Acute immunologic injury of rat lung has been induced by the intrabronchial injection of heterologous antibody and the intravenous injection of radiolabeled antigen. Within 4 h an acute hemorrhagic neutrophil-rich exudate develops in alveolar and interstitial areas and then gradually fades. Lung injury in this model can be quantitated by measurements of increased vascular permeability and extractable hemoglobin. By the use of immunofluorescent techniques, alveolar and interstitial deposits of antigen and antibody have been demonstrated, but not the third component of complement (C3). Although not found in relation to immune complexes, C3 is nevertheless present in damaged lung as measured by accumulation of radiolabeled C3 from the circulation. Ablation experiments indicate the requirement for both circulating neutrophils and C3 for the development of lung injury. These studies provide definition for the development of lung damage induced by immune complexes.
Kent J. Johnson, Peter A. Ward
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Inhibition of the lectin pathway of complement activation reduces LPS-induced acute respiratory distress syndrome in mice.
Ali YM, Lynch NJ, Shaaban AA, Rizk DE, Abdel-Rahman SH, Khatri P, Yabuki M, Yaseen S, Dudler T, Demopulos G, Schwaeble WJ |
Frontiers in immunology | 2023 |
Cardamonin inhibits LPS-induced inflammatory responses and prevents acute lung injury by targeting myeloid differentiation factor 2
L Yang, W Luo, Q Zhang, S Hong, Y Wang, AV Samorodov, N Chattipakorn, VN Pavlov, G Liang |
Phytomedicine : international journal of phytotherapy and phytopharmacology | 2021 |
Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating the homeostatic protein DEL-1
Tomoki Maekawa, Hikaru Tamura, Hisanori Domon, Takumi Hiyoshi, Toshihito Isono, Daisuke Yonezawa, Naoki Hayashi, Naoki Takahashi, Koichi Tabeta, Takeyasu Maeda, Masataka Oda, Athanasios Ziogas, Vasileia Ι. Alexaki, Triantafyllos Chavakis, Yutaka Terao, George Hajishengallis |
JCI Insight | 2020 |
Effect of nitric oxide synthase inhibitors in acute lung injury due to blunt lung trauma in rats
AG Akgül |
Turkish Journal of Thoracic and Cardiovascular Surgery | 2019 |
Recombinant chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS) protects against LPS-induced lung injury in mice
YM Ali, AM El-Aziz, M Mabrook, AA Shabaan, RB Sim, R Hassan |
Clinical Immunology | 2018 |
CRC Handbook of Animal Models of Pulmonary Disease
J Owen |
2018 | |
Bigelovii A Protects against Lipopolysaccharide-Induced Acute Lung Injury by Blocking NF- κ B and CCAAT/Enhancer-Binding Protein δ Pathways
C Yan, F Guan, Y Shen, H Tang, D Yuan, H Gao, X Feng |
Mediators of Inflammation | 2016 |
Bronchial lesions of mouse model of asthma are preceded by immune complex vasculitis and induced bronchial associated lymphoid tissue (iBALT)
IC Guest, S Sell |
Laboratory Investigation | 2015 |
Baclofen, a GABABR Agonist, Ameliorates Immune-Complex Mediated Acute Lung Injury by Modulating Pro-Inflammatory Mediators
S Jin, ML Merchant, JD Ritzenthaler, KR McLeish, ED Lederer, E Torres-Gonzalez, M Fraig, MT Barati, AB Lentsch, J Roman, JB Klein, MJ Rane, N Palaniyar |
PloS one | 2015 |
Silica Triggers Inflammation and Ectopic Lymphoid Neogenesis in the Lungs in Parallel with Accelerated Onset of Systemic Autoimmunity and Glomerulonephritis in the Lupus-Prone NZBWF1 Mouse
MA Bates, C Brandenberger, I Langohr, K Kumagai, JR Harkema, A Holian, JJ Pestka, J Crispin |
PloS one | 2015 |
Formation, Clearance, Deposition, Pathogenicity, and Identification of Biopharmaceutical-related Immune Complexes: Review and Case Studies
JL Rojko, MG Evans, SA Price, B Han, G Waine, M DeWitte, J Haynes, B Freimark, P Martin, JT Raymond, W Evering, MC Rebelatto, E Schenck, C Horvath |
Toxicologic pathology | 2014 |
Inhibition of Complement Activation Alleviates Acute Lung Injury Induced by Highly Pathogenic Avian Influenza H5N1 Virus Infection
S Sun, G Zhao, C Liu, X Wu, Y Guo, H Yu, H Song, L Du, S Jiang, R Guo, S Tomlinson, Y Zhou |
American journal of respiratory cell and molecular biology | 2013 |
Direct Leukocyte Migration across Pulmonary Arterioles and Venules into the Perivascular Interstitium of Murine Lungs during Bleomycin Injury and Repair
