Rabbit renomedullary interstitial cells were isolated and grown in tissue culture. These cells synthesize 0.8 ng of prostaglandin E2 (PGE2) per microgram cellular protein per hour in monolayer tissue culture; prostaglandins A2 and F2alpha (PGA2 and PGF2alpha) biosynthesis was 10 and 5% of PGE2 biosynthesis, respectively. Arachidonic acid markedly stimulated the production of PGE2 and PGF2alpha, with conversion rates of 0.24 and 0.02%/h, respectively. Angiotensin II, hyperosmolality, bradykinin, and arginine vasopressin each stimulated PGE2 biosynthesis; maximum stimulation was 20, 3.7, 3.6, and 3.2 times basal production, respectively. PGE2 biosynthesis by the renomedullary interstitial cells was inhibited by isoproterenol, potassium, nonsteroidal anti-inflammatory agents (indomethacin, naproxen, ibuprofen, suprofen, meclofenamate, and acetylsalicylic acid), mepacrine (a phospholipase inhibitor), hydrocortisone, and cortisone. The rabbit renomedullary interstitial cell in tissue culture is a model system for the study of hormonal regulation of PGE2 biosynthesis.
R M Zusman, H R Keiser
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Annals of the New York Academy of Sciences | 1982 |
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The American Journal of Medicine | 1982 |
Disorders of urinary concentration and dilution
RL Jamison, RE Oliver |
The American Journal of Medicine | 1982 |
In vitro prostaglandin synthesis by various rat renal preparations
J Sraer, W Siess, L Moulonguet-Doleris, JP Oudinet, F Dray, R Ardaillou |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1982 |
The involvement of the renin-angiotensin-aldosterone system, the corticotropin-glucocorticoid system, antidiuretic hormone, catecholamines and prostaglandins
M Marin-Grez |
Biochemical Pharmacology | 1982 |
Relationship between calcium stimulation of cyclic GMP and lipid peroxidation in the rat kidney: Evidence for involvement of calmodulin and separate pathways of peroxidation in cortex versus inner medulla
PA Craven, FR DeRubertis |
Metabolism | 1982 |
Hypertensive Cardiovascular Disease: Pathophysiology and Treatment
A Amery, R Fagard, P Lijnen, J Staessen |
1982 | |
Cyclic Nucleotides
JW Kebabian, JA Nathanson |
1982 | |
Arterial Hypertension
J Rosenthal |
1982 | |
Effects of angiotensin II on phosphatidylinositol and polyphosphoinositide turnover in rat kidney. Mechanism of prostaglandin release
JE Benabe, LA Spry, AR Morrison |
The Journal of biological chemistry | 1982 |
Arachidonic acid metabolism in isolated rat aorta. Dependence of prostacyclin biosynthesis on extracellular potassium concentration
R Düsing, R Scherhag, R Tippelmann, U Budde, K Glänzer, HJ Kramer |
The Journal of biological chemistry | 1982 |
Participation of the Prostaglandins in the Control of Renal Blood Flow during Acute Reduction of Cardiac Output in the Dog
JA Oliver, RR Sciacca, J Pinto, PJ Cannon |
Journal of Clinical Investigation | 1981 |
Prostaglandins and water metabolism: A review with emphasis on in vivo studies
PA Gross, RW Schrier, RJ Anderson |
Kidney International | 1981 |
Role of prostaglandins in the regulation of renal water excretion
HJ Kramer, K Glänzer, R Düsing |
Kidney International | 1981 |
Vasopressin-prostaglandin interactions in the regulation of epithelial cell permeability to water
JS Handler |
Kidney International | 1981 |
Prostaglandins and regulation of blood pressure: Clinical implications
JM Sullivan |
Pharmacology & Therapeutics | 1981 |
THE INTERACTIONS OF PROSTAGLANDINS AND VASOPRESSIN IN THE KIDNEY
LB Kinter, MJ Dunn, TR Beck, R Beeuwkes, A Hassid |
