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Citations to this article

Acute Immunologic Pulmonary Alveolitis
Kent J. Johnson, Peter A. Ward
Kent J. Johnson, Peter A. Ward
Published August 1, 1974
Citation Information: J Clin Invest. 1974;54(2):349-357. https://doi.org/10.1172/JCI107770.
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Research Article

Acute Immunologic Pulmonary Alveolitis

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Abstract

Acute immunologic injury of rat lung has been induced by the intrabronchial injection of heterologous antibody and the intravenous injection of radiolabeled antigen. Within 4 h an acute hemorrhagic neutrophil-rich exudate develops in alveolar and interstitial areas and then gradually fades. Lung injury in this model can be quantitated by measurements of increased vascular permeability and extractable hemoglobin. By the use of immunofluorescent techniques, alveolar and interstitial deposits of antigen and antibody have been demonstrated, but not the third component of complement (C3). Although not found in relation to immune complexes, C3 is nevertheless present in damaged lung as measured by accumulation of radiolabeled C3 from the circulation. Ablation experiments indicate the requirement for both circulating neutrophils and C3 for the development of lung injury. These studies provide definition for the development of lung damage induced by immune complexes.

Authors

Kent J. Johnson, Peter A. Ward

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Thermal injury, intravascular hemolysis, and toxic oxygen products
JR Hatherill, GO Till, LH Bruner, PA Ward
Journal of Clinical Investigation 1986
Inflammatory mechanisms in the Arthus reaction
TJ Williams, PG Hellewell, PJ Jose
Agents and Actions 1986
Concepts of Pathogenesis and Lung Reactivity in Hypersensitivity Pneumonitis
HY Reynolds
Annals of the New York Academy of Sciences 1986
Effect of a mixed function oxidase inducer and inhibitor on monocrotaline pyrrole pneumotoxicity
LH Bruner, LJ Carpenter, P Hamlow, RA Roth
Toxicology and Applied Pharmacology 1986
Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactiva ted virus
GA Prince, AB Jenson, VG Hemming, BR Murphy, EE Walsh, RL Horswood, RM Chanock
Journal of virology 1986
An experimental model for hydrogen peroxide–induced tissue damage. Effects of a single inflammatory mediator on (peri)articular tissues
J Schalkwijk, WB van Berg, LB van de Putte, LA Joosten
Arthritis & Rheumatism 1986
Complement and experimental respiratory failure
PA Ward, KJ Johnson, GO Till
Intensive Care Medicine 1986
Cationization of catalase, peroxidase, and superoxide dismutase. Effect of improved intraarticular retention on experimental arthritis in mice
J Schalkwijk, WB van Berg, LB van de Putte, LA Joosten, L Bersselaar
Journal of Clinical Investigation 1985
Rat Clq: Isolation and purification from normal serum and development of a sensitive hemolytic assay
K Leung, JS Kerr
Immunological Investigations 1985
The pulmonary manifestations of systemic lupus erythematosus
AM Segal, LH Calabrese, M Ahmad, RR Tubbs, CS White
Seminars in Arthritis and Rheumatism 1985
Severe microvascular injury induced by lysosomal releasates of human polymorphonuclear leukocytes. Increase in vasopermeability, hemorrhage, and microthrombosis due to degradation of subendothelial and perivascular matrices
HZ Movat, S Wasi
The American Journal of Pathology 1985
Role of C5 and recruited neutrophils in early clearance of nontypable Haemophilus influenzae from murine lungs
GB Toews, WC Vial, EJ Hansen
Infection and immunity 1985
Lipid peroxidation and acute lung injury after thermal trauma to skin. Evidence of a role for hydroxyl radical
GO Till, JR Hatherill, WW Tourtellotte, MJ Lutz, PA Ward
The American Journal of Pathology 1985
Cutaneous thermal burn and oxidant-mediated acute lung injury: Appearance in serum of lung-related LDH isoenzyme
TM Annesley, GO Till, PA Ward
