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Citations to this article

Superoxide Dismutases in Polymorphonuclear Leukocytes
Marvin L. Salin, Joe M. McCord
Marvin L. Salin, Joe M. McCord
Published October 1, 1974
Citation Information: J Clin Invest. 1974;54(4):1005-1009. https://doi.org/10.1172/JCI107816.
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Concise Publication

Superoxide Dismutases in Polymorphonuclear Leukocytes

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Abstract

Isolated human polymorphonuclear leukocytes were found to contain two distinct superoxide dismutases, electrophoretically identical to the superoxide dismutases found in other human tissues. One is inhibited by cyanide and is located in the cytosol. The other is not inhibited by cyanide and is mitochondrial. These findings disagree with reports by other laboratories, which did not find the cyanide-sensitive cytoplasmic enzyme. The superoxide dismutase-containing preparation of leukocytes released large amounts of superoxide into the medium when the cells were phagocytizing, suggesting that, if the cell population is homogeneous, superoxide production probably takes place on the outer surface of the cell membrane, in addition to inside the phagocytic vacuole.

Authors

Marvin L. Salin, Joe M. McCord

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Biochimica et Biophysica Acta (BBA) - General Subjects 1979
The effect of oxidant stress on diamide-treated human granulocytes
SJ Weiss, AL Sagone
Biochimica et Biophysica Acta (BBA) - General Subjects 1979
Structural and catalytic properties of the solubilized superoxide-generating activity of human polymorphonuclear leukocytes. Solubilization, stabilization in solution, and partial characterization
AI Tauber, EJ Goetzl
Biochemistry 1979
Inborn Errors of Immunity and Phagocytosis
F Güttler, JW Seakins, RA Harkness
1979
Mechanisms of Attachment of Neutrophils to Candida albicans Pseudohyphae in the Absence of Serum, and of Subsequent Damage to Pseudohyphae by Microbicidal Processes of Neutrophils In Vitro
RD Daimond, R Krzesicki
Journal of Clinical Investigation 1978
Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage
T Sacks, CF Moldow, PR Craddock, TK Bowers, HS Jacob
Journal of Clinical Investigation 1978
O2-AND HOST DEFENSE: THE PRODUCTION AND FATE OF O2-IN NEUTROPHILS,§
AI Tauber, BM Babior
Photochemistry and Photobiology 1978
SUPEROXIDE RADICALS, SUPEROXIDE DISMUTASES AND THE AEROBIC LIFESTYLE
I Fridovich
Photochemistry and Photobiology 1978
Demonstration of dopa oxidase activity by purified mammalian superoxide dismutase using polyacrylamide gel electrophoretic separation
TE Brennan, HC Shapiro, LM Edelstein, LM Snyder
AGE 1978
The effect of lead on oxidative hemolysis and erythrocyte defense mechanisms in the rat
BB Gelman, IA Michaelson, JS Bus
Toxicology and Applied Pharmacology 1978
Some Chemical Aspects of Inflammation: A Brief Overview
MW Whitehouse
Australian and New Zealand Journal of Medicine 1978
Role of hydrogen peroxide and peroxidase in the cytotoxicity of Trypanosoma dionisii by human granulocytes
KJ Thorne, RJ Svvennsen, D Franks
Infection and immunity 1978
Variation of Superoxide Dismutase in Bovine Milk
J Holbrook, CL Hicks
Journal of Dairy Science 1978
Modification by metals, sulphydryl reagents and cyanide of the particle stimulated enhancement of oxygen consumption in bovine granulocytes
PH Beswick, TF Slater
Chemico-Biological Interactions 1978
Isolation and characterization of a manganese-containing superoxide dismutase from rat liver
ML Salin, ED Day, JD Crapo
Archives of Biochemistry and Biophysics 1978
Frontiers in Physicochemical Biology
A Michelson
Frontiers in Physicochemical Biology 1978
Superoxide production and reducing activity in human platelets
AJ Marcus, ST Silk, LB Safier, HL Ullman
Journal of Clinical Investigation 1977
Evidence that the superoxide-generating system of human leukocytes is associated with the cell surface
IM Goldstein, M Cerqueira, S Lind, HB Kaplan
Journal of Clinical Investigation 1977
Oxidative killing of microorganisms by phagocytic cells
D Roos
Trends in Biochemical Sciences 1977
Acute inflammation. A review
GB Ryan, G Majno
The American Journal of Pathology 1977
Dosage effects for superoxide dismutase-1 in nucleated cells aneuploid for chromosome 21
WW Feaster, LW Kwok, CJ Epstein
The American Journal of Human Genetics 1977
