Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

The Origin of Chylomicron Phosphatidylcholine in the Rat
Charles M. Mansbach II
Charles M. Mansbach II
Published August 1, 1977
Citation Information: J Clin Invest. 1977;60(2):411-420. https://doi.org/10.1172/JCI108790.
View: Text | PDF
Research Article

The Origin of Chylomicron Phosphatidylcholine in the Rat

  • Text
  • PDF
Abstract

This study investigates the pathways of origin of chylomicron phosphatidylcholine (PC) using a lymph- and bile-fistulated rat infused with a stabilized triolein emulsion. [14C-glycerol]PC was used to evaluate chylomicron PC generated by lyso PC acyltransferase. The percentage of chylomicron PC derived from the PC infused was directly proportional to the PC concentration in the infusate. When the infusate PC concentration was 10 mM, essentially all the chylomicron PC was derived therefrom at 4-6 h of infusion. Incorporation of the radiolabel was not found to be as great in the lymph subnatant PC as in chylomicron PC, suggesting that chylomicron and lymph subnatant PC might be supplied from different PC precursor pools.

Authors

Charles M. Mansbach II

×

Total citations by year

Year: 2024 2022 2021 2018 2016 2015 2012 2011 2010 2008 2006 2004 2002 2001 1999 1998 1997 1996 1994 1993 1992 1991 1990 1988 1987 1986 1984 1983 1982 1981 1980 1979 1978 1965 Total
Citations: 1 1 1 2 1 3 1 2 1 1 2 2 1 5 1 1 2 1 3 1 1 2 4 2 3 2 1 1 4 3 3 2 4 1 66
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (66)

