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Pure Human Big Gastrin IMMUNOCHEMICAL PROPERTIES, DISAPPEARANCE HALF TIME, AND ACID-STIMULATING ACTION IN DOGS
John H. Walsh, … , Haile T. Debas, Morton I. Grossman
John H. Walsh, … , Haile T. Debas, Morton I. Grossman
Published August 1, 1974
Citation Information: J Clin Invest. 1974;54(2):477-485. https://doi.org/10.1172/JCI107783.
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Pure Human Big Gastrin IMMUNOCHEMICAL PROPERTIES, DISAPPEARANCE HALF TIME, AND ACID-STIMULATING ACTION IN DOGS

Abstract

Biological properties of pure natural human “big gastrin” (designated G-34 because it contains 34 amino acid residues) were compared with those of pure natural heptadecapeptide gastrins (G-17) from human and porcine sources. Radioimmunoassay inhibition curves indicated that G-17 was nearly 1.5 times more potent than G-34 with the antibody used in this study. This difference was confirmed by demonstration of increased immunoreactivity generated when G-34 was converted to G-17 by trypsinization.

Authors

John H. Walsh, Haile T. Debas, Morton I. Grossman

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JC Thompson, HR Fender, NI Ramus, HV Villar, PL Rayford 		Annals of Surgery 1975
Letter: Gastrin heterogeneity: simple or complex?
NS Track, JS Rehfeld 		British medical journal 1975
Molluscan gastrin: concentration and molecular forms
E Straus, R Yalow, H Gainer 		Science 1975
Clinical significance of gastrin radioimmunoassay
JH Walsh 		Seminars in Nuclear Medicine 1975
Relative abundance of big and little gastrins in the tumours and blood of patients with the Zollinger Ellison syndrome
GJ Dockray, JH Walsh, E Passaro 		Gut 1975
Amino Terminal Gastrin Fragment in Serum of Zollinger-Ellison Syndrome Patients
GJ Dockray, JH Walsh 		Gastroenterology 1975
Inhibition of Gastric Emptying is a Physiological Action of Cholecystokinin
HT Debas, O Farooq, MI Grossman 		Gastroenterology 1975
INHIBITION OF GASTRIN AND GASTRIC-ACID SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE
SR Bloom, CH Mortimer, MO Thorner, GM Besser, R Hall, A Gomez-Pan, VM Roy, RC Russell, DH Coy, AT Kastin, AV Schally 		The Lancet 1974
Pure human minigastrin: secretory potency and disappearance rate
HT Debas, JH Walsh, MI Grossman 		Gut 1974
Is Gastrin the Major Regulator of Lower Esophageal Sphincter Pressure?
RA Sturdevant 		Gastroenterology 1974
Use of Radioimmunoassay in Endocrine GI Tumours
JH Walsh 		1974
Molecular forms of gastrin in peptic ulcer: comparison of serum and tissue concentrations of G17 and G34 in gastric and duodenal ulcer subjects
J Calam, GJ Dockray, R Walker, HJ Tracy, D Owens 		European Journal of Clinical Investigation 1971
Advances in Metabolic Disorders
G Aurbach, JT Potts 		Advances in Metabolic Disorders 1964

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