Annals of the New York Academy of Sciences | 1981 |
Prostaglandins and vascular tone in experimental obstructive nephropathy
AR Morrison, JE Benabe |
Kidney International | 1981 |
Metabolism of prostaglandins in the kidney
FF Sun, BM Taylor, JC McGuire, PY Wong |
Kidney International | 1981 |
Stimulation by oxygen radicals of prostaglandin production by rat renal glomeruli
L Baud, MP Nivez, D Chansel, R Ardaillou |
Kidney International | 1981 |
Prostaglandin and thromboxane synthesis by rat glomerular epithelial cells
AS Petrulis, M Aikawa, MJ Dunn |
Kidney International | 1981 |
Prostaglandins and Bartter's syndrome
MJ Dunn |
Kidney International | 1981 |
Prostaglandin synthesis by vascular smooth muscle cells is stimulated by bradykinin, prazosin and hydralazine
RD Dyer, JJ Huttner, SY Tan, PJ Mulrow |
Progress in Lipid Research | 1981 |
Regulation of histamine-mediated prostacyclin synthesis in cultured human vascular endothelial cells
NL Baenziger, FJ Fogerty, LF Mertz, LF Chernuta |
Cell | 1981 |
Metabolism of arachidonic acid and prostaglandin synthesis in the preadipocyte clonal line OB17
R Négrel, G Ailhaud |
Biochemical and Biophysical Research Communications | 1981 |
Effects of captopril on urinary excretion of prostaglandins and electrolytes in spontaneously hypertensive rats
M Miyamoto, H Koike, K Ito, M Yamazaki |
European Journal of Pharmacology | 1981 |
Dissociation between renal medullary PGE2-synthesis and urine PGE2-excretion. Antagonism by bumetanide of chlorazanil induced urine PGE2-excretion in rats
UB Olsen |
Prostaglandins | 1981 |
9 The kinins and prostaglandins in hypertension
K Abe |
Clinics in Endocrinology and Metabolism | 1981 |
High urine flow rate increases prostaglandin E excretion in the conscious dog
LF Wright, SG Rosenblatt, MD Lifschitz |
Prostaglandins | 1981 |
Transport-active renal tubular epithelial cells (MDCK and LLC-PK1) in culutre. Prostaglandin biosynthesis and its regulation by peptide hormones and ionophore
A Hassid |
Prostaglandins | 1981 |
Influence of angiotensins (I, II & III) on prostaglandin production by minced rat renal medulla
H Satoh, K Matsukura, R Yamada, S Satoh |
Prostaglandins | 1981 |
Prostaglandins, Vasopressin, and Renal Water Reabsorption
RM Zusman |
Medical Clinics of North America | 1981 |
Prostaglandins, antidiuretic hormone and renin angiotensin system
NA Terragno |
Hypertension | 1981 |
Bartter's syndrome: a disorder of vascular reactivity. Arthur C. Corcoran Memorial Lecture
FC Bartter |
Hypertension | 1981 |
Contribution of prostaglandins to the antihypertensive action of captopril in essential hypertension
TJ Moore, FR Crantz, NK Hollenberg, RJ Koletsky, MS Leboff, SL Swartz, L Levine, S Podolsky, RG Dluhy, GH Williams |
Hypertension | 1981 |
Direct action of kallikrein and other proteases on the renin-angiotensin system
S Suzuki, R Franco-Saenz, SY Tan, PJ Mulrow |
Hypertension | 1981 |
Contemporary Nephrology
S Klahr, SG Massry |
1981 | |
The effect of prostaglandin E2 and ADH on diffusional water permeability in the collecting duct of an isolated rat papilla
C Ray, T Morgan |
Pflügers Archiv - European Journal of Physiology | 1981 |
Calcium-dependent action of osmolality on adenosine 3',5'-monophosphate accumulation in rat renal inner medulla: evidence for a relationship to calcium-responsive arachidonate release and prostaglandin synthesis
PA Craven, R Briggs, FR DeRubertis |
Journal of Clinical Investigation | 1980 |
Urinary Concentrating Defect of Adrenal Insufficiency PERMISSIVE ROLE OF ADRENAL STEROIDS ON THE HYDROOSMOTIC RESPONSE ACROSS THE RABBIT CORTICAL COLLECTING TUBULE
