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Citations to this article

The pathophysiology of acid-base changes in chronically phosphate-depleted rats: bone-kidney interactions.
M Emmett, … , Z S Agus, R G Narins
M Emmett, … , Z S Agus, R G Narins
Published February 1, 1977
Citation Information: J Clin Invest. 1977;59(2):291-298. https://doi.org/10.1172/JCI108640.
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Research Article

The pathophysiology of acid-base changes in chronically phosphate-depleted rats: bone-kidney interactions.

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Abstract

Acid-base disturbances may develop secondary to the changes in renal tubular function and bone dynamics which attend phosphate depletion (PD). This work characterizes the acid-base status of rats fed a low phosphate diet. After 18 days, PD rats had marked calciuria (pair-fed controls: 0.3 +/- 0.2; PD 32.2 +/- 2.5 mueq/h; P less than 0.001), severe bicarbonaturia (controls: 0; PD 17.6 +/- 0.2 meq/h; P less than 0.001), and negative net acid excretion (controls: 44.5 +/- 2.9; PD: --6.6 +/- 2.5 meq/h; P less than 0.001), but plasma pH, HCO3, and PCO2 were equal in both groups. After 45 days, plasma HCO3 fell to 21.1 +/- 0.9 meq/liter in PD (controls: 23.6 +/- 0.5 meq/liter; P less than 0.05), while bicarbonaturia (controls: 0.4 +/- 0.2; PD: 3.8 +/- 1 mueq/h; P less than 0.02) and calciuria were present but diminished. These data suggested the coexistence of bone HCO3 mobilization and renal HCO3 wasting in PD. To test this thesis, bicarbonaturia was eliminated by nephrectomy. 24 h later plasma HCO3 was higher in PD rats (controls: 19.3 +/- 0.02; PD: 22.6 +/- 0.8 meq/liter; P less than 0.05), consistend with the presence of extrarenal HCO3 production. After inhibition of bone resorption with colchicine (1 mg/kg), plasma HCO3 decreased to 16.8 +/- 0.6 meq/liter in PD rats (controls): 26.4 +/- 1 meq/liter; P less than 0.001) while bicarbonaturia persisted. These data indicate that the plasma HCO3 in PD is the net result of renal HCO3 wasting and bone HCO3 mobilization. These combined effects maintain normal blood HCO3 initially (18 days) but with time (45 days), bone resorption diminishes and the acidifying renal tubular defect predominates.

Authors

M Emmett, S Goldfarb, Z S Agus, R G Narins

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Total citations by year

Year: 2024 2016 2009 1999 1998 1997 1993 1991 1989 1987 1985 1984 1983 1982 1981 1980 1979 1978 1977 Total
Citations: 1 1 1 1 1 2 1 2 1 2 2 3 2 6 1 4 3 3 1 38
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (38)

Title and authors Publication Year
Phosphate Depletion Mobilizes Bone Bicarbonate
Emmett M
Journal of the American Society of Nephrology : JASN 2024
Endocrinology
C Napier, SH Pearce
Endocrinology 2016
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Type II Na-P i cotransport is regulated transcriptionally by ambient bicarbonate/carbon dioxide tension in OK cells
AW Jehle, H Hilfiker, MF Pfister, J Biber, E Lederer, R Krapf, H Murer
American journal of physiology. Renal physiology 1999
Metabolic Bone Disease and Clinically Related Disorders
FR Singer, SM Krane
Metabolic Bone Disease and Clinically Related Disorders 1998
Phosphate depletion diminishes Mg2+ uptake in mouse distal convoluted tubule cells
LJ Dai, PA Friedman, GA Quamme
Kidney International 1997
Suki and Massry’s THERAPY OF RENAL DISEASES AND RELATED DISORDERS
WN Suki, SG Massry
1997
Phosphate deprivation inhibits NH4+ transport in OK cells
JG Chen, SA Kempson
Biochimica et Biophysica Acta (BBA) - Biomembranes 1993
Role of bone in regulation of systemic acid-base balance
J Green, CR Kleeman
Kidney International 1991
Nephrology
M Hatano
Nephrology 1991
Hypophosphatemia
SD DVM, KJ Moreland
Journal of Veterinary Internal Medicine 1989
Dietary NaCl determines severity of potassium depletion–induced metabolic alkalosis
RE Hernandez, M Schambelan, MG Cogan, J Colman, RC Morris, A Sebastian
Kidney International 1987
Recent Developments in Alcoholism
M Galanter
1987
Role of alcohol in clinical nephrology
A Heidland, WH Hörl, RM Schaefer, M Teschner, J Weipert, E Heidbreder
Klinische Wochenschrift 1985
Complications of total parenteral nutrition
JP Knochel
Kidney International 1985
Hypophosphaturia impairs the renal defense against metabolic acidosis
HN Hulter
Kidney International 1984
The Effects of Alcohol on Blood Pressure and Electrolytes
G Kaysen, RH Noth
Medical Clinics of North America 1984
Pathogenese und Klinik der Harnsteine X
W Vahlensieck, G Gasser
1984
The Acidosis of Chronic Renal Failure
S Sabatini
Medical Clinics of North America 1983
Nephrology Forum
JJ Cohen, JT Harrington, JP Kassirer
1983
Renal and systemic acid-base effects of the chronic administration of hypercalcemia-producing agents: Calcitriol, PTH, and intravenous calcium
HN Hulter, A Sebastian, RD Toto, EL Bonner, LP Ilnicki, M McTigue
Kidney International 1982
Effects of two models of hypercalcemia on renal acid base metabolism
P Mitnick, A Greenberg, T Coffman, E Kelepouris, CJ Wolf, S Goldfarb, J Schell, D Senesky
Kidney International 1982
Acute hypophosphatemia
E Ritz
Kidney International 1982
Effect of calcium and phosphate on bicarbonate and fluid transport by proximal tubules in vitro
TD McKinney, P Myers
Kidney International 1982
Phosphate homeostasis and hypophosphatemia
JS Stoff
The American Journal of Medicine 1982
Regulation of Phosphate and Mineral Metabolism
SG Massry, JM Letteri, E Ritz
1982
Contemporary Nephrology
S Klahr, SG Massry
1981
Distal acidification defect induced by phosphate deprivation
JA Arruda, NK Julka, H Rubinstein, S Sabatini, NA Kurtzman
Metabolism 1980
Renal Handling of Phosphate
SG Massry, H Fleisch
1980
Phosphate and Minerals in Health and Disease
SG Massry, E Ritz, H Jahn
1980
Pathogenese
H Cottier
1980
Renal Tubular Sites of Altered Calcium Transport in Phosphate-depleted Rats
K Lau, ZS Agus, M Goldberg, S Goldfarb
Journal of Clinical Investigation 1979
Bone maturation in the vitamin D, phosphate deficient rat and the response to acid loading
JE Russell, LV Avioli
Calcified Tissue International 1979
Contemporary Metabolism
N Freinkel
1979
Effects of phosphate depletion on acid-base status in dogs
RW Schmidt
Metabolism 1978
Homeostasis of Phosphate and Other Minerals
SG Massry, E Ritz, A Rapado
1978
Impaired distal nephron acidification in chronically phosphate depleted rats
TW Kurtz, CH Hsu
Pflügers Archiv - European Journal of Physiology 1978
Renal tubular effects of chronic phosphate depletion
S Goldfarb, GR Westby, M Goldberg, ZS Agus
Journal of Clinical Investigation 1977

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