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Research Article Free access | 10.1172/JCI108564

Persistence of thromboxane A2-like material and platelet release-inducing activity in plasma.

J B Smith, C Ingerman, and M J Silver

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Published November 1, 1976 - More info

Published in Volume 58, Issue 5 on November 1, 1976
J Clin Invest. 1976;58(5):1119–1122. https://doi.org/10.1172/JCI108564.
© 1976 The American Society for Clinical Investigation
Published November 1, 1976 - Version history
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Abstract

During the incubation of arachidonic acid with platelet-rich plasma, a persistent activity appeared that caused the release of [14C]5-hydroxytryptamine from indomethacin-treated platelets. By the time-course of its appearance and disappearance, this release-inducing activity could be dissociated from prostaglandin endoperoxides and associated with thromboxane A2-like material. This material persists in plasma because of its continued production and increased stability.

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