Journal of Free Radicals in Biology & Medicine 1985
An in vitro model of leukocyte mediated injury to the corneal epithelium
SA Elgebaly, C Gillies, F Forouhar, M Hashem, M Baddour, J O'rourke, DL Kreutzer
Current Eye Research 1985
Fibrin: Mediator of in vivo and in vitro injury and inflammation
FN Rowland, MJ Donovan, C Gillies, J O'rourke, DL Kreutzer
Current Eye Research 1985
In Reply: Local Immunopathologic Findings in Bronchiolitis Associated with Collagen Vascular Diseases
A Lahdensuo, J Mattila, A Vilppula
Chest 1985
Acute lung injury in rat caused by immunoglobulin A immune complexes
KJ Johnson, BS Wilson, GO Till, PA Ward
Journal of Clinical Investigation 1984
Pulmonary response of fifth component of complement-sufficient and -deficient mice to hyperoxia
DA Parrish, BC Mitchell, PM Henson, GL Larsen
Journal of Clinical Investigation 1984
Leukocyte-mediated injury to corneal endothelial cells. A model of tissue injury
SA Elgebaly, F Forouhar, C Gillies, S Williams, J O'Rourke, DL Kreutzer
The American Journal of Pathology 1984
Immunologic mechanisms of parenchymal lung injury
WF Willoughby, JB Willoughby
Environmental Health Perspectives 1984
Polymyositis and interstitial lung disease in a patient with anti-Jo1 prototype
CA Wasicek, M Reichlin, M Montes, G Raghu
The American Journal of Medicine 1984
Diffuse Pulmonary Interstitial Fibrosis
K Fan, DE Orsogna
Chest 1984
In vitro and in vivo stimulation of rat neutrophils and alveolar macrophages by immune complexes. Production of O-2 and H2O2
PA Ward, RE Duque, MC Sulavik, KJ Johnson
The American Journal of Pathology 1983
Auto-antibody dependent activation of the autologous classical complement pathway by guinea-pig red cells treated with influenza virus or neuraminidase: in vitro and in vivo study
CR Lambre, M Thibon, SL Maho, GD Bella
Immunology 1983
Hypersensitivity pneumonitis in man. Light- and electron-microscopic studies of 18 lung biopsies
O Kawanami, F Basset, R Barrios, JG Lacronique, VJ Ferrans, RG Crystal
The American Journal of Pathology 1983
Demonstration of inflammatory mediator-induced inflammation and endothelial cell damage in the anterior segment of the eye
FN Rowland, MJ Donovan, M Lindsay, WI Weiss, J O'Rourke, DL Kreutzer
The American Journal of Pathology 1983
Experimental granulomatous lung disease in guinea pigs: Morphology and collagen analysis
JD Fulmer, A Flint, DE Law
Lung 1983
Intravascular activation of complement and acute lung injury. Dependency on neutrophils and toxic oxygen metabolites
GO Till, KJ Johnson, R Kunkel, PA Ward
Journal of Clinical Investigation 1982
PULMONARY MICROVASCULAR ALTERATIONS AND INJURY INDUCED BY COMPLEMENT FRAGMENTS: SYNERGISTIC EFFECT OF COMPLEMENT ACTIVATION, NEUTROPHIL SEQUESTRATION, AND PROSTAGLANDINS
PM Henson, GL Larsen, RO Webster, BC Mitchell, AJ Goins, JE Henson
Annals of the New York Academy of Sciences 1982
Acute and progressive lung injury after contact with phorbol myristate acetate
KJ Johnson, PA Ward
The American Journal of Pathology 1982
Immune complex-mediated lung injury produced by horseradish peroxidase (HRP) and anti-HRP antibodies in rats
B Bellon, JF Bernaudin, C Mandet, B Chamak, J Kuhn, P Druet
The American Journal of Pathology 1982
The Distribution of Soluble Antigens Instilled into the Respiratory Tract
Y Yoshizawa, CA Dawson, RC Roberts, VL Moore
Chest 1982
In vivo damage of rat lungs by oxygen metabolites
KJ Johnson, JC 3rd, J Kaplan, PA Ward
Journal of Clinical Investigation 1981
Suppression of acute and chronic inflammation by orally administered prostaglandins
SL Kunkel, H Ogawa, PB Conran, PA Ward, RB Zurier
Arthritis & Rheumatism 1981
Oleic-acid-induced lung injury in the rat. Failure of indomethacin treatment or complement depletion to ablate lung injury
BF Dickey, RS Thrall, JR McCormick, PA Ward
The American Journal of Pathology 1981
The chemotactic response of tumor cells. A model for cancer metastasis
WC Lam, EJ Delikatny, FW Orr, J Wass, J Varani, PA Ward
