The development of antibody in response to invasive infection with type III strains of group B Streptococcus was studied in sera from 31 infants and 4 adults by means of a quantitative radioactive antigen-binding assay. Low concentrations of antibody were consistently found in the acute sera of patients who developed clinical illness. Although adults with puerperal sepsis and infants with bone or joint infection uniformly demonstrated significant rises in serum antibody concentration after recovery, much lower levels of antibody were detected in convalescent sera from infants recovering from meningitis or sepsis. The median antibody concentration in sera from 43 parturients with type III strains of group B Streptococcus isolated from vaginal cultures whose neonates failed to develop symptomatic disease was significantly greater than that in sera from 29 mothers of infants with invasive, type III, group B streptococcal infection. Study of paired maternal and cord sera demonstrated a significant correlation between the antibody concentration in a mother's serum and that in her neonate.
C J Baker, D L Kasper, IRAB Tager, A Paredes, S Alpert, W M McCormack, D Goroff
Title and authors | Publication | Year |
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Development and validation of a 6-plex Luminex-based assay for measuring human serum antibodies to group B streptococcus capsular polysaccharides
Gaylord MA, Larrier M, Giordano-Schmidt D, Grube CD, Singh S, Nguyen HH, McKeen A, Tan CY, Anderson AS, Kalina WV, Pavliakova D, Giardina PC |
Human Vaccines & Immunotherapeutics | 2024 |
Serocorrelates of protection against infant group B streptococcus disease
KL Doare, B Kampmann, J Vekemans, PT Heath, D Goldblatt, MH Nahm, C Baker, MS Edwards, G Kwatra, N Andrews, SA Madhi, AS ter Meulen, AS Anderson, B Corsaro, P Fischer, A Gorringe |
The Lancet Infectious Diseases | 2019 |
Gram-Positive Pathogens
VA Fischetti, RP Novick, JJ Ferretti, DA Portnoy, M Braunstein, JI Rood |
2019 | |
Surface Structures of Group B Streptococcus Important in Human Immunity
LC Paoletti, DL Kasper, VA Fischetti, RP Novick, JJ Ferretti, DA Portnoy, M Braunstein, JI Rood |
Microbiology spectrum | 2019 |
Progress toward a group B streptococcal vaccine
JY Song, JH Lim, S Lim, Z Yong, HS Seo |
Human Vaccines & Immunotherapeutics | 2018 |
A Time to Save
CJ Baker |
Journal of the Pediatric Infectious Diseases Society | 2017 |
Review on the association of Group B Streptococcus capsular antibody and protection against invasive disease in infants
Z Dangor, G Kwatra, A Izu, SG Lala, SA Madhi |
Expert Review of Vaccines | 2015 |
Group B streptococcal infections in the newborn infant and the potential value of maternal vaccination
A Berardi, C Cattelani, R Creti, R Berner, Z Pietrangiolillo, I Margarit, D Maione, F Ferrari |
Expert Review of Anti-infective Therapy | 2015 |
Preventing Newborn Infection with Maternal Immunization
S Black, I Margarit, R Rappuoli |
Science Translational Medicine | 2013 |
Maternal Antibody at Delivery Protects Neonates From Early Onset Group B Streptococcal Disease
CJ Baker, VJ Carey, MA Rench, MS Edwards, SL Hillier, DL Kasper, R Platt |
The Journal of Infectious Diseases | 2013 |
Vaccines
RW Sutter, OM Kew, SL Cochi, RB Aylward |
Human vaccines | 2013 |
An overview of global GBS epidemiology
KL Doare, PT Heath |
Vaccine | 2013 |
The spectrum of perinatal group B streptococcal disease
CJ Baker |
Vaccine | 2013 |
Persistence of functional antibodies to group B streptococcal capsular polysaccharides following immunization with glycoconjugate vaccines
MS Edwards, HJ Lane, SL Hillier, MA Rench, CJ Baker |
Vaccine | 2012 |
Preventing the broad spectrum of perinatal morbidity and mortality through group B streptococcal vaccination
MS Edwards, B Gonik |
Vaccine | 2012 |
Infectious Diseases of the Fetus and Newborn
V Nizet, JS Bradley |
Infectious Diseases of the Fetus and Newborn | 2011 |
