To investigate the role of glucagon in regulating hepatic glucose production in man, selective glucagon deficiency was produced in four normal men by infusing somatostatin (0.9 mg/h) and regular pork insulin (150-muU/kg per min) for 2 h. Exogenous glucose was infused to maintain euglycemia. Arterial plasma glucagon levels fell by greater than 50% whereas plasma insulin levels were maintained in the range of 10-14 muU/ml. In response to these hormonal changes, net splanchnic glucose production (NSGP) fell by 75% and remained suppressed for the duration of the study. In contrast, when somatostatin alone was administered to normal men, resulting in combined insulin and glucagon deficiency (euglycemia again maintained), NSGP fell markedly but only transiently, reaching its nadir at 15 min. Thereafter, NSGP rose progressively, reaching the basal rate at 105 min. These data indicate that the induction of selective glucagon deficiency in man (with basal insulin levels maintained) is associated with a marked and sustained fall in hepatic glucose production. We conclude, therefore, that basal glucagon plays an important role in the maintenance of basal hepatic glucose production in normal man.
J E Liljenquist, G L Mueller, A D Cherrington, U Keller, J-L Chiasson, J M Perry, W W Lacy, D Rabinowitz
Year: | 2024 | 2020 | 2019 | 2017 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1998 | 1997 | 1996 | 1995 | 1993 | 1992 | 1991 | 1990 | 1989 | 1988 | 1987 | 1986 | 1985 | 1984 | 1983 | 1982 | 1981 | 1980 | 1979 | 1978 | 1964 | Total |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Citations: | 1 | 2 | 3 | 1 | 5 | 3 | 2 | 3 | 7 | 5 | 2 | 6 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 5 | 1 | 1 | 1 | 2 | 2 | 3 | 2 | 3 | 3 | 5 | 1 | 2 | 3 | 3 | 3 | 9 | 3 | 5 | 8 | 1 | 113 |
Title and authors | Publication | Year |
---|---|---|
The impact of glucagon to support postabsorptive glucose flux and glycemia in healthy rats and its attenuation in male Zucker diabetic fatty rats
Estes SK, Shiota C, O\u2019Brien TP, Printz RL, Shiota M |
American journal of physiology. Endocrinology and metabolism | 2024 |
Roux-en-Y gastric bypass surgery improves hepatic glucose metabolism and reduces plasma kisspeptin levels in morbidly obese patients with type 2 diabetes
CR Flynn, VL Albaugh, RA Tamboli, JM Gregory, A Bosompem, RM Sidani, JJ Winnick |
AJP Gastrointestinal and Liver Physiology | 2020 |
Glucagon and Liver Fat are Downregulated in Response to Very Low-calorie Diet in Patients with Obesity and Type-2 Diabetes
SL Haas, P Löfgren, P Stål, J Hoffstedt |
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association | 2020 |
Growth hormone enhances the recovery of hypoglycemia via ventromedial hypothalamic neurons
IC Furigo, GO Souza, PD Teixeira, D Guadagnini, R Frazão, EO List, JJ Kopchick, PO Prada, J Donato |
The FASEB Journal | 2019 |
Metabolic effects of glucagon in humans
MM Adeva-Andany, R Funcasta-Calderón, C Fernández-Fernández, E Castro-Quintela, N Carneiro-Freire |
Journal of Clinical & Translational Endocrinology | 2019 |