MJ Schwartz, JP Kokko |
Journal of Clinical Investigation | 1980 |
Increased renal secretion of norepinephrine and prostaglandin E2 during sodium depletion in the dog
JA Oliver, J Pinto, RR Sciacca, PJ Cannon |
Journal of Clinical Investigation | 1980 |
Direct action of rat urinary kallikrein on rat kidney to release renin
S Suzuki, R Franco-Saenz, SY Tan, PJ Mulrow |
Journal of Clinical Investigation | 1980 |
Tissue culture in nephrology: Potential and limits for the study of renal disease
M Horster |
Klinische Wochenschrift | 1980 |
Determination, Source, Metabolism, and Functional Role of Renal Prostaglandins
JC Frölich, LA Walker |
Clinical and Experimental Hypertension | 1980 |
Renal effects of drugs that inhibit prostaglandin synthesis
MJ Dunn, EJ Zambraski |
Kidney International | 1980 |
The Kallikrein-Kinin System in Essential Hypertension
HR Keiser |
Clinical and Experimental Hypertension | 1980 |
The bicellular and reflexive membrane junctions of renomedullary interstitial cells: Functional implications of reflexive gap junctions
RA Majack, WJ Larsen |
American Journal of Anatomy | 1980 |
Regulation of prostaglandin E2 synthesis by angiotensin II, potassium, osmolality, and dexamethasone
RM Zusman, HR Keiser |
Kidney International | 1980 |
Prostaglandin synthesis and renal function in man
J Haylor |
The Journal of Physiology | 1980 |
Biochemical Aspects of Renal Function
F Kiil, OM Sejersted, PA Steen |
Biochemical Aspects of Renal Function | 1980 |
The role of urinary prostaglandin E and cyclic AMP in the polyuria of hypokalemia in rats
HG Gullner, FC Bartter |
Prostaglandins and Medicine | 1980 |
Effect of propranolol on the urinary excretion of prostaglandin E and plasma benin activity in hypertensive patients
M Sato, K Abe, M Yasujima, Y Otsuka, S Chiba, T Haruyama, K Sato, Y Imai, Y Sakurai, T Ito, K Omata, K Yoshinaga |
Prostaglandins and Medicine | 1980 |
Is prostaglandin a mediator for the inhibitory action of histamine, hydrocortisone, and isoproterenol?
C Staszak, JS Goodwin |
Cellular Immunology | 1980 |
Calcium and O2-dependent control of inner medullary cGMP: Possible role for Ca2+-dependent arachidonate release and prostaglandin synthesis in expression of the action of osmolality on renal inner medullary guanosine 3′5′ monophosphate
PA Craven, FR DeRubertis |
Metabolism | 1980 |
Sar1-Ile8-angiotensin II decreases urinary PGE2 and PGF2α excretion in rabbits on dietary sodium restriction
RA Stahl, AA Attallah |
European Journal of Pharmacology | 1980 |
Sodium intake as a determinant of urinary prostaglandin E2 excretion
SY Tan, DW Sandwisch, PJ Mulrow |
Prostaglandins and Medicine | 1980 |
Immunocytochemical localization of the prostaglandin-forming cyclooxygenase in the cerebellar cortex
WL Smith, DI Gutekunst, RH Lyons |
Prostaglandins | 1980 |
Prostaglandin synthesis by rat isolated glomeruli and glomerular cultured cells
J Sraer, J Foidart, D Chansel, P Mahieu, R Ardaillou |
International Journal of Biochemistry | 1980 |
Converting enzyme inhibition and the kidney
LG Meggs, NK Hollenberg |
Hypertension | 1980 |
A comparison of angiotensin II and angiotensin III as vasoconstrictors in the mesenteric circulation of dogs
SL Britton, JM Sexton, MJ Fiksen-Olsen, PG Werness, JC Romero |
Circulation research | 1980 |
Identification of an angiotensin receptor in rabbit renomedullary interstitial cells in tissue culture. Correlation with prostaglandin biosynthesis
CA Brown, RM Zusman, E Haber |
Circulation research | 1980 |
Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics
