JCI - Citations to Increased Collagen Synthesis by Scleroderma Skin Fibroblasts In Vitro A POSSIBLE DEFECT IN THE REGULATION OR ACTIVATION OF THE SCLERODERMA FIBROBLAST

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Increased Collagen Synthesis by Scleroderma Skin Fibroblasts In Vitro A POSSIBLE DEFECT IN THE REGULATION OR ACTIVATION OF THE SCLERODERMA FIBROBLAST

E. Carwile LeRoy

E. Carwile LeRoy

Published October 1, 1974
Citation Information: J Clin Invest. 1974;54(4):880-889. https://doi.org/10.1172/JCI107827.

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Citations to this article (450)

Title and authors	Publication	Year
Perspective to precision medicine in scleroderma. Komura K, Yanaba K, Bouaziz JD, Yoshizaki A, Hasegawa M, Varga J, Takehara K, Matsushita T	Frontiers in immunology	2024
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A Positive Feedback Loop Exists between Estradiol and IL-6 and Contributes to Dermal Fibrosis Baker Frost D, Savchenko A, Takamura N, Wolf B, Fierkens R, King K, Feghali-Bostwick C	International journal of molecular sciences	2024
Systemic sclerosis and acute heart failure in prosthetic heart valve patients: A retrospective analysis. Khattar G, Wei C, Davis A, Saliba F, Aoun L, Mourad O, Achkar MA, Rosenberg A, Grovu R, Bradu S, El-Sayegh S, Mustafa A	Journal of scleroderma and related disorders	2024
MKP-1 Deficiency Exacerbates Skin Fibrosis in a Mouse Model of Scleroderma. Scotece M, Hämäläinen M, Leppänen T, Vuolteenaho K, Moilanen E	International journal of molecular sciences	2023
Circulating Collagen Metabolites and the Enhanced Liver Fibrosis (ELF) Score as Fibrosis Markers in Systemic Sclerosis. Chen C, Wang L, Wu J, Lu M, Yang S, Ye W, Guan M, Liang M, Zou H	Frontiers in pharmacology	2022
Contribution of HLA and KIR Alleles to Systemic Sclerosis Susceptibility and Immunological and Clinical Disease Subtypes. Hanson AL, Sahhar J, Ngian GS, Roddy J, Walker J, Stevens W, Nikpour M, Assassi S, Proudman S, Mayes MD, Kenna TJ, Brown MA	Frontiers in Genetics	2022
Efficacy of Fractional CO(2) Laser for Improvement of Limited Mouth Opening in Systemic Sclerosis. Bhat YJ, Bashir Y, Latif I, Daing A, Devi R, Shah IH, Akhtar S, Rather S, Nabi N, Saqib NU	Journal of Cutaneous and Aesthetic Surgery	2022
The hard problem: Mechanotransduction perpetuates the myofibroblast phenotype in scleroderma fibrosis A Leask	Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society	2021
TGFβ-1 Induced Cross-Linking of the Extracellular Matrix of Primary Human Dermal Fibroblasts ME Semkova, JJ Hsuan	International journal of molecular sciences	2021
Microfluidic arrays of dermal spheroids: a screening platform for active ingredients of skincare products Z Chen, S Kheiri, A Gevorkian, EW Young, V Andre, T Deisenroth, E Kumacheva	Lab on a Chip	2021
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Bi-directional communication: Conversations between fibroblasts and immune cells in systemic sclerosis JC Worrell, S O'Reilly	Journal of Autoimmunity	2020
New developments on skin fibrosis - Essential signals emanating from the extracellular matrix for the control of myofibroblasts JN Schulz, M Plomann, G Sengle, D Gullberg, T Krieg, B Eckes	Matrix biology : journal of the International Society for Matrix Biology	2018
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Novel optical assessments of tissue composition and viability using fluorescence spectroscopy and tissue oxygenation spectrophotometry in patients with systemic sclerosis: a pilot study J Allen, CD Maria, SG Urwin, A Murray, L Ottewell, B Griffiths	Physiological Measurement	2018
Clinical significance of autoantibodies in dermatomyositis and systemic sclerosis DM Tartar, L Chung, DF Fiorentino	Clinics in Dermatology	2018
Proteomic Analysis of Human Scleroderma Fibroblasts Response to Transforming Growth Factor-ß B Chaigne, G Clary, ML Gall, N Dumoitier, C Fernandez, S Lofek, P Chafey, P Moinzadeh, T Krieg, CP Denton, L Mouthon	Proteomics. Clinical applications	2018
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Transforming growth factor β-inhibitor Repsox downregulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin-induced mice skin fibrosis M Ide, M Jinnin, Y Tomizawa, Z Wang, I Kajihara, S Fukushima, Y Hashizume, Y Asano, H Ihn	Experimental Dermatology	2017
LR8 expression in fibroblasts of healthy and fibrotic human tissues A Etikala, G Bruce, K Hudkins, G Raghu, AS Narayanan	Biochemistry and Biophysics Reports	2017
Long non-coding RNA TSIX is upregulated in scleroderma dermal fibroblasts and controls collagen mRNA stabilization Z Wang, M Jinnin, K Nakamura, M Harada, H Kudo, W Nakayama, K Inoue, T Nakashima, N Honda, S Fukushima, H Ihn	Experimental Dermatology	2016
Establishment and gene expression analysis of disease-derived induced pluripotent stem cells of scleroderma Z Wang, K Nakamura, M Jinnin, H Kudo, M Goto, T Era, T Kira, T Nakashima, S Fukushima, H Ihn	Journal of Dermatological Science	2016
Dysregulated interleukin-23 signalling contributes to the increased collagen production in scleroderma fibroblasts via balancing microRNA expression W Nakayama, M Jinnin, Y Tomizawa, K Nakamura, H Kudo, K Inoue, K Makino, N Honda, I Kajihara, S Fukushima, H Ihn	Rheumatology	2016
Dermal fibroblasts induce cell cycle arrest and block epithelial-mesenchymal transition to inhibit the early stage melanoma development L Zhou, K Yang, RR Wickett, Y Zhang	Cancer Medicine	2016
Composition of TWIST1 dimers regulates fibroblast activation and tissue fibrosis K Palumbo-Zerr, A Soare, P Zerr, A Liebl, R Mancuso, M Tomcik, B Sumova, C Dees, CW Chen, T Wohlfahrt, T Mallano, A Distler, A Ramming, K Gelse, C Mihai, O Distler, G Schett, JH Distler	Annals of the rheumatic diseases	2016
Emerging strategies for treatment of systemic sclerosis D Khanna, JH Distler, P Sandner, O Distler	Journal of Scleroderma and Related Disorders	2016
Functional autoantibodies in systemic sclerosis J Günther, J Rademacher, JM van Laar, E Siegert, G Riemekasten	Seminars in Immunopathology	2015
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Tribbles homologue 3 stimulates canonical TGF-β signalling to regulate fibroblast activation and tissue fibrosis M Tomcik, K Palumbo-Zerr, P Zerr, B Sumova, J Avouac, C Dees, A Distler, R Becvar, O Distler, G Schett, L Senolt, JH Distler	Annals of the rheumatic diseases	2015
Mice overexpressing integrin αv in fibroblasts exhibit dermal thinning of the skin Z Wang, M Jinnin, Y Kobayashi, H Kudo, K Inoue, W Nakayama, N Honda, K Makino, I Kajihara, T Makino, S Fukushima, Y Inagaki, H Ihn	Journal of Dermatological Science	2015
Connective Tissue Disorders Associated with Vasculitis and Vaso-Occlusive Disease of the Hand B Michelotti, M Rizzo, SL Moran	Hand Clinics	2015
Pathogenesis of Systemic Sclerosis D Pattanaik, M Brown, BC Postlethwaite, AE Postlethwaite	Frontiers in immunology	2015
Activation of the Thromboxane A2 Receptor by 8-Isoprostane Inhibits the Pro-Angiogenic Effect of Vascular Endothelial Growth Factor in Scleroderma PS Tsou, MA Amin, PL Campbell, G Zakhem, B Balogh, G Edhayan, RA Ohara, E Schiopu, D Khanna, AE Koch, DA Fox	Journal of Investigative Dermatology	2015
Activating transcription factor 3 regulates canonical TGFβ signalling in systemic sclerosis T Mallano, K Palumbo-Zerr, P Zerr, A Ramming, B Zeller, C Beyer, C Dees, J Huang, T Hai, O Distler, G Schett, JH Distler	Annals of the rheumatic diseases	2015
Autoantibodies to angiotensin and endothelin receptors in systemic sclerosis induce cellular and systemic events associated with disease pathogenesis A Kill, C Tabeling, R Undeutsch, AA Kühl, J Günther, M Radic, MO Becker, H Heidecke, M Worm, M Witzenrath, GR Burmester, D Dragun, G Riemekasten	Arthritis Research & Therapy	2014
Molecular and cellular basis of scleroderma B Eckes, P Moinzadeh, G Sengle, N Hunzelmann, T Krieg	Journal of Molecular Medicine	2014
Proinflammatory effects of diesel exhaust nanoparticles on scleroderma skin cells A Mastrofrancesco, M Alfè, E Rosato, V Gargiulo, C Beatrice, GD Blasio, B Zhang, DS Su, M Picardo, S Fiorito	Journal of Immunology Research	2014
Vitamin D receptor regulates TGF- signalling in systemic sclerosis P Zerr, S Vollath, K Palumbo-Zerr, M Tomcik, J Huang, A Distler, C Beyer, C Dees, K Gela, O Distler, G Schett, JH Distler	Annals of the rheumatic diseases	2014
S100A4 amplifies TGF-β-induced fibroblast activation in systemic sclerosis M Tomcik, K Palumbo-Zerr, P Zerr, J Avouac, C Dees, B Sumova, A Distler, C Beyer, LA Cerezo, R Becvar, O Distler, M Grigorian, G Schett, L Senolt, JH Distler	Annals of the rheumatic diseases	2014
Deciphering the pro-fibrotic phenotype of fibroblasts in systemic sclerosis C Maier, JH Distler, C Beyer	Experimental Dermatology	2014
Clinical and molecular description of a 17q21.33 microduplication in a girl with severe kyphoscoliosis and developmental delay S Kemeny, C Pebrel-Richard, E Eymard-Pierre, M Gay-Bellile, L Gouas, C Goumy, A Tchirkov, C Francannet, P Vago	European Journal of Medical Genetics	2014
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Detection of hair-microRNAs as the novel potent biomarker: Evaluation of the usefulness for the diagnosis of scleroderma Z Wang, M Jinnin, H Kudo, K Inoue, W Nakayama, N Honda, K Makino, I Kajihara, S Fukushima, Y Inoue, H Ihn	Journal of Dermatological Science	2013
The emerging role of epigenetics in rheumatic diseases S Gay, AG Wilson	Rheumatology	2013
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Hair miR-29a levels are decreased in patients with scleroderma R Takemoto, M Jinnin, Z Wang, H Kudo, K Inoue, W Nakayama, A Ichihara, T Igata, I Kajihara, S Fukushima, H Ihn	Experimental Dermatology	2013
