Citations to this article

Prostaglandin-stimulated bone resorption by rheumatoid synovia. A possible mechanism for bone destruction in rheumatoid arthritis.
D R Robinson, … , A H Tashjian Jr, L Levine
D R Robinson, … , A H Tashjian Jr, L Levine
Published November 1, 1975
Citation Information: J Clin Invest. 1975;56(5):1181-1188. https://doi.org/10.1172/JCI108195.
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Research Article

Prostaglandin-stimulated bone resorption by rheumatoid synovia. A possible mechanism for bone destruction in rheumatoid arthritis.

Abstract

Synovial tissue from patients with rheumatoid arthritis was maintained in organ culture for 3-14 days. Conditioned media from these synovial cultures contained bone resorption-stimulating activity, measured in vitro by using calcium release from mouse calvaria as the assay system. The synovial cultures also produce prostaglandin E2 (PGE2) as measured by serologic methods. The production of both the bone resorption-stimulating activity and PGE2 was inhibited by more than 90% by treatment of the synovial cultures with indomethacin (5 mug/ml). In contrast, treatment of the synovial cultures with colchicine (0.1 mug/ml) caused a marked and parallel increase in the concentration of both bone resorption-stimulating activity and PGE2 in the conditioned media. The bone resorption-stimulating activity was quantitatively extracted into diethyl ether. Within the limits of experimental error, all of the bone resorption-stimulating activity in medium was accounted for by its content of PGE2, itself a potent osteolytic factor. We conclude that the bone resorption-stimulating activity produced by rheumatoid synovia in culture is PGE2.

Authors

D R Robinson, A H Tashjian Jr, L Levine

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F Eggelmeijer, HG Otten, HH Rooy, MR Daha, FC Breedveld 		Rheumatology International 1990
Tumor necrosis factor inhibitor: purification, NH2−terminal amino acidsequence and evidence for anti-inflammatory and immunomodulatory activities
P Seckinger, E Vey, G Turcatti, P Wingfield, JM Dayer 		European Journal of Immunology 1990
Vitamin D metabolism in rats with adjuvant-induced arthritis
CB Langman, KK Ford, LM Pachman, F Glorieux 		Journal of Bone and Mineral Research 1990
AHR-15010-A Novel Anti-arthritic Agent
JC Nolan, DA Walsh, Y Lo, CE Gathright, CH Radvany, M Foxwell, L Whitman, G Graff, LF Sancilio 		Journal of Pharmacy and Pharmacology 1990
Mononuclear cells enhance prostaglandin E2 production of polymorphonuclear leukocytes via tumor necrosis factor α
H Akama, Y Ichikawa, Y Matsushita, T Shinozawa, M Homma 		Biochemical and Biophysical Research Communications 1990
Phospholipases in biology and medicine
E Kaiser, P Chiba, K Zaky 		Clinical Biochemistry 1990
Identification of prostaglandin E2 and leukotriene B4 in the synovial fluid of painful, dysfunctional temporomandibular joints
JH Quinn, NG Bazan 		Journal of Oral and Maxillofacial Surgery 1990
Effects of helodermin on fetal rat bone metabolism in vitro
J Pfeilschifter, A Naumann, M Oechsner, R Ziegler 		Biochemical and Biophysical Research Communications 1990
Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors
AB Mukherjee 		1990
Bradykinin stimulates prostaglandin E2 formation in isolated human osteoblast-like cells
sten Ljunggren, J Rosenquist, M Ransj, UH Lerner 		Bioscience Reports 1990
Partial purification and characterisation of a synovial fluid inhibitor of osteoblasts
RA Hazelton, R Vedam, PP Masci, AN Whitaker 		Annals of the rheumatic diseases 1990
Gelenkzerstörung bei entzündlichen rheumatischen Erkrankungen
W Mohr, KH Emmert 		1990