Higher glucagon-to-insulin ratio is associated with elevated glycated hemoglobin levels in type 2 diabetes patients
M Lee, M Kim, JS Park, S Lee, J You, CW Ahn, KR Kim, S Kang |
The Korean Journal of Internal Medicine | 2019 |
Modeling Glucagon Action in Patients With Type 1 Diabetes
A Emami, JE Youssef, R Rabasa-Lhoret, J Pineau, JR Castle, A Haidar |
IEEE J BIOMED HEALTH | 2017 |
Glucagon – Early breakthroughs and recent discoveries
B Ahrén |
Peptides | 2015 |
The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice
JM Spaeth, CS Hunter, L Bonatakis, M Guo, CA French, I Slack, M Hara, SE Fisher, J Ferrer, EE Morrisey, BZ Stanger, R Stein |
Diabetologia | 2015 |
Involvement of steatosis-induced glucagon resistance in hyperglucagonaemia
MP Suppli, A Lund, JI Bagger, T Vilsbøll, FK Knop |
Medical Hypotheses | 2015 |
Pancreatic α-Cell Dysfunction in Type 2 Diabetes: Old Kids on the Block
JS Moon, KC Won |
Diabetes & Metabolism Journal | 2015 |
Physiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease
DA Sandoval, DA D'Alessio |
Physiological reviews | 2015 |
Tissue-specific insulin signaling in the regulation of metabolism and aging: Insulin Signaling in Metabolism and Aging
J Zhang, F Liu |
IUBMB Life | 2014 |
Comprehensive Physiology
SN Cheuvront, RW Kenefick |
Comprehensive Physiology | 2014 |
Pronounced reduction of postprandial glucagon by lixisenatide: a meta-analysis of randomized clinical trials
B Ahrén, JF Gautier, R Berria, W Stager, R Aronson, CJ Bailey |
Diabetes Obesity and Metabolism | 2014 |
Hypothalamic glucagon signaling inhibits hepatic glucose production
PI Mighiu, JT Yue, BM Filippi, MA Abraham, M Chari, CK Lam, CS Yang, NR Christian, MJ Charron, TK Lam |
Nature Medicine | 2013 |
Glucagon clearance is regulated by nutritional state: evidence from experimental studies in mice
A Zhou, G Pacini, B Ahrén, DZ D’Argenio |
Diabetologia | 2013 |
Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover
Robert H. Unger, Alan Cherrington |
Journal of Clinical Investigation | 2012 |
Minireview: Glucagon in the Pathogenesis of Hypoglycemia and Hyperglycemia in Diabetes
PE Cryer |
Endocrinology | 2012 |
Evidence against a physiologic role for acute changes in CNS insulin action in the rapid regulation of hepatic glucose production
CJ Ramnanan, DS Edgerton, AD Cherrington |
Cell Metabolism | 2012 |
Brain Insulin Action Augments Hepatic Glycogen Metabolism without altering Glucose Production or Gluconeogenesis in the Dog
Christopher Ramnanan, Viswanathan Saraswathi, Marta Smith, Patrick Donahue, Ben Farmer, Tiffany Farmer, Doss Neal, Phil Williams, Maggie Lautz, Andrea Mari, Alan Cherrington, Dale Edgerton |
Journal of Clinical Investigation | 2011 |
Physiologic action of glucagon on liver glucose metabolism
CJ Ramnanan, DS Edgerton, G Kraft, AD Cherrington |
Diabetes, Obesity and Metabolism | 2011 |
The physiological regulation of glucose flux into muscle in vivo
DH Wasserman, L Kang, JE Ayala, PT Fueger, RS Lee-Young |
The Journal of experimental biology | 2011 |
The role of dysregulated glucagon secretion in type 2 diabetes
D D'Alessio |
Diabetes, Obesity and Metabolism | 2011 |
