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Citations to this article

Heart muscle performance after experimental viral myocarditis.
C O Adesanya, … , N A Young, W H Abelmann
C O Adesanya, … , N A Young, W H Abelmann
Published March 1, 1976
Citation Information: J Clin Invest. 1976;57(3):569-575. https://doi.org/10.1172/JCI108312.
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Research Article

Heart muscle performance after experimental viral myocarditis.

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Abstract

As part of an inquiry into possible antecedents of idiopathic cardiomyopathy, acute experimental coxsackie virus myocarditis was studied for late structural and functional sequelae. Myocarditis was induced in 12- and 22-day-old hamsters by inoculation with coxsackie virus B3. Early viremia occurred, followed by virus replication in heart muscle. Maximum peak developed tension (Tpd) of isometrically contracting isolated heart muscle was depressed 17 and 43% in the animals inoculated at 12 days, and studied 18 and 90 days later, respectively, as compared to their uninoculated controls. In both infected groups, less muscle stretch was required to reach the length at which Tpd was produced. Animals studied 180 days after inoculation did not differ from controls. The muscles from animals inoculated at 22 days of age and studied 18 days later showed a 15% depression of Tpd compared to their controls. Glycerinated muscles from this infected group developed 50% less tension than their controls. The muscles of hamsters inoculated with virus at 22 days and studied 90 and 180 days later showed no change in Tpd. The data suggest that contractility and compliance of heart muscle are decreased 18 days after inoculation, but recover by 90 days if the animals are inoculated at age 22 days. However, if the animals are inoculated at a younger age (12 days), depression of myocardial performance persists for at least an additional 90 days. It is concluded that the inflammatory stage of experimental acute coxsackie virus B3 myocarditis in the Syrian golden hamster may be followed by residual alterations in contractile proteins and myocardial function.

Authors

C O Adesanya, A H Goldberg, W P Phear, K A Thorp, N A Young, W H Abelmann

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Total citations by year

Year: 2007 2004 2000 1992 1990 1989 1988 1985 1984 1983 1982 1980 Total
Citations: 1 1 1 1 1 1 2 2 2 1 1 1 15
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (15)

Title and authors Publication Year
Cardiovascular Medicine
JT Willerson, HJ Wellens, JN Cohn, DR Holmes
2007
AIDS and Heart Disease
J Wang, J Morgan
AIDS and Heart Disease: Effects on Oxidative Damage 2004
Myocarditis
AM Feldman, D McNamara
New England Journal of Medicine 2000
Lymphocytic active myocarditis characterized by numerous clusters of lymphocytes: A chronic variant of myocarditis?
M Okabe, K Fukuda, Y Nakashima, T Hiroki, K Arakawa, M Kikuchi
American Heart Journal 1992
Viral Heart Disease
TJ Montague, GD Lopaschuk, NJ Davies
Chest 1990
A Prospective, Randomized, Controlled Trial of Prednisone for Dilated Cardiomyopathy
JE Parrillo, RE Cunnion, SE Epstein, MM Parker, AF Suffredini, M Brenner, GL Schaer, ST Palmeri, RO Cannon, D Alling, JT Wittes, VJ Ferrans, ER Rodriguez, AS Fauci
New England Journal of Medicine 1989
The Dilated Cardiomyopathies: Experimental Aspects
WH Abelmann
Cardiology Clinics 1988
Coxsackieviruses
M Bendinelli, H Friedman
1988
Natural history of left ventricular function in neonatal coxsackie myocarditis
A Rozkovec, G Cambridge, M King, KA Hallidic-Smith
Pediatric Cardiology 1985
Prognosis and treatment of cardiomyopathy and myocarditis
JB O'Connell, MR Costanzo-Nordin, RS Engelmeier, DE Wallis, JA Robinson, PJ Scanlon
Heart and Vessels 1985
Lymphocytic myocarditis presenting as unexplained ventricular arrhythmias: Diagnosis with endomyocardial biopsy and response to immunosuppression
PA Vignola, K Aonuma, PS Swaye, JJ Rozanski, RL Blankstein, J Benson, AJ Gosselin, JW Lister
Journal of the American College of Cardiology 1984
Classification and natural history of primary myocardial disease
WH Abelmann
Progress in Cardiovascular Diseases 1984
Animal models of cardiomyopathy
A Matsumori, C Kawai
International Journal of Cardiology 1983
Unresolved problems in Haemophilia
CD Forbes, GD Lowe
1982
Viral myocarditis. A review
JF Woodruff
The American Journal of Pathology 1980

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