Bradykinin-2 receptor-mediated release of 3H-arachidonic acid and formation of prostaglandin E2 in human gingival fibroblasts
T Modeer, O Ljunggren, UH Lerner 		Journal of Periodontal Research 1990
Significance of rheumatoid factor isotypes in seronegative rheumatoid arthritis
F Eggelmeijer, HG Otten, HH de Rooy, MR Daha, FC Breedveld 		Rheumatology International 1990
Effects of diclofenac, indomethacin, tolfenamic acid and hydrocortisone on prostanoid production in healthy and rheumatic synovial cells
E Moilanen 		Agents and Actions 1989
Theoretical mechanism for the gastrointestinal safety of etodolac: Selective sparing of cytoprotective prostaglandins
D Dvornik, DK Lee 		Clinical Rheumatology 1989
Changes in the metaphysis and diaphysis of the femur proximal to the knee in rabbits with experimentally induced inflammatory arthritis
E Bogoch, N Gschwend, B Bogoch, B Rahn, S Perren 		Arthritis & Rheumatism 1989
An Epstein-Barr virus-transformed B cell line produces autoregulatory interleukin-1 that regulates bone remodeling
S Hanazawa, S Amano, A Hamano, H Katoh, T Honda, M Takada, S Hirose, S Kitano 		Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1989
Local production of IgA- and IgM-rheumatoid factors in adult periodontal disease
HZ Hirsch, A Tarkowski, WJ Koopman, J Mestecky 		Journal of Clinical Immunology 1989
Bone metabolism in patients with rheumatoid arthritis
JW Bijlsma 		Clinical Rheumatology 1988
Stimulatory effect on bone resorption of interleukin-1-like cytokine produced by an osteoblast-rich population of mouse calvarial cells
S Amano, S Hanazawa, K Hirose, Y Ohmori, S Kitano 		Calcified Tissue International 1988
Chemical and biological characterization of the lipopolysaccharide of the oral pathogen Wolinella recta ATCC 33238
J Gillespie, ST Weintraub, GG Wong, SC Holt 		Infection and immunity 1988
The role of non-steroidal anti-inflammatory drugs in the management of periodontal disease
PA Heasman 		Journal of Dentistry 1988
Hypercalcemia
JP Bilezikian 		Disease-a-Month 1988
Prostaglandins and surgical diseases: Part I
BM Jaffe, C LaRosa, K Kimura 		Current Problems in Surgery 1988
Clinical Approach to Infection in the Compromised Host
RH Rubin, LS Young 		1988
Eicosanoids in Inflammatory Conditions of the Lung, Skin and Joints
M Church, C Robinson 		1988
Relationship of cAMP and calcium messenger systems in prostaglandin-stimulated UMR-106 cells
DT Yamaguchi, TJ Hahn, TG Beeker, CR Kleeman, S Muallem 		The Journal of biological chemistry 1988
Immune-based erosive inflammatory joint disease of the dog: canine rheumatoid arthritis
D Bennett 		Journal of Small Animal Practice 1987
Determinants of axial bone loss in rheumatoid arthritis
PN Sambrook, JA Eisman, GD Champion, MG Yeates, NA Pocock, S Eberl 		Arthritis & Rheumatism 1987
Synthesis of arachidonate oxidation products by synovial joint tissues during the development of chronic erosive arthritis
B Henderson, GA Higgs 		Arthritis & Rheumatism 1987
Modifications of the mouse calvarial technique improve the responsiveness to stimulators of bone resorption
UH Lerner 		Journal of Bone and Mineral Research 1987
Mechanical and chemical factors in tendon healing
CA Carlstedt 		Acta Orthopaedica 1987
Knee arthroplasty in rheumatoid arthritis
I Hvid, P Kj˦rsgaard-Andersen, JO Wethelund, O Sneppen 		The Journal of Arthroplasty 1987
Systemic Inflammatory Disease and the Eye
WJ Dinning 		Systemic Inflammatory Disease and the Eye 1987
Relation between bone erosions and rheumatoid factor isotypes
JA Arnason, T Jonsson, A Brekkan, K Sigurjonsson, H Valdimarsson 		Annals of the rheumatic diseases 1987
Inhibitory effects of anti-inflammatory drugs on type II collagen induced arthritis in rats