International Review of Cell and Molecular Biology
A Chavez, M Smith, D Mehta |
International Review of Cell and Molecular Biology Volume 290 | 2011 |
Actions physiologiques du glucagon
G Kraft, AD Cherrington |
Médecine des Maladies Métaboliques | 2011 |
Glucagon as a Critical Factor in the Pathology of Diabetes
DS Edgerton, AD Cherrington |
Diabetes | 2011 |
Glucagon deficiency reduces hepatic glucose production and improves glucose tolerance in adult mice
AS Hancock, A Du, J Liu, M Miller, CL May |
Molecular Endocrinology | 2010 |
Textbook of Diabetes
PM Jones, SJ Persaud |
Textbook of Diabetes | 2010 |
Adjunct therapy for type 1 diabetes mellitus
HE Lebovitz |
Nature Reviews Endocrinology | 2010 |
Glucagon Supports Postabsorptive Plasma Glucose Concentrations in Humans With Biologically Optimal Insulin Levels
BA Cooperberg, PE Cryer |
Diabetes | 2010 |
The Physiology of Glucagon
GJ Taborsky |
Journal of diabetes science and technology | 2010 |
Novartis Foundation Symposia
EJ Campbell |
Ciba Foundation Symposium 44 - Research and Medical Practice: Their Interaction | 2008 |
Islet cell function: α and β cells - partners towards normoglycaemia
B Göke |
International Journal of Clinical Practice | 2008 |
A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects
MO Weickert, CV Loeffelholz, M Roden, V Chandramouli, A Brehm, P Nowotny, MA Osterhoff, F Isken, J Spranger, BR Landau, AF Pfeiffer, M Möhlig |
American journal of physiology. Endocrinology and metabolism | 2007 |
The Role of α-Cell Dysregulation in Fasting and Postprandial Hyperglycemia in Type 2 Diabetes and Therapeutic Implications
BE Dunning, JE Gerich |
Endocrine reviews | 2007 |
Basal insulin, glucagon, and growth hormone replacement
SM Breckenridge, B Raju, AM Arbelaez, BW Patterson, BA Cooperberg, PE Cryer |
American journal of physiology. Endocrinology and metabolism | 2007 |
Pancreatic islet dysfunction in type 2 diabetes: a rational target for incretin-based therapies
J Meece |
Current Medical Research and Opinion | 2007 |
Glucagon, in Concert With Insulin, Supports the Postabsorptive Plasma Glucose Concentration in Humans
SM Breckenridge, BA Cooperberg, AM Arbelaez, BW Patterson, PE Cryer |
Diabetes | 2007 |
Pharmacokinetics and Pharmacodynamics of Vildagliptin??in??Patients?? with Type??2??Diabetes??Mellitus:
YL He, D Serra, Y Wang, J Campestrini, GJ Riviere, C F, JJ Holst, S Schwartz, JC Nielsen, M Ligueros-Saylan |
Clinical Pharmacokinetics | 2007 |
Islet Dysfunction: An Underlying Defect in the Pathophysiology of Type 2 Diabetes
R Pratley |
Endocrinology & Metabolism Clinics of North America | 2006 |
Maintenance of the postabsorptive plasma glucose concentration: insulin or insulin plus glucagon?
B Raju, PE Cryer |
American journal of physiology. Endocrinology and metabolism | 2005 |
Differential effect of saturated and polyunsaturated fatty acids on hepatic glucose metabolism in humans
JN Clore, JS Stillman, J Li, SJ O'Keefe, JR Levy |
American journal of physiology. Endocrinology and metabolism | 2004 |
La variabilité glycémique asymptomatique: comment l'évaluer et quelle est son incidence clinique ?