PM Wang, DL Kachel, MF Cesta, WJ 2nd |
The American Journal of Pathology | 2011 |
Respiratory involvement in systemic lupus erythematosus
D Carmier, S Marchand-Adam, P Diot, E Diot |
Revue des Maladies Respiratoires | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Attenuation of IgG immune complex-induced acute lung injury by silencing C5aR in lung epithelial cells
L Sun, RF Guo, H Gao, JV Sarma, FS Zetoune, PA Ward |
The FASEB Journal | 2009 |
Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury
JL Dooley, D Abdel-Latif, CD st Laurent, L Puttagunta, D Befus, P Lacy |
American journal of physiology. Lung cellular and molecular physiology | 2009 |
Upregulation of phagocyte-derived catecholamines augments the acute inflammatory response
MA Flierl, D Rittirsch, BA Nadeau, JV Sarma, DE Day, AB Lentsch, MS Huber-Lang, PA Ward |
PloS one | 2009 |
DELAY OF LPS-INDUCED ACUTE LUNG INJURY RESOLUTION BY SOLUBLE IMMUNE COMPLEXES IS NEUTROPHIL DEPENDENT
CL Wu, LY Lin, HM Yeh, MC Chan, CH Yang, CM Hsueh |
Shock | 2009 |
Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury
JL Dooley, D Abdel-Latif, CD st. Laurent, L Puttagunta, D Befus, P Lacy |
American journal of physiology. Lung cellular and molecular physiology | 2009 |
Requirement for Vav proteins in post-recruitment neutrophil cytotoxicity in IgG but not complement C3-dependent injury
A Utomo, J Hirahashi, D Mekala, K Asano, M Glogauer, X Cullere, TN Mayadas |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Acute lung injury induced by lipopolysaccharide is independent of complement activation
D Rittirsch, MA Flierl, DE Day, BA Nadeau, SR McGuire, LM Hoesel, K Ipaktchi, FS Zetoune, JV Sarma, L Leng, MS Huber-Lang, TA Neff, R Bucala, PA Ward |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Ability of Antioxidant Liposomes to Prevent Acute and Progressive Pulmonary Injury
LM Hoesel, MA Flierl, AD Niederbichler, D Rittirsch, SD McClintock, JS Reuben, MJ Pianko, W Stone, H Yang, M Smith, JV Sarma, PA Ward |
Antioxidants & Redox Signaling | 2008 |
Atteinte respiratoire au cours du lupus érythémateux systémique
D Carmier, S Marchand-Adam, P Diot, E Diot |
Revue des Maladies Respiratoires | 2008 |
Anti-KC autoantibody:KC complexes cause severe lung inflammation in mice via IgG receptors
A Krupa, MJ Walencka, V Shrivastava, T Loyd, R Fudala, CW Frevert, TR Martin, AK Kurdowska |
American journal of respiratory cell and molecular biology | 2007 |
Matrix metalloproteinase-3 (stromelysin-1) in acute inflammatory tissue injury
KC Nerusu, RL Warner, N Bhagavathula, SD McClintock, KJ Johnson, J Varani |
Experimental and Molecular Pathology | 2007 |
Diesel exhaust particulate-induced activation of Stat3 requires activities of EGFR and Src in airway epithelial cells
D Cao, TL Tal, LM Graves, I Gilmour, W Linak, W Reed, PA Bromberg, JM Samet |
American journal of physiology. Lung cellular and molecular physiology | 2007 |
Role of Interleukin-6 in Immune Complex Induced Models of Vascular Injury
SD McClintock, AG Barron, EW Olle, MP Deogracias, RL Warner, M Opp, KJ Johnson |
Inflammation | 2006 |
REGULATION OF LUNG INFLAMMATION IN THE MODEL OF IGG IMMUNE-COMPLEX INJURY
H Gao, T Neff, PA Ward |
Annual Review of Pathology: Mechanisms of Disease | 2006 |
Attenuation of half sulfur mustard gas-induced acute lung injury in rats
SD McClintock, LM Hoesel, SK Das, GO Till, T Neff, RG Kunkel, MG Smith, PA Ward |
Journal of Applied Toxicology | 2006 |
Site of Blood Vessel Damage and Relevance of CD18 in a Murine Model of Immune Complex-Mediated Vasculitis
A Sindrilaru, S Seeliger, JM Ehrchen, T Peters, J Roth, K Scharffetter-Kochanek, CH Sunderkötter |
Journal of Investigative Dermatology | 2006 |
Relationship of Acute Lung Inflammatory Injury to Fas/FasL System
TA Neff, RF Guo, SB Neff, JV Sarma, CL Speyer, H Gao, KD Bernacki, M Huber-Lang, S McGuire, LM Hoesel, NC Riedemann, B Beck-Schimmer, FS Zetoune, PA Ward |
The American Journal of Pathology | 2005 |
Hypersensitivity pneumonitis
LC Mohr |
Current Opinion in Pulmonary Medicine | 2004 |
Matrix metalloproteinases in acute inflammation: induction of MMP-3 and MMP-9 in fibroblasts and epithelial cells following exposure to pro-inflammatory mediators in vitro