K Yamaki, H Nakagawa, S Tsurufuji 		Annals of the rheumatic diseases 1987
Biochemical Mechanisms of Articular Destruction
CL Mainardi 		Rheumatic diseases clinics of North America 1987
Unique properties of auranofin as a potential anti-rheumatic drug
ML Barrett, GP Lewis 		Agents and Actions 1986
Enhanced phospholipase activity in peripheral blood monocytes from patients with rheumatoid arthritis
JS Bomalaski, MA Clark, RB Zurier 		Arthritis & Rheumatism 1986
Formation of a synovial-like membrane at the bone-cement interface: Its role in bone resorption and implant loosening after total hip replacement
SR Goldring, M Jasty, MS Roelke, CM Rourke, FR Bringhurst, WH Harris 		Arthritis & Rheumatism 1986
Clonal differences in prostaglandin synthesis among osteosarcoma cell lines
SB Rodan, G Wesolowski, GA Rodan 		Journal of Bone and Mineral Research 1986
Enhanced interleukin 1 generation by monocytes in vitro is temporally linked to an early event in the onset or exacerbation of rheumatoid arthritis
A Shore, S Jaglal, EC Keystone 		Clinical & Experimental Immunology 1986
Differential effects of 1,25-dihydroxyvitamin D3 on human lymphocytes and monocyte/macrophages: Inhibition of interleukin-2 and augmentation of interleukin-1 production
AK Bhalla, EP Amento, SM Krane 		Cellular Immunology 1986
Uptake of fatty acids and their mobilization from phospholipids in cultured monocyte-macrophages from rheumatoid arthritis patients
JS Bomalaski, CS Goldstein, AT Dailey, SD Douglas, RB Zurier 		Clinical Immunology and Immunopathology 1986
Advances in Immunopharmacology
R Lewis, K Austen 		Advances in Immunopharmacology 1986
Clinical Endocrinology
A Labhart 		Clinical Endocrinology 1986
Therapeutics in Rheumatology
JM Moll, HA Bird, A Rushton 		1986
The effects of prostaglandin E2 in growing rats: Increased metaphyseal hard tissue and cortico-endosteal bone formation
WS Jee, K Ueno, YP Deng, DM Woodbury 		Calcified Tissue International 1985
Patterns and Mechanisms of Localized Bone Invasion by Tumors: Studies with Squamous Carcinomas of the Head and Neck
RL Carter, JG Batsakis 		Critical Reviews in Clinical Laboratory Sciences 1985
The effects of calcium regulating hormones on bone resorption by isolated human osteoclastoma cells
TJ Chambers, K Fuller, PM McSheehy, JA Pringle 		The Journal of Pathology 1985
Quantitative histologic studies on the pathogenesis of periarticular osteoporosis in rheumatoid arthritis
S Shimizu, S Shiozawa, K Shiozawa, S Imura, T Fujita 		Arthritis & Rheumatism 1985
Prostaglandin and hydroxyeicosatetraenoic acid synthesis by human mesenchymal tumors
RA Knazek, CL Yee, J Costa 		International Journal of Cancer 1985
A HISTOMORPHOMETRIC ANALYSIS OF SUBCHONDRAL BONE IN JUVENILE ARTHROPATHY OF THE DOG KNEE
I Holm, C Bünger, F Melsen 		Acta Pathologica Microbiologica Scandinavica Series A :Pathology 1985
The synovial lining cell: Biology and pathobiology
B Henderson, ER Pettipher 		Seminars in Arthritis and Rheumatism 1985
Bacterial flora in spontaneously occurring aural cholesteatomas in Mongolian gerbils
RS Fulghum, RA Chole 		Infection and immunity 1985
Adult-onset Still's disease complicated by hypercalcaemia: possible relationship with rapidly destructive polyarthritis
JM Wouters, PG Froeling, LB van de Putte 		Annals of the rheumatic diseases 1985
Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria
AH Tashjian, EF Voelkel, M Lazzaro, FR Singer, AB Roberts, R Derynck, ME Winkler, L Levine 		Proceedings of the National Academy of Sciences 1985
Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts
JM Dayer, B Beutler, A Cerami 		Journal of Experimental Medicine 1985
Cyclic adenosine 3′5′ monophosphate stimulates prostaglandin E production by human adherent synovial cells
