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Concanavalin A inhibits tissue factor coagulant activity.
F A Pitlick
F A Pitlick
Published January 1, 1975
Citation Information: J Clin Invest. 1975;55(1):175-179. https://doi.org/10.1172/JCI107908.
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Concanavalin A inhibits tissue factor coagulant activity.

Abstract

Concanavalin A (con A) is a potent inhibitor of coagulant activity of native tissue factor. Coagulant activity is recovered by addition of alpha-methyl-D-glucoside to inhibited tissue factor. Inclusion of alpha-methyl-D-glucose during incubation of con A with tissue factor preserves coagulant activity. These data suggest that con A interacts reversibly with a carbohydrate residue in such a way as to inhibit coagulant activity of the molecule. Purified tissue factor apoprotein has been recombined with mixed brain phospholipids or purified phospholipids (phosphatidyl ethanolamine or a mixture of phosphatidyl choline with phosphatidyl serine). These preparations were also completely but reversibly inhibited by con A. Thus, purified tissue factor apoprotein appears to donate the affected carbohydrate residue.

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F A Pitlick

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