B Guerci |
Diabetes & Metabolism | 2003 |
FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis
G Boden, P Cheung, TP Stein, K Kresge, M Mozzoli |
American journal of physiology. Endocrinology and metabolism | 2002 |
ENERGY AND SUBSTRATE METABOLISM IN PATIENTS WITH CHRONIC EXTENSIVE GRAFT-VERSUS-HOST DISEASE:
C Zauner, W Rabitsch, B Schneeweiss, M Schiefermeier, HT Greinix, F Keil, K Ratheiser, P Kalhs |
Transplantation | 2001 |
Effects of glucocorticoids on hepatic sensitivity to insulin and glucagon in man
M Dirlewanger, PH Schneiter, N Paquot, E Jequier, V Rey, L Tappy |
Clinical Nutrition | 2000 |
Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans
KF Petersen, D Laurent, DL Rothman, GW Cline, GI Shulman |
Journal of Clinical Investigation | 1998 |
Effects of glucagon on postpranidal carbohydrate metabolism in nondiabetic humans
JW Frank, M Camilleri, GM Thomforde, SF Dinneen, RA Rizza |
Metabolism | 1998 |
Hyperglucagonemia and the immediate fate of dietary leucine: A kinetic study in humans
JS Marchini, LM Marks, D Darmaun, VR Young, M Krempf |
Metabolism | 1998 |
Indomethacin stimulates glucose production in adults with uncomplicated falciparum malaria
E Dekker, JA Romijn, HV Thien, MT Ackermans, E Endert, PA Kager, LT Thuy, HP Sauerwein |
Metabolism | 1998 |
Principles of Perinatal—Neonatal Metabolism
RM Cowett |
1998 | |
Theoretical analysis of the mechanisms of chronic hyperinsulinemia
RL Summers, JP Montani, LH Woodward, TG Coleman, JE Hall |
Computers in Biology and Medicine | 1997 |
Gliclazide potentiates suppression of hepatic glucose production in non—insulin-dependent diabetic patients
A Riccio, G Lisato, SV de Kreutzenberg, S Marchetto, M Turrin, A Tiengo, SD Prato |
Metabolism | 1996 |
Role of glucagon in maintenance of euglycemia in fed and fasted rats
CL Brand, PN Jorgensen, U Knigge, J Warberg, I Svendsen, JS Kristensen, JJ Holst |
American journal of physiology. Endocrinology and metabolism | 1995 |
3 Action of insulin on glucose metabolism in vivo
YJ Hannele |
Baillière's Clinical Endocrinology and Metabolism | 1993 |
Contribution of glucose/glucose 6-phosphate cycle activity to insulin resistance in Type 2 (non-insulin-dependent) diabetes mellitus
DP Rooney, RD Neely, O Beatty, NP Bell, B Sheridan, AB Atkinson, ER Trimble, PM Bell |
Diabetologia | 1993 |
Idiopathic reactive hypoglycemia: a role for glucagon?
F Leonetti, L Morviducci, A Giaccari, P Sbraccia, S Caiola, D Zorretta, O Lostia, G Tamburrano |
Journal of Endocrinological Investigation | 1992 |
Glucose appearance rate following protein ingestion in normal subjects
MA Khan, MC Gannon, FQ Nuttall |
Journal of the American College of Nutrition | 1992 |
Hepatic fuel metabolism during muscular work: role and regulation
DH Wasserman, AD Cherrington |
American journal of physiology. Endocrinology and metabolism | 1991 |
Principles of Perinatal-Neonatal Metabolism
RM Cowett |
1991 | |
Diabetic Hyperglycemia: Link to Impaired Glucose Transport in Pancreatic β Cells
RH Unger |
Science | 1991 |
Neuroendocrine mechanisms involved in regulation of body weight, food intake and metabolism
AB Steffens, JH Strubbe, B Balkan, AJ Scheurink |
Neuroscience & Biobehavioral Reviews | 1990 |
Insulin
P Cuatrecasas, S Jacobs |
Insulin | 1990 |
Recent Advances in Carbohydrate Nutrition and Metabolism in Diabetes Mellitus
JW Anderson |
Journal of the American College of Nutrition | 1989 |
Alterations in Digestive Function Caused by Pancreatic Disease
JE Doty, AS Fink, JH Meyer |
Surgical Clinics of North America | 1989 |
Regulation of Carbohydrate Metabolism and Response to Hypoglycemia