DG Baker, DF Baumgarten, JS Bomalaski, RB Zurier 		Prostaglandins 1985
Hypercalciuria in children with juvenile rheumatoid arthritis: Association with hematuria
FB Stapleton, AS Hanissian, LA Miller 		The Journal of Pediatrics 1985
Stimulus-dependent inhibition of superoxide generation by prostaglandins
JB Sedgwick, ML Berube, RB Zurier 		Clinical Immunology and Immunopathology 1985
Calcium in Biological Systems
RP Rubin, GB Weiss, JW Putney 		1985
Enhanced prostanoid release from monocytes of patients with rheumatoid arthritis and active systemic lupus erythematosus
M Seitz, W Hunstein 		Annals of the rheumatic diseases 1985
Prostaglandin (PG) E2 generation by cultured canine synovial fibroblasts exposed to microcrystals containing calcium
DJ McCarty, HS Cheung 		Annals of the rheumatic diseases 1985
Bone turnover in early rheumatoid arthritis. 1. Biochemical and kinetic indexes
PN Sambrook, BM Ansell, S Foster, JM Gumpel, R Hesp, J Reeve, JM Zanelli 		Annals of the rheumatic diseases 1985
The pathobiology of the osteoclast
TJ Chambers 		Journal of clinical pathology 1985
Prostaglandins and Immunity
JS Goodwin 		1985
Flurbiprofen: A Potent Inhibitor of Alveolar Bone Resorption in Beagles
RC Williams, MK Jeffcoat, ML Kaplan, P Goldhaber, HG Johnson, WJ Wechter 		Science 1985
An electron microscopic study of the synovial-bone junction in rheumatoid arthritis
H Ishikawa, O Ohno, K Hirohata 		Rheumatology International 1984
Effects of prostaglandin E2 on responses of T-cell subsets to mitogen and autologous non-T-cell stimulation
M Honda, AD Steinberg 		Clinical Immunology and Immunopathology 1984
Influence of prostaglandins on electrolyte metabolism of human trabecular bone in vitro
E Keck, A Schärtl, TB West, HL Krüskemper, G Delling 		Prostaglandins 1984
Ametantrone inhibits prostaglandin — mediated resorption in bone organ culture
MR Warner, MS Rappaport, NS Krieger, RF Novak, PH Stern 		Prostaglandins 1984
Immunodermatology
RE Schopf, M Jung, B Morsches, K Bork 		Immunodermatology 1984
Nonsteroidal Anti-Inflammatory Drugs and Modulation of Cartilaginous Changes in Osteoarthritis and Rheumatoid Arthritis Clinical Implications
JH Herman, EV Hess 		The American Journal of Medicine 1984
Bone Resorption Factors in Chronic Otitis Media
H Moriyama, CH Chun, M Abramson, M Kato 		Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 1984
Rheumatoid synovial cell hormone responses modulated by cell-cell interactions
SR Goldring, , SM Krane 		Inflammation 1984
Prostaglandin E2 binding and cyclic AMP production in isolated bone cells
RM Dziak, D Hurd, KT Miyasaki, M Brown, N Weinfeld, E Hausmann 		Calcified Tissue International 1983
The effect of prostaglandins on the lysosomal function in the cervix uteri
K Joh, UN Riede, HP Zahradnik 		Archives of Gynecology 1983
Inhibition of osteoclastic motility by prostaglandins I2, E1, E2 and 6-oxo-E1
TJ Chambers, NN Ali 		The Journal of Pathology 1983
Further observations on mechanisms of bone destruction by squamous carcinomas of the head and neck: the role of host stroma
SW Tsao, JF Burman, MR Pittam, RL Carter 		British Journal of Cancer 1983
Characterization of blood mononuclear cells of rheumatoid arthritis patients
M Seitz, P Vogt, W Müller, W Hunstein, D Gemsa 		Clinical Immunology and Immunopathology 1983
Case report: Massive osteolysis in a case of rheumatoid arthritis: Clinical, histologic and biochemical findings
JM Mbuyi-Muamba, J Dequeker, A Burssens 		Metabolic Bone Disease and Related Research 1983
Prostaglandins and anti-inflammatory drugs
DR Robinson 		Disease-a-Month 1983
Prostaglandins and the Inflammatory Response
