JCI - Citations to Alpha-1-antitrypsin content in the serum, alveolar macrophages, and alveolar lavage fluid of smoking and nonsmoking normal subjects.

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Alpha-1-antitrypsin content in the serum, alveolar macrophages, and alveolar lavage fluid of smoking and nonsmoking normal subjects.

G N Olsen, … , R H Waldman, H J Karmgard

G N Olsen, … , R H Waldman, H J Karmgard

Published February 1, 1975
Citation Information: J Clin Invest. 1975;55(2):427-430. https://doi.org/10.1172/JCI107947.

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Citations to this article (67)

Title and authors	Publication	Year
Clinical Study Support by Long-Term Stability Studies of Alpha1-Proteinase Inhibitor and Urea in Relevant Biological Matrices Engelmaier A, Zimmermann M, Butterweck HA, Weber A	Pharmaceuticals	2025
Maternal serum alpha-1 antitrypsin levels in spontaneous preterm and term pregnancies. Tissarinen P, Tiensuu H, Haapalainen AM, Ronkainen E, Laatio L, Vääräsmäki M, Öhman H, Hallman M, Rämet M	Scientific Reports	2024
Alpha-1-antitrypsin and its variant-dependent role in COVID-19 pathogenesis Stevens CS, Oguntuyo KY, Kowdle S, Brambilla L, Haas G, Gowlikar A, Siddiquey MN, Schilke RM, Woolard MD, Zhang H, Acklin JA, Ikegame S, Huang CT, Lim JK, Cross RW, Geisbert TW, Ivanov SS, Kamil JP, Lee B		2023
α 1 -Antitrypsin Deficiency P Strnad, ML Brantly, R Bals		2019
Bronchoalveolar Lavage of Murine Lungs to Analyze Inflammatory Cell Infiltration LV Hoecke, ER Job, X Saelens, K Roose	Journal of visualized experiments : JoVE	2017
iTRAQ-Based Proteomics Analysis of Serum Proteins in Wistar Rats Treated with Sodium Fluoride: Insight into the Potential Mechanism and Candidate Biomarkers of Fluorosis Y Wei, B Zeng, H Zhang, C Chen, Y Wu, N Wang, Y Wu, L Shen	International journal of molecular sciences	2016
Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency EE Cummings, LP OReilly, DE King, RM Silverman, MT Miedel, CJ Luke, DH Perlmutter, GA Silverman, SC Pak, R Aldabe	PloS one	2015
MWCNT of different physicochemical properties causes similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs SS Poulsen, AT Saber, A Williams, O Andersen, C Købler, R Atluri, ME Pozzebon, SP Mucelli, M Simion, D Rickerby, A Mortensen, P Jackson, ZO Kyjovska, K Mølhave, NR Jacobsen, KA Jensen, CL Yauk, H Wallin, S Halappanavar, U Vogel	Toxicology and Applied Pharmacology	2014
Active Trafficking of Alpha 1 Antitrypsin across the Lung Endothelium AD Lockett, MB Brown, N Santos-Falcon, NI Rush, H Oueini, AJ Oberle, E Bolanis, MA Fragoso, DN Petrusca, KA Serban, KS Schweitzer, RG Presson, M Campos, I Petrache, S Ahmad	PloS one	2014
Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition LA Roddick, V Bhakta, WP Sheffield	BMC Biochemistry	2013
Distribution and levels of alpha-1-antitrypsin in the lung and plasma in smokers and chronic obstructive pulmonary disease A Linja-aho, W Mazur, T Toljamo, P Nieminen, S Ohlmeier, M Rönty, VL Kinnula	APMIS	2012
Inhalation of LPS induces inflammatory airway responses mimicking characteristics of chronic obstructive pulmonary disease : LPS inhalation as an early human COPD model M Korsgren, M Linden, N Entwistle, J Cook, P Wollmer, M Andersson, B Larsson, L Greiff	Clinical Physiology and Functional Imaging	2011
Standardization of Bronchoalveolar Lavage Method Based on Suction Frequency Number and Lavage Fraction Number Using Rats JA Song, HS Yang, JS Lee, SJ Kwon, KJ Jung, JD Heo, KH Cho, CW Song, KH Lee	Toxicological Research	2010
Biomarkers of lung damage associated with tobacco smoke in induced sputum A Comandini, P Rogliani, A Nunziata, M Cazzola, G Curradi, C Saltini	Respiratory Medicine	2009
