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Glucagon and Insulin Binding to Liver Membranes in a Partially Nephrectomized Uremic Rat Model
Vijay Soman, Philip Felig
Vijay Soman, Philip Felig
Published July 1, 1977
Citation Information: J Clin Invest. 1977;60(1):224-232. https://doi.org/10.1172/JCI108759.
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Research Article

Glucagon and Insulin Binding to Liver Membranes in a Partially Nephrectomized Uremic Rat Model

Abstract

To investigate the role of glucagon and insulin receptor binding in the glucagon hypersensitivity and insulin resistance which characterize the glucose intolerance of uremia, liver plasma membranes were prepared from control rats (blood urea nitrogen [BUN] 15±1 mg/100 ml, creatinine 0.7±0.2 mg/100 ml), and from 70% nephrectomized rats (BUN 30±2 mg/100 ml, creatinine 2.2±0.2 mg/100 ml), and from 90% nephrectomized rats (BUN 46±3 mg/100 ml, creatinine 4.20±0.7 mg/100 ml), 4 wk after surgery. As compared to controls, the 90% nephrectomized rats had significantly higher levels of plasma glucose (95±4 vs. 125±11 mg/100 ml), plasma insulin (28±9 vs. 52±11 μU/ml), and plasma glucagon (28±5 vs. 215±18 pg/ml). Similar, but less marked, elevations were observed in the 70% nephrectomized animals.

Authors

Vijay Soman, Philip Felig

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Year: 2015 1998 1997 1992 1989 1986 1984 1983 1982 1981 1980 1979 1978 1977 1948 Total
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Citations to this article (43)

Title and authors Publication Year
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JD Kopple 		Kidney International 1978
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V Soman, P Felig 		Nature 1978
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