JS Bomalaski, PK Williamson, RB Zurier 		Clinics in Laboratory Medicine 1983
Self-associating IgG rheumatoid factors stimulate monocytes to release prostaglandins and mononuclear cell factor that stimulates collagenase and prostaglandin production by synovial cells
FA Nardella, JM Dayer, M Roelke, SM Krane, M Mannik 		Rheumatology International 1983
Effects of prostaglandins E1, E2, and F2 alpha on N-acetyl-beta-glucosaminidase activities of human synovial cells in culture
BJ Clarris, LP Malcolm 		Annals of the rheumatic diseases 1983
Activation of serum complement inhibits collagen synthesis in fetal rat bone in organ culture
BE Kream, LG Raisz, AL Sandberg 		Calcified Tissue International 1982
Parathyroid hormone and calcitonin interactions in bone: Irradiation-induced inhibition of escape in vitro
NS Krieger, RS Feldman, AH Tashjian 		Calcified Tissue International 1982
An analysis of piroxicam in rodent models of arthritis
IG Otterness, DL Larson, JG Lombardino 		Agents and Actions 1982
Immunoelectron microscopic demonstration of prostaglandin e in rheumatoid synovium
S Shiozawa, RC Williams, M Ziff 		Arthritis & Rheumatism 1982
Aspirin-induced hypocalcemia in the rat
Y Kato, H Senzaki, H Ogura 		Toxicology and Applied Pharmacology 1982
Prostaglandins, immune responses, and murine lupus
RB Zurier 		Arthritis & Rheumatism 1982
Effects of all-trans-retinoic acid (retinoic acid) and 4-hydroxyphenylretinamide on synovial cells and articular cartilage
CE Brinckerhoff, H Nagase, JE Nagel, ED Harris 		Journal of the American Academy of Dermatology 1982
Stimulation of prostaglandin E2 synthesis in chondrocytes by a factor derived from activated macrophages
JC Colan, W Pickett, K English, AL Oronsky, SS Kerwar 		Prostaglandins 1982
The synovial prostaglandin system in chronic inflammatory arthritis: differential effects of steroidal and nonsteroidal anti-inflammatory drugs
GD Anderson, SD Hauser, KL McGarity, ME Bremer, PC Isakson, SA Gregory 		Journal of Clinical Investigation 1981
Protein synthesis in rheumatoid synovial tissue
JD Smiley, WL Hoffman 		Springer Seminars in Immunopathology 1981
Endotoxin inhibition of macrophage-mediated bone resorption
AJ Kahn, SL Teitelbaum 		Calcified Tissue International 1981
Induction of collagenase and prostaglandin synthesis in synovial fibroblasts treated with monosodium urate crystals
RM McMillan, CA Vater, P Hasselbacher, J Hahn, ED Harris 		Journal of Pharmacy and Pharmacology 1981
Microfocal radiography in the quantitative assessment of experimentally induced inflammatory arthritis in guinea-pigs
JC Buckland-Wright 		The Journal of Pathology 1981
Cellular and humoral factors modulate connective tissue destruction and repair in arthritic diseases
JM Dayer, SM Krane, SR Goldring 		Seminars in Arthritis and Rheumatism 1981
Survival of rheumatoid synovium implanted into nude mice
CE Brinckerhoff, ED Harris 		The American Journal of Pathology 1981
Mechanism of stimulation of prostaglandin synthesis by a factor from rheumatoid synovial tissue
DR Robinson, D Bastian, PJ Hamer, DM Pichiarallo, ML Stephenson 		Proceedings of the National Academy of Sciences 1981
Prostaglandins as mediators of paraneoplastic syndromes: Review and up-date
SA Metz, JR McRae, RP Robertson 		Metabolism 1981
The synovial prostaglandin system in chronic inflammatory arthritis: differential effects of steroidal and nonsteroidal anti-inflammatory drugs
GD Anderson, SD Hauser, KL McGarity, ME Bremer, PC Isakson, SA Gregory 		Journal of Clinical Investigation 1981
Effects of various anti-inflammatory and anti-rheumatic agents on the synthesis, secretion, and activity of a cartilage proteoglycan-degrading enzyme and other macrophage enzymes
