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Citations to this article

Prostaglandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture. Stimulation by angiotensin II, bradykinin, and arginine vasopressin.
R M Zusman, H R Keiser
R M Zusman, H R Keiser
Published July 1, 1977
Citation Information: J Clin Invest. 1977;60(1):215-223. https://doi.org/10.1172/JCI108758.
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Research Article

Prostaglandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture. Stimulation by angiotensin II, bradykinin, and arginine vasopressin.

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Abstract

Rabbit renomedullary interstitial cells were isolated and grown in tissue culture. These cells synthesize 0.8 ng of prostaglandin E2 (PGE2) per microgram cellular protein per hour in monolayer tissue culture; prostaglandins A2 and F2alpha (PGA2 and PGF2alpha) biosynthesis was 10 and 5% of PGE2 biosynthesis, respectively. Arachidonic acid markedly stimulated the production of PGE2 and PGF2alpha, with conversion rates of 0.24 and 0.02%/h, respectively. Angiotensin II, hyperosmolality, bradykinin, and arginine vasopressin each stimulated PGE2 biosynthesis; maximum stimulation was 20, 3.7, 3.6, and 3.2 times basal production, respectively. PGE2 biosynthesis by the renomedullary interstitial cells was inhibited by isoproterenol, potassium, nonsteroidal anti-inflammatory agents (indomethacin, naproxen, ibuprofen, suprofen, meclofenamate, and acetylsalicylic acid), mepacrine (a phospholipase inhibitor), hydrocortisone, and cortisone. The rabbit renomedullary interstitial cell in tissue culture is a model system for the study of hormonal regulation of PGE2 biosynthesis.