RL Warner, N Bhagavathula, KC Nerusu, H Lateef, E Younkin, KJ Johnson, J Varani |
Experimental and Molecular Pathology | 2004 |
Lung Biology in Health and Disease: Lung Injury and Disease
W Macnee, I Rahman |
Lung Biology in Health and Disease: Experimental Models and Therapeutic Potential | 2004 |
Stat3 Activation in Acute Lung Injury
H Gao, RF Guo, CL Speyer, J Reuben, TA Neff, LM Hoesel, NC Riedemann, SD McClintock, JV Sarma, NV Rooijen, FS Zetoune, PA Ward |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Mediators and regulation of neutrophil accumulation in inflammatory responses in lung: insights from the IgG immune complex model,
RF Guo, PA Ward |
Free radical biology & medicine | 2002 |
Activator Protein-1 Activation in Acute Lung Injury
RF Guo, AB Lentsch, JV Sarma, L Sun, NC Riedemann, SD McClintock, SR McGuire, NV Rooijen, PA Ward |
The American Journal of Pathology | 2002 |
Altered neutrophil trafficking during sepsis
RF Guo, NC Riedemann, IJ Laudes, VJ Sarma, RG Kunkel, KA Dilley, JD Paulauskis, PA Ward |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Oxygen/Nitrogen Radicals: Cell Injury and Disease
V Vallyathan, X Shi, V Castranova |
2002 | |
Endogenous regulation of the acute inflammatory response
Peter A Ward, Alex B Lentsch |
Molecular and Cellular Biochemistry | 2002 |
Role of Stromelysin 1 and Gelatinase B in Experimental Acute Lung Injury
RL Warner, L Beltran, EM Younkin, CS Lewis, SJ Weiss, J Varani, KJ Johnson |
American journal of respiratory cell and molecular biology | 2001 |
Vaccine-enhanced respiratory syncytial virus disease in cotton rats following immunization with Lot 100 or a newly prepared reference vaccine
DD Porter, GA Prince, KC Yim, SJ Curtis |
Journal of General Virology | 2001 |
Transcriptional mechanisms of acute lung injury
J Fan, RD Ye, AB Malik |
American journal of physiology. Lung cellular and molecular physiology | 2001 |
Augmented metalloproteinase activity and acute lung injury in copper-deficient rats
AB Lentsch, A Kato, JT Saari, DA Schuschke |
American journal of physiology. Lung cellular and molecular physiology | 2001 |
Regulatory Effects of Eotaxin on Acute Lung Inflammatory Injury
RF Guo, AB Lentsch, RL Warner, M Huber-Lang, JV Sarma, T Hlaing, MM Shi, NW Lukacs, PA Ward |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Role of IL-18 in Acute Lung Inflammation
JA Jordan, RF Guo, EC Yun, V Sarma, RL Warner, LD Crouch, G Senaldi, TR Ulich, PA Ward |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Leukocyte Recruitment and the Acute Inflammatory Response
P Kubes, PA Ward |
Brain Pathology | 2000 |
Anti-Inflammatory Effects of Mutant Forms of Secretory Leukocyte Protease Inhibitor
MS Mulligan, AB Lentsch, M Huber-Lang, RF Guo, V Sarma, CD Wright, TR Ulich, PA Ward |
The American Journal of Pathology | 2000 |
Regulation of inflammatory vascular damage
AB Lentsch, PA Ward |
The Journal of Pathology | 2000 |
Role of CC Chemokines (Macrophage Inflammatory Protein-1β, Monocyte Chemoattractant Protein-1, RANTES) in Acute Lung Injury in Rats
NM Bless, M Huber-Lang, RF Guo, RL Warner, H Schmal, BJ Czermak, TP Shanley, LD Crouch, AB Lentsch, V Sarma, MS Mulligan, HP Friedl, PA Ward |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Mechanisms of Enhanced Lung Injury during Sepsis
BJ Czermak, M Breckwoldt, ZB Ravage, M Huber-Lang, H Schmal, NM Bless, HP Friedl, PA Ward |
The American Journal of Pathology | 1999 |
Synergistic Enhancement of Chemokine Generation and Lung Injury by C5a or the Membrane Attack Complex of Complement
BJ Czermak, AB Lentsch, NM Bless, H Schmal, HP Friedl, PA Ward |
The American Journal of Pathology | 1999 |
Activation and Regulation of NFκB during Acute Inflammation
AB Lentsch, PA Ward |
Clinical Chemistry and Laboratory Medicine | 1999 |
Inhibition of NF-kappaB activation and augmentation of IkappaBbeta by secretory leukocyte protease inhibitor during lung inflammation
AB Lentsch, JA Jordan, BJ Czermak, KM Diehl, EM Younkin, V Sarma, PA Ward |
The American Journal of Pathology | 1999 |
Understanding the Pathogenesis of Inflammation Using Rodent Models Identification of a Transcription Factor (NF B) Necessary for Development of Inflammatory Injury