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases
VG Fowler, WM Scheld, AS Bayer |
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases | 2010 |
Group B Streptococcus and pregnancy: a review
JW Larsen, JL Sever |
American Journal of Obstetrics and Gynecology | 2008 |
Naturally occurring antibodies for the group B streptococcal surface immunogenic protein (Sip) in pregnant women and newborn babies
SD Manning, S Wood, K Kasha, D Martin, S Rioux, B Brodeur, HD Davies |
Vaccine | 2006 |
Infectious Diseases of the Fetus and Newborn Infant
RC Orscheln, HR Shinefield, JW st. Geme |
Infectious Diseases of the Fetus and Newborn Infant | 2006 |
Serotypes and clinical manifestations of invasive group B streptococcal infections in western Sweden 1998-2001
E Persson, S Berg, B Trollfors, P Larsson, E Ek, E Backhaus, BE Claesson, L Jonsson, G Radberg, T Ripa, S Johansson |
Clinical Microbiology and Infection | 2004 |
Type III group B streptococcal polysaccharide induces antibodies that cross-react with Streptococcus pneumoniae type 14
HK Guttormsen, CJ Baker, MH Nahm, LC Paoletti, SM Zughaier, MS Edwards, DL Kasper |
Infection and immunity | 2002 |
Protection from group B streptococcal infection in neonatal mice by maternal immunization with recombinant Sip protein
D Martin, S Rioux, E Gagnon, M Boyer, J Hamel, N Charland, BR Brodeur |
Infection and immunity | 2002 |
Cognate stimulatory B-cell-T-cell interactions are critical for T-cell help recruited by glycoconjugate vaccines
HK Guttormsen, AH Sharpe, AK Chandraker, AK Brigtsen, MH Sayegh, DL Kasper |
Infection and immunity | 1999 |
Measurement of human antibodies to type III group B Streptococcus
DL Kasper, MR Wessels, HK Guttormsen, LC Paoletti, MS Edwards, CJ Baker |
Infection and immunity | 1999 |
Measurement of Human Antibodies to Type III Group B Streptococcus
DL Kasper, MR Wessels, HK Guttormsen, LC Paoletti, MS Edwards, CJ Baker |
Infection and immunity | 1999 |
Minimization of the number of pregnant women to be treated with preventive procedure against GBS infection by means of antibody measurement
K Hoshina |
Pediatrics International | 1997 |
Immune response to type III group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine
DL Kasper, LC Paoletti, MR Wessels, HK Guttormsen, VJ Carey, HJ Jennings, CJ Baker |
Journal of Clinical Investigation | 1996 |
Immunogenicity of group B Streptococcus type III polysaccharide-tetanus toxoid vaccine in baboons
LC Paoletti, RC Kennedy, TC Chanh, DL Kasper |
Infection and immunity | 1996 |
Safety and immunogenicity of a tetravalent group B streptococcal polysaccharide vaccine in healthy adults
KL Kotloff, A Fattom, L Basham, A Hawwari, S Harkonen, R Edelman |
Vaccine | 1996 |
Role of C5a-ase in group B streptococcal resistance to opsonophagocytic killing
S Takahashi, Y Nagano, N Nagano, O Hayashi, F Taguchi, Y Okuwaki |
Infection and immunity | 1995 |
Demonstration of circulating group B streptococcal immune complexes in neonates with meningitis
JG Vallejo, CJ Baker, MS Edwards |
Journal of clinical microbiology | 1994 |
Recurrent group B streptococcal infections in infants: Clinical and microbiologic aspects
PA Green, KV Singh, BE Murray, CJ Baker |
The Journal of Pediatrics | 1994 |
Stability and Activity of Intravenous Immunoglobulin with Neonatal Dextrose and Total Parenteral Nutrient Solutions
CA Lindsay, K Dang, JM Adams, CN Ou, CJ Baker |
The Annals of pharmacotherapy | 1994 |
Maternal immunity and antibody response of neonatal mice to pneumococcal type 19F polysaccharide
CJ Lee, ED Ching, JH Vickers |
Journal of clinical microbiology | 1991 |
Response to Type III Polysaccharide in Women Whose Infants Have Had Invasive Group B Streptococcal Infection
CJ Baker, MA Rench, DL Kasper |
New England Journal of Medicine | 1990 |
Risk factors for perinatal group B streptococcal disease after amniotic fluid colonization