Authors

R M Zusman, H R Keiser

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JC Frölich, G Fejes-Toth
Klinische Wochenschrift 1982
SODIUM AND POTASSIUM BALANCE IN THE BRATTLEBORO RAT
S Opava-Stitzer, E Fernández-Repollet, P Stern
Annals of the New York Academy of Sciences 1982
Role of renal prostaglandins during antidiuresis and water diuresis in man
RM Walker, RS Brown, JS Stoff
Kidney International 1982
Ion transport by the cortical and outer medullary collecting tubule
JB Stokes
Kidney International 1982
INTERSTITIAL CELLS IN THE RENAL MEDULLA OF BRATTLEBORO RATS: EFFECTS OF LONG TERM VASOPRESSIN TREATMENT
B Sundelin, SO Bohman
Annals of the New York Academy of Sciences 1982
Actions of angiotensin II on the isolated spontaneously hypertensive rat kidney
TH Steele, JH Gottstein, L Challoner-Hue, JL Underwood
Kidney International 1982
Stimulation of prostaglandin E2 biosynthesis in rat dental pulp explants in vitro by 5-hydroxytryptamine
M Hirafuji, K Terashima, S Satoh, Y Ogura
Archives of Oral Biology 1982
Modulation of prostaglandin of the renal vascular action of arginne vasopressin
JA Oliver, RR Sciacca, GL Cren, PJ Cannon
Prostaglandins 1982
Effect of dietary sodium intake on the metabolism of prostaglandins in the kidney in hypertensive patients
M Sato, K Abe, T Haruyama, M Yasujima, K Sato, S Chiba, Y Imai, M Hiwatari, Y Kasai, J Tajima, S Itoh, M Seino, T Goto, K Yoshinaga
Prostaglandins, Leukotrienes and Medicine 1982
Arachidonic acid metabolism, prostaglandins and the kidney
DJ Levenson, CE Simmons, BM Brenner
The American Journal of Medicine 1982
Disorders of urinary concentration and dilution
RL Jamison, RE Oliver
The American Journal of Medicine 1982
In vitro prostaglandin synthesis by various rat renal preparations
J Sraer, W Siess, L Moulonguet-Doleris, JP Oudinet, F Dray, R Ardaillou
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1982
The involvement of the renin-angiotensin-aldosterone system, the corticotropin-glucocorticoid system, antidiuretic hormone, catecholamines and prostaglandins
M Marin-Grez
Biochemical Pharmacology 1982
Relationship between calcium stimulation of cyclic GMP and lipid peroxidation in the rat kidney: Evidence for involvement of calmodulin and separate pathways of peroxidation in cortex versus inner medulla
PA Craven, FR DeRubertis
Metabolism 1982
Hypertensive Cardiovascular Disease: Pathophysiology and Treatment
A Amery, R Fagard, P Lijnen, J Staessen
1982
Cyclic Nucleotides
JW Kebabian, JA Nathanson
1982
Arterial Hypertension
J Rosenthal
1982
Effects of angiotensin II on phosphatidylinositol and polyphosphoinositide turnover in rat kidney. Mechanism of prostaglandin release
JE Benabe, LA Spry, AR Morrison
The Journal of biological chemistry 1982
Arachidonic acid metabolism in isolated rat aorta. Dependence of prostacyclin biosynthesis on extracellular potassium concentration
R Düsing, R Scherhag, R Tippelmann, U Budde, K Glänzer, HJ Kramer
The Journal of biological chemistry 1982
Participation of the Prostaglandins in the Control of Renal Blood Flow during Acute Reduction of Cardiac Output in the Dog
JA Oliver, RR Sciacca, J Pinto, PJ Cannon
Journal of Clinical Investigation 1981
Prostaglandins and water metabolism: A review with emphasis on in vivo studies
PA Gross, RW Schrier, RJ Anderson
Kidney International 1981
Role of prostaglandins in the regulation of renal water excretion
HJ Kramer, K Glänzer, R Düsing
Kidney International 1981
Vasopressin-prostaglandin interactions in the regulation of epithelial cell permeability to water
JS Handler
Kidney International 1981
Prostaglandins and regulation of blood pressure: Clinical implications
JM Sullivan
Pharmacology & Therapeutics 1981
THE INTERACTIONS OF PROSTAGLANDINS AND VASOPRESSIN IN THE KIDNEY
LB Kinter, MJ Dunn, TR Beck, R Beeuwkes, A Hassid
Annals of the New York Academy of Sciences 1981
Prostaglandins and vascular tone in experimental obstructive nephropathy
AR Morrison, JE Benabe
Kidney International 1981
Metabolism of prostaglandins in the kidney
FF Sun, BM Taylor, JC McGuire, PY Wong
Kidney International 1981
Stimulation by oxygen radicals of prostaglandin production by rat renal glomeruli
L Baud, MP Nivez, D Chansel, R Ardaillou
Kidney International 1981
Prostaglandin and thromboxane synthesis by rat glomerular epithelial cells
AS Petrulis, M Aikawa, MJ Dunn
Kidney International 1981
Prostaglandins and Bartter's syndrome
MJ Dunn
Kidney International 1981
Prostaglandin synthesis by vascular smooth muscle cells is stimulated by bradykinin, prazosin and hydralazine
RD Dyer, JJ Huttner, SY Tan, PJ Mulrow
Progress in Lipid Research 1981
Regulation of histamine-mediated prostacyclin synthesis in cultured human vascular endothelial cells
