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Vitamin B6 Metabolism in Chronic Alcohol Abuse: PYRIDOXAL PHOSPHATE LEVELS IN PLASMA AND THE EFFECTS OF ACETALDEHYDE ON PYRIDOXAL PHOSPHATE SYNTHESIS AND DEGRADATION IN HUMAN ERYTHROCYTES
Lawrence Lumeng, Ting-Kai Li
Lawrence Lumeng, Ting-Kai Li
Published March 1, 1974
Citation Information: J Clin Invest. 1974;53(3):693-704. https://doi.org/10.1172/JCI107607.
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Vitamin B6 Metabolism in Chronic Alcohol Abuse: PYRIDOXAL PHOSPHATE LEVELS IN PLASMA AND THE EFFECTS OF ACETALDEHYDE ON PYRIDOXAL PHOSPHATE SYNTHESIS AND DEGRADATION IN HUMAN ERYTHROCYTES

Abstract

The plasma pyridoxal-5′-phosphate (PLP) level of alcoholic subjects has been compared with that of non-alcoholic individuals in order to ascertain the incidence of abnormal vitamin B6 metabolism in chronic alcohol abuse. 66 alcoholic subjects were selected on the basis that they did not exhibit abnormal liver function tests and hematologic findings. 35 of them had plasma PLP concentrations less than 5 ng/ml, the lowest value encountered in 94 control subjects, indicating a high incidence of deranged PLP metabolism in alcoholic patients even when hepatic and hematologic abnormalities are absent. The biochemical basis for the altered PLP metabolism in chronic alcohol abuse was examined. Low plasma PLP levels in alcoholics were not accompanied by decreased pyridoxal kinase and pyridoxine phosphate oxidase activities in erythrocytes. Further studies with erythrocytes demonstrated that the cellular content of PLP is determined not only by the activities of these PLP-synthesizing enzymes but also by the activity of a phosphate-sensitive, membrane-associated, neutral phosphatase, which hydrolyzes phosphorylated B6 compounds.

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Lawrence Lumeng, Ting-Kai Li

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CS Lieber 		1976
Vitamin B6 metabolism in chronic alcohol abuse The effect of ethanol oxidation on hepatic pyridoxal 5'-phosphate metabolism
RL Vech, L Lumeng, TK Li 		Journal of Clinical Investigation 1975
THE PLATELET DEFECT IN ALCOHOLISM
DH Cowan 		Annals of the New York Academy of Sciences 1975
ALCOHOL AND HEMATOPOIESIS
RS Hillman 		Annals of the New York Academy of Sciences 1975
HEMATOLOGIC ABNORMALITIES INVOLVING VITAMIN B6AND FOLATE METABOLISM IN ALCOHOLIC SUBJECTS
JD Hines 		Annals of the New York Academy of Sciences 1975
Assay for human erythrocyte pyridoxine kinase
CJ Chern, E Beutler 		Analytical Biochemistry 1975
Sideroblasts, Siderocytes, and Sideroblastic Anemia
GE Cartwright, A Deiss 		New England Journal of Medicine 1975
Distribution of pyridoxal-5-phosphate in human blood between the cells and the plasma: Effect of oral administration of pyridoxine on the ratio in Down's and hyperactive patients
HN Bhagavan, M Coleman, DB Coursin 		Biochemical Medicine 1975
Maternal and fetal plasma levels of pyridoxal phosphate at term: Adequacy of vitamin B6 supplementation during pregnancy
RE Cleary, L Lumeng, TK Li 		American Journal of Obstetrics and Gynecology 1975
Serum pyridoxal in active peptic ulceration
CR Sanderson, RE Davis 		Gut 1975
Characterization of the pyridoxal 5'-phosphate and pyridoxamine 5'-phosphate hydrolase activity in rat liver. Identity with alkaline phosphatase
L Lumeng, TK Li 		The Journal of biological chemistry 1975
Regulation of pyridoxal 5′-phosphate metabolism in liver
TK Li, L Lumeng, RL Veitch 		Biochemical and Biophysical Research Communications 1974
Alkaline Phosphatase
MM Kaplan 		New England Journal of Medicine 1972

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