HM Silver, RS Gibbs, BM Gray, HC Dillon |
American Journal of Obstetrics and Gynecology | 1990 |
Experimental model of type IV Streptococcus agalactiae (group B streptococcus) infection in mice with early development of septic arthritis
L Tissi, P Marconi, P Mosci, L Merletti, P Cornacchione, E Rosati, S Recchia, C von Hunolstein, G Orefici |
Infection and immunity | 1990 |
Group B Streptococcal Infections
CJ Baker, MS Edwards |
Annals of the New York Academy of Sciences | 1988 |
Immunization of Pregnant Women with a Polysaccharide Vaccine of Group B Streptococcus
CJ Baker, MA Rench, MS Edwards, RJ Carpenter, BM Hays, DL Kasper |
New England Journal of Medicine | 1988 |
Passive protection by human sera in mice against challenge with strains of group B streptococci
Y Ichiman, K Yoshida |
Medical Microbiology and Immunology | 1986 |
Infectious Diseases in the Female Patient
RP Galask, B Larsen |
1986 | |
Colonization and infection of mothers and neonates with group B streptococci in three Italian hospitals
A Visconti, G Orefici, AM Notarnicola |
Journal of Hospital Infection | 1985 |
Monoclonal Antibodies Against Bacteria
J Heckels, M Virji |
Monoclonal Antibodies Against Bacteria | 1985 |
Immunoprophylaxis and immunotherapy of neonatal group B streptococcal infections
SP Gotoff |
Infection | 1985 |
The mode of action of antibody in neutrophil bactericidal activity against highly pathogenic group-B streptococci
PH Cleat, CR Coid |
Medical Microbiology and Immunology | 1984 |
Immunoglobulin G and M composition of naturally occurring antibody to type III group B streptococci
BF Anthony, NF Concepcion, CA Wass, DC Heiner |
Infection and immunity | 1984 |
Type-specific capsular antigen is associated with virulence in late-onset group B Streptococcal type III disease
ME Klegerman, KM Boyer, CK Papierniak, L Levine, SP Gotoff |
Infection and immunity | 1984 |
Class specificity of naturally acquired and vaccine-induced antibody to type III group B streptococcal capsular polysaccharide: determination with a radioimmunoprecipitin assay
MS Edwards, PA Fuselier, MA Rench, DL Kasper, CJ Baker |
Infection and immunity | 1984 |
Fetal Physiology and Medicine
RP Rivers |
Fetal Physiology and Medicine | 1984 |
Immunoprophylaxis and immunotherapy of neonatal group B streptococcal infections.
Gotoff SP |
Infection | 1984 |
Immunochemical analysis and immunogenicity of the type II group B streptococcal capsular polysaccharide
DL Kasper, CJ Baker, B Galdes, E Katzenellenbogen, HJ Jennings |
Journal of Clinical Investigation | 1983 |
Effect of continuous heparin infusion on bactericidal activity for group B streptococci in neonatal sera
MS Edwards, GJ Buffone, MA Rench, ME Speer, PA Fuselier, CJ Baker |
The Journal of Pediatrics | 1983 |
Antibody to type III group B Streptococcus in the rhesus monkey
JW Larsen, JS Harper, WT London, CJ Baker, BL Curfman, DL Kasper, JL Sever |
American Journal of Obstetrics and Gynecology | 1983 |
Quantitation of in vitro opsonic activity of human antibody induced by a vaccine consisting of the type III-specific polysaccharide of group B streptococcus
BJ Cueninck, TK Eisenstein, TS McIntosh, GD Shockman, RM Swenson |
Infection and immunity | 1983 |
Isolation, chemical composition, and molecular size of extracellular type II and type Ia polysaccharides of group B streptococci
BJ Cueninck, TF Greber, TK Eisenstein, RM Swenson, GD Shockman |
Infection and immunity | 1983 |
Antibody-independent classical pathway-mediated opsonophagocytosis of type Ia, group B streptococcus
CJ Baker, MS Edwards, BJ Webb, DL Kasper |
Journal of Clinical Investigation | 1982 |
Magnitude of colonization and sepsis by group B streptococci in newborn infants
DV Lim, KS Kanarek, ME Peterson |
Current Microbiology | 1982 |
Immunospecificity and quantitation of an enzyme-linked immunosorbent assay for group B streptococcal antibody
BF Anthony, NF Concepcion, SA McGeary, JI Ward, DC Heiner, P Shapshak, RA Insel |
