The Number of Glycine Residues Which Limits Intact Absorption of Glycine Oligopeptides in Human Jejunum

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Abstract

Studies were performed to determine whether glycine peptides of four or more glycine residues can be transported by the peptide carrier system, previously shown to transport diglycine and triglycine. When human jejunum was perfused with tetraglycine solutions, the rate of tetraglycine disappearance increased linearly as the concentration was increased over the range of 12.5-50 mM, however, the rate was slow in comparison to diglycine and triglycine disappearance rates.

Authors

Siamak A. Adibi, Emile L. Morse