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Impaired IL-17 Signaling Pathway Contributes to the Increased Collagen Expression in Scleroderma Fibroblasts T Nakashima, M Jinnin, K Yamane, N Honda, I Kajihara, T Makino, S Masuguchi, S Fukushima, Y Okamoto, M Hasegawa, M Fujimoto, H Ihn	Journal of immunology (Baltimore, Md. : 1950)	2012
TGF-β–Mediated Downregulation of MicroRNA-196a Contributes to the Constitutive Upregulated Type I Collagen Expression in Scleroderma Dermal Fibroblasts N Honda, M Jinnin, I Kajihara, T Makino, K Makino, S Masuguchi, S Fukushima, Y Okamoto, M Hasegawa, M Fujimoto, H Ihn	Journal of immunology (Baltimore, Md. : 1950)	2012
Caveolin-1 Signaling in Lung Fibrosis E Tourkina, S Hoffman	The open rheumatology journal	2012
Fibrosis in systemic sclerosis: common and unique pathobiology S Bhattacharyya, J Wei, WG Tourtellotte, M Hinchcliff, CG Gottardi, J Varga	Fibrogenesis & Tissue Repair	2012
Brenner and Rector's The Kidney C Brugnara, KU Eckardt	Brenner and Rector's The Kidney	2012
Characterization of the phenotype of high collagen-producing fibroblast clones in systemic sclerosis, using a new modified limiting-dilution method : Characterization of high collagen-producing fibroblast clones in systemic sclerosis L Zhu, D Gao, J Yang, M Li	Clinical and Experimental Dermatology	2012
Discoidin Domain Receptor 2–microRNA 196a–Mediated Negative Feedback against Excess Type I Collagen Expression Is Impaired in Scleroderma Dermal Fibroblasts K Makino, M Jinnin, J Aoi, A Hirano, I Kajihara, T Makino, K Sakai, S Fukushima, Y Inoue, H Ihn	Journal of Investigative Dermatology	2012
microRNA-92a expression in the sera and dermal fibroblasts increases in patients with scleroderma T Sing, M Jinnin, K Yamane, N Honda, K Makino, I Kajihara, T Makino, K Sakai, S Masuguchi, S Fukushima, H Ihn	Rheumatology	2012
Matrix Metalloproteinases: A Review of Their Structure and Role in Systemic Sclerosis W Peng, J Yan, Y Wan, B Wang, J Tao, G Yang, H Pan, J Wang	Journal of Clinical Immunology	2012
Abscisic acid ameliorates the systemic sclerosis fibroblast phenotype in vitro S Bruzzone, F Battaglia, E Mannino, A Parodi, F Fruscione, G Basile, A Salis, L Sturla, S Negrini, F Kalli, S Stringara, G Filaci, E Zocchi, D Fenoglio	Biochemical and Biophysical Research Communications	2012
Constitutive activation of c-Abl/protein kinase C-δ/Fli1 pathway in dermal fibroblasts derived from patients with localized scleroderma: c-Abl/PKC-δ/Fli1 pathway in localized scleroderma S Noda, Y Asano, K Akamata, N Aozasa, T Taniguchi, T Takahashi, Y Ichimura, T Toyama, H Sumida, K Yanaba, Y Tada, M Sugaya, T Kadono, S Sato	British Journal of Dermatology	2012
microRNA-150 Down-Regulation Contributes to the Constitutive Type I Collagen Overexpression in Scleroderma Dermal Fibroblasts via the Induction of Integrin β3 N Honda, M Jinnin, T Kira-Etoh, K Makino, I Kajihara, T Makino, S Fukushima, Y Inoue, Y Okamoto, M Hasegawa, M Fujimoto, H Ihn	The American Journal of Pathology	2012
Scleroderma dermal fibroblasts overexpress vascular endothelial growth factor due to autocrine transforming growth factor β signaling I Kajihara, M Jinnin, N Honda, K Makino, T Makino, S Masuguchi, K Sakai, S Fukushima, Y Inoue, H Ihn	Modern Rheumatology	2012
Clinical significance of serum levels of secretory leukocyte protease inhibitor in patients with systemic sclerosis N Aozasa, Y Asano, K Akamata, S Noda, Y Masui, Z Tamaki, Y Tada, M Sugaya, T Kadono, S Sato	Modern Rheumatology	2012
Combining experimental and mathematical modeling to reveal mechanisms of macrophage-dependent left ventricular remodeling YF Jin, HC Han, J Berger, Q Dai, ML Lindsey	BMC Systems Biology	2011
The epigenetics of autoimmunity F Meda, M Folci, A Baccarelli, C Selmi	Cellular and Molecular Immunology	2011
Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities S Bhattacharyya, J Wei, J Varga	Nature Reviews Rheumatology	2011
A System Out of Breath: How Hypoxia Possibly Contributes to the Pathogenesis of Systemic Sclerosis TW van Hal, L Bon, TR Radstake	International Journal of Rheumatology	2011
Vascular involvement in systemic sclerosis (scleroderma) D Pattanaik, M Brown, AE Postlethwaite	Journal of inflammation research	2011
Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism Y Chen, A Leask, DJ Abraham, L Kennedy, X Shi-Wen, CP Denton, CM Black, LS Verjee, M Eastwood	Fibrogenesis & Tissue Repair	2011
Harper's Textbook of Pediatric Dermatology HM Goodyear	Harper's Textbook of Pediatric Dermatology	2011
Fibroblast abnormalities in the pathogenesis of systemic sclerosis A Usategui, MJ Rey, JL Pablos	Expert Review of Clinical Immunology	2011
Clinical significance of serum levels of secretory leukocyte protease inhibitor in patients with systemic sclerosis N Aozasa, Y Asano, K Akamata, S Noda, Y Masui, Z Tamaki, Y Tada, M Sugaya, T Kadono, S Sato	Modern Rheumatology	2011
Bayesian parameter estimation for nonlinear modelling of biological pathways O Ghasemi, ML Lindsey, T Yang, N Nguyen, Y Huang, YF Jin	BMC Systems Biology	2011
Increased Accumulation of Extracellular Thrombospondin-2 Due to Low Degradation Activity Stimulates Type I Collagen Expression in Scleroderma Fibroblasts I Kajihara, M Jinnin, K Yamane, T Makino, N Honda, T Igata, S Masuguchi, S Fukushima, Y Okamoto, M Hasegawa, M Fujimoto, H Ihn	The American Journal of Pathology	2011
Circulating miR-142-3p levels in patients with systemic sclerosis : miR-142-3p levels in systemic sclerosis K Makino, M Jinnin, I Kajihara, N Honda, K Sakai, S Masuguchi, S Fukushima, Y Inoue, H Ihn	Clinical and Experimental Dermatology	2011
Handbook of Epigenetics LB Riley, DW Anderson	Handbook of Epigenetics	2011
Effect of oxidative stress on protein tyrosine phosphatase 1B in scleroderma dermal fibroblasts PS Tsou, NN Talia, AJ Pinney, A Kendzicky, S Piera-Velazquez, SA Jimenez, JR Seibold, K Phillips, AE Koch	Arthritis & Rheumatism	2011
Scleroderma-like properties of skin from caveolin-1-deficient mice: Implications for new treatment strategies in patients with fibrosis and systemic sclerosis R Castello-Cros, D Whitaker-Menezes, A Molchansky, G Purkins, LJ Soslowsky, DP Beason, F Sotgia, RV Iozzo, MP Lisanti	Cell cycle (Georgetown, Tex.)	2011
The impact of Fli1 deficiency on the pathogenesis of systemic sclerosis Y Asano, AM Bujor, M Trojanowska	Journal of Dermatological Science	2010
Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy J Wei, S Bhattacharyya, WG Tourtellotte, J Varga	Autoimmunity Reviews	2010
Proteomic Analysis Identification of a Pattern of Shared Alterations in the Secretome of Dermal Fibroblasts from Systemic Sclerosis and Nephrogenic Systemic Fibrosis FD Galdo, MA Shaw, SA Jimenez	The American Journal of Pathology	2010
Increased mRNA expression of collagen V gene in pulmonary fibrosis of systemic sclerosis ER Parra, WR Teodoro, J Morais, ML Katayama, R Souza, NH Yoshinari, VL Capelozzi	European Journal of Clinical Investigation	2010
Future treatments in systemic sclerosis Y ASANO	The Journal of Dermatology	2010
Animal models of systemic sclerosis: Prospects and limitations C Beyer, G Schett, O Distler, JH Distler	Arthritis & Rheumatism	2010
Rook's Textbook of Dermatology: Burns/Rook's Textbook of Dermatology PS Friedmann, MR Ardern-Jones, CA Holden	Rook's Textbook of Dermatology: Burns/Rook's Textbook of Dermatology	2010
Recent Advances in the Treatment of Systemic Sclerosis VK Bournia, PG Vlachoyiannopoulos, C Selmi, HM Moutsopoulos, ME Gershwin	Clinical Reviews in Allergy & Immunology	2009
Histomorphometric analysis of cutaneous remodeling in the early stage of the scleroderma model CC de Oliveira, AP Velosa, ER Parra, VL Capelozzi, WR Teodoro, NH Yoshinari	Clinics (São Paulo, Brazil)	2009
Predictors of the scleroderma phenotype in fibroblasts from systemic sclerosis patients Q Qi, Q Guo, G Tan, Y Mao, H Tang, C Zhou, F Zeng	Journal of the European Academy of Dermatology and Venereology	2009
Overview of pathogenesis of systemic sclerosis DJ Abraham, T Krieg, J Distler, O Distler	Rheumatology	2009
A novel de novo 1.1 Mb duplication of 17q21.33 associated with cognitive impairment and other anomalies FR Zahir, S Langlois, K Gall, P Eydoux, MA Marra, JM Friedman	American Journal of Medical Genetics Part A	2009
Scleroderma A Gabrielli, EV Avvedimento, T Krieg	New England Journal of Medicine	2009
Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis: association with pulmonary fibrosis T Hara, F Ogawa, K Yanaba, Y Iwata, E Muroi, K Komura, M Takenaka, K Shimizu, M Hasegawa, M Fujimoto, S Sato	The Journal of rheumatology	2009
Dermatological Phototherapy and Photodiagnostic Methods H Hönigsmann, CA Elmets, J Krutmann		2009
Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts Y Chen, A Leask, DJ Abraham, D Pala, X Shiwen, K Khan, S Liu, DE Carter, S Wilcox-Adelman, P Goetinck, CP Denton, CM Black, AA Pitsillides, CE Sarraf, M Eastwood	Arthritis & Rheumatism	2008
Decreased expression of caveolin 1 in patients with systemic sclerosis: Crucial role in the pathogenesis of tissue fibrosis FD Galdo, F Sotgia, CJ de Almeida, JF Jasmin, M Musick, MP Lisanti, SA Jiménez	Arthritis & Rheumatism	2008
Up-regulated macrophage migration inhibitory factor protects apoptosis of dermal fibroblasts in patients with systemic sclerosis JY Kim, SK Kwok, KH Hur, HJ Kim, NS Kim, SA Yoo, WU Kim, CS Cho	Clinical & Experimental Immunology	2008
Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-β pathway - implication of C-Krox and Sp1 E Renard, C Chadjichristos, M Kypriotou, G Beauchef, P Bordat, A Dompmartin, RL Widom, K Boumediene, JP Pujol, P Galéra	Journal of Cellular and Molecular Medicine	2008
Expression of insulin-like growth factor-I in lesional and non-lesional skin of patients with morphoea MM Fawzi, SO Tawfik, AM Eissa, MH El-Komy, MR Abdel-Halim, OG Shaker	British Journal of Dermatology	2008
Effect of γδ T cell supernatant on human skin fibroblast proliferation and collagen production - Possible role of transforming growth factor-β and basic fibroblast growth factor T Ohtsuka	International Journal of Dermatology	2008