AB Lentsch, PA Ward |
ILAR journal / National Research Council, Institute of Laboratory Animal Resources | 1999 |
Role of Matrix Metalloproteinases in Models of Macrophage-Dependent Acute Lung Injury: Evidence for Alveolar Macrophage as Source of Proteinases
DF Gibbs, TP Shanley, RL Warner, HS Murphy, J Varani, KJ Johnson |
American journal of respiratory cell and molecular biology | 1999 |
Essential Role of Alveolar Macrophages in Intrapulmonary Activation of NF- κ B
AB Lentsch, BJ Czermak, NM Bless, NV Rooijen, PA Ward |
American journal of respiratory cell and molecular biology | 1999 |
Sepsis and Organ Dysfunction
AE Baue, G Berlot, A Gullo, JL Vincent |
1999 | |
Molecular and Cellular Basis of Inflammation
CN Serhan, PA Ward |
1999 | |
Cytokine-induced neutrophil chemoattractant in a rat model of lipopolysaccharide-induced acute lung injury
H Yamasawa, Y Ishii, S Kitamura |
Inflammation | 1999 |
NF-kappaB activation during IgG immune complex-induced lung injury: requirements for TNF-alpha and IL-1beta but not complement
AB Lentsch, BJ Czermak, NM Bless, PA Ward |
The American Journal of Pathology | 1998 |
Lipid mediators, tumor necrosis factor and nitric oxide and their interactions in immune-complex-induced lung injury
WT de Lima, AA Steil, M Russo, N Starobinas, CF Teixeira, S Jancar |
European Journal of Pharmacology | 1998 |
Modulation by lipid mediators of immune complex-induced lung inflammation in mice
AA Steil, WT de Lima, S Jancar |
European Journal of Pharmacology | 1998 |
Cytokine and adhesion molecule requirements for lung injury induced by anti-glomerular basement membrane antibody
M S Mulligan, A B Lentsch, T P Shanley, M Miyasaka, K J Johnson, P A Ward |
Inflammation | 1998 |
EFFECT OF COMPLEMENT INHIBITION WITH SOLUBLE COMPLEMENT RECEPTOR 1 ON PIG ALLOTRANSPLANT LUNG FUNCTION1:
AF Pierre, AM Xavier, M Liu, SD Cassivi, TF Lindsay, HC Marsh, AS Slutsky, SH Keshavjee |
Transplantation | 1998 |
In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13
AB Lentsch, TP Shanley, V Sarma, PA Ward |
Journal of Clinical Investigation | 1997 |
Phagocytes and the Lung
PA Ward |
Annals of the New York Academy of Sciences | 1997 |
Protective effects of an aptamer inhibitor of neutrophil elastase in lung inflammatory injury
NM Bless, D Smith, J Charlton, BJ Czermak, H Schmal, HP Friedl, PA Ward |
Current Biology | 1997 |
Role of the complement system in pulmonary disorders
JF Regal |
Immunopharmacology | 1997 |
Recruitment of inflammatory cells into lung: Roles of cytokines, adhesion molecules, and complement
PA Ward |
Journal of Laboratory and Clinical Medicine | 1997 |
Requirement and role of C5a in acute lung inflammatory injury in rats
MS Mulligan, E Schmid, B Beck-Schimmer, GO Till, HP Friedl, RB Brauer, TE Hugli, M Miyasaka, RL Warner, KJ Johnson, PA Ward |
Journal of Clinical Investigation | 1996 |
N-Acetylcysteine pretreatment of cardiac surgery patients influences plasma neutrophil elastase and neutrophil influx in bronchoalveolar lavage fluid
WA Backer, B Amsel, PG Jorens, L Bossaert, PS Hiemstra, P Noort, FJ Overveld |
Intensive Care Medicine | 1996 |
Role of Complement, Chemokines, & Regulatory Cytokines in Acute Lung Injury
PA Ward |
Annals of the New York Academy of Sciences | 1996 |
Immune complex induced arthritis in rats: role of lipid mediators on cell infiltration
FA Rocha, LE Andrade, S Jancar |
Mediators of Inflammation | 1996 |
Rous-Whipple Award Lecture. Role of complement in lung inflammatory injury
PA Ward |
The American Journal of Pathology | 1996 |
Sequential appearance of inflammatory mediators in rat bronchoalveolar lavage fluid after oleic acid-induced lung injury
S Syrbu, R S Thrall, H M Smilowitz |
Experimental Lung Research | 1996 |
N-Acetylcysteine pretreatment of cardiac surgery patients influences plasma neutrophil elastase and neutrophil influx in bronchoalveolar lavage fluid
WA Backer, B Amsel, PG Jorens, L Bossaert, PS Hiemstra, P van Noort, FJ van Overveld |
Intensive Care Medicine | 1996 |
The role of cytokines and adhesion molecules in the development of inflammatory injury
TP Shanley, RL Warner, PA Ward |
Molecular Medicine Today | 1995 |
The regulation of pulmonary immunity.
