Citations to this article

The Number of Glycine Residues Which Limits Intact Absorption of Glycine Oligopeptides in Human Jejunum
Siamak A. Adibi, Emile L. Morse
Siamak A. Adibi, Emile L. Morse
Published November 1, 1977
Citation Information: J Clin Invest. 1977;60(5):1008-1016. https://doi.org/10.1172/JCI108851.
View: Text | PDF
Research Article Article has an altmetric score of 1

The Number of Glycine Residues Which Limits Intact Absorption of Glycine Oligopeptides in Human Jejunum

Abstract

Studies were performed to determine whether glycine peptides of four or more glycine residues can be transported by the peptide carrier system, previously shown to transport diglycine and triglycine. When human jejunum was perfused with tetraglycine solutions, the rate of tetraglycine disappearance increased linearly as the concentration was increased over the range of 12.5-50 mM, however, the rate was slow in comparison to diglycine and triglycine disappearance rates.

Authors

Siamak A. Adibi, Emile L. Morse

×

Total citations by year

Year: 2020 2019 2011 2010 2009 2008 2007 2006 2004 2002 1996 1994 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1980 1979 1962 Total
Citations: 1 1 1 1 1 2 1 2 1 3 4 3 1 5 1 3 3 1 6 5 2 4 3 2 4 1 62
Citation information

Citations to this article (62)

