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Citations to this article

The acute effect of chlorothiazide on serum-ionized calcium. Evidence for a parathyroid hormone-dependent mechanism.
M M Popovtzer, … , E B Reeve, R W Schrier
M M Popovtzer, … , E B Reeve, R W Schrier
Published June 1, 1975
Citation Information: J Clin Invest. 1975;55(6):1295-1302. https://doi.org/10.1172/JCI108049.
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Research Article

The acute effect of chlorothiazide on serum-ionized calcium. Evidence for a parathyroid hormone-dependent mechanism.

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Abstract

The acute effects of chlorothiazide (CTZ) on total (TSCA) and ionized (SCA-plus 2) serum calcium concentrations were studied in three groups of people: (a) eight subjects with normal parathyroid function; (b) six patients with hypoparathyroidism; and (c) two patients with hyperparathyroidism. Most subjects were studied on four occasions; at least 3 days intervened between studies on an individual subject. During each experiment the subject received an i.v. influsion of 5% dextrose in water at 1 ml/min from 8 a.m. to 4 p.m. Additions to the infusions were (a) none; (b) CTZ to deliver 3.33 mg/kg/h; (c) parathyroid extract to deliver 1 U/kg/h; or (d) both CTZ and parathyroid extract at the rates previously indicated. CTZ, when used, was added to the infusion at 10 a.m., parathyroid extract at 8 a.m. When CTZ was infused, the diuretic-induced losses of Na and water were replaced by i.v. infusion. In normal subjects 2 h after the start of CTZ infusion, there was a transient increase in SCA-plus 2 which coincided in time of day with a transient decrease in SCA-plus 2 in control experiments. At that time of day SCA-plus 2 was 4.18 plus or minus 0.12 mg/100 ml in control experiments and 4.56 plus or minus 0.08 in experiments with CTZ, P smaller than 0.025. The corresponding values for (TSCA) were 9.32 plus or minus 0.15 and 9.80 plus or minus 0.30, P smaller than 0.01. Such differences were not observed in the group with hypoparathyroidism. In the two patients with hyperparathyroidism, CTZ produced sustained increases in TSCA and SCA-plus 2. In normal subjects and those with hypoparathyroidism, CTZ plus parathyroid extract infusion resulted in sustained increases in both SCA-plus 2 and TSCA throughout the periods of observation when compared to experiments in which only parathyroid extract was infused, P smaller than 0.01 in all instances. The results suggest that the acute hypercalcemic action of CTZ requires the presence of circulating parathyroid hormone.

Authors

M M Popovtzer, V L Subryan, A C Alfrey, E B Reeve, R W Schrier

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Total citations by year

Year: 2017 2014 2013 2012 2011 2010 2009 2006 1999 1998 1994 1990 1988 1987 1984 1983 1982 1981 1980 1979 1978 1977 1976 Total
Citations: 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 6 2 1 2 2 1 1 33
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (33)