The roles of chemokines in the development of systemic sclerosis M HASEGAWA	Japanese Journal of Clinical Immunology	2008
Regulation of collagen gene expression in the Tsk2 mouse T Barisic-Dujmovic, I Boban, SH Clark	Journal of Cellular Physiology	2008
Autocrine TGF-β signaling in the pathogenesis of systemic sclerosis H Ihn	Journal of Dermatological Science	2008
Úlceras digitales en la esclerosis sistémica EB Catalán, JA Ivorra, JA Sancho, IC Vedejo, NF Comella, JI Cortés	Seminarios de la Fundación Española de Reumatología	2008
Proteomic analysis of CTGF-activated lung fibroblasts: identification of IQGAP1 as a key player in lung fibroblast migration GS Bogatkevich, A Ludwicka-Bradley, CB Singleton, JR Bethard, RM Silver	American journal of physiology. Lung cellular and molecular physiology	2008
Differential Dynamic Properties of Scleroderma Fibroblasts in Response to Perturbation of Environmental Stimuli M Xiong, FC Arnett, X Guo, H Xiong, X Zhou, R Khanin	PloS one	2008
SYSTEMIC SCLEROSIS: A PROTOTYPIC MULTISYSTEM FIBROTIC DISORDER John Varga and David Abraham	Journal of Clinical Investigation	2007
Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts M Jinnin, H Ihn, Y Mimura, Y Asano, K Tamaki	Arthritis & Rheumatism	2007
Contribution of single nucleotide polymorphisms of the IL1A gene to the cleavage of precursor IL-1α and its transcription activity Y Kawaguchi, A Tochimoto, M Hara, M Kawamoto, T Sugiura, S Saito, N Kamatani	Immunogenetics	2007
Interstitial Lung Disease in Systemic Sclerosis P Ostojic, MM Cerinic, R Silver, K Highland, N Damjanov	Lung	2007
Pathogenese der systemischen Sklerodermie M Fabri, T Krieg	Der Hautarzt	2007
Scleroderma - news to tell B Eckes, N Hunzelmann, P Moinzadeh, T Krieg	Archives of Dermatological Research	2007
Molecular pathways as novel therapeutic targets in systemic sclerosis M Trojanowska, J Varga	Current Opinion in Rheumatology	2007
T cells expressing allograft inflammatory factor 1 display increased chemotaxis and induce a profibrotic phenotype in normal fibroblasts in vitro FD Galdo, SA Jiménez	Arthritis & Rheumatism	2007
Relationship between matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases systems and autoantibody patterns in systemic sclerosis M Montagnana, A Volpe, G Lippi, P Caramaschi, GL Salvagno, D Biasi, LM Bambara, GC Guidi	Clinical Biochemistry	2007
Molecular pathways as novel therapeutic targets in systemic sclerosis: M Trojanowska, J Varga	Current Opinion in Rheumatology	2007
Cartilage oligomeric matrix protein is overexpressed by scleroderma dermal fibroblasts G Farina, R Lemaire, JH Korn, RL Widom	Matrix Biology	2006
Involvement of alphavbeta5 integrin in the establishment of autocrine TGF-beta signaling in dermal fibroblasts derived from localized scleroderma Y Asano, H Ihn, M Jinnin, Y Mimura, K Tamaki	Journal of Investigative Dermatology	2006
Potential regulatory elements of the constitutive up-regulated alpha2(I) collagen gene in scleroderma dermal fibroblasts M Jinnin, H Ihn, Y Mimura, Y Asano, K Tamaki	Biochemical and Biophysical Research Communications	2006
Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts Y Chen, X Shi-wen, M Eastwood, CM Black, CP Denton, A Leask, DJ Abraham	Arthritis & Rheumatism	2006
Lack of increased expression of cell surface markers for circulating fibrocyte progenitors in limited scleroderma R Russo, H Medbury, A Guiffre, H Englert, N Manolios	Clinical Rheumatology	2006
Chemokines and Chemokine Receptors in Scleroderma T Yamamoto	International Archives of Allergy and Immunology	2006
Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin N Louneva, G Huaman, J Fertala, SA Jiménez	Arthritis & Rheumatism	2006
Antifibrotic effects of hepatocyte growth factor on scleroderma fibroblasts and analysis of its mechanism R Sherriff-Tadano, A Ohta, F Morito, M Mitamura, Y Haruta, S Koarada, Y Tada, K Nagasawa, I Ozaki	Modern Rheumatology	2006
Serum levels of tissue inhibitors of metalloproteinase 2 in patients with systemic sclerosis with duration more than 2 years: correlation with cardiac and pulmonary abnormalities A Shahin, A Elsawaf, S Ramadan, O Shaker, M Amin, M Taha	Mediators of Inflammation	2006
Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts Y Asano, H Ihn, K Yamane, M Jinnin, K Tamaki	The American Journal of Pathology	2006
DNA topoisomerase I binding to fibroblasts induces monocyte adhesion and activation in the presence of anti-topoisomerase I autoantibodies from systemic sclerosis patients J Hénault, G Robitaille, JL Senécal, Y Raymond	Arthritis & Rheumatism	2006
Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts Y Wang, PS Fan, B Kahaleh	Arthritis & Rheumatism	2006
Anaesthesia, Pain, Intensive Care and Emergency A.P.I.C.E A Gullo		2006
Increase in platelet non-integrin type I collagen receptor in patients with systemic sclerosis TM Chiang, H Takayama, AE Postlethwaite	Thrombosis Research	2005
Constitutive thrombospondin-1 overexpression contributes to autocrine transforming growth factor-beta signaling in cultured scleroderma fibroblasts Y Mimura, H Ihn, M Jinnin, Y Asano, K Yamane, K Tamaki	The American Journal of Pathology	2005
Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease Y Chen, X Shi-Wen, J Beek, L Kennedy, M McLeod, EA Renzoni, G Bou-Gharios, S Wilcox-Adelman, PF Goetinck, M Eastwood, CM Black, DJ Abraham, A Leask	The American Journal of Pathology	2005
Scleroderma, fibroblasts, signaling, and excessive extracellular matrix H Ihn	Current Rheumatology Reports	2005
Alpha2(I) collagen gene regulation by protein kinase C signaling in human dermal fibroblasts M Jinnin, H Ihn, K Yamane, Y Mimura, Y Asano, K Tamaki	Nucleic Acids Research	2005
Involvement of alphavbeta5 integrin-mediated activation of latent transforming growth factor beta1 in autocrine transforming growth factor beta signaling in systemic sclerosis fibroblasts Y Asano, H Ihn, K Yamane, M Jinnin, Y Mimura, K Tamaki	Arthritis & Rheumatism	2005
Differential effects of the immunosuppressant FK-506 on human alpha2(I) collagen gene expression and transforming growth factor beta signaling in normal and scleroderma fibroblasts Y Asano, H Ihn, K Yamane, M Jinnin, Y Mimura, K Tamaki	Arthritis & Rheumatism	2005
Constitutively phosphorylated Smad3 interacts with Sp1 and p300 in scleroderma fibroblasts H Ihn, K Yamane, Y Asano, M Jinnin, K Tamaki	Rheumatology (Oxford, England)	2005
Effects of Hepatocyte Growth Factor on the Expression of Type I Collagen and Matrix Metalloproteinase-1 in Normal and Scleroderma Dermal Fibroblasts M Jinnin, H Ihn, Y Mimura, Y Asano, K Yamane, K Tamaki	Journal of Investigative Dermatology	2005
Anti-DNA topoisomerase II α autoantibodies in Japanese patients with systemic sclerosis I Hayakawa, M Hasegawa, K Takehara, S Sato	Archives of Dermatological Research	2005
Matrix metalloproteinase-1 up-regulation by hepatocyte growth factor in human dermal fibroblasts via ERK signaling pathway involves Ets1 and Fli1 M Jinnin, H Ihn, Y Mimura, Y Asano, K Yamane, K Tamaki	Nucleic Acids Research	2005
Wound healing: Abnormalities and future therapeutic targets M Kapoor, I Appleton	Current Anaesthesia and Critical Care	2005
Autoimmune Diseases of the Skin M Hertl		2005
Increased Expression of Integrin α v β 3 Contributes to the Establishment of Autocrine TGF-β Signaling in Scleroderma Fibroblasts Y Asano, H Ihn, K Yamane, M Jinnin, Y Mimura, K Tamaki	Journal of immunology (Baltimore, Md. : 1950)	2005
Impaired Smad7-Smurf-mediated negative regulation of transforming growth factor (TGF)-beta signaling in scleroderma fibroblasts Yoshihide ASANO, Hironobu IHN, Kenichi YAMANE, Masahide Kubo, Kunihiko TAMAKI	Journal of Clinical Investigation	2004
Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors Y Kawaguchi, K Takagi, M Hara, C Fukasawa, T Sugiura, E Nishimagi, M Harigai, N Kamatani	Arthritis & Rheumatism	2004
Autoantibody against matrix metalloproteinase-3 in patients with systemic sclerosis C Nishijima, I Hayakawa, T Matsushita, K Komura, M Hasegawa, K Takehara, S Sato	Clinical & Experimental Immunology	2004
Direct binding of anti-DNA topoisomerase I autoantibodies to the cell surface of fibroblasts in patients with systemic sclerosis J H�nault, M Tremblay, I Cl�ment, Y Raymond, JL Sen�cal	Arthritis & Rheumatism	2004
Is Rituximab a Potential New Therapy in Systemic Sclerosis? FA Wollheim	JCR: Journal of Clinical Rheumatology	2004
Histopathological changes of cervical tissue in women with systemic sclerosis C Evruke, D Ertunc, F Doran, S Ozbek, O Kadayifci	Pathology International	2004
Different low doses of broad-band UVA in the treatment of morphea and systemic sclerosis. A clinico-pathologic study M El-Mofty, W Mostafa, M El-Darouty, M Bosseila, H Nada, R Yousef, S Esmat, M El-Lawindy, M Assaf, G El-Enani	Photodermatology, Photoimmunology and Photomedicine	2004
High plasminogen activator inhibitor type 2 expression is a hallmark of scleroderma fibroblasts in vitro D Kessler-Becker, S Smola, T Krieg, B Eckes	Experimental Dermatology	2004
Regulation of PDGF and its receptors in fibrotic diseases JC Bonner	Cytokine & Growth Factor Reviews	2004
Increased Expression Levels of Integrin αvβ5 on Scleroderma Fibroblasts Y Asano, H Ihn, K Yamane, M Kubo, K Tamaki	The American Journal of Pathology	2004
Progress in research into systemic sclerosis B Kahaleh	The Lancet	2004
Hepatic manifestations of autoimmune rheumatic diseases S Abraham, S Begum, D Isenberg	Annals of the rheumatic diseases	2004
Increased expression levels of integrin alphavbeta5 on scleroderma fibroblasts Y Asano, H Ihn, K Yamane, M Kubo, K Tamaki	The American Journal of Pathology	2004