Title and authors Publication Year
Sex differences in the association between dietary choline intake and total bone mineral density among adolescents aged 12–19 in the United States
Gong H, Jiang J, Choi S, Huang S
Frontiers in Nutrition 2024
A single-day mouse mesenteric lymph surgery in mice: an updated approach to study dietary lipid absorption, chylomicron secretion, and lymphocyte dynamics.
Dedousis N, Teng L, Kanshana JS, Kohan AB
Journal of lipid research 2022
The Impact of Conjugation Position and Linker Chemistry on the Lymphatic Transport of a Series of Glyceride and Phospholipid Mimetic Prodrugs
S Han, T Quach, L Hu, SF Lim, G Gracia, NL Trevaskis, JS Simpson, CJ Porter
Journal of Pharmaceutical Sciences 2021
Hydrolysis Activity of Pyloric Cecal Enterocytes of Brown Trout ( Salmo trutta ) toward Monoacylglycerol and Lysophosphatidylcholine
K Li, B Egelandsdal, RE Olsen
Lipids 2018
Emerging Issues in Fish Larvae Research
M Yúfera
2018
Control of chylomicron export from the intestine
CM Mansbach, S Siddiqi
AJP Gastrointestinal and Liver Physiology 2016
Gene regulation of lipid and phospholipid metabolism in Atlantic cod (Gadus morhua) larvae
K Li, MA Østensen, K Attramadal, P Winge, T Sparstad, AM Bones, O Vadstein, E Kjørsvik, Y Olsen
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2015
Atlantic cod (Gadus morhua) larvae can biosynthesis phospholipid de novo from 2-oleoyl-glycerol and glycerol precursors
K Li, RE Olsen, MA Østensen, D Altin, E Kjørsvik, Y Olsen
Fish Physiology and Biochemistry 2015
Choline deficiency impairs intestinal lipid metabolism in the lactating rat
RP da Silva, KB Kelly, ED Lewis, KA Leonard, S Goruk, JM Curtis, DF Vine, SD Proctor, CJ Field, RL Jacobs
The Journal of Nutritional Biochemistry 2015
Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz
Protein Engineering for Therapeutics Part B 2012
Dietary methyl-consuming compounds and metabolic syndrome
SS Zhou, YM Zhou, D Li, YZ Lun
Hypertension Research 2011
Different functions of intestinal and liver-type fatty acid-binding proteins in intestine and in whole body energy homeostasis
WS Lagakos, AM Gajda, L Agellon, B Binas, V Choi, B Mandap, T Russnak, YX Zhou, J Storch
AJP Gastrointestinal and Liver Physiology 2011
Favored Reaction Mechanism of Calcium-Dependent Phospholipase A 2 . Insights from Density Functional Exploration
M Leopoldini, N Russo, M Toscano
The Journal of Physical Chemistry B 2010
Dietary phosphatidylcholine affects postprandial plasma levels and digestibility of lipid in common carp ( Cyprinus carpio)
I Geurden, S Kaushik, G Corraze
British Journal of Nutrition 2008
Dietary Fats and Risk of Chronic Disease
V Ziboh, K Vang, B Morrissey, J Weineger, S Naguwa, ME Gershwin, M Watnik
Dietary Fats and Risk of Chronic Disease 2006
Lymphatic chylomicron size is inversely related to biliary phospholipid secretion in mice
A Werner, R Havinga, F Perton, F Kuipers, HJ Verkade
AJP Gastrointestinal and Liver Physiology 2006
Treatment of EFA deficiency with dietary triglycerides or phospholipids in a murine model of extrahepatic cholestasis
A Werner, R Havinga, F Kuipers, HJ Verkade
AJP Gastrointestinal and Liver Physiology 2004
Administration of phosphatidylcholine–cholesterol liposomes partially reconstitutes fat absorption in chronically bile-diverted rats
T Nishioka, R Havinga, S Tazuma, F Stellaard, F Kuipers, HJ Verkade
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2004
Intestinal Absorption and Lymphatic Transport of a High γ-Linolenic Acid Canola Oil in Lymph Fistula Sprague-Dawley Rats
P Tso, K Ding, S DeMichele, YS Huang
The Journal of nutrition 2002
Regulation of intestinal apolipoprotein A-I synthesis by dietary phosphatidylcholine in newborn swine
H Wang, J Du, S Lu, Y Yao, F Hunter, DD Black
Lipids 2001
The intestine expresses pancreatic triacylglycerol lipase: regulation by dietary lipid
JT Mahan, GD Heda, RH Rao, CM Mansbach
AJP Gastrointestinal and Liver Physiology 2001
Intestinal Lipid Metabolism
CM Mansbach, P Tso, A Kuksis
2001
Interfacial Enzymology: The Secreted Phospholipase A 2 -Paradigm
OG Berg, MH Gelb, MD Tsai, MK Jain
Chemical Reviews 2001
Sources of eicosanoid precursor fatty acid pools in tissues
L Zhou, Å Nilsson
Journal of lipid research 2001
Regulation of apolipoprotein secretion by biliary lipids in newborn swine intestinal epithelial cells
H Wang, R Roberson, J Du, JK Eshun, HM Berschneider, DD Black
AJP Gastrointestinal and Liver Physiology 1999
Long-Term Adaptation to High-Fat Diets Modifies the Nature and Output of Postprandial Intestinal Lymph Fatty Acid in Rats
P Degrace, C Caselli, A Bernard
The Journal of nutrition 1998
Dietary lipids influence the activity of Δ 5 -desaturase and phospholipid fatty acids in rat enterocyte microsomal membranes
M Keelan, MT Clandinin, AB Thomson
Canadian Journal of Physiology and Pharmacology 1997
Intestinal absorption of essential fatty acids under physiological and essential fatty acid-deficient conditions
DM Minich, RJ Vonk, HJ Verkade
Journal of lipid research 1997
Drugs Affecting Lipid Metabolism
AM Gotto, R Paoletti, LC Smith, AL Catapano, AS Jackson
1996
Dietary ω3 fatty acids and cholesterol modify enterocyte microsomal membrane phospholipids, cholesterol content and phospholipid enzyme activities in diabetic rats
M Keelan, K Doring, M Tavernini, E Wierzbicki, MT Clandinin, AB Thomson