PC Butler, RA Rizza |
Endocrinology and metabolism clinics of North America | 1989 |
Effect of DG5128 on epinephrine and glucagon induced glucose output from the isolated perfused rat liver
M Usami, Y Seino, T Taminato, M Seno, G Koh, M Ohno, M Ikeda, H Imura |
Life Sciences | 1988 |
Similar effects of pulsatile and constant intravenous insulin delivery
W Kerner, J Brückel, H Zier, P Arias, C Thun, R Moncayo, EF Pfeiffer |
Diabetes Research and Clinical Practice | 1988 |
Alterations in carbohydrate metabolism as they apply to reproductive endocrinology
EE Wallach, MP Diamond, AC Wentz, AD Cherrington |
Fertility and Sterility | 1988 |
Role of counterregulatory hormones in the regulation of hepatic glucose metabolism
L Saccà |
Diabetes / Metabolism Reviews | 1987 |
Insulin, glucagon, and glucose as regulators of hepatic glucose uptake and production in vivo
AD Cherrington, RW Stevenson, KE Steiner, MA Davis, SR Myers, BA Adkins, NN Abumrad, PE Williams |
Diabetes / Metabolism Reviews | 1987 |
Hepatic response to insulin in control of glucose kinetics in the neonatal lamb
RM Cowett, D Tenenbaum |
Metabolism | 1987 |
Basal glucose homeostasis with and without fixed concentrations of glucagon and insulin
RA Jackson, JB Hamling, BM Sim, PM Blix, JB Jaspan, S Markanday, JD Nabarro |
Metabolism | 1987 |
Effect of somatostatin on nonesterified fatty acid levels modifies glucose homeostasis during fasting
GK Hendrick, RT Frizzell, AD Cherrington |
American journal of physiology. Endocrinology and metabolism | 1987 |
Interaction between insulin and counterregulatory hormones in control of substrate utilization in health and diabetes during exercise
DH Wasserman, M Vranic |
Diabetes / Metabolism Reviews | 1986 |
Mechanisms of insulin resistance in non-insulin-dependent (type II) diabetes
JM Olefsky, TP Ciaraldi, OG Kolterman |
The American Journal of Medicine | 1985 |
Pathogenesis of insulin resistance and hyperglycemia in non-insulin-dependent diabetes mellitus
JM Olefsky |
The American Journal of Medicine | 1985 |
Effects of glucagon on plasma amino acids
G Boden, I Rezvani, OE Owen |
Journal of Clinical Investigation | 1984 |
Role of basal glucagon levels in the regulation of splanchnic glucose output and ketogenesis in insulin-deficient humans
O Björkman, P Felig, J Wahren |
Clinical Physiology | 1984 |
Glucose counterregulation during prolonged hypoglycemia in normal humans
GB Bolli, IS Gottesman, PE Cryer, JE Gerich |
American journal of physiology. Endocrinology and metabolism | 1984 |
Release of Glucagon in Male Alcoholics with Vagal Neuropathy
ET Tan, DG Lambie, RH Johnson, EA Whiteside |
Alcoholism, clinical and experimental research | 1983 |
Glucagon II
PJ Lefebvre |
1983 | |
A 6-hour nocturnal interruption of a continuous subcutaneous insulin infusion: 2. Marked attenuation of the metabolic deterioration by somatostatin
AJ Scheen, G Krzentowski, M Castillo, PJ Lefbvre, AS Luyckx |
Diabetologia | 1983 |
METABOLIC EVENTS IN INFANTS OF DIABETIC MOTHERS DURING FIRST 24 HOURS AFTER BIRTH I
C Kühl, GE Andersen, J Hertel, L Mølsted-Pedersen |
Acta Paediatrica | 1982 |
Transient hepatic response to glucagon in man: role of insulin and hyperglycemia
E Ferrannini, RA DeFronzo, RS Sherwin |
American journal of physiology. Endocrinology and metabolism | 1982 |
Cyclic Nucleotides
JW Kebabian, JA Nathanson |
1982 | |
Influence of hypoglucagonemia on splanchnic glucose output during leg exercise in man
O Björkman, P Felig, L Hagenfeldt, J Wahren |
Clinical Physiology | 1981 |
Hormonal and metabolic control of hepatic carbohydrate metabolism