Lipscomb MF, Bice DE, Lyons CR, Schuyler MR, Wilkes D |
Advances in immunology | 1995 |
Vascular Endothelium
MA Gimbrone, MI Cybulsky, N Kume, T Collins, N Resnick |
Annals of the New York Academy of Sciences | 1994 |
Oxygen radicals, cytokines, adhesion molecules, and lung injury
PA Ward |
Environmental Health Perspectives | 1994 |
Advances in Pharmacology
B Drenger, Y Ginosar, Y Gozal |
Advances in Pharmacology | 1994 |
Cellular Adhesion
BW Metcalf, BJ Dalton, G Poste, J Schatz |
1994 | |
Novel delivery of antioxidant enzyme catalase to alveolar macrophages by Fc receptor-mediated endocytosis
J Harrison, X Shi, L Wang, J K Ma, Y Rojanasakul |
Pharmaceutical Research | 1994 |
Interaction of viable group a streptococci and hydrogen peroxide in killing of vascular endothelial cells
I Ginsburg, J Varani |
Free radical biology & medicine | 1993 |
Complement component C5 modulates the systemic tumor necrosis factor response in murine endotoxic shock
PA Barton, JS Warren |
Infection and immunity | 1993 |
Tumor necrosis factor alpha regulates in vivo intrapulmonary expression of ICAM-1
MS Mulligan, AA Vaporciyan, M Miyasaka, T Tamatani, PA Ward |
The American Journal of Pathology | 1993 |
Effects of alprazolam on influenza virus infection in stressed mice
M Freire-Garabal, JL Balboa, JC Fernandez-Rial, MJ Núñez, A Belmonte |
Pharmacology Biochemistry and Behavior | 1993 |
Host Defense Dysfunction in Trauma, Shock and Sepsis
E Faist, JL Meakins, FW Schildberg |
1993 | |
Involvement of Platelet-Endothelial Cell Adhesion Molecule-1 in Neutrophil Recruitment in Vivo
AA Vaporciyan, HM DeLisser, HC Yan, II Mendiguren, SR Thom, ML Jones, PA Ward, SM Albelda |
Science | 1993 |
Neutrophil-dependent acute lung injury. Requirement for P-selectin (GMP-140)
MS Mulligan, MJ Polley, RJ Bayer, MF Nunn, JC Paulson, PA Ward |
Journal of Clinical Investigation | 1992 |
Relationship between interleukin-1 beta and platelet-activating factor in the pathogenesis of acute immune complex alveolitis in the rat
JS Warren |
The American Journal of Pathology | 1992 |
Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis
MS Mulligan, S Moncada, PA Ward |
British Journal of Pharmacology | 1992 |
Immune-complex alveolitis in the rat: evidence for platelet activating factor and leukotrienes as mediators of the vascular lesions
WT de Lima, P Sirois, S Jancar |
European Journal of Pharmacology | 1992 |
Effect of Acute Inflammatory Lung Injury on the Expression of Monocyte Chemoattractant Protein-1 (MCP-1) in Rat Pulmonary Alveolar Macrophages
JK Brieland, ML Jones, SJ Clarke, JB Baker, JS Warren, JC Fantone |
American journal of respiratory cell and molecular biology | 1992 |
Biological Oxidants: Generation and Injurious Consequences
AW Segal, JH Nugent |
Biological Oxidants: Generation and Injurious Consequences | 1992 |
Human Lung Fibroblast Subpopulations with Different C1q Binding and Functional Properties
A Akamine, G Raghu, AS Narayanan |
American journal of respiratory cell and molecular biology | 1992 |
The Complement System
A Agostoni, M Cicardi, M Gardinali, L Bergamaschini |
International journal of immunopathology and pharmacology | 1992 |
New insights into mechanisms of oxyradical and neutrophil mediated lung injury
PA Ward, MS Mulligan |
Klinische Wochenschrift | 1991 |
Paf, cytokines, toxic oxygen products and cell injury
PA Ward, JS Warren, J Varani, KJ Johnson |
Molecular Aspects of Medicine | 1991 |
Repeated episodes of C5a-induced neutrophil influx do not result in pulmonary fibrosis
JA Harris, DM Hyde, Q Wang, MY Stovall, SN Giri |
Inflammation | 1991 |
Contrasting roles for tumor necrosis factor in the pathogeneses of IgA and IgG immune complex lung injury
JS Warren, PA Barton, ML Jones |
The American Journal of Pathology | 1991 |
Intrapulmonary interleukin 1 mediates acute immune complex alveolitis in the rat
JS Warren |
Biochemical and Biophysical Research Communications | 1991 |
Oxidative Damage & Repair
A Sevanian |
Oxidative Damage & Repair | 1991 |
Experimental Hypersensitivity Pneumonitis in the Rat: Histopathology and T-cell Subset Compartmentalization
HB Richerson, JD Coon, D Lubaroff |
American journal of respiratory cell and molecular biology | 1991 |
Overview of the Process of Cellular Injury in Interstitial Lung Disease
PA Ward |
Chest | 1991 |
Hydrogen peroxide-induced cell and tissue injury: Protective effects of Mn2+
J Varani, I Ginsburg, DF Gibbs, PS Mukhopadhyay, C Sulavik, KJ Johnson, JM Weinberg, US Ryan, PA Ward |
Inflammation | 1991 |
Lung injury in acute experimental pancreatitis, in rats: II. Functional Studies
CO Feddersen, S Willemer, W Karges, A Püchner, G Adler, PV Wichert |
International Journal of Gastrointestinal Cancer | 1991 |
Role of O2− in neutrophil recruitment into sites of dermal and pulmonary vasculitis
JS Warren, KR Yabroff, DM Mandel, KJ Johnson, PA Ward |
Free radical biology & medicine | 1990 |