Title and authors Publication Year
Key transporters leading to specific protoporphyrin IX accumulation in cancer cell following administration of aminolevulinic acid in photodynamic therapy/diagnosis
HW Lai, T Nakayama, S Ogura 		International Journal of Clinical Oncology 2020
Transport Versus Hydrolysis: Reassessing Intestinal Assimilation of Di‐ and Tripeptides by LC–MS/MS Analysis
F Rohm, H Daniel, B Spanier 		Molecular Nutrition & Food Research 2019
Efficacy of a Fish Protein Hydrolysate in Malnourished Children
KO Nesse, AP Nagalakshmi, P Marimuthu, M Singh 		Indian Journal of Clinical Biochemistry 2011
Desempenho de frangos de corte alimentados com ingrediente de alta digestibilidade nas fases de criação pré-inicial e inicial
HM Dallmann, VS de Avila, PA de Brum, PT Costa, A Coldebella, PR Dallmann, JC Maier, F Rutz 		Pesquisa Agropecuária Brasileira 2010
Protein hydrolysates in sports nutrition
AH Manninen 		Nutrition & Metabolism 2009
Milk Proteins
T Considine, J Flanagan 		Milk Proteins 2008
The angiotensin converting enzyme inhibitory tripeptides Ile-Pro-Pro and Val-Pro-Pro show increasing permeabilities with increasing physiological relevance of absorption models
M Foltz, A Cerstiaens, A Meensel, R Mols, PC van der Pijl, GS Duchateau, P Augustijns 		Peptides 2008
Angiotensin Converting Enzyme Inhibitory Peptides from a Lactotripeptide-Enriched Milk Beverage Are Absorbed Intact into the Circulation
M Foltz, EE Meynen, V Bianco, C van Platerink, TM Koning, J Kloek 		The Journal of nutrition 2007
Amino Acid Absorption in Portal Blood After Duodenal Infusions of a Soy Protein Hydrolysate Prepared by a Novel Soybean Protease D3
T Kodera, H Hara, Y Nishimori, N Nio 		Journal of Food Science 2006
Physiology of the Gastrointestinal Tract
DJ Drucker 		Physiology of the Gastrointestinal Tract 2006
The intestinal H+/peptide symporter PEPT1: structure–affinity relationships
M Brandsch, I Knütter, FH Leibach 		European Journal of Pharmaceutical Sciences 2004
Absorption of Val–Tyr with in Vitro Angiotensin I-Converting Enzyme Inhibitory Activity into the Circulating Blood System of Mild Hypertensive Subjects
T Matsui, K Tamaya, E Seki, K Osajima, K Matsumoto, T Kawasaki 		Biological & Pharmaceutical Bulletin 2002
Val-Tyr As A Natural Antihypertensive Dipeptide Can Be Absorbed Into The Human Circulatory Blood System
T Matsui, K Tamaya, E Seki, K Osajima, K Matsumoto, T Kawasaki 		Clinical and Experimental Pharmacology and Physiology 2002
Protein Delivery
LM Sanders, RW Hendren 		2002
The intestinal peptide carrier: A potential transport system for small peptide derived drugs
E Walter, T Kissel, GL Amidon 		Advanced Drug Delivery Reviews 1996
Prodrugs of peptides and peptidomimetics for improved formulation and delivery
R Oliyai 		Advanced Drug Delivery Reviews 1996
Structural requirements for intestinal absorption of peptide drugs
GM Pauletti, S Gangwar, GT Knipp, MM Nerurkar, FW Okumu, K Tamura, TJ Siahaan, RT Borchardt 		Journal of Controlled Release 1996
Angiotensin I Converting Enzyme Inhibitory Peptides Generated from Oligopeptides by Intestinal Mucosa Peptidases
E SEKI, K OSAJIMA, H MATSUFUJI, T MATSUI, Y OSAJIMA 		Journal of the agricultural chemical society of Japan 1996
Substrate specificity of the di/tripeptide transporter in human intestinal epithelia (Caco-2): identification of substrates that undergo H(+)-coupled absorption
DT Thwaites, BH Hirst, NL Simmons 		British Journal of Pharmacology 1994
Substrate specificity of the di/tripeptide transporter in human intestinal epithelia (Caco-2): identification of substrates that undergo H+-coupled absorption
DT Thwaites, BH Hirst, NL Simmons 		British Journal of Pharmacology 1994
Repletion of nutritional parameters in surgical patients receiving peptide versus amino acid elemental feedings
P Donald, E Miller, B Schirmer 		Nutrition Research 1994
(D) Routes of delivery: Case studies
D Harris, JH Liaw, JR Robinson 		Advanced Drug Delivery Reviews 1992
Comporternent de quelques di-, tri- et tétrapeptides vis-à-vis du cuivre(II). Étude en potentiométrie (électrode de cuivre) et en spectrométrie infrarouge
E Lati, C Dauphin, M Hamon 		Analytica Chimica Acta 1991
Peptide and protein drugs: II. Non-parenteral routes of delivery
XH Zhou, AL Po 		International Journal of Pharmaceutics 1991
Physiological Aspects of Digestion and Metabolism in Ruminants
K Olsson, K Dahlborn, BE Karlberg, L Eriksson 		Physiological Aspects of Digestion and Metabolism in Ruminants 1991
Isolation and characterization of circulating low molecular weight peptides in steer, sheep and rat portal and peripheral blood
CJ Seal, DS Parker 		Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 1991
Effect of Simultaneous Ingestion of L-Amino Acids and Whole Protein on Plasma Amino Acid and Urea Nitrogen Concentrations in Humans
SS Gropper, PB Acosta 		JPEN. Journal of parenteral and enteral nutrition 1991
