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Citations to this article

The Mechanism of Bicarbonate Secretion in Rabbit Ileum Exposed to Choleragen
Kenneth A. Hubel
Kenneth A. Hubel
Published April 1, 1974
Citation Information: J Clin Invest. 1974;53(4):964-970. https://doi.org/10.1172/JCI107662.
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Research Article

The Mechanism of Bicarbonate Secretion in Rabbit Ileum Exposed to Choleragen

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Abstract

Bicarbonate may be secreted into the intestinal lumen in cholera because: HCO3− ions are transported, or because OH− ions accumulate and react with dissolved CO2 to form HCO3−. If HCO3− ions are transported into the lumen from the interstitial fluid, lumenal PCO2 should increase (HCO3− ⇌ OH− + CO2); if OH− accumulates, PCO2 should diminish. Net movement of H2O, and HCO3−, and changes in pH and PCO2 in lumenal fluid were studied in adjacent segments of rabbit ileum in vivo, one of which was exposed to choleragen. 4 h after exposure, segments were drained and infused with gassed Krebs-Henseleit solution whose PCO2 exceeded arterial PCO2. After 45 min, fluid was collected anaerobically from control and cholera segments. Among 13 cholera segments, lumenal PCO2 diminished by a mean of 8.4 torr and was less than femoral arterial blood in six instances. In the paired control segments, mean PCO2 increased by 4.4 torr, and was always greater than arterial PCO2. Dilution could not account for the low PCO2 in cholera segments because in hypertonic solutions that caused water to move into the lumen, the PCO2 did not differ from control values obtained with isotonic solutions. The results suggest that OH− accumulation (by addition of OH− or removal of H+) causes HCO3− secretion in cholera. This does not result from secretion of some other base (e.g., HPO4−), because HCO3− accounts for most of the base in the lumenal fluid. The PCO2 changes suggest that OH− reacts with CO2 at the cell-lumen interface, but reaction at the cell-interstitial fluid interface cannot be excluded.

Authors

Kenneth A. Hubel

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Total citations by year

Year: 2020 2010 2008 1996 1995 1991 1988 1987 1983 1981 1980 1979 1978 1977 1976 1975 Total
Citations: 1 1 1 2 1 2 2 1 1 1 1 2 1 4 2 4 27
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (27)

Title and authors Publication Year
A mitochondria-targeted coenzyme Q peptoid induces superoxide dismutase and alleviates salinity stress in plant cells
KG Asfaw, Q Liu, X Xu, C Manz, S Purper, R Eghbalian, SW Münch, I Wehl, S Bräse, E Eiche, B Hause, I Bogeski, U Schepers, M Riemann, P Nick
Scientific Reports 2020
Current Topics in Membranes
TC Wagenknecht, Z Liu
Structure and Function of Calcium Release Channels 2010
Novartis Foundation Symposia
EJ Campbell
Ciba Foundation Symposium 44 - Research and Medical Practice: Their Interaction 2008
Cyclic Adenosine-3′,5′-Monophosphate Production Is Greater in Rabbit Duodenal Crypt Than in Villus Cells
M Amelsberg, A Amelsberg, MA Ainsworth, DL Hogan, JI Isenberg
Scandinavian Journal of Gastroenterology 1996
Molecular Biology of Membrane Transport Disorders
SG Schultz, TE Andreoli, AM Brown, DM Fambrough, JF Hoffman, MJ Welsh
1996
Dietary Fiber
BO Schneeman, LF Tinker
Pediatric Clinics of North America 1995
Mechanism of intestinal secretion. Effect of serotonin on rabbit ileal crypt and villus cells
U Sundaram, RG Knickelbein, JW Dobbins
Journal of Clinical Investigation 1991
Mechanism of intestinal secretion: effect of cyclic AMP on rabbit ileal crypt and villus cells
U Sundaram, RG Knickelbein, JW Dobbins
Proceedings of the National Academy of Sciences 1991
The effect of heat-stable Escherichia coli enterotoxin, theophylline and forskolin on cyclic nucleotide levels and mucosal surface (acid microclimate) pH in rat proximal jejunum in vivo
AT McKie, M Kusel, GT McEwan, ML Lucas
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1988
The effect of heat-stable escherichia coli enterotoxin, theophylline and forskolin on cyclic nucleotide levels and mucosal surface (acid microclimate) pH in rat proximal jejunum in vivo
AT McKie, M Kusel, GT McEwan, ML Lucas
Biochimica et Biophysica Acta (BBA) - Bioenergetics 1988
Membrane Transport Processes in Organized Systems
TE Andreoli, JF Hoffman, DD Fanestil, SG Schultz
1987
Colon
L Bustos-Fernández
1983
Chloride transport and intracellular chloride activity in the presence of theophylline in Amphiuma small intestine
JF White
The Journal of Physiology 1981
Absorption of Short-Chain Fatty Acids by the Colon
H Ruppin, S Bar-Meir, KH Soergel, CM Wood, MG Schmitt
Gastroenterology 1980
Inter-relationship of sodium, chloride, bicarbonate and acetate transport by the colon of the pig
RA Argenzio, SC Whipp
The Journal of Physiology 1979
Transport Organs
G Giebisch
1979
Physiology of Membrane Disorders
TE Andreoli, JF Hoffman, DD Fanestil
1978
Effect of heat stable and heat labile Escherichia coli enterotoxins, cholera toxin and theophylline on unidirectional sodium and chloride fluxes in the proximal and distal jejunum of weanling swine
DL Hamilton, WE Roe, NO Nielsen
Canadian journal of comparative medicine. Revue canadienne de médecine comparée 1977
HCO3 transport in rat jejunum: relationship to NaCl and H2O transport in vivo
RB Podesta, DF Mettrick
American journal of physiology. Endocrinology and metabolism 1977
Interrelationship of Na, HCO3, and volatile fatty acid transport by equine large intestine
RA Argenzio, M Southworth, JE Lowe, CE Stevens
American journal of physiology. Endocrinology and metabolism 1977
Absorption of short-chain fatty acids from the human ileum
MG Schmitt, KH Soergel, CM Wood, JJ Steff
The American Journal of Digestive Diseases 1977
Effect of aspirin on normal and cholera toxin-stimulated intestinal electrolyte transport
RK Farris, EJ Tapper, DW Powell, SM Morris
Journal of Clinical Investigation 1976
Ion Transport Changes During Calcitonin-Induced Intestinal Secretion in Man
TK Gray, P Brannan, D Juan, SG Morawski, JS Fordtran
Gastroenterology 1976
Effect of Klebsiella pneumoniae enterotoxin on intestinal transport in the rat
FA Klipstein, IR Horowitz, RF Engert, EA Schnenk
Journal of Clinical Investigation 1975
The mechanism of action of cholera toxin in pigeon erythrocyte lysates
RG Knickelbein, PS Aronson, JW Dobbins
Journal of Clinical Investigation 1975
The mechanism of action of cholera toxin in pigeon erythrocyte lysates
RG Knickelbein, PS Aronson, JW Dobbins
Journal of Clinical Investigation 1975
The mechanism of action of cholera toxin in pigeon erythrocyte lysates
RG Knickelbein, PS Aronson, JW Dobbins
Journal of Clinical Investigation 1975

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