Title and authors Publication Year
Medical and Surgical Treatment of Parathyroid Diseases
WA Hashem, CJ Orr, AA Khan
Medical and Surgical Treatment of Parathyroid Diseases 2017
Arterielle Hypertonie
A Fritz, M Arzt
Somnologie - Schlafforschung und Schlafmedizin 2014
Pediatric Critical Care Medicine
JL Wynn, JA Hazelzet, TP Shanley, HR Wong, DS Wheeler
Pediatric Critical Care Medicine 2014
Seldin and Giebisch's The Kidney
CJ Cooper, LD Dworkin, WL Henrich
Seldin and Giebisch's The Kidney 2013
Brenner and Rector's The Kidney
C Brugnara, KU Eckardt
Brenner and Rector's The Kidney 2012
Regulation of Fluids and Electrolytes
D Ellis
Smith s Anesthesia for Infants and Children 2011
Electrolyte disturbances associated with commonly prescribed medications in the intensive care unit
MS Buckley, JM LeBlanc, MJ Cawley
Critical Care Medicine 2010
The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion
L Kantham, SJ Quinn, OI Egbuna, K Baxi, R Butters, JL Pang, MR Pollak, D Goltzman, EM Brown
American journal of physiology. Endocrinology and metabolism 2009
Regulation of Fluids and Electrolytes in Infants and Children
D Ellis
Smith s Anesthesia for Infants and Children 2006
Dietary Magnesium, Not Calcium, Regulates Renal Thiazide Receptor
DD Fanestil, RH Hyde, P Blakely, DA Vaughn
Journal of the American Society of Nephrology : JASN 1999
Metabolic Bone Disease and Clinically Related Disorders
FR Singer, SM Krane
Metabolic Bone Disease and Clinically Related Disorders 1998
The modulatory effect of endogenous parathyroid hormone on the action of hydrochlorothiazide in pseudohypoparathyroidism type I
K Mizunashi, Y Furukawa, K Abe, K Yoshinaga
Calcified Tissue International 1994
Renal control of extracellular calcium
D Rouse, WN Suki
Kidney International 1990
Treatment
KH Neidner
Clinics in Dermatology 1988
MAGNESURIA INDUCED BY THIAZIDES AND THE INFLUENCE OF TRIAMTERENE
M Labeeuw, N Pozet, P Zech, A Hadj-Aissa, J Sassard
Fundamental & Clinical Pharmacology 1987
Herzinsuffizienz
G Autenrieth, R Bayer, DW Behrenbeck, G Biamino, HD Bolte, F Burkart, WD Bussmann, J Cyran, E Erdmann, B Heierli, F Krück, T Linderer, G Rahlf, G Riecker, R Schröder, G Steinbeck, BE Strauer, KO Stumpe, E Uhlich, J Zähringer
1984
90. Kongreß: Gehalten zu Wiesbaden vom 29. April bis 3. Mai 1984
JF Bergmann
1984
Cardiac therapy
MR Rosen, BF Hoffman
1983
Disorders of calcium and magnesium homeostasis
ZS Agus, A Wasserstein, S Goldfarb
The American Journal of Medicine 1982
Low Serum Concentrations of Ionized Calcium in Patients with Hypertension
DA McCarron
New England Journal of Medicine 1982
Calcium, magnesium, and phosphorus balance in human and experimental hypertension
DA McCarron
Hypertension 1982
Regulation of Phosphate and Mineral Metabolism
SG Massry, JM Letteri, E Ritz
1982
Pathogenese und Klinik der Harnsteine IX
G Gasser, W Vahlensieck
1982
Arterial Hypertension
J Rosenthal
1982
Ionized Calcium in Body Fluids
WG Robertson, RW Marshall, GN Bowers
Critical Reviews in Clinical Laboratory Sciences 1981
Contemporary Nephrology
S Klahr, SG Massry
1981
Enhanced parathyroid function in essential hypertension: a homeostatic response to a urinary calcium leak
DA McCarron, PA Pingree, RJ Rubin, SM Gaucher, M Molitch, S Krutzik
Hypertension 1980
Calcium Measurements in Serum and Plasma—Total and Ionized
WG Robertson, RW Marshall, M Walser
Critical Reviews in Clinical Laboratory Sciences 1979
Hypercalcaemia in an Adult Hospital Population: Comparison of Inpatients of 1966 with those of 1976
RD Arimott, RA Melick
The Medical Journal of Australia 1979
The pathophysiology and clinical aspects of hypercalcemic disorders
DB Lee, ET Zawada, CR Kleeman
The Western journal of medicine 1978
Treatment of Hypoparathyroid Patients with Chlorthalidone
RH Porter, BG Cox, D Heaney, TH Hostetter, BJ Stinebaugh, WN Suki
New England Journal of Medicine 1978
Metabolic Bone Disease
OL Bijvoet
Metabolic Bone Disease 1977
Measurement of Ionised Calcium in Body Fluids—A Review
WG Robertson
Annals of Clinical Biochemistry 1976

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