NL Baenziger, FJ Fogerty, LF Mertz, LF Chernuta
Cell 1981
Metabolism of arachidonic acid and prostaglandin synthesis in the preadipocyte clonal line OB17
R Négrel, G Ailhaud
Biochemical and Biophysical Research Communications 1981
Effects of captopril on urinary excretion of prostaglandins and electrolytes in spontaneously hypertensive rats
M Miyamoto, H Koike, K Ito, M Yamazaki
European Journal of Pharmacology 1981
Dissociation between renal medullary PGE2-synthesis and urine PGE2-excretion. Antagonism by bumetanide of chlorazanil induced urine PGE2-excretion in rats
UB Olsen
Prostaglandins 1981
9 The kinins and prostaglandins in hypertension
K Abe
Clinics in Endocrinology and Metabolism 1981
High urine flow rate increases prostaglandin E excretion in the conscious dog
LF Wright, SG Rosenblatt, MD Lifschitz
Prostaglandins 1981
Transport-active renal tubular epithelial cells (MDCK and LLC-PK1) in culutre. Prostaglandin biosynthesis and its regulation by peptide hormones and ionophore
A Hassid
Prostaglandins 1981
Influence of angiotensins (I, II & III) on prostaglandin production by minced rat renal medulla
H Satoh, K Matsukura, R Yamada, S Satoh
Prostaglandins 1981
Prostaglandins, Vasopressin, and Renal Water Reabsorption
RM Zusman
Medical Clinics of North America 1981
Prostaglandins, antidiuretic hormone and renin angiotensin system
NA Terragno
Hypertension 1981
Bartter's syndrome: a disorder of vascular reactivity. Arthur C. Corcoran Memorial Lecture
FC Bartter
Hypertension 1981
Contribution of prostaglandins to the antihypertensive action of captopril in essential hypertension
TJ Moore, FR Crantz, NK Hollenberg, RJ Koletsky, MS Leboff, SL Swartz, L Levine, S Podolsky, RG Dluhy, GH Williams
Hypertension 1981
Direct action of kallikrein and other proteases on the renin-angiotensin system
S Suzuki, R Franco-Saenz, SY Tan, PJ Mulrow
Hypertension 1981
Contemporary Nephrology
S Klahr, SG Massry
1981
The effect of prostaglandin E2 and ADH on diffusional water permeability in the collecting duct of an isolated rat papilla
C Ray, T Morgan
Pflügers Archiv - European Journal of Physiology 1981
Calcium-dependent action of osmolality on adenosine 3',5'-monophosphate accumulation in rat renal inner medulla: evidence for a relationship to calcium-responsive arachidonate release and prostaglandin synthesis
PA Craven, R Briggs, FR DeRubertis
Journal of Clinical Investigation 1980
Urinary Concentrating Defect of Adrenal Insufficiency PERMISSIVE ROLE OF ADRENAL STEROIDS ON THE HYDROOSMOTIC RESPONSE ACROSS THE RABBIT CORTICAL COLLECTING TUBULE
MJ Schwartz, JP Kokko
Journal of Clinical Investigation 1980
Increased renal secretion of norepinephrine and prostaglandin E2 during sodium depletion in the dog
JA Oliver, J Pinto, RR Sciacca, PJ Cannon
Journal of Clinical Investigation 1980
Direct action of rat urinary kallikrein on rat kidney to release renin
S Suzuki, R Franco-Saenz, SY Tan, PJ Mulrow
Journal of Clinical Investigation 1980
Tissue culture in nephrology: Potential and limits for the study of renal disease
M Horster
Klinische Wochenschrift 1980
Determination, Source, Metabolism, and Functional Role of Renal Prostaglandins
JC Frölich, LA Walker
Clinical and Experimental Hypertension 1980
Renal effects of drugs that inhibit prostaglandin synthesis
MJ Dunn, EJ Zambraski
Kidney International 1980
The Kallikrein-Kinin System in Essential Hypertension
HR Keiser
Clinical and Experimental Hypertension 1980
The bicellular and reflexive membrane junctions of renomedullary interstitial cells: Functional implications of reflexive gap junctions
RA Majack, WJ Larsen
American Journal of Anatomy 1980
Regulation of prostaglandin E2 synthesis by angiotensin II, potassium, osmolality, and dexamethasone
RM Zusman, HR Keiser
Kidney International 1980
Prostaglandin synthesis and renal function in man
J Haylor
The Journal of Physiology 1980
Biochemical Aspects of Renal Function
F Kiil, OM Sejersted, PA Steen
Biochemical Aspects of Renal Function 1980
The role of urinary prostaglandin E and cyclic AMP in the polyuria of hypokalemia in rats
HG Gullner, FC Bartter
Prostaglandins and Medicine 1980
Effect of propranolol on the urinary excretion of prostaglandin E and plasma benin activity in hypertensive patients
M Sato, K Abe, M Yasujima, Y Otsuka, S Chiba, T Haruyama, K Sato, Y Imai, Y Sakurai, T Ito, K Omata, K Yoshinaga
Prostaglandins and Medicine 1980
Is prostaglandin a mediator for the inhibitory action of histamine, hydrocortisone, and isoproterenol?
C Staszak, JS Goodwin
Cellular Immunology 1980
Calcium and O2-dependent control of inner medullary cGMP: Possible role for Ca2+-dependent arachidonate release and prostaglandin synthesis in expression of the action of osmolality on renal inner medullary guanosine 3′5′ monophosphate