NR Ackerman, SN Jubb, SL Marlowe 		Biochemical Pharmacology 1981
Bone resorptive factor produced by osteosarcoma cells with osteoblastic features is PGE2
SB Rodan, GA Rodan, HA Simmons, RW Walenga, MB Feinstein, LG Raisz 		Biochemical and Biophysical Research Communications 1981
Stimulation of bone resorption in organ culture by cholera toxin
AH Tashjian, JL Ivey 		Biochemical and Biophysical Research Communications 1981
Prostaglandin biosynthesis by lapine articular chondrocytes in culture
CJ Malemud, RW Moskowitz, A Hassid 		Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1981
Anti-inflammatory Agents as Inhibitors of Prostaglandin Synthesis in Man
SA Metz 		Medical Clinics of North America 1981
Change of prostaglandin E level in joint fluids after treatment with flurbiprofen in patients with rheumatoid arthritis and osteoarthritis
M Tokunaga, K Ohuchi, S Yoshizawa, S Tsurufuji, A Rikimaru, E Wakamatsu 		Annals of the rheumatic diseases 1981
Arachìdonate Metabolites in Inflammation
IJ Zeitlin 		Clinics in rheumatic diseases 1981
Demonstration and preliminary characterization of bone resorbing activity in freeze-dried gingiva of dogs
RM Hopps, K Nuki, LG Raisz 		Calcified Tissue International 1980
Monocytes mediate osteoclastic bone resorption by prostaglandin production
JH Dominguez, GR Mundy 		Calcified Tissue International 1980
Prostaglandins and inflammation
BL Trang 		Seminars in Arthritis and Rheumatism 1980
Connective tissue activation
SL Myers, CW Castor 		Arthritis & Rheumatism 1980
Interaction of Immune and Connective Tissue Cells
JH Korn 		International Journal of Dermatology 1980
Lack of platelet effect with the aspirin analog, salsalate
D Estes, K Kaplan 		Arthritis & Rheumatism 1980
Effect of Ibuprofen on Mass and Composition of Fracture Callus and Bone:An Experimental Study on Adult Rat
H Törnkvist, TS Lindholm 		Scandinavian Journal of Rheumatology 1980
Potential therapeutic applications of aspirin and other cyclo-oxygenase inhibitors
AE Farah, F Rosenberg 		British Journal of Clinical Pharmacology 1980
Physiology and pharmacological regulation of bone resorption
KJ Ibbotson, SM D'Souza, JA Kanis, DL Douglas, RG Russell 		Metabolic Bone Disease and Related Research 1980
Prostaglandins: their possible role in the pathogenesis of pulpal and periapical diseases, part 2
M Torabinejad, LK Bakland 		Journal of Endodontics 1980
Inhibition by Retinoic Acid of Collagenase Production in Rheumatoid Synovial Cells
CE Brinckerhoff, RM McMillan, JM Dayer, ED Harris 		New England Journal of Medicine 1980
The Joints and Synovial Fluid
DA McCARTY 		The Joints and Synovial Fluid 1980
Prostaglandins and Otitis Media: Studies in the Chinchilla
TT Jung, DM Smith, SK Juhn, JM Gerrard 		Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 1980
Effect of Prostaglandin on the Composition of Chinchilla Middle Ear Effusion
TT Jung, SK Juhn, DM Smith, JM Gerrard 		The Annals of otology, rhinology, and laryngology 1980
Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics
P Frick, GA von Harnack, GA Martini, A Prader, HP Wolff 		1980
Inflammation: Mechanisms and Treatment
DA Willoughby, JP Giroud 		1980
Participation of monocyte-macrophages and lymphocytes in the production of a factor that stimulates collagenase and prostaglandin release by rheumatoid synovial cells
JM Dayer, J Bréard, L Chess, SM Krane 		Journal of Clinical Investigation 1979
A cat model for the evaluation of mechanisms of bone resorption: Induction of bone loss by simulated immune complexes and inhibition by indomethacin
M Torbinejad, J Clagett, D Engel 		Calcified Tissue International 1979
Cyclic AMP as a second messenger in the skeletal actions of parathyroid hormone: A decade-old hypothesis