Invited Review: The Nitrogen Source of Elemental Diets—an Unresolved Issue?
GK Grimble, DB Silk 		Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 1990
Peptides in Human Nutrition
GK Grimble, DB Silk 		Nutrition Research Reviews 1989
Characteristics of tripeptide transport in human jejunal brush-border membrane vesicles
D Wilson, JA Barry, K Ramaswamy 		Biochimica et Biophysica Acta (BBA) - Biomembranes 1989
Simultaneous analysis of different species involved in hexaglycine hydrolysis
DS Kalonia, S Musunuri, J Tanglertpaibul 		Journal of Chromatography A 1989
Praxis der parenteralen und enteralen Ernährung in der Chirurgie
M Heberer, B Günther 		1988
Wahl der Nahrungsproteine—Grundlagen und Diätetik
CA Barth, P Fürst 		1988
Specificity and mechanism of influence of amino acid residues on hepatic clearance of oligopeptides
YB Lombardo, EL Morse, SA Adibi 		The Journal of biological chemistry 1988
Effect of peptide chain length on absorption of egg protein hydrolysates in the normal human jejunum
GK Grimble, RG Rees, PP Keohane, T Cartwright, M Desreumaux, DB Silk 		Gastroenterology 1987
The transport of an intact oligopeptide across adult mammalian jejunum
K Takaori, J Burton, M Donowitz 		Biochemical and Biophysical Research Communications 1986
Peptides and Related Drugs: A Review of Their Absorption, Metabolism, and Excretion
MJ Humphrey, PS Ringrose 		Drug Metabolism Reviews 1986
Kinetics and Characteristics of Absorption From an Equimolar Mixture of 12 Glycyl-Dipeptides in Human Jejunum
HJ Steinhardt, SA Adibi 		Gastroenterology 1986
Small-Bowel Transplantation
E Deltz, A Thiede, H Hamelmann 		1986
Targeting of Drugs With Synthetic Systems
G Gregoriadis, J Senior, G Poste 		1986
Delivery Systems for Peptide Drugs
SS Davis, L Illum, E Tomlinson 		1986
Assimilation of alpha-glutamyl-peptides by human erythrocytes. A possible means of glutamate supply for glutathione synthesis
GF King, PW Kuchel 		Biochemical Journal 1985
The assimilation of tri- and tetrapeptides by human erythrocytes
JI Vandenberg, GF King, PW Kuchel 		Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1985
Influence of protein composition and hydrolysis method on intestinal absorption of protein in man
PP Keohane, GK Grimble, B Brown, RC Spiller, DB Silk 		Gut 1985
Protein digestion and amino acid and peptide absorption
DB Silk, GK Grimble, RG Rees 		Proceedings of the Nutrition Society 1985
Grundlagen und Klinik der enteralen Ernährung
FW Ahnefeld, A Grünert 		1985
Synthesis of analogs and oligomers of N-(2-aminoethyl)glycine and their gastrointestinal absorption in the rat
EP Heimer, HE Gallo-Torres, AM Felix, M Ahmad, TJ LamBros, F Scheidl, J Meienhofer 		International Journal of Peptide and Protein Research 1984
Pharmacology of Intestinal Permeation I
TZ Csáky 		1984
Intestinal assimilation of a proline-containing tetrapeptide. Role of a brush border membrane postproline dipeptidyl aminopeptidase IV
A Morita, YC Chung, HJ Freeman, RH Erickson, MH Sleisenger, YS Kim 		Journal of Clinical Investigation 1983
Current Topics in Membranes and Transport
J Gliemann, WD Rees 		Current Topics in Membranes and Transport 1983
Dünndarm A
F Bazzoli, R Böhmer, WF Caspary, H Dombrowski, B Eckhardt, B Elsenhans, A Encke, A Ferguson, W Forth, H Fromm, A Gangl, S Gutschmidt, U Hopfer, GJ Kreijs, B Lembcke, KH zum Büschenfelde, G Mödder, G Nell, HF Otto, H Peerenboom, G Rehner, G Rettenmaier, EO Riecken, JW Robinson, K Rommel, H Ruppin, J Seifert, KH Soergel, S Strobel, L Vollrath, R Wanitschke, HJ Weis 		1983
Human Protein Digestion and Absorption: Normal Mechanisms and Protein-energy Malnutrition
HJ Freeman, MA Sleisenger, YS Kim 		1983
A micro-electrode study of oligopeptide absorption by the small intestinal epithelium of Necturus maculosus
CA Boyd, MR Ward 		The Journal of Physiology 1982
Enrichment of glycine pool in plasma and tissues by glycine, di-, tri-, and tetraglycine
SA Adibi, EL Morse 		American journal of physiology. Endocrinology and metabolism 1982
Disorders of Nitrogen Absorption
D Silk 		1982
Digestion and Absorption of Dietary Protein in Man
DB Silk 		Proceedings of the Nutrition Society 1980
Comparison of the absorption of two protein hydrolysates and their effects on water and electrolyte movements in the human jejunum
PD Fairclough, JE Hegarty, DB Silk, ML Clark 		Gut 1980
Intestinal handling of two tetrapeptides by rodent small intestine in vitro
D Burston, E Taylor, DM Matthews 		Biochimica et Biophysica Acta (BBA) - Biomembranes 1979
Protein digestion and absorption in man
HJ Freeman, YS Kim, MH Sleisenger 		The American Journal of Medicine 1979
Protein Digestion and Absorption
HL Bleich, ES Boro, MH Sleisenger, YS Kim 		New England Journal of Medicine 1979
Effect of Amino Acids on Purified Rat Intestinal Brush-Border Membrane Aminooligopeptidase
YS Kim, EJ Brophy 		Gastroenterology 1979
Verhandlungen der Deutschen Gesellschaft für Innere Medizin
B Schlegel 		1962

Advertisement