Journal of clinical microbiology | 1982 |
Group B, type III streptococcal cell wall: composition and structural aspects revealed through endo-N-acetylmuramidase-catalyzed hydrolysis
BJ Cueninck, GD Shockman, RM Swenson |
Infection and immunity | 1982 |
Bactericidal capacity of newborn phagocytes against group B beta-hemolytic streptococci
ID Becker, OM Robinson, TS Bazán, M López-Osuna, RR Kretschmer |
Infection and immunity | 1981 |
Antibody to group B Streptococcus type III in human sera measured by a mouse protection test
RS Baltimore, CJ Baker, DL Kasper |
Infection and immunity | 1981 |
Effects of route and time of administration of antiserum on protection of mice from lethal infection due to group B Streptococcus type III
BF Stanton, RS Baltimore, DG Shedd |
Infection and immunity | 1981 |
Recurrent infection associated with penicillin-tolerantgroup B streptococci: A report of two cases
JD Siegel, KM Shannon, BM DePasse |
The Journal of Pediatrics | 1981 |
Immunology of Human Infection
AJ Nahmias, RJ OReilly |
1981 | |
Antibody levels in mothers colonised with group B streptococci during pregnancy and in their newborn infants, as measured by an enzyme linked immunosorbent assay
PH Cleat, J Ross, JR Needham |
Medical Microbiology and Immunology | 1980 |
The role of specific antibody in alternative complement pathway-mediated opsonophagocytosis of type III, group B Streptococcus
MS Edwards, A Nicholson-Weller, CJ Baker, DL Kasper |
Journal of Experimental Medicine | 1980 |
Enzyme-linked immunosorbent assay for group B streptococcal antibodies
NS Rote, NL Taylor, AO Shigeoka, JR Scott, HR Hill |
Infection and immunity | 1980 |
Prevalence of type-specific group B streptococcal antibody in pregnant women
RE Behrman, LC Vogel, KM Boyer, CA Gadzala, SP Gotoff |
The Journal of Pediatrics | 1980 |
Influence of Preimmunization Antibody Levels on the Specificity of the Immune Response to Related Polysaccharide Antigens
CJ Baker, DL Kasper, MS Edwards, G Schiffman |
New England Journal of Medicine | 1980 |
The natural history of group B streptococcal colonization in the pregnant woman and her offspring
CJ Baker, BJ Webb, DL Kasper, MD Yow, CW Beachler |
American Journal of Obstetrics and Gynecology | 1980 |
Chronische posttraumatische Osteomyelitis
G Lob |
1980 | |
Immunodeterminant specificity of human immunity to type III group B streptococcus
DL Kasper, CJ Baker, RS Baltimore, JH Crabb, G Schiffman, HJ Jennings |
Journal of Experimental Medicine | 1979 |
Group B streptococcal infection: a review and update
JM Knox |
The British journal of venereal diseases | 1979 |
Group B streptococcal colonization and antibody status in lower socioeconomic parturient women
CW Beachler, CJ Baker, DL Kasper, DK Fleming, BJ Webb, MD Yow |
American Journal of Obstetrics and Gynecology | 1979 |
Immunogenicity of polysaccharides from type III, group B Streptococcus
CJ Baker, MS Edwards, DL Kasper |
Journal of Clinical Investigation | 1978 |
Detection of group B streptococcal antibodies in human sera by radioimmunoassay: concentrations of type-specific antibodies in sera of adults and infants infected with group B streptococci
HW Wilkinson |
Journal of clinical microbiology | 1978 |
Association of elevated levels of extracellular neuraminidase with clinical isolates of type III group B streptococci
TW Milligan, CJ Baker, DC Straus, SJ Mattingly |
Infection and immunity | 1978 |
Vaccines for the prevention of encapsulated bacterial diseases: current status, problems and prospects for the future
JB Robbins |
Immunochemistry | 1978 |
An etiologic shift in infantile osteomyelitis: The emergence of the group B streptococcus
MS Edwards, CJ Baker, ML Wagner, LH Taber, FF Barrett |
The Journal of Pediatrics | 1978 |
Group B streptococcal long-chain reaction
P Stewardson-Krieger, K Albrandt, RR Kretschmer, SP Gotoff |
Infection and immunity | 1977 |