WA Peck 		Calcified Tissue International 1979
Regulation of bradykinin-induced cyclic AMP response by quinacrine and prostaglandin E2 and F2? in human synovial fibroblasts
JV Fahey, DS Newcombe 		Inflammation 1979
Release of cartilage proteoglycan degrading enzyme activity by thioglycollate stimulated mouse peritoneal macrophages in culture
N Ackerman, S Jubb, B Trimble, B Yoxall 		Agents and Actions 1979
PROSTAGLANDINS AND THEIR REGULATION IN RHEUMATOID INFLAMMATION
DR Robinson, JM Dayer, SM Krane 		Annals of the New York Academy of Sciences 1979
Effects of naproxen on connective tissue changes in the adjuvant arthritic rat
NR Ackerman, WH Rooks, L Shott, H Genant, P Maloney, E West 		Arthritis & Rheumatism 1979
Monocytes regulate osteoclast-activating factor production by releasing prostaglandins
T Yoneda, GR Mundy 		Journal of Experimental Medicine 1979
Prostaglandins: promulgators of pain
NL Rhodus 		Anesthesia Progress 1979
Effects of human mononuclear cell factor on cultured rheumatoid synovial cells
JM Dayer, SR Goldring, DR Robinson, SM Krane 		Biochimica et Biophysica Acta (BBA) - General Subjects 1979
Skeletal Research: an Experimental Approach
EA Tonna 		Skeletal Research: an Experimental Approach 1979
Bone Resorption in Chronic Otitis Media
BJ Gantz, J Maynard, RM Bumsted, CC Huang, M Abramson 		The Annals of otology, rhinology, and laryngology 1979
Hypercalcaemia in rheumatoid arthritis: investigation of its causes and implications
AC Kennedy, RF Allam, PJ Rooney, ME Watson, A Fairney, KD Buchanan, CJ Hillyard 		Annals of the rheumatic diseases 1979
Naproxen
EJ Segre 		Clinics in rheumatic diseases 1979
Prostaglandin PGE2: A possible mechanism for bone destruction in calcinosis circumscripta
A Caniggia, C Gennari, A Vattimo, F Runci, S Bombardieri 		Calcified Tissue Research 1978
Localization of prostaglandin synthetase in chicken epiphyseal cartilage
FK Northington, TD Oglesby, Y Ishikawa, RE Wuthier 		Calcified Tissue Research 1978
Involvement of prostaglandins from rheumatoid synovium in inhibition of articular cartilage metabolism
L Lippiello, K Yamamoto, D Robinson, HJ Mankin 		Arthritis & Rheumatism 1978
Cyclic AMP and prostaglandin E in perfusates of rat hind paws during the development of adjuvant arthritis
MJ Parnham, IL Bonta, MJ Adolfs 		Annals of the rheumatic diseases 1978
Lysosomes and the connective tissue diseases
L Bitensky 		Journal of clinical pathology. Supplement (Royal College of Pathologists) 1978
Massive osteolysis
JL Ross, R Schinella, L Shenkman 		The American Journal of Medicine 1978
Molecular Basis of Biological Degradative Processes
HJ Müller-Eberhard 		Molecular Basis of Biological Degradative Processes 1978
Proceedings of the 1977 Laurentian Hormone Conference
IJ Chopra, DH Solomon, U Chopra, SY Wu, DA Fisher, Y Nakamura 		Proceedings of the 1977 Laurentian Hormone Conference 1978
Stimulation of prostaglandin production in bone by phorbol diesters and melittin
AH Tashjian, JL Ivey, B Delclos, L Levine 		Prostaglandins 1978
Prostaglandins and chronic inflammation
IL Bonta, MJ Parnham 		Biochemical Pharmacology 1978
Epidermal growth factor stimulates prostaglandin production and bone resorption in cultured mouse calvaria
AH Tashjian, L Levine 		Biochemical and Biophysical Research Communications 1978
Inhibition of Bone Resorption in Vitro by a Cartilage-Derived Anticollagenase Factor
JE Horton, FH Wezeman, KE Kuettner 		Science 1978
Big and Little Forms of Osteoclast Activating Factor
GR Mundy, LG Raisz, JL Shapiro, JG Bandelin, RJ Turcotte 		Journal of Clinical Investigation 1977
Prostaglandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture. Stimulation by angiotensin II, bradykinin, and arginine vasopressin