The American Journal of Pathology 1981
Suppression by superoxide dismutase of immune-complex--induced pulmonary alveolitis and dermal inflammation
JR McCormick, MM Harkin, KJ Johnson, PA Ward
The American Journal of Pathology 1981
Antibody-mediated injury to proximal tubules in the rat kidney induced by passive transfer of homologous anti-brush border serum
B Noble, DL Mendrick, JR Brentjens, GA Andres
Clinical Immunology and Immunopathology 1981
Vasculitis pulmonares
JM Prat
Archivos de Bronconeumología 1981
The effect of in situ formation of antigen-antibody complexes in the glomerulus on subsequent glomerular localization of passively administered immune complexes
PM Ford, I Kosatka
Immunology 1980
Leukocytes in chemotactic-fragment-induced lung inflammation. Vascular emigration and alveolar surface migration
JO Shaw
The American Journal of Pathology 1980
Zymosan-induced experimental hypersensitivity pneumonitis in rabbits
R Barrios, GG Santos, J Figueroa, PA Reyes
The American Journal of Pathology 1980
In vitro and in vivo effects of antibody to rat angiotensin converting enzyme
JR McCormick, RS Thrall, A Kerlin, PA Ward
Clinical Immunology and Immunopathology 1980
Acute Pulmonary Injury Induced by Immune Complexes
DJ Pearson, MS Mentnech, M Gamble, G Taylor, FH Green
Experimental Lung Research 1980
C5 chemotactic fragment induces leukocyte production of tissue factor activity: a link between complement and coagulation
TW Muhlfelder, J Niemetz, D Kreutzer, D Beebe, PA Ward, SI Rosenfeld
Journal of Clinical Investigation 1979
Suppression of immune complex vasculitis in rats by prostaglandin
SL Kunkel, RS Thrall, RG Kunkel, JR McCormick, PA Ward, RB Zurier
Journal of Clinical Investigation 1979
Chemotactic factor inactivator release from rat leukocytes
JD Hunt, PA Ward
Inflammation 1979
Immunopathology of the lung: a review
KJ Johnson, WE Chapman, PA Ward
The American Journal of Pathology 1979
Acute inflammatory pulmonary reactions induced by chemotactic factors
U Desai, DL Kreutzer, H Showell, CV Arroyave, PA Ward
The American Journal of Pathology 1979
Immune complex injury of the lung
PA Ward
The American Journal of Pathology 1979
Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin
RS Thrall, JR McCormick, RM Jack, RA McReynolds, PA Ward
The American Journal of Pathology 1979
Immunologic (Nonasthmatic) Disease of the Lung
PA Ward
Chest 1979
HYPERGAMMAGLOBULINEMIC PURPURA IN CYSTIC FIBROSIS
HE Nielsen, S Lundh, SV Jacobsen, N Høiby
Acta Paediatrica 1978
Other fungal antigens
L Kaufman
Journal of Allergy and Clinical Immunology 1978
Circulating Immune Complexes in the Idiopathic Interstitial Pneumonias
RB Dreisin, MI Schwarz, AN Theofilopoulos, RE Stanford
New England Journal of Medicine 1978
Suppression of immune complex-induced inflammation by the chemotactic factor inactivator
KJ Johnson, TP Anderson, PA Ward
Journal of Clinical Investigation 1977
IMMUNE COMPLEXES IN CYSTIC FIBROSIS
PO SchiØtz, N HØiby, F Juhl, H Permin, H Nielsen, SE SVEHAG
Acta Pathologica Microbiologica Scandinavica Section C Immunology 1977
Immunopathogenesis of hypersensitivity pneumonitis
M Schatz, R Patterson, J Fink
Journal of Allergy and Clinical Immunology 1977
Regulatory dysfunction in leukotaxis
PA Ward, KJ Johnson, DL Kreutzer
The American Journal of Pathology 1977
Immune-complex disease in guinea pig lungs
AK Roska, JC Garancis, VL Moore, P Abramoff
Clinical Immunology and Immunopathology 1977
Immunologically induced lung disease in guinea pigs
T Santives, AK Roska, GT Hensley, VL Moore, JN Fink, P Abramoff
Journal of Allergy and Clinical Immunology 1976
Antileukotactic properties of tumor cells
JP Brozna, PA Ward
Journal of Clinical Investigation 1975
Case 28-1975: Pulmonary Infiltrates in a Woman with Sjögren's Syndrome
RC Cabot, RE Scully, JJ Galdabini, BU McNeely, GL Snider, MA Weiss
New England Journal of Medicine 1975

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