine pancreas
J Morisset, S Julien, J Lainé
Journal of Histochemistry & Cytochemistry 2003
The somatostatin receptor-adenylate cyclase system in rat pancreatic acinar membranes after temporary pancreaticobiliary duct ligation
E Rodríguez-Martín, I Álvaro-Alonso, G Bodega, E Arilla
Life Sciences 1997
Cholecystokinin, neuropeptide Y and galanin modulate the release of pancreatic somatostatin-25 and somatostatin- 14 in vitro
CD Eilertson, NM Carneiro, JD Kittilson, C Comley, MA Sheridan
Regulatory Peptides 1996
Presynaptic modulation by VIP, secretin and isoproterenol of somatostatin release from enriched enteric synaptosomes: role of cAMP
M Kurjak, V Schusdziarra, HD Allescher
European Journal of Pharmacology 1996
Lactational changes in the rat exocrine pancreas somatostatin receptors and modulation of guanylate cyclase
E Rodríguez-Martín, G Muñoz-Acedo, C García-Escribano, M Rodríguez-Puyol, E Arilla
Biochimica et Biophysica Acta 1996
Insulinotropic effects of cholecystokinin, gastric inhibitory polypeptide and glucagon-like peptide-1 during perifusion of short-term cultured canine isolated islets
MP van der Burg, OR Guicherit, M Frölich, HG Gooszen
Regulatory Peptides 1995
The effect of pentagastrin on the somatostatin receptor/effector system in rat pancreatic acinar membranes
I Alvaro-Alonso, G Muñoz-Acedo, E Arilla
Regulatory Peptides 1994
Intracellular Ca2+ signals in human-derived pancreatic somatostatin-secreting cells (QGP-1N)
PE Squires, B Amiranoff, MJ Dunne
Pflügers Archiv - European Journal of Physiology 1994
Effects of pancreastatin and chromogranin A on insulin release stimulated by various insulinotropic agents
J Ishizuka, K Tatemoto, DV Cohn, JC Thompson, GH Greeley
Regulatory Peptides 1991
Role of cholecystokinin in the control of gastric somatostatin in the rat: in vivo and in vitro studies
R Eissele, I Koop, M Schaar, H Koop, R Arnold
Regulatory Peptides 1991
Helodermin and islet hormone release in isolated rat pancreas
HC Fehmann, R Göke, B Göke, R Eissele, R Arnold
International Journal of Gastrointestinal Cancer 1991
Role of gastrin and cholecystokinin in the growth-promoting action of bombesin on the gastroduodenal mucosa and the pancreas
A Dembiński, PK Konturek, SJ Konturek
Regulatory Peptides 1990
Insulin
P Cuatrecasas, S Jacobs
Insulin 1990
Responses of the pancreatic A cell during hypoglycemia and hyperglycemia are dependent on the B cell
DK McCulloch, PK Raghu, DJ Koerker, JP Palmer, LJ Klaff
Metabolism 1989
Cholecystokinin in the entero-insular axis
Y Okabayashi, M Otsuki, S Baba
Diabetes Research and Clinical Practice 1989
Paradoxical effects of endogenous and exogenous insulin on amino acid transport activity in the isolated rat pancreas: somatostatin-14 inhibits insulin action
PS Norman, Y Habara, GE Mann
Diabetologia 1989
Somatostatin inhibits the effect of secretin on bile flow and on hepatic bilirubin transport in the rat
GL Ricci, J Fevery
Gut 1989
Immunoextracted calcitonin in human gastric secretion
E Bucht, O Wisén, B Granberg, HE Sjöberg
Peptides 1988
The Pathology of the Endocrine Pancreas in Diabetes
PJ Lefèbvre, DG Pipeleers
1988
Gastrointestinal peptides and insulin secretion
R Ebert, W Creutzfeldt
Diabetes / Metabolism Reviews 1987
Somatostatin
SR Bloom, JM Polak
British medical journal (Clinical research ed.) 1987
Cholecystokinin (CCK8) regulates glucagon, insulin, and somatostatin secretion from isolated rat pancreatic islets: interaction with glucose