RM Zusman, HR Keiser 		Journal of Clinical Investigation 1977
Immunohistochemical localization of prostaglandin e in rheumatoid synovial tissues
G Husby, AD Bankhurst, RC Williams 		Arthritis & Rheumatism 1977
Effect of prostaglandin endoperoxides and metabolites on bone resorption in vitro
LG Raisz, JW Dietrich, HA Simmons, HW Seyberth, W Hubbard, JA Oates 		Nature 1977
Biological activities of prostaglandin analogues and metabolites on bone in organ culture
AH Tashjian, JE Tice, K Sides 		Nature 1977
Direct immunochemical detection of prostaglandin-e and cyclic nucleotides in human malignant tumors
G Husby, RG Strickland, GL Rigler, GT Peake, RC Williams 		Cancer 1977
Effects of colchicine on cyclic AMP levels in human leukocytes
SA Rudolph, P Greengard, SE Malawista 		Proceedings of the National Academy of Sciences 1977
Prostaglandin regulation of macrophage collagenase production
LM Wahl, CE Olsen, AL Sandberg, SE Mergenhagen 		Proceedings of the National Academy of Sciences 1977
Fibroblast heterogeneity and prostaglandin regulation of subpopulations
SD Ko, RC Page, AS Narayanan 		Proceedings of the National Academy of Sciences 1977
Prostaglandin production by rheumatoid synovial cells: stimulation by a factor from human mononuclear Cells
JM Dayer, DR Robinson, SM Krane 		Journal of Experimental Medicine 1977
Synthesis of collagen by chondrocytes in suspension culture: modulation by calcium, 3':5'-cyclic AMP, and prostaglandins
K Deshmukh, BD Sawyer 		Proceedings of the National Academy of Sciences 1977
The effect of prostaglandins on cultured lapine articular chondrocytes
CJ Malemud, L Sokoloff 		Prostaglandins 1977
Cyclic AMP response to prostaglandin E1 in mononuclear cells from peripheral blood and synovial fluid of patients with rheumatoid arthritis
RB Zurier, J Doty, A Goldenberg 		Prostaglandins 1977
Effects of hydrocortisone on the hypercalcemia and plasma levels of 13,14-dihydro-15-keto-prostaglandin E2 in mice bearing the HSDM1 fibrosarcoma
AH Tashjian, EF Voelkel, L Levine 		Biochemical and Biophysical Research Communications 1977
Direct Resorption of Bone by Human Monocytes
GR Mundy, AJ Altman, MD Gondek, JG Bandelin 		Science 1977
Bone Involvement in Rheumatoid Arthritis
A Kennedy, R Lindsay 		Clinics in rheumatic diseases 1977
Bone resorption in organ culture: inhibition by the divalent cation ionophores A23187 and X-537A
JL Ivey, DR Wright, AH Tashjian 		Journal of Clinical Investigation 1976
Abortogenic activity of antiserum to alpha-foetoprotein
GJ Mizejewski, PM Grimley 		Nature 1976
Recent insights into the pathogenesis of the proliferative lesion in rheumatoid arthritis
ED Harris 		Arthritis & Rheumatism 1976
Prostaglandin mediation of collagenase-induced bone resorption
M Dowsett, AR Eastman, DM Easty, GC Easty, TJ Powles, AM Neville 		Nature 1976
Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells
JM Dayer, SM Krane, RG Russell, DR Robinson 		Proceedings of the National Academy of Sciences 1976
Effects of prostaglandins and other drugs on the cyclic AMP content of cultured bone cells
JH Yu, H Wells, WJ Ryan, WS Lloyd 		Prostaglandins 1976
The effect of anti-inflammatory agents on human synovial fibroblast prostaglandin synthetase
DS Newcombe, Y Ishikawa 		Prostaglandins 1976
Regulation of Calcium Metabolism
RG Russell 		Annals of Clinical Biochemistry 1976
Prostaglandins, Hypercalcemia and Cancer
AH Tashjian 		New England Journal of Medicine 1975
The Prostaglandins
MF Cuthbert 		The Prostaglandins 1972
Arthritis Research
CB Favour, RE Ritts, TB Bayles 		New England Journal of Medicine 1956

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