The effects of neutrophils and phospholipase A2 on transvascular albumin flux in isolated rabbit lungs
MR Littner, FD Lott |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 1990 |
Induction and Exacerbation of Emphysema in Hamsters with Human Neutrophil Elastase Inactivated Reversibly by a Peptide Boronic Acid
PJ Stone, EC Ljucey, GL Snider |
American journal of respiratory and critical care medicine | 1990 |
Inhibition of Lung Injury, Inflammation, and Interstitial Pulmonary Fibrosis by Polyethylene Glycol-conjugated Catalase in a Rapid Inhalation Model of Asbestosis
BT Mossman, JP Marsh, A Sesko, S Hill, MA Shatos, J Doherty, J Petruska, KB Adler, D Hemenway, R Mickey, P Vacek, E Kagan |
American journal of respiratory and critical care medicine | 1990 |
Evidence for the role of platelet-activating factor in immune complex vasculitis in the rat
JS Warren, DM Mandel, KJ Johnson, PA Ward |
Journal of Clinical Investigation | 1989 |
Tumor necrosis factor participates in the pathogenesis of acute immune complex alveolitis in the rat
JS Warren, KR Yabroff, DG Remick, SL Kunkel, SW Chensue, RG Kunkel, KJ Johnson, PA Ward |
Journal of Clinical Investigation | 1989 |
Monokine-induced lung injury in rats: Similarities to monocrotaline-induced pneumotoxicity
MN Gillespie, JW Olson, B Hennig, DA Cohen, CJ McClain, SE Goldblum |
Toxicology and Applied Pharmacology | 1989 |
Regulation of delayed-type hypersensitivity-like responses in the mouse lung, determined with histological procedures: serotonin, T-cell suppressor-inducer factor and high antigen dose tolerance regulate the magnitude of T-cell dependent inflammatory reactions
J Garssen, FP Nijkamp, SS Wagenaar, A Zwart, PW Askenase, HV Loveren |
Immunology | 1989 |
The Effect of Acute Inflammatory Lung Injury on the Respiratory Burst and Protein Kinase C Activity of Rat Pulmonary Alveolar Macrophages
JK Brieland, K Balazovich, JC Fantone |
American journal of respiratory and critical care medicine | 1989 |
Oxygen radicals, inflammation, and tissue injury
PA Ward, JS Warren, KJ Johnson |
Free radical biology & medicine | 1988 |
The role of oxygen radicals in immune complex injury
KT Oldham, KS Guice, PA Ward, KJ Johnson |
Free radical biology & medicine | 1988 |
Macrophage-derived cytokines amplify immune complex-triggered O2-. responses by rat alveolar macrophages
JS Warren, SL Kunkel, TW Cunningham, KJ Johnson, PA Ward |
The American Journal of Pathology | 1988 |
Pulmonary damage induced in mice by a monoclonal antibody to proteins associated with pig pulmonary surfactant
Y Fujita, K Kogishi, Y Suzuki |
Experimental Lung Research | 1988 |
The Respiratory Burst and Its Physiological Significance
AJ Sbarra, RR Strauss |
1988 | |
Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats
SW Chang, CO Feddersen, PM Henson, NF Voelkel |
Journal of Clinical Investigation | 1987 |
Acute respiratory failure induced by bleomycin and hyperoxia: Pulmonary edema, cell kinetics, and morphology
ME Goad, AF Tryka, HP Witschi |
Toxicology and Applied Pharmacology | 1987 |
Isolation and characterization of circulating immune complexes from patients with pneumococcal pneumonia
MA Mellencamp, LC Preheim, TL McDonald |
Infection and immunity | 1987 |
Modulation of acute immune complex-mediated tissue injury by the presence of polyionic substances
JS Warren, PA Ward, KJ Johnson, I Ginsburg |
The American Journal of Pathology | 1987 |
In vitro activation of rat neutrophils and alveolar macrophages with IgA and IgG immune complexes. Implications for immune complex-induced lung injury
JS Warren, SL Kunkel, KJ Johnson, PA Ward |
The American Journal of Pathology | 1987 |
The observation of immune complex formation and deposition in the eyes of living rabbits
PA Meyer |
Clinical & Experimental Immunology | 1987 |
Lack of effect of deferoxamine, dimethyl sulfoxide, and catalase on monocrotaline pyrrole pulmonary injury
LH Bruner, K Johnson, LJ Carpenter, RA Roth |
Journal of Toxicology and Environmental Health | 1987 |
Prostaglandin E1 prevents increased lung microvascular permeability during intravascular complement activation in sheep
MH Gee, MV Tahamont, JT Flynn, JW Cox, RH Pullen, NA Andreadis |
Circulation research | 1987 |
Thermal injury, intravascular hemolysis, and toxic oxygen products
JR Hatherill, GO Till, LH Bruner, PA Ward |
Journal of Clinical Investigation | 1986 |
Inflammatory mechanisms in the Arthus reaction
TJ Williams, PG Hellewell, PJ Jose |
Agents and Actions | 1986 |
Concepts of Pathogenesis and Lung Reactivity in Hypersensitivity Pneumonitis
HY Reynolds |
Annals of the New York Academy of Sciences | 1986 |
Effect of a mixed function oxidase inducer and inhibitor on monocrotaline pyrrole pneumotoxicity
LH Bruner, LJ Carpenter, P Hamlow, RA Roth |
Toxicology and Applied Pharmacology | 1986 |
Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactiva ted virus
GA Prince, AB Jenson, VG Hemming, BR Murphy, EE Walsh, RL Horswood, RM Chanock |
Journal of virology | 1986 |