Subcellular distribution of superoxide dismutases in human neutrophils. Influence of myeloperoxidase on the measurement of superoxide dismutase activity
RF Rest, JK Spitznagel
Biochemical Journal 1977
Superoxide dismutase: A photochemical augmentation assay
HP Misra, I Fridovich
Archives of Biochemistry and Biophysics 1977
Identity and activities of superoxide dismutase in parenchymal and nonparenchymal cells from rat liver
TJ van Berkel, JK Kruijt, RG Slee, JF Koster
Archives of Biochemistry and Biophysics 1977
Subcellular superoxide dismutase activity in phagocytozing human blood polymorphonuclear leucocytes
C Auclair, J Hakim, P Boivin
FEBS Letters 1977
Superoxide dismutase: “Positive” spectrophotometric assays
HP Misra, I Fridovich
Analytical Biochemistry 1977
Purification of human granulocyte catalase in chronic myeloid leukemia
T Olofsson, I Olsson
Biochimica et Biophysica Acta (BBA) - Enzymology 1977
Role of vitamin E in glutathione-induced oxidant stress: methemoglobin, lipid peroxidation, and hemolysis
NR Brownlee, JJ Huttner, RV Panganamala, DG Cornwell
Journal of lipid research 1977
The alteration of superoxide dismutase, catalase, glutathione peroxidase, and NAD(P)H cytochrome c reductase in guinea pig polymorphonuclear leukocytes and alveolar macrophages during hyperoxia
M Rister, RL Baehner
Journal of Clinical Investigation 1976
A comparative study of superoxide dismutase activity in polymorphonuclear leukocytes, monocytes, and alveolar macrophages of the guinea pig
M Rister, RL Baehner
Journal of Cellular Physiology 1976
Trisomie 21 et superoxyde dismutase-1 (IPO-A)
PM Sinet, J Couturier, B Dutrillaux, M Poissonnier, O Raoul, MO Rethoré, D Allard, J Lejeune, H Jerome
Experimental Cell Research 1976
Superoxide independence of paraquat toxicity in Escherichia coli
RS Simons, PS Jackett, ME Carroll, DB Lowrie
Toxicology and Applied Pharmacology 1976
Free Radicals in Biology
WA Pryor
Free Radicals in Biology 1976
Effects of dietary selenium and tocopherol on glutathione peroxidase and superoxide dismutase activities in rat phagocytes
RE Serfass, HE Ganther
Life Sciences 1976
Participation of superoxide anions at the prostaglandin phase of carrageenan foot-oedema
O Yoshihiko
Biochemical Pharmacology 1976
Leukocyte Membrane Determinants Regulating Immune Reactivity
RF Mortensen, TF Lint, AP Osmand, H Gewurz
Leukocyte Membrane Determinants Regulating Immune Reactivity 1976
Iron and Copper Proteins
KT Yasunodu, HF Mower, O Hayaishi
1976
Catalase, superoxide dismutase, and virulence of Staphylococcus aureus. In vitro and in vivo studies with emphasis on staphylococcal--leukocyte interaction
GL Mandell
Journal of Clinical Investigation 1975
The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes
RB Johnston, BB Keele, HP Misra, JE Lehmeyer, LS Webb, RL Baehner, KV RaJagopalan
Journal of Clinical Investigation 1975
Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis
IM Goldstein, D Roos, HB Kaplan, G Weissmann
Journal of Clinical Investigation 1975
Free radicals and inflammation. Protection of phagocytosine leukocytes by superoxide dismutase
ML Salin, JM McCord
Journal of Clinical Investigation 1975
Localization of NADH oxidase on the surface of human polymorphonuclear leukocytes by a new cytochemical method
RT Briggs, DB Drath, ML Karnovsky, MJ Karnovsky
The Journal of Cell Biology 1975
Superoxide production by phagocytic leukocytes
DB Drath, ML Karnovsky
Journal of Experimental Medicine 1975
Oxygen metabolism of catalase-negative and catalase-positive strains of Lactobacillus plantarum
AA Yousten, JL Johnson, M Salin
Journal of bacteriology 1975
Attachment and ingestion of gonococci human neutrophils
JA Dilworth, JO Hendley, GL Mandell
Infection and immunity 1975
Oxygen toxicity
G Smith, TG Shields
Pharmacology & Therapeutics. Part B: General and Systematic Pharmacology 1975
Mechanisms of H2O2 formation by leukocytes
K Takanaka, PJ O'Brien
Archives of Biochemistry and Biophysics 1975
Generation of superoxide anions by leucocytes treated with cytochalasin E
A Nakagawara, S Minakami
Biochemical and Biophysical Research Communications 1975
Superoxide dismutase activities of blood platelets in trisomy 21
PM Sinet, F Lavelle, AM Michelson, H Jerome
Biochemical and Biophysical Research Communications 1975
Red Cell Enzymes
NV Paniker, P Hochstein
Critical Reviews in Clinical Laboratory Sciences 1975
Neurobiology of Aging
JM Ordy, KR Brizzee
Neurobiology of Aging 1975
Methods of Biochemical Analysis: Glick/Methods
D Glick
1960

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