EJ Verspohl, HP Ammon
Pflügers Archiv - European Journal of Physiology 1987
Exocrine secretion of pancreatic hormones: possible mechanisms
PM Pour, RE Hauser
International Journal of Gastrointestinal Cancer 1987
Functional receptors for VIP, GIP, Glucagon-29 and -37 in the HGT-1 human gastric cancer cell line
S Emami, E Chastre, H Bodéré, C Gespach, D Bataille, G Rosselin
Peptides 1986
Somatostatin: A peptide with unexpected physiologic activities
P Brazeau
The American Journal of Medicine 1986
Secretin and its C-terminal hexapeptide potentiates insulin release in mouse islets
H Kofod, B Hansen, A Lernmark, CJ Hedeskov
American journal of physiology. Endocrinology and metabolism 1986
Pathogenesis and Treatment of Diabetes Mellitus
JK Radder, HH Lemkes, HM Krans
1986
Pancreatic polypeptide in somatostatinoma
D Pinsard, S Odent, D Chadenas
Digestive Diseases and Sciences 1986
Somatostatin and intestinal calcium transport in the rat
G Rümenapf, E Hessdörfer, PO Schwille
Regulatory Peptides 1985
Modulation of motilin-induced somatostatin release in dogs by naloxone
R Schick, V Schusdziarra
Peptides 1985
Effects of Atropine on Gip-Induced Insulin and Pancreatic Polypeptide Release in Man
PF Amland, R Jorde, PG Burhol, KE Giercksky
Scandinavian Journal of Gastroenterology 1985
Contribution of the pancreas to circulating somatostatin-like immunoreactivity in the normal dog
GJ Taborsky, JW Ensinck
Journal of Clinical Investigation 1984
Regulation of somatostatin secretion in man: Study of the role of free fatty acids and ketone bodies
M Beylot, JA Chayvialle, JP Riou, JC Souquet, G Sautot, R Cohen, R Mornex
Metabolism 1984
Effect of caerulein administration on portal plasma somatostatin in dogs
J Kasanuki, S Fujimoto, H Marino, A Kanatsuka, T Imaizumi, H Koseki, R Kaneko, Y Tokumasa, S Yoshida
Gastroenterologia Japonica 1984
Immunocytochemical localization of glucagonlike and gastric inhibitory polypeptidelike peptides in the pancreatic islets and gastrointestinal tract
PH Smith
American Journal of Anatomy 1983
Hypogastrinemia in streptozotocin diabetes with islet transplantation-reconstitution
PJ Fabri, CJ Weber, WR Gower, K Reemtsma
Journal of Surgical Research 1983
Somatostatin-like immunoreactivity in pancreatic extracts of a sahelian lizard (varanus exanthematicus) during starvation
M Dupé-Godet, Y Adjovi
Comparative Biochemistry and Physiology Part A: Physiology 1983
Comparison of somatostatin distribution in pancreatic duct ligated rats and streptozotocin diabetic rats
W Lee, H Wakasugi, H Ibayashi
Gastroenterologia Japonica 1983
Peripherally administered somatostatin reduces feeding by a vagal mediated mechanism
AS Levine, JE Morley
Pharmacology Biochemistry and Behavior 1982
Effects of chronic administration of somatostatin on rat exocrine pancreas
J Morisset, P Génik, A Lord, TE Solomon
Regulatory Peptides 1982
Wirkung von Caerulein auf Blutglukose, Seruminsulin, Glucagon, Prolaktin und Wachstumshormon vor und während einer oralen Glukosebelastung bei Gesunden und Diabetikern
R Landgraf, T Eversmann, MM Landgraf-Leurs
Klinische Wochenschrift 1981
Secretory effects of gastric inhibitory polypeptide on the isolated perfused porcine pancreas
SL Jensen, JJ Holst, OV Nielsen, KB Lauritsen
Acta Physiologica Scandinavica 1981
The milieu interieur and the islets of Langerhans
RH Unger
Diabetologia 1981
Somatostatin and diabetes