P Frick, GA von Harnack, GA Martini, A Prader, HP Wolff |
1980 | |
The Renal Papilla and Hypertension
AK Mandal, SO Bohman |
1980 | |
Captopril and Hypertension
DB Case, EH Sonnenblick, JH Laragh |
1980 | |
Glomerular Hemodynamics in Rats with Chronic Sodium Depletion EFFECT OF SARALASIN
RW Steiner, BJ Tucker, RC Blantz |
Journal of Clinical Investigation | 1979 |
Renal prostaglandins: Relationship to the development of blood pressure and concentrating capacity in pre-term and full term healthy infants
R Joppich, B Scherer, PC Weber |
European Journal of Pediatrics | 1979 |
Effect of indomethacin and adrenocorticotrophic hormone on renal function in man: An experimental model of inappropriate antidiuresis
RM Zusman, JM Vinci, RE Bowden, D Horwitz, HR Keiser |
Kidney International | 1979 |
Prostaglandin synthesis by isolated rat renal glomeruli
J Sraer, JD Sraer, D Chansel, F Russo-Marie, B Kouznetzova, R Ardaillou |
Molecular and Cellular Endocrinology | 1979 |
Prostacyclin (PGI2) activity in rat kidney-stimulated by angiotensin II
K Silberbauer, H Sinzinger, M Winter |
Experimental and Molecular Pathology | 1979 |
A unique affinity and adaptation of renomedullary interstitial cells for hypertonic medium
M Kuroda, H Ueno, S Sakato, N Funaki, R Takeda |
Prostaglandins | 1979 |
Variability in rates of urine prostaglandin E excretion
MA Kirschenbaum, ER Serros, A Lowe |
Prostaglandins | 1979 |
Influence of angiotensins (I, II, & III), bradykinin and arachidonic acid on renomedullary PGE production in vitro
M Anees, P Sweet, SY Tan, PJ Mulrow |
Prostaglandins | 1979 |
Formation of 1a, 1b dihomoprostaglandin E2 by rabbit renal interstitial cell cultures
LM Cagen, RM Zusman, JJ Pisano |
Prostaglandins | 1979 |
The renal kallikrein-kinin system
NG Levinsky |
Circulation research | 1979 |
Practical Applications of Prostaglandins and their Synthesis Inhibitors
SM Karim |
1979 | |
Effects of osmolality and oxygen availability on soluble cyclic AMP-dependent protein kinase activity of rat renal inner medulla
FR DeRubertis, PA Craven |
Journal of Clinical Investigation | 1978 |
Role of prostaglandin E (PGE) in the modulation of the action of vasopressin on water flow in the urinary bladder of the toad and mammalian kidney
J Orloff, R Zusman |
The Journal of Membrane Biology | 1978 |
Cortex and medulla of rat kidney generate different amounts of PG I2-like activity
K Silberbauer, H Sinzinger |
Thrombosis Research | 1978 |
Urinary excretion of prostaglandin E2 and prostaglandin F2α in potassium-deficient rats
VL Hood, DM J. |
Prostaglandins | 1978 |
Evidence for a prostaglandin-independent defect in chloride reabsorption in the loop of henle as a proximal cause of Bartter's syndrome
JR Gill, FC Bartter |
The American Journal of Medicine | 1978 |
Redistribution of intrarenal blood flow following adh administration: Lack of inhibition by blockade of prostaglandin cyclooxygenase
LA Walker, JG Gerber, JC Frölich, AS Nies |
Prostaglandins and Medicine | 1978 |
Formation of 6-keto-PGF1α by collecting tubule cells isolated from rabbit renal papillae
FC Grenier, WL Smith |
Prostaglandins | 1978 |
Renal excretion of prostaglandins E2 and F2alpha in diabetes insipidus rats
MJ Dunn, HP Greely, H Valtin, LB Kintner, RB rd |
American journal of physiology. Endocrinology and metabolism | 1978 |
Interrelations of the renal kallikrein-kinin system and renal prostaglandins in the conscious rat. Influence of mineralocorticoids
A Nasjletti, JC McGiff, J Colina-Chourio |
Circulation research | 1978 |
Free Radicals in Biology
WA Pryor |
Free Radicals in Biology | 1976 |