PA Craven, FR DeRubertis
Metabolism 1980
Sar1-Ile8-angiotensin II decreases urinary PGE2 and PGF2α excretion in rabbits on dietary sodium restriction
RA Stahl, AA Attallah
European Journal of Pharmacology 1980
Sodium intake as a determinant of urinary prostaglandin E2 excretion
SY Tan, DW Sandwisch, PJ Mulrow
Prostaglandins and Medicine 1980
Immunocytochemical localization of the prostaglandin-forming cyclooxygenase in the cerebellar cortex
WL Smith, DI Gutekunst, RH Lyons
Prostaglandins 1980
Prostaglandin synthesis by rat isolated glomeruli and glomerular cultured cells
J Sraer, J Foidart, D Chansel, P Mahieu, R Ardaillou
International Journal of Biochemistry 1980
Converting enzyme inhibition and the kidney
LG Meggs, NK Hollenberg
Hypertension 1980
A comparison of angiotensin II and angiotensin III as vasoconstrictors in the mesenteric circulation of dogs
SL Britton, JM Sexton, MJ Fiksen-Olsen, PG Werness, JC Romero
Circulation research 1980
Identification of an angiotensin receptor in rabbit renomedullary interstitial cells in tissue culture. Correlation with prostaglandin biosynthesis
CA Brown, RM Zusman, E Haber
Circulation research 1980
Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics
P Frick, GA von Harnack, GA Martini, A Prader, HP Wolff
1980
The Renal Papilla and Hypertension
AK Mandal, SO Bohman
1980
Captopril and Hypertension
DB Case, EH Sonnenblick, JH Laragh
1980
Glomerular Hemodynamics in Rats with Chronic Sodium Depletion EFFECT OF SARALASIN
RW Steiner, BJ Tucker, RC Blantz
Journal of Clinical Investigation 1979
Renal prostaglandins: Relationship to the development of blood pressure and concentrating capacity in pre-term and full term healthy infants
R Joppich, B Scherer, PC Weber
European Journal of Pediatrics 1979
Effect of indomethacin and adrenocorticotrophic hormone on renal function in man: An experimental model of inappropriate antidiuresis
RM Zusman, JM Vinci, RE Bowden, D Horwitz, HR Keiser
Kidney International 1979
Prostaglandin synthesis by isolated rat renal glomeruli
J Sraer, JD Sraer, D Chansel, F Russo-Marie, B Kouznetzova, R Ardaillou
Molecular and Cellular Endocrinology 1979
Prostacyclin (PGI2) activity in rat kidney-stimulated by angiotensin II
K Silberbauer, H Sinzinger, M Winter
Experimental and Molecular Pathology 1979
A unique affinity and adaptation of renomedullary interstitial cells for hypertonic medium
M Kuroda, H Ueno, S Sakato, N Funaki, R Takeda
Prostaglandins 1979
Variability in rates of urine prostaglandin E excretion
MA Kirschenbaum, ER Serros, A Lowe
Prostaglandins 1979
Influence of angiotensins (I, II, & III), bradykinin and arachidonic acid on renomedullary PGE production in vitro
M Anees, P Sweet, SY Tan, PJ Mulrow
Prostaglandins 1979
Formation of 1a, 1b dihomoprostaglandin E2 by rabbit renal interstitial cell cultures
LM Cagen, RM Zusman, JJ Pisano
Prostaglandins 1979
The renal kallikrein-kinin system
NG Levinsky
Circulation research 1979
Practical Applications of Prostaglandins and their Synthesis Inhibitors
SM Karim
1979
Effects of osmolality and oxygen availability on soluble cyclic AMP-dependent protein kinase activity of rat renal inner medulla
FR DeRubertis, PA Craven
Journal of Clinical Investigation 1978
Role of prostaglandin E (PGE) in the modulation of the action of vasopressin on water flow in the urinary bladder of the toad and mammalian kidney
J Orloff, R Zusman
The Journal of Membrane Biology 1978
Cortex and medulla of rat kidney generate different amounts of PG I2-like activity
K Silberbauer, H Sinzinger
Thrombosis Research 1978
Urinary excretion of prostaglandin E2 and prostaglandin F2α in potassium-deficient rats
VL Hood, DM J.
Prostaglandins 1978
Evidence for a prostaglandin-independent defect in chloride reabsorption in the loop of henle as a proximal cause of Bartter's syndrome
JR Gill, FC Bartter
The American Journal of Medicine 1978
Redistribution of intrarenal blood flow following adh administration: Lack of inhibition by blockade of prostaglandin cyclooxygenase
LA Walker, JG Gerber, JC Frölich, AS Nies
Prostaglandins and Medicine 1978
Formation of 6-keto-PGF1α by collecting tubule cells isolated from rabbit renal papillae
FC Grenier, WL Smith
Prostaglandins 1978
Renal excretion of prostaglandins E2 and F2alpha in diabetes insipidus rats
MJ Dunn, HP Greely, H Valtin, LB Kintner, RB rd
American journal of physiology. Endocrinology and metabolism 1978
Interrelations of the renal kallikrein-kinin system and renal prostaglandins in the conscious rat. Influence of mineralocorticoids
A Nasjletti, JC McGiff, J Colina-Chourio
Circulation research 1978
Free Radicals in Biology
WA Pryor
Free Radicals in Biology 1976

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