Gene expression profiling of fibroblasts from a human progeroid disease (mandibuloacral dysplasia, MAD #248370) through cDNA microarrays Francesca Amati, Michela Biancolella, Maria Rosaria D'Apice, Stefano Gambardella, Ruggiero Mango, Paolo Sbraccia, Monica D'Adamo, Katia Margiotti, Annamaria Nardone, Marc Lewis, Giuseppe Novelli	Gene expression	2004
Phosphatidylinositol 3-Kinase Is Involved in α2(I) Collagen Gene Expression in Normal and Scleroderma Fibroblasts Y Asano, H Ihn, K Yamane, M Jinnin, Y Mimura, K Tamaki	Journal of immunology (Baltimore, Md. : 1950)	2004
Function Blocking Autoantibodies Against Matrix Metalloproteinase-1 in Patients with Systemic Sclerosis S Sato, I Hayakawa, M Hasegawa, M Fujimoto, K Takehara	Journal of Investigative Dermatology	2003
Epidemiology and pathogenesis of scleroderma K Chen, A See, S Shumack	Australasian Journal of Dermatology	2003
Transforming growth factor-β: A mediator of cell regulation in acute respiratory distress syndrome JF Dhainaut, J Charpentier, JD Chiche	Critical Care Medicine	2003
Cytokine regulation of pulmonary fibrosis in scleroderma SP Atamas, B White	Cytokine & Growth Factor Reviews	2003
Evaluation of caspase 1 and sFas serum levels in patients with systemic sclerosis: correlation with lung dysfunction, joint and bone involvement B Dziankowska-Bartkowiak, E Waszczykowska, A Zalewska, A Sysa-Jedrzejowska	Mediators of Inflammation	2003
Fibrosis in scleroderma EY Kissin, JH Korn	Rheumatic Disease Clinics of North America	2003
Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts E Gore-Hyer, J Pannu, EA Smith, G Grotendorst, M Trojanowska	Arthritis & Rheumatism	2003
Animal Models of Human Inflammatory Skin Diseases J Carroll	Animal Models of Human Inflammatory Skin Diseases: Induction by Oral Allergen	2003
Animal Models of Human Inflammatory Skin Diseases: Induction by Transfer of Cellular Immmunity A Gilliam	Animal Models of Human Inflammatory Skin Diseases: Induction by Oral Allergen	2003
Transcriptional activation of α1(III) procollagen gene in Tsk2/+ dermal fibroblasts PJ Christner, T Yufit, J Peters, R McGrath, RF Conway, SA Jiménez	Biochemical and Biophysical Research Communications	2003
Fibroblast and endothelial apoptosis in systemic sclerosis: JB Jun, M Kuechle, JM Harlan, KB Elkon	Current Opinion in Rheumatology	2003
Identification of PLOD2 as Telopeptide Lysyl Hydroxylase, an Important Enzyme in Fibrosis AJ van der Slot, AM Zuurmond, AF Bardoel, C Wijmenga, HE Pruijs, DO Sillence, J Brinckmann, DJ Abraham, CM Black, N Verzijl, J DeGroot, R Hanemaaijer, JM TeKoppele, TW Huizinga, RA Bank	The Journal of biological chemistry	2003
Collagen turnover is diminished by different clones of skin fibroblasts from early- but not late-stage systemic sclerosis CS Zurita-Salinas, E Krötzsch, LD de León, J Alcocer-Varela	Rheumatology International	2003
Increased transcriptional activities of transforming growth factor ? receptors in scleroderma fibroblasts K Yamane, H Ihn, M Kubo, K Tamaki	Arthritis & Rheumatism	2002
Decreased MMP-9 activity in the serum of patients with diffuse cutaneous systemic sclerosis K Kikuchi, M Kubo, T Hoashi, K Tamaki	Clinical and Experimental Dermatology	2002
The polymorphism of telomerase RNA component gene in patients with systemic sclerosis T Ohtsuka, A Yamakage, S Yamazaki	British Journal of Dermatology	2002
The polymorphism of transforming growth factor-beta1 gene in Japanese patients with systemic sclerosis T Ohtsuka, A Yamakage, S Yamazaki	British Journal of Dermatology	2002
The protein kinase C delta inhibitor, rottlerin, downregulates collagen gene expression in normal and systemic sclerosis fibroblasts Sergio A. Jimenez, Svetlana Gaidarova, Biagio Saitta, Nora Sandorfi, David J. Herrich, Joan C. Rosenbloom, Umberto Kucich, William R. Abrams, Joel Rosenbloom	Journal of Clinical Investigation	2001
Combined Treatment with Calcipotriol Ointment and Low-Dose Ultraviolet A1 Phototherapy in Childhood Morphea A Kreuter, T Gambichler, A Avermaete, T Jansen, M Hoffmann, K Hoffmann, P Altmeyer, G Kobyletzki, M Bacharach-Buhles	Pediatric Dermatology	2001
An increase of mature type skin collagen cross-link, histidinohydroxylysinonorleucine, in the sclerotic skin of morphea M Tamura, O Ishikawa	Journal of Dermatological Science	2001
Blockade of endogenous transforming growth factor ? signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: Association with increased expression of transforming growth factor ? receptors H Ihn, K Yamane, M Kubo, K Tamaki	Arthritis & Rheumatism	2001
Up-regulated expression of transforming growth factor ? receptors in dermal fibroblasts in skin sections from patients with localized scleroderma M Kubo, H Ihn, K Yamane, K Tamaki	Arthritis & Rheumatism	2001
Oxidative stress in scleroderma: Maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway P Sambo, SS Baroni, M Luchetti, P Paroncini, S Dusi, G Orlandini, A Gabrielli	Arthritis & Rheumatism	2001
Cloning and Functional Analysis of a Family of Nuclear Matrix Transcription Factors (NP/NMP4) that Regulate Type I Collagen Expression in Osteoblasts P Thunyakitpisal, M Alvarez, K Tokunaga, JE Onyia, J Hock, N Ohashi, H Feister, SJ Rhodes, JP Bidwell	Journal of Bone and Mineral Research	2001
Reduction in dermal fibrosis in the tight-skin (Tsk) mouse after local application of halofuginone M Pines, A Domb, M Ohana, J Inbar, O Genina, R Alexiev, A Nagler	Biochemical Pharmacology	2001
D-penicillamine in systemic sclerosis? Yes! TA K	Scandinavian Journal of Rheumatology	2001
CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD Signaling A Holmes, DJ Abraham, S Sa, X Shiwen, CM Black, A Leask	The Journal of biological chemistry	2001
δEF1 Binds to a Far Upstream Sequence of the Mouse Pro-α1(I) Collagen Gene and Represses Its Expression in Osteoblasts C Terraz, D Toman, M Delauche, P Ronco, J Rossert	The Journal of biological chemistry	2001
The Th1/Th2 paradigm in the pathogenesis of scleroderma, and its modulation by thalidomide SJ Oliver	Current Rheumatology Reports	2000
Bone marrow transplantation in the treatment of systemic sclerosis F Viganego, R Nash, DE Furst	Current Rheumatology Reports	2000
Alterations in the regulation of expression of the αl(I) collagen gene (COL1A1) in systemic sclerosis (scleroderma) SA Jimenez, B Saitta	Springer Seminars in Immunopathology	2000
Increased phosphorylation of transcription factor Sp1 in scleroderma fibroblasts: Association with increased expression of the type I collagen gene H Ihn, K Tamaki	Arthritis & Rheumatism	2000
Increased interleukin-17 production in patients with systemic sclerosis K Kurasawa, K Hirose, H Sano, H Endo, H Shinkai, Y Nawata, K Takabayashi, I Iwamoto	Arthritis & Rheumatism	2000
Role of apoptosis and transforming growth factor β1 in fibroblast selection and activation in systemic sclerosis A Jelaska, JH Korn	Arthritis & Rheumatism	2000
Cytokine modulation of extracellular matrix gene expression: relevance to fibrotic skin diseases J Uitto, D Kouba	Journal of Dermatological Science	2000
Interactions of fibroblasts with the extracellular matrix: implications for the understanding of fibrosis B Eckes, D Kessler, M Aumailley, T Krieg	Springer Seminars in Immunopathology	2000
Circulating collagen metabolites in systemic sclerosis. Differences between limited and diffuse form and relationship with pulmonary involvement A Scheja, M Wildt, FA Wollheim, A Akesson, T Saxne	Rheumatology	2000
Serum levels of tissue inhibitor of metalloproteinases 2 in patients with systemic sclerosis N Yazawa, K Kikuchi, H Ihn, M Fujimoto, M Kubo, T Tamaki, K Tamaki	Journal of the American Academy of Dermatology	2000
Autocrine Overexpression of CTGF Maintains Fibrosis: RDA Analysis of Fibrosis Genes in Systemic Sclerosis X Shi-wen, D Pennington, A Holmes, A Leask, D Bradham, JR Beauchamp, C Fonseca, RM Bois, GR Martin, CM Black, DJ Abraham	Experimental Cell Research	2000
Regulation of matrix biosynthesis and degradation in systemic sclerosis: RL Widom	Current Opinion in Rheumatology	2000
Differential expression of nitric oxide by dermal microvascular endothelial cells from patients with scleroderma LI Romero, DN Zhang, JP Cooke, HK Ho, E Avalos, R Herrera, GS Herron	Vascular medicine (London, England)	2000
Endogenous IL-1α from systemic sclerosis fibroblasts induces IL-6 and PDGF-A Y Kawaguchi, M Hara, TM Wright	Journal of Clinical Investigation	1999
Serum Xylosyltransferase: a New Biochemical Marker of the Sclerotic Process in Systemic Sclerosis C Gotting, S Sollberg, J Kuhn, C Weilke, C Huerkamp, T Brinkmann, T Krieg, K Kleesiek	Journal of Investigative Dermatology	1999
Fibroblast heterogeneity in physiological conditions and fibrotic disease A Jelaska, D Strehlow, JH Korn	Springer Seminars in Immunopathology	1999
Detection of soluble α1 integrin in human serum I Bank, P Weiss, R Doolman, M Book, BA Sela	Journal of Laboratory and Clinical Medicine	1999
Vorträge und Dia-Klinik der 16. Fortbildungswoche 1998 Fortbildungswoche für Praktische Dermatologie und Venerologie e.V. c/o Klinik und Poliklinik für Dermatologie und Allergologie Ludwig-Maximilians-Universität München in Verbindung mit dem Berufsverband der Deutschen Dermatologen e.V G Plewig, H Wolff		1999
Interactions of fibroblasts with the extracellular matrix: implications for the understanding of fibrosis. Eckes B, Kessler D, Aumailley M, Krieg T	Springer Seminars in Immunopathology	1999
Demonstration of increased levels of type I collagen mRNA using quantitative polymerase chain reaction in fibrotic and granulomatous skin diseases Tasanen, Palatsi, Oikarinen	British Journal of Dermatology	1998
Expression of platelet-derived growth factor B-chain and platelet-derived growth factor β-receptor in fibroblasts of scleroderma Z Xue-yi, Z Jian-zhong, T Ping, M Sheng-qing	Journal of Dermatological Science	1998
Modulation of basal expression of the human α1(I) procollagen gene (COL1A1) by tandem NF-1/Sp1 promoter elements in normal human dermal fibroblasts CM Artlett, SJ Chen, J Varga, SA Jimenez	Matrix Biology	1998