A Jakob |
Molecular Aspects of Medicine | 1981 |
THE METABOLIC EFFECTS OF CHRONIC HYPERGLUCAGONAEMIA
A Nankervis, J Proietto, KW Ng, FP Alford, R Larkins |
Clinical Endocrinology | 1981 |
Glucagon-Biochemistry, Physiology and Pathophysiology
H Schenck |
Acta Medica Scandinavica | 1981 |
Effect of intermittent physiologic hyperglucagonemia on postprandial plasma glucose levels in normal man
K Mackes, R Rizza, J Gerich |
Metabolism | 1981 |
Influence of somatostatin on gastric motility and meal absorption in rhesus monkeys, Macaca mulatta
DJ Koerker, BC Hansen |
Metabolism | 1981 |
A familial glucagonoma syndrome
PW Stacpoole, J Jaspan, AG Kasselberg, SA Halter, K Polonsky, FW Gluck, JE Liljenquist, D Rabin |
The American Journal of Medicine | 1981 |
Somatostatin and diabetes
JE Gerich |
The American Journal of Medicine | 1981 |
Current Topics in Cellular Regulation
G Cahill, T Aoki, R Smith |
Current Topics in Cellular Regulation | 1981 |
Glucagon deficiency and hyperaminoacidemia after total pancreatectomy
G Boden, RW Master, I Rezvani, JP Palmer, TE Lobe, OE Owen |
Journal of Clinical Investigation | 1980 |
Somatostatin infusion in liver cirrhosis: Glucagon control of glucose homeostasis
AV Greco, L Altomonte, G Ghirlanda, AG Rebuzzi, R Manna, A Bertoli |
Diabetologia | 1980 |
Treatment of intractable neonatal hypoglycemia with somatostatin plus glucagon
ZT Bloomgarden, H Sundell, LW Rogers, JA O'Neill, JE Liljenquist |
The Journal of Pediatrics | 1980 |
Hormonal mechanisms of recovery from insulin-induced hypoglycemia in man
J Gerich, J Davis, M Lorenzi, R Rizza, N Bohannon, J Karam, S Lewis, R Kaplan, T Schultz, P Cryer |
American journal of physiology. Endocrinology and metabolism | 1979 |
Importance of hypoglycemia-induced glucose production during isolated glucagon deficiency
AD Cherrington, JE Liljenquist, GI Shulman, PE Williams, WW Lacy |
American journal of physiology. Endocrinology and metabolism | 1979 |
Possible mechanism by which somatostatin-induced glucagon suppression improves glucose tolerance during insulinopaenia in man
JE Liljenquist, ZT Bloomgarden, AD Cherrington, JM Perry, D Rabin |
Diabetologia | 1979 |
Contemporary Metabolism
N Freinkel |
1979 | |
Studies on alpha-adrenergic activation of hepatic glucose output. Insulin inhibition of alpha-adrenergic and glucagon actions in normal and calcium-depleted hepatocytes
PF Blackmore, F Assimacopoulos-Jeannet, TM Chan, JH Exton |
The Journal of biological chemistry | 1979 |
Effect of glucagon on glucose production during insulin deficiency in the dog
AD Cherrington, WW Lacy, JL Chiasson |
Journal of Clinical Investigation | 1978 |
Role of glucagon in the pathogenesis of diabetes: The status of the controversy
RH Unger |
Metabolism | 1978 |
Glucose metabolism in intact man: The responsiveness of splanchnic and peripheral tissues to insulin
D Rabinowitz, JE Liljenquist |
Metabolism | 1978 |
Mesenchymal tumor hypoglycemia
SL Jensen, C Kühl, KB Lauritsen, AJ Moody |
The American Journal of Surgery | 1978 |
Regulatory Mechanisms of Carbohydrate Metabolism
SJ Pilkis, TH Claus, JP Riou, AD Cherrington, JL Chiasson, JE Liljenquist, WW Lacy, CR Park |
Regulatory Mechanisms of Carbohydrate Metabolism | 1978 |
Pathophysiology of Diabetes Mellitus
R Sherwin, P Felig |
Medical Clinics of North America | 1978 |
Somatostatin and Diabetes
RA Rizza, JE Gerich |
Medical Clinics of North America | 1978 |
Glucagon and Diabetes
P Raskin, RH Unger |
Medical Clinics of North America | 1978 |
Advances in Metabolic Disorders
G Aurbach, JT Potts |
Advances in Metabolic Disorders | 1964 |