Using His bundle recording techniques, we examined direct and autonomically mediated conduction system effects of quinidine in five cardiac transplant recipients who have anatomically denervated hearts. We made control conduction interval and refractory period measurements, and then infused 10 mg/kg quinidine gluconate over a 20-min period. At 30 min, we determined the electrophysiologic changes induced by quinidine. Quinidine significantly increased the atrial-His (AH) interval (from 97+/-9 [SEM] to 108+/-7 ms, P less than 0.001), the His-ventricular (HV) inteval (from 43.9 +/- 1 to 52.8 +/- 3 ms, P less than 0.01), the donor heart sinus cycle length (from 599 +/- 38 to 630 +/- 56 ms, P less than 0.08), and the atrial effective refractory period (from 214 +/- 14 to 241 +/- 11 ms, P less than 0.01). Quinidine significantly decreased the innervated, remnant atrial sinus cycle length (from 847 +/- 104 to 660 +/- 96 ms, P less than 0.01) and the blood pressure. The mean plasma concentration of quinidine at the time that electrophysiologic measurements were repeated was 4.37 +/- 0.449 micrograms/ml. We conclude that quinidine's predominant sinus nodal and atrioventricular nodal effects in man are autonomically mediated and opposite to its direct actions upon these structures. On the other hand, quinidine's prevailing effect on atrial refractoriness and His-Purkinje conduction in man is direct.
J W Mason, R A Winkle, A K Rider, E B Stinson, D C Harrison
Title and authors | Publication | Year |
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Correction of the QRS duration for heart rate
JW Mason, DG Strauss, M Vaglio, F Badilini |
Journal of Electrocardiology | 2019 |
Differentiating Drug-Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil
L Johannesen, J Vicente, JW Mason, C Sanabria, K Waite-Labott, M Hong, P Guo, J Lin, JS Sørensen, L Galeotti, J Florian, M Ugander, N Stockbridge, DG Strauss |
Clinical Pharmacology & Therapeutics | 2014 |
Management of the Cardiac Transplant Recipient: Roles of the Transplant Cardiologist and Primary Care Physician
LE Wagoner |
The American Journal of the Medical Sciences | 1997 |
The Transplantation and Replacement of Thoracic Organs
DK Cooper, LW Miller, GA Patterson |
1996 | |
Task force 4: Function of the heart trnsplant recipient
JB Young, WL Winters, R Bourge, BF Uretsky |
Journal of the American College of Cardiology | 1993 |
The effectiveness and safety of the simultaneous administration of quinidine and amiodarone in the conversion of chronic atrial fibrillation
NZ Kerin, M Ansari-Leesar, K Faitel, C Narala, H Frumin, A Cohen |
American Heart Journal | 1993 |
Direct and autonomically mediated effects of oral quinidine on RR/QT relation after an abrupt increase in heart rate
R Cappato, L Codeca, G Guardigli, T Toselli, GE Antonioli, P Alboni |
Journal of the American College of Cardiology | 1993 |
Over-the-Counter Medications in Cardiac Transplant Recipients: Guidelines for Use
EA Hartshorn, KD Lake, JG Nolen, RA Slaker, TJ Reutzel, SK Milfred, DF Solbrack, FM Hoffman |
The Annals of pharmacotherapy | 1992 |
The surgically denervated, transplanted human heart
MR Bristow |
Circulation | 1990 |
Cardiac Arrhythmias: The Role of Pharmacologic Intervention
TS Klitzner, WF Friedman |
Cardiology Clinics | 1989 |
Drug effects on the sinus node a clinical perspective
NJ Linker, AJ Camm |
Cardiovascular Drugs and Therapy | 1988 |
The mammalian sinoatrial node
T Opthof |
Cardiovascular Drugs and Therapy | 1988 |
Intensive care of the cardiac transplant recipient
KL Stein, JM Darby, A Grenvik |
Journal of Cardiothoracic Anesthesia | 1988 |
A Metrical Approach to the Basic and Clinical Pharmacology of Antiarrhythmic Drugs
MF Arnsdorf, JA Wasserstrom |
Journal of Basic and Clinical Physiology and Pharmacology | 1987 |
Differing electrophysiological effects of class IA, IB and IC antiarrhythmic drugs on guinea-pig sinoatrial node
T Campbell |
British Journal of Pharmacology | 1987 |
Effects of orthotopic heart transplantation on sympathetic control mechanisms in congestive heart failure
TB Levine, MT Olivari, JN Cohn |
The American Journal of Cardiology | 1986 |
The Pathophysiology and Pharmacotherapy of Myocardial Infarction
BS Denenberg, JF Spann |
