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Citations to this article

The electrophysiologic effects of quinidine in the transplanted human heart.
J W Mason, … , E B Stinson, D C Harrison
J W Mason, … , E B Stinson, D C Harrison
Published March 1, 1977
Citation Information: J Clin Invest. 1977;59(3):481-489. https://doi.org/10.1172/JCI108663.
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Research Article

The electrophysiologic effects of quinidine in the transplanted human heart.

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Abstract

Using His bundle recording techniques, we examined direct and autonomically mediated conduction system effects of quinidine in five cardiac transplant recipients who have anatomically denervated hearts. We made control conduction interval and refractory period measurements, and then infused 10 mg/kg quinidine gluconate over a 20-min period. At 30 min, we determined the electrophysiologic changes induced by quinidine. Quinidine significantly increased the atrial-His (AH) interval (from 97+/-9 [SEM] to 108+/-7 ms, P less than 0.001), the His-ventricular (HV) inteval (from 43.9 +/- 1 to 52.8 +/- 3 ms, P less than 0.01), the donor heart sinus cycle length (from 599 +/- 38 to 630 +/- 56 ms, P less than 0.08), and the atrial effective refractory period (from 214 +/- 14 to 241 +/- 11 ms, P less than 0.01). Quinidine significantly decreased the innervated, remnant atrial sinus cycle length (from 847 +/- 104 to 660 +/- 96 ms, P less than 0.01) and the blood pressure. The mean plasma concentration of quinidine at the time that electrophysiologic measurements were repeated was 4.37 +/- 0.449 micrograms/ml. We conclude that quinidine's predominant sinus nodal and atrioventricular nodal effects in man are autonomically mediated and opposite to its direct actions upon these structures. On the other hand, quinidine's prevailing effect on atrial refractoriness and His-Purkinje conduction in man is direct.

Authors

J W Mason, R A Winkle, A K Rider, E B Stinson, D C Harrison

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Total citations by year

Year: 2019 2014 1997 1996 1993 1992 1990 1989 1988 1987 1986 1985 1984 1983 1981 1980 1979 1978 1977 Total
Citations: 1 1 1 1 3 1 1 1 3 2 3 2 5 8 3 2 4 2 2 46
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (46)