JE Gerich
The American Journal of Medicine 1981
The milieu interieur and the islets of Langerhans
RH Unger
Diabetologia 1981
Pancreatic somatostatin secretion is suppressed by splanchnic nerve stimulation
MW Roy, MS Jones, RE Miller
Diabetologia 1981
Somatostatin inhibition of basal and carbachol-stimulated gastrin release in rat antral organ culture
RF Harty, DG Maico, JE McGuigan
Gastroenterology 1981
Effects of two cholecystokinin variants, CCK-39 and CCK-8, on basal and stimulated insulin secretion
B Ahrén, I Lundquist
Acta Diabetologica 1981
Selective inhibition by somatostatin of cyclic AMP production in rat gastric glands
C Gespach, C Dupont, D Bataille, G Rosselin
FEBS Letters 1980
Progress in Hormone Biochemistry and Pharmacology
M Briggs, A Corbin
1980
The Entero-insular Axis and the Metabolic Effects of Gastro-enteropancreatic Polypeptides
J Dupré
1980
Somatostatin and the Gastrointestinal Tract
R Arnold, P Lankisch
1980
Gastric Inhibitory Polypeptide
R Ebert, W Creutzfeldt
1980
Secretion of somatostatin from the normal and diabetic pancreas: Studies in vitro
K Hermansen
Diabetologia 1980
Discrepancies between the Doses of Cholecystokinin or Caerulein-Stimulating Exocrine and Endocrine Responses in Perfused Isolated Rat Pancreas
M Otsuki, C Sakamoto, H Yuu, M Maeda, S Morita, A Ohki, N Kobayashi, K Terashi, K Okano, S Baba
Journal of Clinical Investigation 1979
Effect of 24-Hour Somatostatin Infusion on Glucose Homeostasis and on the Levels of Somatomedin A and Pancreatic and Thyroid Hormones in Man
PE Lins, S Efendic, K Hall
Acta Medica Scandinavica 1979
Evidence for a regulatory role of the stomach in islet cell function
V Schusdziarra, D Rouiller, RH Unger
Life Sciences 1979
Characterization of immunoreactive components of insulin and somatostatin in canine pancreatic juice
JM Conlon, D Rouiller, G Boden, RH Unger
FEBS Letters 1979
Characterization of somatostatin release from the pancreas: the role of potassium
K Hermansen, SE Christensen, H Ørskov
Scandinavian Journal of Clinical & Laboratory Investigation 1979
Characterisation of somatostatin release from the pancreas: The role of calcium and acetylcholine
K Hermansen, SE Christensen, H rskov
Diabetologia 1979
Pancreatic and Gastric Somatostatin Release in Response to Intragastric and Intraduodenal Nutrients and HCl in the Dog
V Schusdziarra, V Harris, JM Conlon, A Arimura, R Unger
Journal of Clinical Investigation 1978
Properties of endogenous somatostatin-like immunoreactivity and synthetic somatostatin in dog plasma
JM Conlon, CB Srikant, E Ipp, V Schusdziarra, W Vale, RH Unger
Journal of Clinical Investigation 1978
Vasoactive intestinal peptide stimulates pancreatic somatostatin release
E Ipp, RE Dobbs, RH Unger
FEBS Letters 1978
Somatostatin release from isolated perfused rat stomach
T Chiba, Y Seino, Y Goto, S Kadowaki, T Taminato, H Abe, Y Kato, S Matsukura, M Nozawa, H Imura
Biochemical and Biophysical Research Communications 1978
Studies of the physiology and pathophysiology of the pancreatic D cell
V Schusdziarra, E Ipp, V Harris, RE Dobbs, P Raskin, L Orci, RH Unger
Metabolism 1978
Somatostatin and Diabetes
RA Rizza, JE Gerich
Medical Clinics of North America 1978
Advances in Metabolic Disorders
G Aurbach, JT Potts
Advances in Metabolic Disorders 1964

← Previous 1 2 3 4 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 1 Wikipedia pages
6 readers on Mendeley
See more details