An experimental model for hydrogen peroxide–induced tissue damage. Effects of a single inflammatory mediator on (peri)articular tissues
J Schalkwijk, WB van Berg, LB van de Putte, LA Joosten |
Arthritis & Rheumatism | 1986 |
Complement and experimental respiratory failure
PA Ward, KJ Johnson, GO Till |
Intensive Care Medicine | 1986 |
Cationization of catalase, peroxidase, and superoxide dismutase. Effect of improved intraarticular retention on experimental arthritis in mice
J Schalkwijk, WB van Berg, LB van de Putte, LA Joosten, L Bersselaar |
Journal of Clinical Investigation | 1985 |
Rat Clq: Isolation and purification from normal serum and development of a sensitive hemolytic assay
K Leung, JS Kerr |
Immunological Investigations | 1985 |
The pulmonary manifestations of systemic lupus erythematosus
AM Segal, LH Calabrese, M Ahmad, RR Tubbs, CS White |
Seminars in Arthritis and Rheumatism | 1985 |
Severe microvascular injury induced by lysosomal releasates of human polymorphonuclear leukocytes. Increase in vasopermeability, hemorrhage, and microthrombosis due to degradation of subendothelial and perivascular matrices
HZ Movat, S Wasi |
The American Journal of Pathology | 1985 |
Role of C5 and recruited neutrophils in early clearance of nontypable Haemophilus influenzae from murine lungs
GB Toews, WC Vial, EJ Hansen |
Infection and immunity | 1985 |
Lipid peroxidation and acute lung injury after thermal trauma to skin. Evidence of a role for hydroxyl radical
GO Till, JR Hatherill, WW Tourtellotte, MJ Lutz, PA Ward |
The American Journal of Pathology | 1985 |
Cutaneous thermal burn and oxidant-mediated acute lung injury: Appearance in serum of lung-related LDH isoenzyme
TM Annesley, GO Till, PA Ward |
Journal of Free Radicals in Biology & Medicine | 1985 |
An in vitro model of leukocyte mediated injury to the corneal epithelium
SA Elgebaly, C Gillies, F Forouhar, M Hashem, M Baddour, J O'rourke, DL Kreutzer |
Current Eye Research | 1985 |
Fibrin: Mediator of in vivo and in vitro injury and inflammation
FN Rowland, MJ Donovan, C Gillies, J O'rourke, DL Kreutzer |
Current Eye Research | 1985 |
In Reply: Local Immunopathologic Findings in Bronchiolitis Associated with Collagen Vascular Diseases
A Lahdensuo, J Mattila, A Vilppula |
Chest | 1985 |
Acute lung injury in rat caused by immunoglobulin A immune complexes
KJ Johnson, BS Wilson, GO Till, PA Ward |
Journal of Clinical Investigation | 1984 |
Pulmonary response of fifth component of complement-sufficient and -deficient mice to hyperoxia
DA Parrish, BC Mitchell, PM Henson, GL Larsen |
Journal of Clinical Investigation | 1984 |
Leukocyte-mediated injury to corneal endothelial cells. A model of tissue injury
SA Elgebaly, F Forouhar, C Gillies, S Williams, J O'Rourke, DL Kreutzer |
The American Journal of Pathology | 1984 |
Immunologic mechanisms of parenchymal lung injury
WF Willoughby, JB Willoughby |
Environmental Health Perspectives | 1984 |
Polymyositis and interstitial lung disease in a patient with anti-Jo1 prototype
CA Wasicek, M Reichlin, M Montes, G Raghu |
The American Journal of Medicine | 1984 |
Diffuse Pulmonary Interstitial Fibrosis
K Fan, DE Orsogna |
Chest | 1984 |
In vitro and in vivo stimulation of rat neutrophils and alveolar macrophages by immune complexes. Production of O-2 and H2O2
PA Ward, RE Duque, MC Sulavik, KJ Johnson |
The American Journal of Pathology | 1983 |
Auto-antibody dependent activation of the autologous classical complement pathway by guinea-pig red cells treated with influenza virus or neuraminidase: in vitro and in vivo study
CR Lambre, M Thibon, SL Maho, GD Bella |
Immunology | 1983 |
Hypersensitivity pneumonitis in man. Light- and electron-microscopic studies of 18 lung biopsies
O Kawanami, F Basset, R Barrios, JG Lacronique, VJ Ferrans, RG Crystal |
The American Journal of Pathology | 1983 |
Demonstration of inflammatory mediator-induced inflammation and endothelial cell damage in the anterior segment of the eye
FN Rowland, MJ Donovan, M Lindsay, WI Weiss, J O'Rourke, DL Kreutzer |
The American Journal of Pathology | 1983 |
Experimental granulomatous lung disease in guinea pigs: Morphology and collagen analysis
JD Fulmer, A Flint, DE Law |
Lung | 1983 |
Intravascular activation of complement and acute lung injury. Dependency on neutrophils and toxic oxygen metabolites
GO Till, KJ Johnson, R Kunkel, PA Ward |
Journal of Clinical Investigation | 1982 |
PULMONARY MICROVASCULAR ALTERATIONS AND INJURY INDUCED BY COMPLEMENT FRAGMENTS: SYNERGISTIC EFFECT OF COMPLEMENT ACTIVATION, NEUTROPHIL SEQUESTRATION, AND PROSTAGLANDINS
PM Henson, GL Larsen, RO Webster, BC Mitchell, AJ Goins, JE Henson |
Annals of the New York Academy of Sciences | 1982 |
Acute and progressive lung injury after contact with phorbol myristate acetate
KJ Johnson, PA Ward |
The American Journal of Pathology | 1982 |
Immune complex-mediated lung injury produced by horseradish peroxidase (HRP) and anti-HRP antibodies in rats
