57% of sera from 124 relatives of 28 patients with systemic lupus erythematosus (SLE) were found to have antibody directed against lymphocytes. The incidence in 60 members of 16 control families was 3%. Both consanguineous and nonconsanguineous relatives had the antibody in their sera. 68% of close household contacts of the SLE patients showed lymphocytotoxic antibody whereas only 23% of consanguineous relatives who had no household contact with the probands had this antibody. These data suggest that environmental factors may be important in the pathogenesis of SLE.
R J DeHoratius, R P Messner
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Systemic Lupus Erythematosus
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Arthritis & Rheumatism | 2005 |
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Lupus | 2002 |
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Pediatric Rheumatology for the Practitioner
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A revised estimate of twin concordance in systemic lupus erythematosus
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International Journal of Dermatology | 1981 |
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Seminars in Arthritis and Rheumatism | 1981 |
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The American Journal of Medicine | 1981 |
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1981 | |
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Arthritis & Rheumatism | 1980 |
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Arthritis & Rheumatism | 1980 |
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Tissue Antigens | 1980 |
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Clinical & Experimental Immunology | 1980 |
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Arthritis & Rheumatism | 1979 |
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The Lancet | 1979 |
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New England Journal of Medicine | 1979 |
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Scottish Medical Journal | 1979 |
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Journal of clinical pathology. Supplement (Royal College of Pathologists) | 1978 |
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Arthritis & Rheumatism | 1977 |
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Acta Pathologica Microbiologica Scandinavica Section C Immunology | 1977 |
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Scandinavian Journal of Immunology | 1976 |
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Arthritis & Rheumatism | 1976 |
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Annals of the New York Academy of Sciences | 1976 |
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The American Journal of Medicine | 1975 |
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New England Journal of Medicine | 1975 |
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