Lipids 1994
Metabolism of chylomicron phosphatidylinositol in the rat: fate in vivo and hydrolysis with lipoprotein lipase and hepatic lipase in vitro
A Nilsson, Q Chen, E Dahlman
Journal of lipid research 1994
Interconversion of alpha-linolenic acid in rat intestinal mucosa: studies in vivo and in isolated villus and crypt cells
Q Chen, A Nilsson
Journal of lipid research 1994
Absorption and distribution of arachidonate in rats receiving lysophospholipids by oral route
G Viola, L Mietto, FE Secchi, L Ping, A Bruni
Journal of lipid research 1993
Incorporation of dietary [14C]arachidonic acid and [3H]eicosapentaenoic acid into tissue lipids during absorption of a fish oil emulsion
A Nilsson, L Hjelte, B Strandvik
Journal of lipid research 1992
Similarities in surface lipids of chylomicrons from glyceryl and alkyl ester feeding: Major components
LY Yang, A Kuksis, JJ Myher
Lipids 1991
Transport of lipophilic molecules by the intestinal lymphatic system
WN Charman, VJ Stella
Advanced Drug Delivery Reviews 1991
Intestinal absorption and plasma transport of dietary triglyceride and phosphatidylcholine in the carp (Cyprinus carpio)
I Noriaki, A Satoshi, M Mitsumasa, K Mitsu
Comparative Biochemistry and Physiology Part A: Physiology 1990
Phospholipases: Old Enzymes With New Meaning
CM Mansbach
Gastroenterology 1990
Hydrolysis of Phosphatidylinositol by Human Pancreatic Phospholipase A 2
H Barros, B Sternby, Å Nilsson
Scandinavian Journal of Gastroenterology 1990
Phospholipids
I Hanin, G Pepeu
1990
Rat intestinal apolipoprotein B gene expression. Evidence for integrated regulation by bile salt, fatty acid, and phospholipid flux
NO Davidson, MJ Drewek, JI Gordon, J Elovson
Journal of Clinical Investigation 1988
Plasma apolipoprotein A-I levels and bile lipid secretion during thoracic duct drainage in the rat
Å Nilsson, B Landin, B Johansson
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1988
3 Postprandial lipaemia
JR Patsch
Baillière's Clinical Endocrinology and Metabolism 1987
Journal of Chromatography Library
GM Patton, SJ Robins
Journal of Chromatography Library 1987
Lecithin
I Hanin, GB Ansell
1987
CTP:phosphocholine cytidylyltransferase in intestinal mucosa
CM Mansbach, A Arnold
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1986
Intracolonic WR 2721 protection of the rat colon from acute radiation injury
HG France, RL Jirtle, CM Mansbach
Gastroenterology 1986
Utilization of individual lecithins in intestinal lipoprotein formation in the rat
GM Patton, SB Clark, JM Fasulo, SJ Robins
Journal of Clinical Investigation 1984
Incorporation of radioactive phospholipid into subclasses of high-density lipoproteins
AR Tall, CB Blum, SM Grundy
American journal of physiology. Endocrinology and metabolism 1983
Intestinal phospholipase, a novel enzyme
CM 2nd, G Pieroni, R Verger
Journal of Clinical Investigation 1982
Studies on fat digestion, absorption, and transport in the suckling rat. III. Composition of bile and evidence for enterohepatic circulation of bile salts
JE Staggers, SC Frost, MA Wells
Journal of lipid research 1982
A re-examination of the fate of glyceride-glycerol in neutral lipid absorption and transport
CM nd, S Parthasarathy
Journal of lipid research 1982
Intestinal absorption of polyenephosphatidylcholine in man
O Zierenberg, SM Grundy
Journal of lipid research 1982
Role of biliary phosphatidylcholine in the absorption and transport of dietary triolein in the rat
P Tso, H Kendrick, JA Balint, WJ Simmonds
Gastroenterology 1981
Intestinal lipoprotein metabolism
PH Green, RM Glickman
Journal of lipid research 1981
Nutritional effects on blood lipid and HDL cholesterol concentrations in two subspecies of African green monkeys (Cercopithecus aethiops)
LL Rudel, JA Reynolds, BC Bullock
Journal of lipid research 1981
Phosphatidylcholine synthesis in the developing small intestine
PG Holtzapple, CM Starr, T Morck
Biochemical Journal 1980
The contribution of serum phosphatidylcholine and lysophosphatidylcholine to lymph phosphatidylcholine
M Steere, CM Mansbach
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1980
Studies on plasma lipoproteins during absorption of exogenous lecithin in man
FU Beil, SM Grundy
Journal of lipid research 1980
Lipid absorption and metabolism
A Kuksis, NA Shaikh, AG Hoffman
Environmental Health Perspectives 1979
Regulation of de novo phosphatidylcholine synthesis in rat intestine
CM nd, S Parthasarathy
The Journal of biological chemistry 1979
The importance of the lysophosphatidylcholine and choline moiety of bile phosphatidylcholine in lymphatic transport of fat
P Tso, J Lam, WJ Simmonds
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1978
Intestinal Lymph Chylomicron Cholesteryl Ester During Duodenal Triolein Infusion at Increasing Rate
SB Clark, KR Norum
Scandinavian Journal of Gastroenterology 1978
Relationship between High Density Lipoproteins and the Rate of In Vitro Serum Cholesterol Esterification
LA Soloff, KG Varma
Scandinavian Journal of Clinical & Laboratory Investigation 1978
Chylomicron composition during duodenal triglyceride and lecithin infusion
SB Clark
American journal of physiology. Endocrinology and metabolism 1978
Advances in Lipid Research
AM Scanu
Advances in Lipid Research 1965

← Previous 1 2 3 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts