Citations to this article

Extractable nuclear antigen effect on the DNA anti-DNA reaction and NZB/NZW mouse nephritis.
A D Morris, … , J Esterly, G C Sharp
A D Morris, … , J Esterly, G C Sharp
Published May 1, 1975
Citation Information: J Clin Invest. 1975;55(5):903-907. https://doi.org/10.1172/JCI108018.
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Research Article

Extractable nuclear antigen effect on the DNA anti-DNA reaction and NZB/NZW mouse nephritis.

Abstract

Extractable nuclear antigen (ENA) is composed of at least two components, one a ribonucleo-protein sensitive to ribonuclease or heat and the other a protein. Antibodies to ENA are associated with a relatively benign clinical course in patients with systemic lupus erythematosus (SLE) in which DNA anti DNA complexes are thought pathogenic. The effect of ENA and anti-ENA on DNA anti-DNA reactions in vitro was studied. ENA effectively inhibited an anti-DNA hemagglutination reaction but no effect was found on binding of radioactive DNA or on the anti-hemocyanin hemagglutination reaction. The inhibitory effect was not abolished by yeast ribonuclease (RNase), heating, or DNase. Anti-ENA HAD NO EFFECT ON ANTI-DNA hemagglutination. In vivo, ENA altered the NZB/NZW mouse nephritis thought to be a model for human SLE nephritis. These results suggest the possiblity of a role for ENA in alteration of diseases due to pathogenic DNA anti-DNA complexes.

Authors

A D Morris, C Littleton, L C Corman, J Esterly, G C Sharp

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Year: 2004 1987 1982 1981 1979 1978 1977 1976 1975 Total
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Citations to this article (19)

Title and authors Publication Year
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The value of specific ANA determination in rheumatology
A Wiik 		Allergy 1987
The value of specific ANA determination in rheumatology.: Update 1986
A Wiik 		Allergy 1987
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GC Sharp 		Arthritis & Rheumatism 1982
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Extractable nuclear antigens
TL Moore, TD Weiss, SH Neucks, AR Baldassare, J Zuckner 		Seminars in Arthritis and Rheumatism 1981
Immunological Aspects of Rheumatology
WC Dick 		1981
Tissue specificity and cellular distribution of Novikoff hepatoma antigenic proteins p39, p49, and p56
WN Schmidt, M Stryjecka-Zimmer, WF nd, RC Briggs, LS Hnilica 		The Journal of biological chemistry 1981
Identification of a clinical subset of systemic lupus erythematosus by antibodies to the sm antigen
DM Winn, JF Wolfe, DA Lindberg, FH Fristoe, L Kingsland, GC Sharp 		Arthritis & Rheumatism 1979
Two-dimensional polyacrylamide gel analysis of nuclear proteins from human tumor cell lines
LC Yeoman, CW Taylor, LM Woolf, H Busch 		Cancer 1978
Clinical significance of antibodies to soluble extractable nuclear antigens (anti-ENA)
A Gaudreau, B Amor, MF Kahn, A Ryckewaert, J Sany, AP Peltier 		Annals of the rheumatic diseases 1978
Morris Hepatomas
HP Morris, WE Criss 		1978
Immune-complex glomerulonephritis in a patient with mixed connective tissue disease
TJ Fuller, AV Richman, D Auerbach, RW Alexander, R Lottenberg, S Longley 		The American Journal of Medicine 1977
Antigenic Proteins of Nucleolar Chromatin of Novikoff Hepatoma Ascites Cells
RK Busch, H Busch 		TUMORI 1977
Antinuclear antibodies (ANA): Immunologic and clinical significance
F Fernandez-Madrid, M Mattioli 		Seminars in Arthritis and Rheumatism 1976
Characteristics of patients with serum antibodies to extractable nuclear antigens
JH Leibfarth, RH Persellin 		Arthritis & Rheumatism 1976
A fetal protein in chromatin of Novikoff hepatoma and Walker 256 carcinosarcoma tumors that is absent from normal and regenerating rat liver
LC Yeoman, JJ Jordan, RK Busch, CW Taylor, HE Savage, H Busch 		Proceedings of the National Academy of Sciences 1976
Mixed Connective Tissue Disease-Overlap Syndromes
GC Sharp 		Clinics in rheumatic diseases 1975

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