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Bacterial Growth In Vivo AN IMPORTANT DETERMINANT OF THE PULMONARY CLEARANCE OF DIPLOCOCCUS PNEUMONIAE IN RATS
Waldemar G. Johanson Jr., … , Stephen J. Jay, Alan K. Pierce
Waldemar G. Johanson Jr., … , Stephen J. Jay, Alan K. Pierce
Published May 1, 1974
Citation Information: J Clin Invest. 1974;53(5):1320-1325. https://doi.org/10.1172/JCI107679.
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Bacterial Growth In Vivo AN IMPORTANT DETERMINANT OF THE PULMONARY CLEARANCE OF DIPLOCOCCUS PNEUMONIAE IN RATS

Abstract

Lung clearance of Diplococcus pneumoniae was markedly reduced in rats with acute hemorrhagic pulmonary edema produced by instillation of hydrochloric acid. Bacterial clearance was enhanced in both control and acid-instilled animals by pretreatment with a bacteriostatic antibiotic, tetracycline, 30 mg/kg. From these data the contributions of bacterial multiplication and bacterial elimination to net lung bacterial clearance were estimated. In control animals the constant for exponential bacterial elimination was -1.4283 (fractional clearance = 76% per h), and the doubling time for the pneumococcus was 170 min. In acid-instilled rats the elimination constant was -0.5336 (fractional clearance = 41% per h), and the doubling time of the pneumococcus was 47 min, approximating the doubling time of 42 min observed with pneumococci grown in broth.

Authors

Waldemar G. Johanson Jr., Stephen J. Jay, Alan K. Pierce

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Citations to this article (27)

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S Ishizuka, M Yamaya, T Suzuki, K Nakayama, M Kamanaka, S Ida, K Sekizawa, H Sasaki 		American journal of respiratory cell and molecular biology 2001
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Aspiration-Induced Pulmonary Injury
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L Mier, D Dreyfuss, B Darchy, JJ Lanore, K Djedaïni, P Weber, P Brun, F Coste 		Intensive Care Medicine 1993
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WJ DePaso 		Clinics in Chest Medicine 1991
Recurrent Pneumonia
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Early clearance of pneumococci from the lungs of decomplemented rats
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Effect of Hydrogen Sulfide on Bacterial Inactivation in the Rat Lung
RE Rogers, J Ferin 		Archives of Environmental Health An International Journal 1981
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Optimal strategies in immunology III. The IgM-IgG switch
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Pulmonary aspiration
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Delayed pulmonary clearance of gram-negative bacteria: The role of intraperitoneal sepsis
JD Richardson, DE Fry, LV Arsdall, LM Flint 		Journal of Surgical Research 1979
Lung bacterial clearance in murine pneumococcal pneumonia
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C Balzs, M Szab, P Szerze, A Levey 		European Journal of Clinical Pharmacology 1977
Determinants of lung bacterial clearance in normal mice
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The Triple Threat of Aspiration Pneumonia
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