Title and authors Publication Year
Correction of the QRS duration for heart rate
JW Mason, DG Strauss, M Vaglio, F Badilini
Journal of Electrocardiology 2019
Differentiating Drug-Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil
L Johannesen, J Vicente, JW Mason, C Sanabria, K Waite-Labott, M Hong, P Guo, J Lin, JS Sørensen, L Galeotti, J Florian, M Ugander, N Stockbridge, DG Strauss
Clinical Pharmacology & Therapeutics 2014
Management of the Cardiac Transplant Recipient: Roles of the Transplant Cardiologist and Primary Care Physician
LE Wagoner
The American Journal of the Medical Sciences 1997
The Transplantation and Replacement of Thoracic Organs
DK Cooper, LW Miller, GA Patterson
1996
Task force 4: Function of the heart trnsplant recipient
JB Young, WL Winters, R Bourge, BF Uretsky
Journal of the American College of Cardiology 1993
The effectiveness and safety of the simultaneous administration of quinidine and amiodarone in the conversion of chronic atrial fibrillation
NZ Kerin, M Ansari-Leesar, K Faitel, C Narala, H Frumin, A Cohen
American Heart Journal 1993
Direct and autonomically mediated effects of oral quinidine on RR/QT relation after an abrupt increase in heart rate
R Cappato, L Codeca, G Guardigli, T Toselli, GE Antonioli, P Alboni
Journal of the American College of Cardiology 1993
Over-the-Counter Medications in Cardiac Transplant Recipients: Guidelines for Use
EA Hartshorn, KD Lake, JG Nolen, RA Slaker, TJ Reutzel, SK Milfred, DF Solbrack, FM Hoffman
The Annals of pharmacotherapy 1992
The surgically denervated, transplanted human heart
MR Bristow
Circulation 1990
Cardiac Arrhythmias: The Role of Pharmacologic Intervention
TS Klitzner, WF Friedman
Cardiology Clinics 1989
Drug effects on the sinus node a clinical perspective
NJ Linker, AJ Camm
Cardiovascular Drugs and Therapy 1988
The mammalian sinoatrial node
T Opthof
Cardiovascular Drugs and Therapy 1988
Intensive care of the cardiac transplant recipient
KL Stein, JM Darby, A Grenvik
Journal of Cardiothoracic Anesthesia 1988
A Metrical Approach to the Basic and Clinical Pharmacology of Antiarrhythmic Drugs
MF Arnsdorf, JA Wasserstrom
Journal of Basic and Clinical Physiology and Pharmacology 1987
Differing electrophysiological effects of class IA, IB and IC antiarrhythmic drugs on guinea-pig sinoatrial node
T Campbell
British Journal of Pharmacology 1987
Effects of orthotopic heart transplantation on sympathetic control mechanisms in congestive heart failure
TB Levine, MT Olivari, JN Cohn
The American Journal of Cardiology 1986
The Pathophysiology and Pharmacotherapy of Myocardial Infarction
BS Denenberg, JF Spann
The Pathophysiology and Pharmacotherapy of Myocardial Infarction 1986
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques
E Jucker
1986
Electrophysiologic, hemodynamic and metabolic effects of intravenous bepridil hydrochloride
JW Upward, K Daly, S Campbell, G Bergman, DE Jewitt
The American Journal of Cardiology 1985
Kombinationstherapie der Herzrhytmusstörungen mit Chinidin und Verapamil
F Bender, K Greeff
1985
Quinidine
JW Mason, LM Hondeghem
Annals of the New York Academy of Sciences 1984
Antimuscarinic action of quinidine on the heart? A study in myocardial preparations from cat hearts
H Nawrath, U Sack, X Zong
British Journal of Pharmacology 1984
Clinical efficacy and electrophysiology of imipramine for ventricular tachycardia
SJ Connolly, LB Mitchell, CD Swerdlow, JW Mason, RA Winkle
The American Journal of Cardiology 1984
Basic Understanding of the Electrophysiologic Actions of Antiarrhythmic Drugs: Sources, Sinks, and Matrices of Information
MF Arnsdorf
Medical Clinics of North America 1984
Sinus Node Function and Dysfunction
S Swiryn, T McDonough, DC Hueter
Medical Clinics of North America 1984
The QT interval historically treated
HB Burchell
Pediatric Cardiology 1983
Electrophysiological effects of quinidine alone and of the combination quinidine-verapamil on av conduction in humans
K Theisen, M Scheininger
Clinical Cardiology 1983
Class I antiarrhythmic agents: Quinidine, procainamide and N-acetylprocainamide, disopyramide
DM Roden, RL Woosley
Pharmacology & Therapeutics 1983
Safety and efficacy of intravenous quinidine
CD Swerdlow, JO Yu, E Jacobson, S Mann, RA Winkle, JC Griffin, DL Ross, JW Mason
The American Journal of Medicine 1983
Unusual atrial potentials in a cardiac transplant recipient. possible synchronization between donor and recipient atria
AL Goldberger, RS Bexton, KJ Hellestrand, R Cory-Pearce, RA Spurrell, TA English, AJ Camm
Journal of Electrocardiology 1983
Cardiac transplantation — the ideal model for electrophysiologic drug testing?
RS Bexton, AJ Camm
International Journal of Cardiology 1983
The direct electrophysiologic effects of disopyramide phosphate in the transplanted human heart
RS Bexton, KJ Hellestrand, R Cory-Pearce, RA Spurrell, TA English, AJ Camm
Circulation 1983
Cardiac therapy
MR Rosen, BF Hoffman
1983
Coronary artery spasm in the denervated transplanted human heart
AJ Buda, RE Fowles, JS Schroeder, SA Hunt, PR Cipriano, EB Stinson, DC Harrison
The American Journal of Medicine 1981
Electrophysiologic evaluation of encainide with use of monophasic action potential recording
RG Samuelsson, DC Harrison
The American Journal of Cardiology 1981
Sino-Atrial Node Transplantation in the Dog
Y Morishita, RA Poirier, RF Rohner
Vascular and endovascular surgery 1981
Antiarrhythmic Drugs
HW Moses, PN Yu
The Journal of Clinical Pharmacology 1980
Overdrive suppression in the transplanted heart: effect of the autonomic nervous system on human sinus node recovery
JW Mason
Circulation 1980
Cardiac abnormalities in myotonic dystrophy
J Motta, C Guilleminault, M Billingham, W Barry, J Mason
The American Journal of Medicine 1979
Clinical electrophysiologic effects of encainide, a newly developed antiarrhythmic agent
M Sami, JW Mason, F Peters, DC Harrison
The American Journal of Cardiology 1979
Canine electrophysiology of encainide, a new antiarrhythmic drug
M Sami, JW Mason, G Oh, DC Harrison
The American Journal of Cardiology 1979
Human heart transplantation
JG Copeland, EB Stinson
Current Problems in Cardiology 1979
Clinical electrophysiologic effects of tocainide
JL Anderson, JW Mason, RA Winkle, PJ Meffin, RE Fowles, L Peters, DC Harrison
Circulation 1978
Antiarrhythmic Drugs: Clinical Pharmacology and Therapeutic Uses
JL Anderson, DC Harrison, PJ Meffin, RA Winkle
Drugs 1978
Hemodynamic effects of intravenously administered quinidine on the transplanted human heart
JW Mason, RA Winkle, NB Ingels, GT Daughters, DC Harrison, EB Stinson
The American Journal of Cardiology 1977
Clinical pharmacokinetics of antiarrhythmic drugs
DC Harrison, PJ Meffin, RA Winkle
Progress in Cardiovascular Diseases 1977

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