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Citations to this article

Investigation of the Physiological Basis for Increased Exercise Threshold for Angina Pectoris after Physical Conditioning
David N. Sim, William A. Neill
David N. Sim, William A. Neill
Published September 1, 1974
Citation Information: J Clin Invest. 1974;54(3):763-770. https://doi.org/10.1172/JCI107814.
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Investigation of the Physiological Basis for Increased Exercise Threshold for Angina Pectoris after Physical Conditioning

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Abstract

Eight patients with coronary heart disease and exertional angina pectoris successfully completed an 11-15 wk program of endurance exercise conditioning. Angina threshold was determined by upright bicycle ergometer exercise and by atrial pacing. The product of heart rate and arterial systolic blood pressure at the exercise angina threshold was higher after conditioning. suggesting that conditioning increased the maximum myocardial O2 supply during exercise. However, when angina was induced by atrial pacing, heart rate, arterial blood pressure, coronary blood flow, and myocardial O2 consumption at the angina threshold were the same before and after conditioning. Myocardial lactate extraction during atrial pacing was abnormal in the same five patients before and after conditioning. Conditioning caused no detectable changes in coronary collaterals as judged by coronary arteriograms.

Authors

David N. Sim, William A. Neill

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Total citations by year

Year: 2020 2017 2012 2011 2008 2006 2004 2003 2001 1999 1998 1995 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 1979 1978 1977 1975 Total
Citations: 1 1 2 1 2 1 2 1 2 1 2 1 1 2 2 2 1 2 4 4 1 3 1 6 7 2 4 4 2 1 66
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Citations to this article (66)

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