Transcriptional activation of the ?1(I) procollagen gene and up-regulation of ?1(I) and ?1(III) procollagen messenger RNA in dermal fibroblasts from tight skin 2 mice PJ Christner, EG Hitraya, J Peters, R McGrath, SA Jim�nez	Arthritis & Rheumatism	1998
Circulating type I collagen degradation products: a new serum marker for clinical severity in patients with scleroderma? Hunzelmann, Risteli, Risteli, Sacher, Vancheeswaran, Black, Krieg	British Journal of Dermatology	1998
Activation of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) mRNA Expression in Scleroderma Skin Fibroblasts L Mattila, K Airola, M Ahonen, M Hietarinta, C Black, U Saarialho-kere, V Kahari	Journal of Investigative Dermatology	1998
Pathophysiology of scleroderma: an update UF Haustein, U Anderegg	Journal of the European Academy of Dermatology and Venereology	1998
Increased Expression of Heat-Shock Protein 47 is Associated with Overproduction of Type I Procollagen in Systemic Sclerosis Skin Fibroblasts K Kuroda, R Tsukifuji, H Shinkai	Journal of Investigative Dermatology	1998
The pathogenesis of cutaneous fibrosis B Liu, MK Connolly	Seminars in Cutaneous Medicine and Surgery	1998
Increased Expression of TGF-β Receptors by Scleroderma Fibroblasts: Evidence for Contribution of Autocrine TGF-β Signaling to Scleroderma Phenotype T Kawakami, H Ihn, W Xu, E Smith, C LeRoy, M Trojanowska	Journal of Investigative Dermatology	1998
Dermatologie C Garbe, G Rassner		1998
Mixed connective tissue disease Y Farhey, EV Hess	Arthritis Care & Research	1997
Increased levels of type I and III collagen and hyaluronan in scleroderma skin K Sosndergaard, L Heickendorff, L Risteli, J Ristelli, H Zachariae, K Stengaard-Pedershn, B Deleuran	British Journal of Dermatology	1997
Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression RL Widom, I Culic, JY Lee, JH Korn	Gene	1997
Scleroderma Fibroblasts Show Increased Responsiveness to Endothelial Cell-Derived IL-1 and bFGF CP Denton, X Shi-wen, CM Black, JD Pearson	Journal of Investigative Dermatology	1997
Tissue Inhibitor of Metalloproteinase 1 (TIMP-1) May Be an Autocrine Growth Factor in Scleroderma Fibroblasts K Kikuchi, T Kadono, M Furue, K Tamaki	Journal of Investigative Dermatology	1997
Increased Proliferation, Collagen, and Fibronectin Production by Hereditary Gingival Fibromatosis Fibroblasts DA Tipton, KJ Howell, MK Dabbous	Journal of Periodontology	1997
High-dose UVA1 radiation therapy for localized scleroderma H Stege, M Berneburg, S Humke, M Klammer, M Grewe, S Grether-Beck, R Boedeker, T Diepgen, K Dierks, G Goerz, T Ruzicka, J Krutmann	Journal of the American Academy of Dermatology	1997
Endothelin may be pathogenic in systemic sclerosis of the heart E Kazzam, A Waldenström, T Hedner, J Hedner, K Caidahl	International Journal of Cardiology	1997
Apoptosis and Proliferation of Fibroblasts During Postnatal Skin Development and Scleroderma in the Tight-skin Mouse JL Pablos, PE Carreira, L Serrano, PD Castillo, JJ Gomez-Reino	Journal of Histochemistry & Cytochemistry	1997
Handbuch der dermatologischen Phototherapie und Photodiagnostik J Krutmann, H Hönigsmann		1997
Connective Tissue Growth Factor Gene Expression in Tissue Sections From Localized Scleroderma, Keloid, and Other Fibrotic Skin Disorders A Igarashi, K Nashiro, K Kikuchi, S Sato, H Ihn, M Fujimoto, GR Grotendorst, K Takehara	Journal of Investigative Dermatology	1996
Transcriptional activation of the α1(1) procollagen gene in systemic sclerosis dermal fibroblasts. Role of intronic sequences EG Hitraya, SA Jiménez	Arthritis & Rheumatism	1996
Differential regulation of transcription and transcript stability of pro-alpha 1(I) collagen and fibronectin in activated fibroblasts derived from patients with systemic scleroderma B Eckes, C Mauch, G Hüppe, T Krieg	Biochemical Journal	1996
PATHOGENESIS OF SCLERODERMA SA Jimenez, E Hitraya, J Varga	Rheumatic Disease Clinics of North America	1996
Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts. Increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts A Jelaska, M Arakawa, G Broketa, JH Korn	Arthritis & Rheumatism	1996
Inhibition of collagen type I synthesis by skin fibroblasts of graft versus host disease and scleroderma patients: Effect of halofuginone O Halevy, A Nagler, F Levi-Schaffer, O Genina, M Pines	Biochemical Pharmacology	1996
Dermal Grafting for a Patient with Scleroderma: Case report M Ho-Asjoe, J Khan, JD Frame	Journal of Plastic and Reconstructive Surgery and Hand Surgery	1996
Animal Models of Scleroderma: Contrasts and Comparisons JV de Water, SA Jimenez, ME Gershwin	International Reviews of Immunology	1995
Different Effects of Basic Fibroblast Growth Factor and Transforming Growth Factor-beta on the Two Platelet-Derived Growth Factor Receptors' Expression in Scleroderma and Healthy Human Dermal Fibroblasts Y Ichiki, E Smith, EC LeRoy, M Trojanowska	Journal of Investigative Dermatology	1995
Oncostatin M Stimulates Collagen and Glycosaminoglycan Production by Cultured Normal Dermal Fibroblasts: Insensitivity of Sclerodermal and Keloidal Fibroblasts MR Duncan, A Hasan, B Berman	Journal of Investigative Dermatology	1995
The tight skin 2 mouse PJ Christner, J Peters, D Hawkins, LD Siracusa, SA Jiménez	Arthritis & Rheumatism	1995
Decreased integrin α2, but normal response to TGF-β in scleroderma fibroblasts K Osada, M Seishima, Y Kitajima, H Yaoita, S Mori	Journal of Dermatological Science	1995
Adhesion Molecules in Scleroderma: Collagen Binding Integrins TS Kupper	International Reviews of Immunology	1995
Serum tissue inhibitor of metalloproteinases in patients with systemic sclerosis K Kikuchi, M Kubo, S Sato, M Fujimoto, K Tamaki	Journal of the American Academy of Dermatology	1995
Myofibroblasts from Scleroderma Skin Synthesize Elevated Levels of Collagen and Tissue Inhibitor of Metalloproteinase (TIMP-1) with Two Forms of TIMP-1 TZ Kirk, ME Mark, CC Chua, BH Chua, MD Mayes	The Journal of biological chemistry	1995
A fibroblast cell line cultured from a hypertrophic scar displays selective downregulation of collagen gene expression: barely detectable messenger RNA levels of the pro?1(III) chain of type III collagen , M Laato, P Muona, R Penttinen, A Oikarinen, J Peltonen	Archives of Dermatological Research	1995
Tubulointerstitial and Cystic Disease of the Kidney SM Dodd		1995
Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-beta L Rudnicka, J Varga, AM Christiano, RV Iozzo, SA Jimenez, J Uitto	Journal of Clinical Investigation	1994
Serum concentration of procollagen type I carboxyterminal propeptide in systemic sclerosis K Kikuchi, H Ihn, S Sato, A Igarashi, Y Soma, Y Ishibashi, K Takehara	Archives of Dermatological Research	1994
The Immunologic and Genetic Basis of Avian Scleroderma, an Inherited Fibrotic Disease of Line 200 Chickens JV de Water, R Boyd, G Wick, ME Gershwin	International Reviews of Immunology	1994
Decreased Collagenase Expression in Cultured Systemic Sclerosis Fibroblasts K Takeda, A Hatamochi, H Ueki, M Nakata, Y Oishi	Journal of Investigative Dermatology	1994
Control of Il-6 Expression and Response in Fibroblasts from Patients with Systemic Sclerosis CA Feghali, KL Bost, DW Boulware, LS Levy	Autoimmunity	1994
Cytokines and systemic sclerosis DM Fagundus, EC Leroy	Clinics in Dermatology	1994
Animal models of systemic sclerosis SA Jimenez, P Christner	Clinics in Dermatology	1994
Lymphocyte modulation of fibroblast function in systemic sclerosis TH Piela-Smith, JH Korn	Clinics in Dermatology	1994
The fibroblast in systemic sclerosis S Sollberg, C Mauch, B Eckes, T Krieg	Clinics in Dermatology	1994
Lung involvement in Scleroderma SN Breit, SC Thornton, R Penny	Clinics in Dermatology	1994
Increased collagen synthesis in skin fibroblasts from patients with primary hypertrophic osteoarthropathy. evidence for trans–activational regulation of collagen transcription SJ Padula, G Broketa, A Sampieri, M Arakawa, MM –Cerinic, E Downie, JH Korn	Arthritis & Rheumatism	1994
Increased endothelin-1 production in fibroblasts derived from patients with systemic sclerosis Y Kawaguchi, K Suzuki, M Hara, T Hidaka, T Ishizuka, M Kawagoe, H Nakamura	Annals of the rheumatic diseases	1994
Control of Fibrosis in Systemic Scleroderma C Mauch, B Eckes, N Hunzelmann, T Oono, E Kozlowska, T Krieg	Journal of Investigative Dermatology	1993
Effects of tumor necrosis factor-? on connective tissue metabolism in normal and scleroderma fibroblast cultures K Takeda, A Hatamochi, M Arakawa, H Ueki	Archives of Dermatological Research	1993
Downregulation of collagen synthesis in fibroblasts within three-dimensional collagen lattices involves transcriptional and posttranscriptional mechanisms B Eckes, C Mauch, G Hüppe, T Krieg	FEBS Letters	1993
Pediatric Rheumatology for the Practitioner JC Jacobs		1993
Effects of methotrexate on glycosaminoglycan production by scleroderma fibroblasts in culture FH van den Hoogen, PM van der Kraan, AM Boerbooms, WB van den Berg, HJ van Lier, LB van de Putte	Annals of the rheumatic diseases	1993
Activation of Dermal Connective Tissue in Scleroderma VM Kähäri	Annals of Medicine	1993
Connective Tissue Diseases ML Turner	Clinics in Plastic Surgery	1993
Mesenchymal cells isolated after acute lung injury manifest an enhanced proliferative phenotype B Chen, V Polunovsky, J White, B Blazar, R Nakhleh, J Jessurun, M Peterson, P Bitterman	Journal of Clinical Investigation	1992
Analysis of collagen gene expression by cultured fibroblasts in morphoea A Hatamochi, M Ono, M Arakawa, K Takeda, H Ueki	British Journal of Dermatology	1992
Increased Adhesion of Fibroblasts from Patients with Scleroderma to Extracellular Matrix Components: In Vitro Modulation by IFN-gamma but Not by TGF-beta S Majewski, N Hunzelmann, CG Schirren, C Mauch, M Aumailley, T Krieg	Journal of Investigative Dermatology	1992
