Citations to this article

3α-Androstanediol Kinetics in Man
T. Kinouchi, R. Horton
T. Kinouchi, R. Horton
Published September 1, 1974
Citation Information: J Clin Invest. 1974;54(3):646-653. https://doi.org/10.1172/JCI107802.
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Research Article

3α-Androstanediol Kinetics in Man

Abstract

Kinetics of 5α-androstane-3α, 17β-diol (3α-diol) were studied in man. Clearance rates were determined by both the constant infusion and single injection techniques. Production rates were calculated as the product of clearance rate data and plasma values in the a.m. obtained by a radioimmunoassay specific for 3α-diol. Mean metabolic clearance rates were 1,776±492 (SD) liters/day in males and 1,297±219 (SD) liters/day in females. Metabolic clearance rates by single injection were similar. Calculated production rates are 208±26 (SD) μg/day in males and 35±11 μg/day in females, which are significantly different. Hepatic extraction of 3α-diol determined by hepatic vein catheterization during constant infusion was 76% which was greater than expected from information on in vitro binding in plasma. The kinetic data is of interest since 3α-diol has a calculated inner pool (V1) volume of 12-14 liters, similar to 17β-hydroxyandrost-4-en-3-one (testosterone) and 5α-androstan-17β-ol-3-one (dihydrotestosterone), but the calculated outer pool (V2) of 33.5 liters is very large as are the metabolic rate and transfer constant. In contrast to testosterone and dihydrotestosterone, 3α-diol, although bound to sex hormone binding globulin, has a high metabolic clearance of which a large fraction represents extrahepatic (splanchnic) metabolism. A production rate of 3α-diol similar to dihydrotestosterone together with rather unique kinetic characteristics encourages further investigation of the biological role of this potent androgen.

Authors

T. Kinouchi, R. Horton

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Citations to this article (35)

Title and authors Publication Year
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Unexpected Virilization in Male Mice Lacking Steroid 5α-Reductase Enzymes
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Pharmacokinetics and pharmacodynamics of FK143, a nonsteroidal inhibitor of steroid 5α-reductase, in healthy volunteers
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Dihydrotestosterone Is a Peripheral Paracrine Hormone
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Clinical signs of androgen excess as risk factors for coronary artery disease*
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VA Giagulli, L Verdonck, R Giorgino, A Vermeulen 		Journal of Steroid Biochemistry 1989
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R Horton 		Clinics in Dermatology 1988
Circulating dihydrotestosterone may not reflect peripheral formation
V Toscano, R Horton 		Journal of Clinical Investigation 1987
Production, clearance, and metabolism of testosterone in men with prostatic cancer
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Determination of 5α-androstane-3α, 17β-diol and 5α-androstane-3β, 17β-diol in human plasma by selected ion monitoring
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5 Dihydrotestosterone metabolism
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R Horton, R Lobo 		Clinics in Endocrinology and Metabolism 1986
Determination of 5α-androstane-3α,17β-diol and 5α-androstane-3β,17β-diol in human plasma by radioimmunoassay
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R Horton 		Journal of the American Geriatrics Society 1984
A comparison of androgen production and clearance in hirsute and obese women
MA Kirschner, E Samojlik, D Silber 		Journal of Steroid Biochemistry 1983
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I Antonlpillal, E Moghissi, SD Frasler, R Horton 		Clinical and Experimental Hypertension 1982
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R Ghanadian 		1982
Alteration in the metabolism of dihydrotestosterone in elderly men with prostate hyperplasia
I Morimoto, A Edmiston, R Horton 		Journal of Clinical Investigation 1980
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G Moneti, M Pazzagli, G Fiorelli, M Serio 		Journal of Steroid Biochemistry 1980
Androgen Metabolism by Rat Epididymis: Metabolic Conversion of3H-Dihydrotestosterone In Vivo and In Vitro
CD Hastings, O Djøseland 		Systems Biology in Reproductive Medicine 1979
Decline in sexual activity in ageing men: correlation with sex hormone levels and testicular changes
A Vermeulen 		Journal of Biosocial Science 1979
Hormonal Steroids
W Nowaczynski, P Landais, T Murakami, M Nowaczynski, D Mavoungou, B Vitullo 		Hormonal Steroids 1979
Metabolism of androgens by the baboon kidney
O Jiro, O Yoshio, RY Kirdani, AA Sandberg 		Journal of Steroid Biochemistry 1979
Sex Steroid Production and Secretion in the Male*,**
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Metabolism of 5α-dihydrotestosterone in human benign hyperplastic prostate
K Malathi, E Gurpide 		Journal of Steroid Biochemistry 1977
Measurement of Androstanediol in Plasma in a Radioimmunoassay using Celite Column Chromatography**Supported by Grant AM 13710 from the National Institutes of Health
J Barberia, L Pages, R Horton 		Fertility and Sterility 1976
In vivo metabolism of 3H-dihydrotestosterone and 3H-androstanediol in adult male rats
EJ Doorn, B Burns, D Wood, CE Bird, AF Clark 		Journal of Steroid Biochemistry 1975

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