The Pathophysiology and Pharmacotherapy of Myocardial Infarction | 1986 |
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques
E Jucker |
1986 | |
Electrophysiologic, hemodynamic and metabolic effects of intravenous bepridil hydrochloride
JW Upward, K Daly, S Campbell, G Bergman, DE Jewitt |
The American Journal of Cardiology | 1985 |
Kombinationstherapie der Herzrhytmusstörungen mit Chinidin und Verapamil
F Bender, K Greeff |
1985 | |
Quinidine
JW Mason, LM Hondeghem |
Annals of the New York Academy of Sciences | 1984 |
Antimuscarinic action of quinidine on the heart? A study in myocardial preparations from cat hearts
H Nawrath, U Sack, X Zong |
British Journal of Pharmacology | 1984 |
Clinical efficacy and electrophysiology of imipramine for ventricular tachycardia
SJ Connolly, LB Mitchell, CD Swerdlow, JW Mason, RA Winkle |
The American Journal of Cardiology | 1984 |
Basic Understanding of the Electrophysiologic Actions of Antiarrhythmic Drugs: Sources, Sinks, and Matrices of Information
MF Arnsdorf |
Medical Clinics of North America | 1984 |
Sinus Node Function and Dysfunction
S Swiryn, T McDonough, DC Hueter |
Medical Clinics of North America | 1984 |
The QT interval historically treated
HB Burchell |
Pediatric Cardiology | 1983 |
Electrophysiological effects of quinidine alone and of the combination quinidine-verapamil on av conduction in humans
K Theisen, M Scheininger |
Clinical Cardiology | 1983 |
Class I antiarrhythmic agents: Quinidine, procainamide and N-acetylprocainamide, disopyramide
DM Roden, RL Woosley |
Pharmacology & Therapeutics | 1983 |
Safety and efficacy of intravenous quinidine
CD Swerdlow, JO Yu, E Jacobson, S Mann, RA Winkle, JC Griffin, DL Ross, JW Mason |
The American Journal of Medicine | 1983 |
Unusual atrial potentials in a cardiac transplant recipient. possible synchronization between donor and recipient atria
AL Goldberger, RS Bexton, KJ Hellestrand, R Cory-Pearce, RA Spurrell, TA English, AJ Camm |
Journal of Electrocardiology | 1983 |
Cardiac transplantation — the ideal model for electrophysiologic drug testing?
RS Bexton, AJ Camm |
International Journal of Cardiology | 1983 |
The direct electrophysiologic effects of disopyramide phosphate in the transplanted human heart
RS Bexton, KJ Hellestrand, R Cory-Pearce, RA Spurrell, TA English, AJ Camm |
Circulation | 1983 |
Cardiac therapy
MR Rosen, BF Hoffman |
1983 | |
Coronary artery spasm in the denervated transplanted human heart
AJ Buda, RE Fowles, JS Schroeder, SA Hunt, PR Cipriano, EB Stinson, DC Harrison |
The American Journal of Medicine | 1981 |
Electrophysiologic evaluation of encainide with use of monophasic action potential recording
RG Samuelsson, DC Harrison |
The American Journal of Cardiology | 1981 |
Sino-Atrial Node Transplantation in the Dog
Y Morishita, RA Poirier, RF Rohner |
Vascular and endovascular surgery | 1981 |
Antiarrhythmic Drugs
HW Moses, PN Yu |
The Journal of Clinical Pharmacology | 1980 |
Overdrive suppression in the transplanted heart: effect of the autonomic nervous system on human sinus node recovery
JW Mason |
Circulation | 1980 |
Cardiac abnormalities in myotonic dystrophy
J Motta, C Guilleminault, M Billingham, W Barry, J Mason |
The American Journal of Medicine | 1979 |
Clinical electrophysiologic effects of encainide, a newly developed antiarrhythmic agent
M Sami, JW Mason, F Peters, DC Harrison |
The American Journal of Cardiology | 1979 |
Canine electrophysiology of encainide, a new antiarrhythmic drug
M Sami, JW Mason, G Oh, DC Harrison |
The American Journal of Cardiology | 1979 |
Human heart transplantation
JG Copeland, EB Stinson |
Current Problems in Cardiology | 1979 |
Clinical electrophysiologic effects of tocainide
JL Anderson, JW Mason, RA Winkle, PJ Meffin, RE Fowles, L Peters, DC Harrison |
Circulation | 1978 |
Antiarrhythmic Drugs: Clinical Pharmacology and Therapeutic Uses
JL Anderson, DC Harrison, PJ Meffin, RA Winkle |
Drugs | 1978 |
Hemodynamic effects of intravenously administered quinidine on the transplanted human heart
JW Mason, RA Winkle, NB Ingels, GT Daughters, DC Harrison, EB Stinson |
The American Journal of Cardiology | 1977 |
Clinical pharmacokinetics of antiarrhythmic drugs
DC Harrison, PJ Meffin, RA Winkle |
Progress in Cardiovascular Diseases | 1977 |