Relaxin Alone and in Conjunction with Interferon-gamma Decreases Collagen Synthesis by Cultured Human Scleroderma Fibroblasts EN Unemori, EA Bauer, EP Amento	Journal of Investigative Dermatology	1992
Sequential dermal microvascular and perivascular changes in the development of scleroderma RJ Prescott, AJ Freemont, CJ Jones, J Hoyland, P Fielding	The Journal of Pathology	1992
Increased expression of tenascin in the dermis in scleroderma J Lacour, A Vitetta, R Chiquet-Ehrismann, A Pisani, J Ortonne	British Journal of Dermatology	1992
Altered regulation of collagen metabolism in scleroderma fibroblasts grown within three-dimensional collagen gels C Mauch, E Kozlowska, B Eckes, T Krieg	Experimental Dermatology	1992
Cultured fibroblasts in avian scleroderma, an autoimmune fibrotic disease, display an activated phenotype MR Duncan, TJ Wilson, JV de Water, B Berman, R Boyd, G Wick, ME Gershwin	Journal of Autoimmunity	1992
Serum Levels of Aminoterminal Type III Procollagen Peptide and Hyaluronan Predict Mortality in Systemic Sclerosis A Scheja, A Ákesson, K Hørslev-petersen	Scandinavian Journal of Rheumatology	1992
Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts: Insensitivity to TGFβ1 stimulation K Kikuchi, CW Hartl, EA Smith, EC LeRoy, M Trojanowska	Biochemical and Biophysical Research Communications	1992
Pathogenesis of fibrosis in acute lung injury PB Bitterman	The American Journal of Medicine	1992
Clinical Comments and a Pathophysiological Discussion of Scleroderma EC LeRoy	The Journal of Dermatology	1992
Scleroderma and the kidney JF Donohoe	Kidney International	1992
Variability in the retraction of collagen lattices by scleroderma fibroblasts-relationship to protein synthesis and clinical data P Gillery, FX Maquart, Y Corre, B Kalis, JP Borel	Clinical and Experimental Dermatology	1991
Steady-State mRNA Levels of Collagens I, III, Fibronectin, and Collagenase in Skin Biopsies of Systemic Sclerosis Patients K Herrmann, M Heckmann, M Kulozik, UF Haustein, T Krieg	Journal of Investigative Dermatology	1991
Endothelin, an endothelial-dependent vasoconstrictor in scleroderma. Enhanced production and profibrotic action MB Kahaleh	Arthritis & Rheumatism	1991
Eosinophil activation in systemic sclerosis R Gustafsson, R Hällgren, K Fredens, O Nettelbladt	Arthritis & Rheumatism	1991
Self Reactive Repertoire of Tight Skin Mouse: Immunochemical and Molecular Characterization of Anti-Topoisomerase I Autoantibodies T Muryoi, KN Kasturi, MJ Kafina, Y Saitoh, O Usuba, JS Perlish, R Fleischmajer, CA Bona	Autoimmunity	1991
Effects of cyclosporin A on cell proliferation and collagen production by human skin fibroblasts M Ono, A Hatamochi, M Arakawa, H Ueki	Journal of Dermatological Science	1991
Regulation of the Proliferation and Biosynthetic Activities of Cultured Human Peyronie's Disease Fibroblasts by Interferons-Alpha, -Beta and -Gamma MR Duncan, B Berman, UO Nseyo	Scandinavian Journal of Urology and Nephrology	1991
International Review of Cytology RA Miller	International Review of Cytology	1991
Response of scleroderma fibroblasts to various growth factors K Takehara, Y Soma, A Igarashi, K Kikuchi, A Moro, Y Ishibashi	Archives of Dermatological Research	1991
Role of estradiol in the development of fibrosis in cystic scleroderma (possible sex-linked predisposition to the disease) LN Kashnikova, MD Grozdova, AF Panasyuk	Bulletin of Experimental Biology and Medicine	1991
Transcriptional control mechanisms for the expression of type I collagen genes B de Crombrugghe, T Vuorio, G Karsenty, S Maity, EC Rutheshouser, H Goldberg	Annals of the rheumatic diseases	1991
Penicillamine in systemic sclerosis: A reappraisal MA Sattar, RT Guindi, TN Sugathan	Clinical Rheumatology	1990
Increased Collagen Synthesis Accompanying Elevated m-RNA Levels in Cultured Werner's Syndrome Fibroblasts M Arakawa, A Hatamochi, K Takeda, H Ueki	Journal of Investigative Dermatology	1990
Pentoxifylline inhibits the proliferation of human fibroblasts derived from keloid, scleroderma and morphoea skin and their production of collagen, glycosaminoglycans and fibronectin B Berman, M Duncan	British Journal of Dermatology	1990
In vitro identification of a subpopulation of fibroblasts that produces high levels of collagen in scleroderma patients BW Needleman, JV Ordonez, D Taramelli, W Alms, K Gayer, J Choi	Arthritis & Rheumatism	1990
Increased expression of type VI collagen genes in systemic sclerosis J Peltonen, L Kähäri, J Uitto, SA Jimenez	Arthritis & Rheumatism	1990
Animal Models of Fibrosis MH Bocchieri, SA Jimenez	Rheumatic diseases clinics of North America	1990
Control of Type I Collagen Genes in Scleroderma and Normal Fibroblasts B de Crombrugghe, T Vuorio, G Karsenty	Rheumatic diseases clinics of North America	1990
Differential regulation of glycosaminoglycan, fibronectin, and collagenase production in cultured human dermal fibroblasts by interferon-alpha,-beta, and-gamma MR Duncan, B Berman	Archives of Dermatological Research	1989
Clonal interactions in fibroblast proliferation: Recognition of self vs. non-self JH Korn, E Downie	Journal of Cellular Physiology	1989
Differential Regulation of Collagen, Glycosaminoglycan, Fibronectin, and Collagenase Activity Production in Cultured Human Adult Dermal Fibroblasts by Interleukin 1-Alpha and Beta and Tumor Necrosis Factor-Alpha and Beta MR Duncan, B Berman	Journal of Investigative Dermatology	1989
Short-term keloid treatment in vivo with human interferon alfa-2b results in a selective and persistent normalization of keloidal fibroblast collagen, glycosaminoglycan, and collagenase production in vitro B Berman, MR Duncan	Journal of the American Academy of Dermatology	1989
Purification of a glycosaminoglycan-stimulatory lymphokine from supernatants of in vitro-activated human mononuclear cells M Tsao, M Ferrarini, C Evans, A Ambro, TL Whiteside	Clinical Immunology and Immunopathology	1989
Fibrosis pulmonar: perspectivas actuales M Jordana, A Xaubet, J Gauldie	Archivos de Bronconeumología	1989
Integument and Mammary Glands TC Jones, U Mohr, RD Hunt		1989
Localization of collagen mRNA in normal and scleroderma skin by in-situ hybridization K Scharffetter, B Lankat-Buttgereit, T Krieg	European Journal of Clinical Investigation	1988
Identification of Collagen Fibrils in Scleroderma Skin JS Perlish, G Lemlich, R Fleischmajer	Journal of Investigative Dermatology	1988
Plasma somatomedin-C levels in systemic sclerosis M Rothe, R Altman, V Falanga	British Journal of Dermatology	1988
Progressive systemic sclerosis: Mode of presentation, rapidly progressive disease course, and mortality based on an analysis of 91 patients EV Lally, SA Jimenez, SR Kaplan	Seminars in Arthritis and Rheumatism	1988
Defective formation of inositol 1,4,5-trisphosphate in bradykinin-stimulated fibroblasts from progressive systemic sclerotic patients M Seishima, Y Yada, S Nagao, S Mori, Y Nozawa	Biochemical and Biophysical Research Communications	1988
Heterogeneous synthetic phenotype of cloned scleroderma fibroblasts may be due to aberrant regulation in the synthesis of connective tissues TL Whiteside, M Ferrarini, P Hebda, RB Buckingham	Arthritis & Rheumatism	1988
Spontaneous In Vitro Release of Alveolar-Macrophage Cytokines after the Intratracheal Instillation of Bleomycin in Rats: Characterization and Kinetic Studies M Jordana, C Richards, LB Irving, J Gauldie	American journal of respiratory and critical care medicine	1988
Mononuclear cell-fibroblast interactions in scleroderma R Gonzalez-Amaro, D Alarcon-Segovia, J Alcocer-Varela, LD de Leon, Y Rosenstein	Clinical Immunology and Immunopathology	1988
Interferon-α and interferon-γ reduce excessive collagen synthesis and procollagen mRNA levels of scleroderma fibroblasts in culture VM Kähäri, J Heino, T Vuorio, E Vuorio	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research	1988
Persistence of a reduced-collagen-producing phenotype in cultured scleroderma fibroblasts after short-term exposure to interferons MR Duncan, B Berman	Journal of Clinical Investigation	1987
Connective tissue responses in blacks in relation to disease: Further observations AP Polednak	American Journal of Physical Anthropology	1987
Inhibition of Prolyl Hydroxylation During Collagen Biosynthesis in Human Skin Fibroblast Cultures by Ethyl 3,4-Dihydroxybenzoate K Majamaa, T Sasaki, J Uitto	Journal of Investigative Dermatology	1987
Regulation of Collagen Gene Expression in Cutaneous Diseases With Dermal Fibrosis: Evidence for Pretranslational Control RP Abergel, ML Chu, EA Bauer, J Uitto	Journal of Investigative Dermatology	1987
Connective tissue activation. xxxi. identification of two molecular forms of a human mesenchymal cell—derived growth factor, connective tissue activating peptide—V AR Cabral, CW Castor	Arthritis & Rheumatism	1987
Fibrosarcoma in a patient with scleroderma RT Greyson-Fleg, WW Scott, FP Kuhajda, D Magid, EK Fishman	Journal of Computed Tomography	1987
An in-vitro comparison of human fibroblasts from normal and oral submucous fibrosis tissue S Meghji, A Scutt, W Harvey, JP Canniff	Archives of Oral Biology	1987
Procollagen gene expression by scleroderma fibroblasts in culture. inhibition of collagen production and reduction of proα(i) and proα1(III) collagen messenger RNA steady-state levels by retinoids A Ohta, J Uitto	Arthritis & Rheumatism	1987
Elevated proα2(I) collagen mRNA levels in cultured scleroderma fibroblasts result from an increased transcription rate of the corresponding gene VM Kähäri, P Multimäki, E Vuorio	FEBS Letters	1987
Paraproteinemia in patients with scleredema A Ohta, J Uitto, AI Oikarinen, R Palatsi, M Mitrane, EA Bancila, JR Seibold, HC Kim	Journal of the American Academy of Dermatology	1987
Abnormal lymphocyte function in scleroderma: A study on identical twins MM Dustoor, MM McInerney, DJ Mazanec, MK Cathcart	Clinical Immunology and Immunopathology	1987