Convenient high-resolution isoelectric focusing (IEF) method for the separation of alpha1-proteinase inhibitor (A1PI) isoforms in A1PI concentrates A Weber, A Engelmaier, MC Owen, HP Schwarz, PL Turecek	Journal of Pharmaceutical and Biomedical Analysis	2007
Inhalation of activated protein C inhibits endotoxin-induced pulmonary inflammation in mice independent of neutrophil recruitment SH Slofstra, AP Groot, NA Maris, PH Reitsma, HT Cate, CA Spek	British Journal of Pharmacology	2006
Prolastin, a pharmaceutical preparation of purified human α1-antitrypsin, blocks endotoxin-mediated cytokine release I Nita, C Hollander, U Westin, SM Janciauskiene	Respiratory Research	2005
Protease inhibitor phenotypes and serum alpha-1-antitrypsin levels in patients with COPD: A study from Hong Kong JS KWOK, JW LAWTON, WW YEW, CH CHAU, J LEE, PC WONG	Respirology	2004
Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice S Song, K Goudy, M Campbell-Thompson, C Wasserfall, M Scott-Jorgensen, J Wang, Q Tang, JM Crawford, TM Ellis, MA Atkinson, TR Flotte	Gene Therapy	2004
Methods in Cell Biology JW Smith	Methods in cell biology	2002
Mapping of Sp1 regulation sites in the promoter of the human ?1-proteinase inhibitor gene Y Maruyama, Y Li, Y Zhang, X Wang, J Sugar, BY Yue	Journal of Cellular Biochemistry	2002
Reporter gene construct containing 1.4-kB ?1-proteinase inhibitor promoter confers expression in the cornea of transgenic mice J Ueda, Y Li, MS Goh, Y Maruyama, J Sugar, BY Yue	The Anatomical Record	2001
Reference distributions for the positive acute phase proteins, alpha1-acid glycoprotein (orosomucoid), alpha1-antitrypsin, and haptoglobin: a comparison of a large cohort to the world's literature R F Ritchie, G E Palomaki, L M Neveux, O Navolotskaia	Journal of Clinical Laboratory Analysis	2001
Reference distributions for the positive acute phase proteins, α1‐acid glycoprotein (orosomucoid), α1‐antitrypsin, and haptoglobin: A comparison of a large cohort to the world’s literature Ritchie RF, Palomaki GE, Neveux LM, Navolotskaia O	Journal of Clinical Laboratory Analysis	2001
Involvement of Sp1 Elements in the Promoter Activity of the α 1 -Proteinase Inhibitor Gene Y Li, LL Zhou, SS Twining, J Sugar, BY Yue	The Journal of biological chemistry	1998
Serum proteins and nutritional status of free-living Thai elderly P Pongpaew	Archives of Gerontology and Geriatrics	1995
Role of a Distal Enhancer Containing a Functional NF-κ B-binding Site in Lipopolysaccharide-induced Expression of a Novel α 1 -Antitrypsin Gene A Ray, X Gao, BK Ray	The Journal of biological chemistry	1995
Expression and structural analysis of a novel highly inducible gene encoding alpha 1-antitrypsin in rabbit BK Ray, X Gao, A Ray	The Journal of biological chemistry	1994
Principles and Practice of Environmental Medicine AB Tarcher		1992
Biochemistry of Pulmonary Emphysema C Grassi, J Travis, L Casali, M Luisetti		1992
Risk factors for emphysema. Cigarette smoking is associated with a reduction in the association rate constant of lung alpha 1-antitrypsin for neutrophil elastase F Ogushi, RC Hubbard, C Vogelmeier, GA Fells, RG Crystal	Journal of Clinical Investigation	1991
The Assessment of α1Proteinase Inhibitor Form and Function in Lung Lavage Fluid from Healthy Subjects SC AFFORD, D BURNETT, EJ CAMPBELL, JD CURY, RA STOCKLEY	Biological Chemistry Hoppe-Seyler	1988
A frameshift mutation results in a truncated alpha 1-antitrypsin that is retained within the rough endoplasmic reticulum RN Sifers, S Brashears-Macatee, VJ Kidd, H Muensch, SL Woo	The Journal of biological chemistry	1988
Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase RC Hubbard, F Ogushi, GA Fells, AM Cantin, S Jallat, M Courtney, RG Crystal	Journal of Clinical Investigation	1987
Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice RN Sifers, JA Carlson, SM Clift, FJ DeMayo, DW Bullock, SL Woo	Nucleic Acids Research	1987
Smoking, alpha 1-antitrypsin and decreased fertility in women MJ Ashley	Medical Hypotheses	1987
Molecular evolution of serpins: homologous structure of the human .alpha.1-antichymotrypsin and .alpha.1-antitrypsin genes J Bao, RN Sifers, VJ Kidd, FD Ledley, SL Woo	Biochemistry	1987
Expression of the alpha-1-antitrypsin gene in mononuclear phagocytes of normal and alpha-1-antitrypsin-deficient individuals JF Mornex, A Chytil-Weir, Y Martinet, M Courtney, JP LeCocq, RG Crystal	Journal of Clinical Investigation	1986
A fast-acting elastase inhibitor in human monocytes E Remold-O'Donnell	Journal of Experimental Medicine	1985
A modified double antibody sandwich enzyme-linked immunosorbent assay for measurement of alpha-1-antitrypsin in biologic fluids JP Michalski, CC McCombs, S Sheth, M McCarthy, R deShazo	Journal of Immunological Methods	1985
Concentration of bronchoalveolar lavage fluid by ultrafiltration: Evidence of differential protein loss and functional inactivation of proteinase inhibitors SC Afford, RA Stockley, JA Kramps, JH Dijkman, D Burnett	Analytical Biochemistry	1985
Increased plasma concentrations of C9, C1-inhibitor and α1-protease inhibitor associated with cigarette smoking RB Bridges, SR Rehm, RJ Wyatt	Life Sciences	1985
Effect of Filtration and Concentration on the Composition of Bronchoalveolar Lavage Fluid S Lam, JC LeRiche, K Kijek	Chest	1985
Human α1-proteinase inhibitor H Loebermann, R Tokuoka, J Deisenhofer, R Huber	Journal of Molecular Biology	1984
α1-Antitrypsin deficiency detection by direct analysis of the mutation in the gene VJ Kidd, RB Wallace, K Itakura, SL Woo	Nature	1983
Assignment of the alpha 1-antitrypsin gene and a sequence-related gene to human chromosome 14 by molecular hybridization EC Lai, FT Kao, ML Law, SL Woo	The American Journal of Human Genetics	1983
The mononuclear phagocytic system: A review A Lasser	Human Pathology	1983
Clinical Utility of Bronchoalveolar Lavage in the Assessment of Interstitial Lung Disease WJ Martin, DR Sanderson	The Annals of otology, rhinology, and laryngology	1983
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Alpha-1-Antitrypsin Deficiency S Idell, AB Cohen	Clinics in Chest Medicine	1983
Sequence homology and structural comparison between the chromosomal human α1-antitrypsin and chicken ovalbumin genes M Leicht, GL Long, T Chandra, K Kurachi, VJ Kidd, M Mace, EW Davie, SL Woo	Nature	1982
Early biochemical reactions in the lung of sheep exposed to asbestos: Evidence for cyclic AMP accumulation in bronchoalveolar lavage fluids I Lemaire, P Sirois, M Rola-Pleszczynski, S Massé, R Bégin	Lung	1981
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Isolation of canine α1-antitrypsin: Its interaction with pulmonary macrophages CT Schnizlein, DE Bice, WC Tuttle	Experimental and Molecular Pathology	1980
Inactivation of Bronchial Mucous Proteinase Inhibitor by Cigarette Smoke and Phagocyte-Derived Oxidants H Carp, A Janoff	Experimental Lung Research	1980
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α1-Antitrypsine et tabac, UNE etude DE 1296 hommes sains J Lellouch, JR Claude, M Thevenin	Clinica Chimica Acta	1979
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Cigarette Smoking Induces Functional Antiprotease Deficiency in the Lower Respiratory Tract of Humans JE Gadek, GA Fells, RG Crystal	Science	1979
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