The objectives of this study were to test the hypothesis in awake dogs that during control conditions endocardial vessels are maximally dilated and to determine whether variables introduced by general anesthesia and thoracotomy modify distribution of myocardial blood flow or impair capacity for augmentation of flow in response to a coronary vasodilator stimulus. Myocardial blood flow was measured in relatively small, 2-3 g, left ventricular epicardial and endocardial samples by using 7-10-μm radioisotope-labeled microspheres during control conditions and during infusion of adenosine in dosages which produced maximum increases in coronary blood flow. Measurements were made initially in awake resting animals and were repeated after pentobarbital anesthesia, thoracotomy, and pericardiotomy.
Frederick R. Cobb, Robert J. Bache, Joseph C. Greenfield Jr.
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Journal of Pharmaceutical Sciences | 1981 |
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Annals of the New York Academy of Sciences | 1980 |
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Circulation research | 1980 |
Linear relationship between the distribution of thallium-201 and blood flow in ischemic and nonischemic myocardium during exercise
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Circulation | 1980 |
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Circulation | 1980 |
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The Journal of Thoracic and Cardiovascular Surgery | 1980 |
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FEBS Letters | 1979 |
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JI Hoffman |
Journal of Biomedical Engineering | 1979 |
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Circulation research | 1979 |
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Circulation research | 1979 |
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Circulation research | 1979 |
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Circulation research | 1979 |
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European Journal of Nuclear Medicine | 1979 |
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Journal of Clinical Investigation | 1978 |
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Circulation | 1978 |
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Circulation research | 1978 |
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Journal of Clinical Investigation | 1977 |
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European Journal of Applied Physiology and Occupational Physiology | 1977 |
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Basic Research in Cardiology | 1977 |
Spatial and temporal heterogeneity of left ventricular perfusion in awake dogs
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American Heart Journal | 1977 |
Distribution of coronary artery flow to the canine right atrium and sinoatrial node
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Circulation research | 1977 |
Effect of maximal coronary vasodilation on transmural myocardial perfusion during tachycardia in the awake dog
RJ Bache, FR Cobb |
Circulation research | 1977 |
Demonstration of alpha-adrenergic coronary control in different layers of canine myocardium by regional myocardial sympathectomy
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Pflügers Archiv - European Journal of Physiology | 1977 |
Intracapillary hemoglobin oxygen saturation and oxygen consumption in different layers of the left ventricular myocardium
J Holtz, WA Grunewald, R Manz, W v. Restorff, E Bassenge |
Pflügers Archiv - European Journal of Physiology | 1977 |
Ischemia-induced alterations in myocardial (Na+ + K+)-ATPase and cardiac glycoside binding
GA Beller, J Conroy, TW Smith |
Journal of Clinical Investigation | 1976 |
Local effects of acute cellular injury on regional myocardial blood flow
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Journal of Clinical Investigation | 1976 |
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J Lekven |
Scandinavian Journal of Clinical & Laboratory Investigation | 1976 |
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SP Bishop, FC White, CM Bloor |
Circulation research | 1976 |
Relationship between blood flow to ischemic regions and extent of myocardial infarction. Serial measurement of blood flow to ischemic regions in dogs
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Circulation research | 1976 |
Transmural distribution of myocardial blood flow during systole in the awake dog
DS Hess, RJ Bache |
Circulation research | 1976 |
Distribution of myocardial blood flow in the exercising dog with restricted coronary artery inflow
RM Ball, RJ Bache |
Circulation research | 1976 |
Regional myocardial blood flow during graded treadmill exercise in the dog
RM Ball, RJ Bache, FR Cobb, JC Greenfield |
Journal of Clinical Investigation | 1975 |
Effects of nitroglycerin on transmural myocardial blood flow in the unanesthetized dog
RJ Bache, RM Ball, FR Cobb, JC Rembert, JC Greenfield |
Journal of Clinical Investigation | 1975 |
Three dimensional geometry of acutely ischemic myocardium
ML Marcus, RE Kerber, J Ehrhardt, FM Abboud |
Circulation | 1975 |
Temporal heterogeneity of myocardial blood flow in anesthetized dogs
HL Falsetti, RJ Carroll, ML Marcus |
Circulation | 1975 |
Uniformity of transmural perfusion in anesthetized dogs with maximally dilated coronary circulations
HF Downey, FA Bashour, RB Boatwright, PE Parker, SJ Kechejian |
Circulation research | 1975 |
Organic Nitrates
P Needleman |
1975 | |
Myocardial Blood Flow Distribution during Ischemia-Induced Coronary Vasodilation in the Unanesthetized Dog
RJ Bache, FR Cobb, JC Greenfield |
Journal of Clinical Investigation | 1974 |