Interleukin-1 increases collagen production and mRNA levels in cultured skin fibroblasts VM Kähäri, J Heino, E Vuorio	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research	1987
Phenotypic plasticity of extracellular matrix gene expression in cultured hamster lung fibroblasts. Regulation of type I procollagen and fibronectin synthesis R Raghow, AH Kang, D Pidikiti	The Journal of biological chemistry	1987
Coordinated regulation of type I and type III collagen production and mRNA levels of pro ?1(I) and pro ?2(I) collagen in cultured morphea fibroblasts T Vuorio, JK Mkel, VM Khri, E Vuorio	Archives of Dermatological Research	1987
Rectovaginal Constriction in Jersey Cattle D Troyer, H Minocha, HW Leipold	Journal of Veterinary Medicine Series A	1986
Type III Collagen Aminopropeptide Levels in Serum of Patients With Progressive Systemic Scleroderma T Krieg, I Langer, H Gerstmeier, J Keller, H Mensing, G Goerz, R Timpl	Journal of Investigative Dermatology	1986
Progressive Nodular Fibrosis of the Skin: Altered Procollagen and Collagenase Expression by Cultured Fibroblasts EA Bauer, J Uitto, DS Cruz, ML Turner	Journal of Investigative Dermatology	1986
Cell-mediated immunity in rheumatic disease SJ Padula, RB Clark, JH Korn	Human Pathology	1986
Persistence of scleroderma-like phenotype in normal fibroblasts after prolonged exposure to soluble mediators from mononuclear cells JG Worrall, TL Whiteside, RK Prince, RB Buckingham, I Stachura, GP Rodnan	Arthritis & Rheumatism	1986
Scleromyxedema associated with scleroderma renal disease and acute psychosis GR Kantor, WF Bergfeld, WE Katzin, OD Reynolds, AP Biscardi, DM Lobur, TA Box, MJ Schreiber, NB Ratliff	Journal of the American Academy of Dermatology	1986
Stimulation of normal human fibroblast collagen production and processing by transforming growth factor-β J Varga, SA Jimenez	Biochemical and Biophysical Research Communications	1986
Bases physiopathologiques des traitements de la sclérodermie systémique O Blétry, C Francès, J Cadranel, P Godeau	La Revue de Médecine Interne	1986
Regulation of Matrix Accumulation JJ Jeffrey	Regulation of Matrix Accumulation	1986
The cardiovascular manifestations of systemic sclerosis (scleroderma) WP Follansbee	Current Problems in Cardiology	1986
Collagen Biosynthesis in Systemic Scleroderma: Regulation of Posttranslational Modifications and Synthesis of Procollagen in Cultured Fibroblasts L Peltonen, A Palotie, R Myllyla, T Krieg, A Oikarinen	Journal of Investigative Dermatology	1985
Inhibition of Collagen Production in Scleroderma Fibroblast Cultures by a Connective Tissue Glycoprotein Extracted from Normal Dermis FX Maquart, G Bellon, J Cornillet-Stoupy, A Randoux, R Triller, B Kalis, JP Borel	Journal of Investigative Dermatology	1985
Increase of collagen content and changes in the collagen fibers in the skin of rats fed with adulterated rapeseed oil involved in a toxic syndrome in Spain MA Lizarbe, FJ Turnay, N Olmo, JJ Llano, JG Gavilanes	Archives of Environmental Contamination and Toxicology	1985
Activation of type I collagen genes in cultured scleroderma fibroblasts T Vuorio, JK M�kel�, E Vuorio	Journal of Cellular Biochemistry	1985
Collagen synthesis regulation by the aminopropeptide of procollagen i in normal and scleroderma fibroblasts JS Perlish, R Timpl, R Fleischmajer	Arthritis & Rheumatism	1985
Selective inhibition of excessive scleroderma fibroblast collagen production by lymphokines from normal human mononuclear cells SA Jimenez, WM McArthur, RI Bashey, J Rosenbloom	Arthritis & Rheumatism	1985
Collagen Synthesis by Scleroderma Fibroblasts T Krieg, JS Perlish, C Mauch, R Fleischmajer	Annals of the New York Academy of Sciences	1985
Mast cells, T cells and abnormal fibrosis HN Claman	Immunology Today	1985
Immunology of Rheumatic Diseases S Gupta, N Talal		1985
Protein, RNA, and DNA synthesis in cultures of skin fibroblasts from healthy subjects and patients with rheumatic diseases OY Abakumova, AF Panasyuk, NG Kutsenko	Bulletin of Experimental Biology and Medicine	1985
Collagen synthesis in scleroderma: Selection of fibroblast populations during subcultures T Krieg, JS Perlish, R Fleischmajer, O Braun-Falco	Archives of Dermatological Research	1985
Pathogenesis of scleroderma: the interrelationship of the immune and vascular hypotheses E M Sternberg	Survey of immunologic research	1985
Selective inhibition of human diploid fibroblast collagen synthesis by interferons SA Jimenez, B Freundlich, J Rosenbloom	Journal of Clinical Investigation	1984
Pathogenesis of Scleroderma EB Lee, GJ Anhalt, JJ Voorhees, LA Diaz	International Journal of Dermatology	1984
Lowered Angiogeneic Capability of Peripheral Blood Lymphocytes in Progressive Systemic Sclerosis (Scleroderma) MJ Kaminski, S Majewski, S Jablonska, M Pawinska	Journal of Investigative Dermatology	1984
Increased biosynthesis of glycosaminoglycans by scleroderma fibroblasts in culture RI Bashey, A Millan, SA Jimenez	Arthritis & Rheumatism	1984
Scleroderma-like alterations in collagen metabolism occurring in the TSK (tight skin) mouse SA Jimenez, A Millan, RI Bashey	Arthritis & Rheumatism	1984
Fibroblast Activation in Scleroderma TK Vuorio, VM Kähäri, A Lehtonen, EI Vuorio	Scandinavian Journal of Rheumatology	1984
Clonal heterogeneity in the fibroblast response to mononuclear cell derived mediators JH Korn, D Torres, E Downie	Arthritis & Rheumatism	1984
Increased type I collagen mRNA levels in cultured scleroderma fibroblasts VM Kähäri, T Vuorio, K Näntö-Salonen, E Vuorio	Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression	1984
Management of sclerodermal finger ulcers F Gahhos, S Ariyan, WH Frazier, CB Cuono	The Journal of Hand Surgery	1984
Transcriptional control of human diploid fibroblast collagen synthesis by γ-interferon J Rosenbloom, G Feldman, B Freundlich, SA Jimenez	Biochemical and Biophysical Research Communications	1984
Immunodermatology RE Schopf, M Jung, B Morsches, K Bork	Immunodermatology	1984
Reduced response of scleroderma fibroblasts to fibroblast growth factor K Nishioka, Y Kobayashi, I Katayama, S Sano	Archives of Dermatological Research	1984
Systemic sclerosis: a collagen or microvascular disease? MI Jayson	BMJ : British Medical Journal	1984
Fibroblast prostaglandin E2 synthesis. Persistence of an abnormal phenotype after short-term exposure to mononuclear cell products JH Korn	Journal of Clinical Investigation	1983
Proline Analogues Inhibit Human Skin Fibroblast Growth and Collagen Production in Culture EM Tan, L Ryhanen, J Uitto	Journal of Investigative Dermatology	1983
Bleomycin-induced cutaneous toxicity in the rat: analysis of histopathology and ultrastructure compared with progressive systemic sclerosis (scleroderma J Mountz, M Minor, R Turner, M Thomas, F Richards, E Pisko	British Journal of Dermatology	1983
Cellular immune dysfunction and the pathogenesis of scleroderma SA Jimenez	Seminars in Arthritis and Rheumatism	1983
Increased Accumulation of Sulfated Glycosaminoglycans in Cultures of Human Fibroblasts from Phenytoin-induced Gingival Overgrowth ML Kantor, TM Hassell	Journal of dental research	1983
A fibroblast mitogen present in scleroderma but not control sera: Inhibition by proteinase inhibitors EC LeRoy, MB Kahaleh, S Mercurio	Rheumatology International	1983
Collagen synthesis in generalized morphea T Krieg, O Braun-Falco, JS Perlish, R Fleischmajer	Archives of Dermatological Research	1983
Rheumatologie C: Spezieller Teil II Wirbelsäule, Weichteile, Kollagenerkrankungen M Aufdermaur, GL Bach, JM Engel, R Filchner, F Graser, E Gundel, H Hess, F Husmann, H Kather, H Kerl, G Klein, W Krämer, H Kresbach, H Leinisch, S Marghescu, R Maurach, W Miehle, W Mohr, H Müller-Fassbender, D Pongratz, W Schmidt-Vanderheyden, P Schneider, B Simon, G Stöckl, S Stotz, F Strian, FJ Wagenhäuser, A Weintraub, D Wessinghage, H Mathies		1983
Rheumatologie A: Allgemeiner Teil GL Bach, R Czurda, JM Engel, O Fischedick, M Franke, K Meythaler, H Müller-Faßbender, P Pfannenstiel, N Thumb, D Wessinghage, H Mathies, H Greiling, A Gressner, K Kleesiek		1983
Acid lysosomal hydrolases in systemic sclerosis and other connective tissue diseases K Herrmann, UF Haustein, HJ Bohme, I Lohrisch	British Journal of Dermatology	1982
Pathogenesis of Scleroderma (Systemic Sclerosis) EC LeRoy	Journal of Investigative Dermatology	1982
Inhibition of Collagen Accumulation in Fibrotic Processes: Review of Pharmacologic Agents and New Approaches with Amino Acids and Their Analogues J Uitto, EM Tan, L Ryhanen	Journal of Investigative Dermatology	1982
Fibroblast selection in scleroderma GR Botstein, GK Sherer, EC Leroy	Arthritis & Rheumatism	1982
Replication and phenotypic expression of control and scleroderma human fibroblasts: responses to growth factors EC LeRoy, S Mercurio, GK Sherer	Proceedings of the National Academy of Sciences	1982
Reversal of End-Stage Kidney Failure in Two Scleroderma Patients Treated With Anticoagulation WR Kohorst, WH Bay	American Journal of Kidney Diseases	1982
Disorders of Mineral Metabolism RK Rude, FR Singer	Disorders of Mineral Metabolism	1982
DISTRIBUTION OF GLYCOSAMINOGLYCANS IN DERMAL CONNECTIVE TISSUE FROM SCLERODERMA PATIENTS S Tajima, T Nishikawa, H Hatano, Y Nagai	The Journal of Dermatology	1982
Increased Collagen Synthesis by Gingival Fibroblasts Derived from a Papillon-Lefevre Patient HS Cheung, RK Landow, M Bauer	Journal of dental research	1982
Some aspects of the modulation and regulation of collagen synthesis in vitro PK Müller, E Kirsch, V Gauss-Müller, T Krieg	Molecular and Cellular Biochemistry	1981
Variability in Collagen and Fibronectin Synthesis by Scleroderma Fibroblasts in Primary Culture R Fleischmajer, JS Perlish, T Krieg, R Timpl	Journal of Investigative Dermatology	1981