B Bellon, JF Bernaudin, C Mandet, B Chamak, J Kuhn, P Druet |
The American Journal of Pathology | 1982 |
The Distribution of Soluble Antigens Instilled into the Respiratory Tract
Y Yoshizawa, CA Dawson, RC Roberts, VL Moore |
Chest | 1982 |
In vivo damage of rat lungs by oxygen metabolites
KJ Johnson, JC 3rd, J Kaplan, PA Ward |
Journal of Clinical Investigation | 1981 |
Suppression of acute and chronic inflammation by orally administered prostaglandins
SL Kunkel, H Ogawa, PB Conran, PA Ward, RB Zurier |
Arthritis & Rheumatism | 1981 |
Oleic-acid-induced lung injury in the rat. Failure of indomethacin treatment or complement depletion to ablate lung injury
BF Dickey, RS Thrall, JR McCormick, PA Ward |
The American Journal of Pathology | 1981 |
The chemotactic response of tumor cells. A model for cancer metastasis
WC Lam, EJ Delikatny, FW Orr, J Wass, J Varani, PA Ward |
The American Journal of Pathology | 1981 |
Suppression by superoxide dismutase of immune-complex--induced pulmonary alveolitis and dermal inflammation
JR McCormick, MM Harkin, KJ Johnson, PA Ward |
The American Journal of Pathology | 1981 |
Antibody-mediated injury to proximal tubules in the rat kidney induced by passive transfer of homologous anti-brush border serum
B Noble, DL Mendrick, JR Brentjens, GA Andres |
Clinical Immunology and Immunopathology | 1981 |
Vasculitis pulmonares
JM Prat |
Archivos de Bronconeumología | 1981 |
The effect of in situ formation of antigen-antibody complexes in the glomerulus on subsequent glomerular localization of passively administered immune complexes
PM Ford, I Kosatka |
Immunology | 1980 |
Leukocytes in chemotactic-fragment-induced lung inflammation. Vascular emigration and alveolar surface migration
JO Shaw |
The American Journal of Pathology | 1980 |
Zymosan-induced experimental hypersensitivity pneumonitis in rabbits
R Barrios, GG Santos, J Figueroa, PA Reyes |
The American Journal of Pathology | 1980 |
In vitro and in vivo effects of antibody to rat angiotensin converting enzyme
JR McCormick, RS Thrall, A Kerlin, PA Ward |
Clinical Immunology and Immunopathology | 1980 |
Acute Pulmonary Injury Induced by Immune Complexes
DJ Pearson, MS Mentnech, M Gamble, G Taylor, FH Green |
Experimental Lung Research | 1980 |
C5 chemotactic fragment induces leukocyte production of tissue factor activity: a link between complement and coagulation
TW Muhlfelder, J Niemetz, D Kreutzer, D Beebe, PA Ward, SI Rosenfeld |
Journal of Clinical Investigation | 1979 |
Suppression of immune complex vasculitis in rats by prostaglandin
SL Kunkel, RS Thrall, RG Kunkel, JR McCormick, PA Ward, RB Zurier |
Journal of Clinical Investigation | 1979 |
Chemotactic factor inactivator release from rat leukocytes
JD Hunt, PA Ward |
Inflammation | 1979 |
Immunopathology of the lung: a review
KJ Johnson, WE Chapman, PA Ward |
The American Journal of Pathology | 1979 |
Acute inflammatory pulmonary reactions induced by chemotactic factors
U Desai, DL Kreutzer, H Showell, CV Arroyave, PA Ward |
The American Journal of Pathology | 1979 |
Immune complex injury of the lung
PA Ward |
The American Journal of Pathology | 1979 |
Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin
RS Thrall, JR McCormick, RM Jack, RA McReynolds, PA Ward |
The American Journal of Pathology | 1979 |
Immunologic (Nonasthmatic) Disease of the Lung
PA Ward |
Chest | 1979 |
HYPERGAMMAGLOBULINEMIC PURPURA IN CYSTIC FIBROSIS
HE Nielsen, S Lundh, SV Jacobsen, N Høiby |
Acta Paediatrica | 1978 |
Other fungal antigens
L Kaufman |
Journal of Allergy and Clinical Immunology | 1978 |
Circulating Immune Complexes in the Idiopathic Interstitial Pneumonias
RB Dreisin, MI Schwarz, AN Theofilopoulos, RE Stanford |
New England Journal of Medicine | 1978 |
Suppression of immune complex-induced inflammation by the chemotactic factor inactivator
KJ Johnson, TP Anderson, PA Ward |
Journal of Clinical Investigation | 1977 |
IMMUNE COMPLEXES IN CYSTIC FIBROSIS
PO SchiØtz, N HØiby, F Juhl, H Permin, H Nielsen, SE SVEHAG |
Acta Pathologica Microbiologica Scandinavica Section C Immunology | 1977 |
Immunopathogenesis of hypersensitivity pneumonitis
M Schatz, R Patterson, J Fink |
Journal of Allergy and Clinical Immunology | 1977 |
Regulatory dysfunction in leukotaxis
PA Ward, KJ Johnson, DL Kreutzer |
The American Journal of Pathology | 1977 |
Immune-complex disease in guinea pig lungs
AK Roska, JC Garancis, VL Moore, P Abramoff |
Clinical Immunology and Immunopathology | 1977 |
Immunologically induced lung disease in guinea pigs
T Santives, AK Roska, GT Hensley, VL Moore, JN Fink, P Abramoff |
Journal of Allergy and Clinical Immunology | 1976 |
Antileukotactic properties of tumor cells
JP Brozna, PA Ward |
Journal of Clinical Investigation | 1975 |
Case 28-1975: Pulmonary Infiltrates in a Woman with Sjögren's Syndrome
RC Cabot, RE Scully, JJ Galdabini, BU McNeely, GL Snider, MA Weiss |
New England Journal of Medicine | 1975 |