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Citations to this article

Regional Myocardial Blood Flow in Awake Dogs
Frederick R. Cobb, … , Robert J. Bache, Joseph C. Greenfield Jr.
Frederick R. Cobb, … , Robert J. Bache, Joseph C. Greenfield Jr.
Published June 1, 1974
Citation Information: J Clin Invest. 1974;53(6):1618-1625. https://doi.org/10.1172/JCI107712.
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Research Article

Regional Myocardial Blood Flow in Awake Dogs

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Abstract

The objectives of this study were to test the hypothesis in awake dogs that during control conditions endocardial vessels are maximally dilated and to determine whether variables introduced by general anesthesia and thoracotomy modify distribution of myocardial blood flow or impair capacity for augmentation of flow in response to a coronary vasodilator stimulus. Myocardial blood flow was measured in relatively small, 2-3 g, left ventricular epicardial and endocardial samples by using 7-10-μm radioisotope-labeled microspheres during control conditions and during infusion of adenosine in dosages which produced maximum increases in coronary blood flow. Measurements were made initially in awake resting animals and were repeated after pentobarbital anesthesia, thoracotomy, and pericardiotomy.

Authors

Frederick R. Cobb, Robert J. Bache, Joseph C. Greenfield Jr.

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Total citations by year

Year: 2021 2019 2018 2015 2014 2013 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 1979 1978 1977 1976 1975 1974 Total
Citations: 2 3 1 1 1 1 1 3 2 1 1 2 3 1 2 6 5 3 6 4 8 6 7 6 13 10 10 9 8 7 6 1 140
Citation information
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Organic Nitrates
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