Human Skin Fibroblasts in Culture: Procollagen Synthesis in the Presence of Sera from Normal Human Subjects and from Patients with Dermal Fibroses EM Tan, J Uitto, EA Bauer, AZ Eisen	Journal of Investigative Dermatology	1981
Investigation of type i and type iii collagens of the lung in progressive systemic sclerosis JM Seyer, AH Kang, G Rodnan	Arthritis & Rheumatism	1981
Three siblings with scleroderma (systemic sclerosis) and two with raynaud's phenomenon from a single kindred WB Sheldon, DP Lurie, HR Maricq, MB Kahaleh, FA Delustro, A Gibofsky, EC Leroy	Arthritis & Rheumatism	1981
Synthesis of Collagen and Sulfated Glycosaminoglycans by Normal and Scleroderma Fibroblasts in Culture, with and without Addition of Cyclofenil T Kjellström, J Malmquist, B Persson	Acta Medica Scandinavica	1981
Collagen disease: A new perspective CL Mainardi, AH Kang	The American Journal of Medicine	1981
Proliferative Diseases MB Sporn, ED Harris	The American Journal of Medicine	1981
The Connective Tissue in Scleroderma EC Leroy	Collagen and Related Research	1981
Scleroderma: Oral manifestations Y Marmary, R Glaiss, S Pisanty	Oral Surgery, Oral Medicine, Oral Pathology	1981
Survenue d'une sclérodermie chez un porteur chronique d'antigène HBs Analyse critique du rôle éventuel de complexes immuns HBs — anti HBs PY Hatron, B Devulder, G Maecker, B Gosselin, P Wattre	La Revue de Médecine Interne	1981
The artificial granuloma DL Boros, MA Lande, L Carrick	Clinical Immunology and Immunopathology	1981
Immunologic enhancement of collagen accumulation in progressive systemic sclerosis (PSS) MK Cathcart, RS Krakauer	Clinical Immunology and Immunopathology	1981
Scleroderma fibroblasts: Some aspects of in vitro assessment of collagen synthesis T Krieg, C Luderschmidt, L Weber, PK Mller, O Braun-Falco	Archives of Dermatological Research	1981
Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production JH Korn, PV Halushka, EC LeRoy	Journal of Clinical Investigation	1980
Connective tissue activation SL Myers, CW Castor	Arthritis & Rheumatism	1980
Interaction of Immune and Connective Tissue Cells JH Korn	International Journal of Dermatology	1980
The Ultrastructure of Collagen in the Dermis of Tight-skin (Tsk) Mutant Mice DN Menton, RA Hess	Journal of Investigative Dermatology	1980
Immunofluorescence Analysis of Collagen, Fibronectin, and Basement Membrane Protein in Scleroderma Skin R Fleischmajer, W Dessau, R Timpl, T Krieg, C Luderschmidt, M Wiestner	Journal of Investigative Dermatology	1980
Changes in the Growth and Metabolism of Cells Cultured from Normal, Sclerotic and Rheumatoid Connective Tissue Brought about by D-Penicillamine and by Sodium Salicylate GC Priestley	Journal of Investigative Dermatology	1980
Griseofulvin for eosinophilic fasciitis M Giordano, M Ara, C Cicala, G Valentini, U Chianese	Arthritis & Rheumatism	1980
Alpha-1-antitrypsin in progressive systemic sclerosis JR Seibold, RM Iammarino, GP Rodnan	Arthritis & Rheumatism	1980
Collagen metabolism: a comparison of diseases of collagen and diseases affecting collagen RR Minor	The American Journal of Pathology	1980
Human respiratory nasal mucosa in progressive systemic sclerosis (scleroderma) AM Talaat, MN Kamel, MT Aziz, NA Shaaban	The Journal of Laryngology & Otology	1980
Morphea and lichen sclerosus et atrophicus J Uitto, DJ Cruz, EA Bauer, AZ Eisen	Journal of the American Academy of Dermatology	1980
Scleroderma and Other Diseases Associated with Cutaneous Sclerosis JJ Chanda	Medical Clinics of North America	1980
Alterations of collagen in lichen amyloidosus D Tsambaos, R Bolling	Archives of Dermatological Research	1980
The gastrointestinal manifestations of scleroderma: Pathogenesis and management S Cohen, I Laufer, WJ Snape, YF Shiau, GM Levine, S Jimenez	Gastroenterology	1980
Scleroderma INCREASED BIOSYNTHESIS OF TRIPLE-HELICAL TYPE I AND TYPE III PROCOLLAGENS ASSOCIATED WITH UNALTERED EXPRESSION OF COLLAGENASE BY SKIN FIBROBLASTS IN CULTURE J Uitto, EA Bauer, AZ Eisen	Journal of Clinical Investigation	1979
COLLAGEN IN CUTANEOUS DISEASES EA Bauer, J Uitto	International Journal of Dermatology	1979
Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro RF Diegelmann, IK Cohen, BJ McCoy	Journal of Cellular Physiology	1979
Characterization of dermal collagen in systemic sclerosis C Lovell, A Nicholls, V Duance, A Bailey	British Journal of Dermatology	1979
Skin thickness and collagen content in progressive systemic sclerosis and localized scleroderma GP Rodnan, E Lipinski, J Luksick	Arthritis & Rheumatism	1979
Increase in fibronectin in the deep dermis of involved skin in progressive systemic sclerosis SM Cooper, AJ Keyser, AD Beaulieu, E Ruoslahti, ME Nimni, FP Quismorio	Arthritis & Rheumatism	1979
Collagen Heterogeneity in Systemic Scleroderma and Other Diseases M Adam, C Dostal, Z Deyl	Clinical Chemistry and Laboratory Medicine	1979
Skin Collagen Biosynthesis In Patients With Rheumatoid Arthritis Treated With D-Penicillamine D Schorn, MJ Francis, M Loudon, AG Mowat	Scandinavian Journal of Rheumatology	1979
Endothelial injury in scleroderma MB Kahaleh, GK Sherer, EC LeRoy	Journal of Experimental Medicine	1979
The Biosynthesis of Collagen and Its Disorders DJ Prockop, KI Kivirikko, L Tuderman, NA Guzman	New England Journal of Medicine	1979
Case 31-1979: A 24-Year-Old Man with Swelling of the Hands and Feet and Eosinophilia RC Cabot, RE Scully, JJ Galdabini, BU McNeely, ED Harris, RL Trelstad	New England Journal of Medicine	1979
Reverse transcriptase in a patient with scleroderma ER McCabe, JH Kersey, PR Vandersteen, GJ Vosika	Biochemical Medicine	1979
Progressive Systemic Sclerosis: Clinical Features and Pathogenesis of Cutaneous Involvement (Scleroderma) GP Rodnan	Clinics in rheumatic diseases	1979
Part IV: Colchicine D ALARCÓN-SEGOVIA	Clinics in rheumatic diseases	1979
Progressive Systemic Sclerosis: Metabolism of Connective Tissue MI Jayson, JB Weiss	Clinics in rheumatic diseases	1979
Part II: D-Penicillamine VA Nassonova, MM IVANOVA	Clinics in rheumatic diseases	1979
Localized Forms of Scleroderma S Jablonska, GP Rodnan	Clinics in rheumatic diseases	1979
Inhibiting effect of procollagen peptides on collagen biosynthesis in fibroblast cultures M Wiestner, T Krieg, D Hörlein, RW Glanville, P Fietzek, PK Müller	The Journal of biological chemistry	1979
Pathology of collagen degradation. A review R Pérez-Tamayo	The American Journal of Pathology	1978
Chronic cutaneous graft-versus-host disease in man HM Shulman, GE Sale, KG Lerner, EA Barker, PL Weiden, K Sullivan, B Gallucci, ED Thomas, R Storb	The American Journal of Pathology	1978
Medical Management of Renal Scleroderma PJ Cannon	New England Journal of Medicine	1978
Renal Lesions in Scleroderma MI Salomon, J Lamovec, V Tchertkoff	Angiology	1978
Aminoterminal extension peptides from type I procollagen normalize excessive collagen synthesis of scleroderma fibroblasts T Krieg, D Hrlein, M Wiestner, PK Mller	Archives of Dermatological Research	1978
Calcium ion uptake by cultures of skin fibroblasts from normal subjects and from patients with systemic connective tissue disorders MD Grozdova, AF Panasyuk, IL Sharlova	Bulletin of Experimental Biology and Medicine	1978
THE PATHOPHYSIOLOGY OF SCLERODERMA R Fleischmajer	International Journal of Dermatology	1977
Connective tissue synthesis by cultured scleroderma fibroblasts RI Bashey, JS Perlish, S Nochumson, RE Stephens, R Fleischmajer	Arthritis & Rheumatism	1977
Collagen synthesis by scleroderma fibroblasts in culture SA Jimenez, RI Bashey	Arthritis & Rheumatism	1977
(D)-Penicillamine Treatment in Systemic Sclerosis (Scleroderma): Effect on Nutritional Capillary Circulation HÅ Mellstedt, B Fagrell, G Holm, M Björkholm	Scandinavian Journal of Rheumatology	1977
Hexamethylene bisacetamide induces morphologic changes and increased synthesis of procollagen in cell line from glioblastoma multiforme AS Rabson, R Stern, TS Tralka, J Costa, J Wilczek	Proceedings of the National Academy of Sciences	1977
Increased sensitivity of scleroderma fibroblasts in culture to stimulation of protein and collagen synthesis by serum RI Bashey, SA Jimenez	Biochemical and Biophysical Research Communications	1977
Fibroblasts from a patient with scleroderma reveal abnormal metabolism T Krieg, PK Mller, G Goerz	Archives of Dermatological Research	1977
Penicillamine Therapy in Systemic Sclerosis MI Jayson, C Lovell, CM Black, RS Wilson	Proceedings of the Royal Society of Medicine	1977
Lymphokine stimulation of collagen accumulation RL Johnson, M Ziff	Journal of Clinical Investigation	1976
Connective tissue synthesis by cultured scleroderma fibroblasts. I. In vitro collagen synthesis by normal and scleroderma dermal fibroblasts JS Perlish, RI Bashey, RE Stephens, R Fleischmajer	Arthritis & Rheumatism	1976
Skin capillary abnormalities as indicators of organ involvement in scleroderma (systemic sclerosis), Raynaud's syndrome and dermatomyositis HR Maricq, G Spencer-Green, EC LeRoy	The American Journal of Medicine	1976
The diagnostic application of specific anti-procollagen sera G Wick, D Kraft, EM Kokoschka, R Timpl	Clinical Immunology and Immunopathology	1976
Biochemistry of Collagen GN Ramachandran, AH Reddi		1976
Clinical Aspects of Vinyl Chloride Disease: Collagen Studies in Acro-Osteolysis MI Jayson, AJ Bailey, C Black, KL Jones	Proceedings of the Royal Society of Medicine	1976
Dupuytren’s Disease: Controversial Aspects of Management ER PEACOCK	Clinics in Plastic Surgery	1976
Collagenase in scleroderma AH Brady	Journal of Clinical Investigation	1975
URACIL-SPECIFIC ANTI-R.N.A. ANTIBODIES IN SCLERODERMA D Alarcón-Segovia, E Fishbein, E García-Ortigoza, S Estrada-Parra	The Lancet	1975
Pathogenesis of systemic sclerosis: A vascular hypothesis PM Campbell, EC LeRoy	Seminars in Arthritis and Rheumatism	1975
Rapidly Progressive Renal Failure in a Young Woman DG Scarpelli	New England Journal of Medicine	1975

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