J. H. Morse, … , J. Lindenbaum, S. I. Morse
Citation Information: J Clin Invest. 1977;60(3):683-692. https://doi.org/10.1172/JCI108820.
J. H. Morse, … , J. Lindenbaum, S. I. Morse
Published September 1, 1977
Citation Information: J Clin Invest. 1977;60(3):683-692. https://doi.org/10.1172/JCI108820.
Abstract
The purified lymphocytosis promoting factor (LPF) from Bordetella pertussis was found to be a potent mitogen for peripheral blood lymphocytes (PBL) from normal adults as well as for cord blood lymphocytes. Proliferation occurred in autologous plasma or fetal calf serum, regardless of previous exposure to pertussis infection or immunization. Only one adult human serum, from a physician constantly working with B. pertussis, inhibited the mitogenic response to LPF and this serum was shown to contain precipitating antibody against LPF. The proliferative effect of LPF was characteristic of a “nonspecific” mitogen and not of antigen stimulation of sensitized cells.
Authors
J. H. Morse, A. S. Kong, J. Lindenbaum, S. I. Morse
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