The interaction of human neutrophils adherent to plastic petri dishes with the purified chemotactic factors C5a and kallikrein increased their rate of aerobic glycolysis 25-120% and the activity of their hexose monophosphate shunt (HMPS) 100-600%, reaching a plateau after 2 hr at 37 degrees C. The stimulation of either pathway required a chemotactically active stimulus since neither C5 nor prekallikrein or inactivated kallikrein could enhance metabolic activity. Marked suppression of the neutrophil chemotactic response by preincubation with a chemotactic factor to achieve deactivation, 5 x 10(-7) M diisopropyl fluorophosphate, or the neutrophil immobilizing factor (NIF) did not prevent the stimulation of HMPS activity or glycolysis by chemotactic factors. The metabolic inhibitors iodoacetate and 6-aminonicotinamide at concentrations which blocked enhancement of glycolysis or HMPS activity, respectively, partially suppressed the chemotactic response of neutrophils to the chemotactic factors. The capacity of a chemotactic factor to stimulate glucose metabolism of human neutrophils is associated with a maximal chemotactic response, but this stimulation is not alone sufficient for chemotaxis.
E J Goetzl, K F Austen
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Complement
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Diabetic Medicine | 1986 |
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Mechanism of action of the group A streptococcal C5a inactivator
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Neutrophil oxygen reduction: The enzymes and the products
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Biochemical and Biophysical Research Communications | 1984 |
Immunodermatology
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Immunodermatology | 1984 |
Regulation of Leukocyte Function
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Experientia | 1983 |
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Pulmonary injury induced by phorbol myristate acetate following intravenous administration in rabbits. Acute respiratory distress followed by pulmonary interstitial pneumonitis and pulmonary fibrosis
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Cellular and Subcellular Mediators of Acute Inflammation
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Neue-Aspekte zur durchblutungssteigernden und insulinähnlichen Wirkung der Muskelarbeit: Mögliche Beteiligung des Kallikrein-Kinin-Prostaglandin Systems
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Klinische Wochenschrift | 1982 |
Modulation of the action of insulin in relation to the energy state in skeletal muscle tissue: Possible involvement of kinins and prostaglandins
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Molecular and Cellular Endocrinology | 1982 |
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Non-enzymatic extramicrosomal bioactivation of chemical carcinogens by phagocytes: A proposed new pathway
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Chemotactic activity generated from the fifth component of complement by plasma kallikrein of the rabbit
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Immunological Aspects of Rheumatology
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Eosinopenia of Acute Infection PRODUCTION OF EOSINOPENIA BY CHEMOTACTIC FACTORS OF ACUTE INFLAMMATION
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Biological effects of the human complement fragments C5a and C5ades Arg on neutrophil function
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Immunopharmacology | 1980 |
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Cutaneous infections and disorders of inflammation
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The Journal of Pediatrics | 1980 |
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Macrophages and Lymphocytes
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Inflammation: Mechanisms and Treatment: Proceedings of the Fourth International Meeting on Future Trends in Inflammation Organized by the European Biological Research Association and held in London, 18th–22nd February 1980
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1980 | |
Lectin-Mediated Induction of Human Neutrophil Chemotaxis, Chemokinesis, and Cap Formation
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Infection and immunity | 1980 |
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Journal of Clinical Investigation | 1979 |
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Phagocyte Chemotaxis
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Enhancement of human neutrophil bactericidal activity by chemotactic factors
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Infection and immunity | 1979 |
Enhancement of hexose uptake in human polymorphonuclear leukocytes by activated complement component C5a
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Proceedings of the National Academy of Sciences | 1979 |
Chemotactic deactivation of human neutrophils: possible relationship to stimulation of oxidative metabolism
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Infection and immunity | 1979 |
Superoxide production induced in rabbit polymorphonuclear leukocytes by synthetic chemotactic peptides and A23187
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The American Journal of Pathology | 1979 |
The in vitro effects of propranolol and atenolol on neutrophil motility and post-phagocytic metabolic activity
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Immunology | 1979 |
Cell Biology and Immunology of Leukocyte Function
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Cell Biology and Immunology of Leukocyte Function | 1979 |
Cell elastimetry in the study of normal and abnormal movement of human neutrophils
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Clinical Immunology and Immunopathology | 1979 |
Interrelationship between oxygen consumption, superoxide anion and hydrogen peroxide formation in phagocytosing guinea pig polymorphonuclear leucocytes
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Molecular and Cellular Biochemistry | 1979 |
CHEMOTAXIS IN CUTANEOUS DISEASE
MV Dahl |
International Journal of Dermatology | 1978 |
Chemotaxis by polymorphonuclear leukocytes
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The Journal of Cell Biology | 1978 |
The effect of chemotactic factors and agents which influence neutrophil movement on anaerobic glycolysis and hexose monophosphate shunt activity
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Immunology | 1978 |
Evaluation of various filter membranes for boyden-type leukocyte migration studies
TW Jungi |
Journal of Immunological Methods | 1978 |
Phagocytosis: A Review
MN Walters, JM Papadimitriou, WG Spector |
Critical Reviews in Toxicology | 1978 |
Stimulation of human eosinophil and neutrophil polymorphonuclear leukocyte chemotaxis and random migration by 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid
EJ Goetzl, JM Woods, RR Gorman |
Journal of Clinical Investigation | 1977 |
Acute inflammation. A review
GB Ryan, G Majno |
The American Journal of Pathology | 1977 |
Effects of tobacco smoke on chemotaxis and glucose metabolism of polymorphonuclear leukocytes
RB Bridges, JH Kraal, LJ Huang, BM Chancellor |
Infection and immunity | 1977 |
Effects of cigarette smoke components on in vitro chemotaxis of human polymorphonuclear leukocytes
RB Bridges, JH Kraal, LJ Huang, MB Chancellor |
Infection and immunity | 1977 |
Electron microscopic observations of the interaction of casein micelles and milk fat globules with bovine polymorphonuclear leucocytes during the phagocytosis of staphylococci in milk
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Journal of Comparative Pathology | 1977 |
H2O2 Generation in subcellular fractions of leukocytes assayed by cytochrome c peroxidase method
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FEBS Letters | 1977 |
Elaboration of toxic oxygen by-products by neutrophils in a model of immune complex disease
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Journal of Clinical Investigation | 1976 |
Metabolic perturbation of the inflammatory cells
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Agents and Actions | 1976 |
Membrane Receptors on Neutrophils
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Immunological Investigations | 1976 |
Modulation of human eosinophil polymorphonuclear leukocyte migration and function
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The American Journal of Pathology | 1976 |
Recognition and response in mononuclear and granular phagocytes
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Clinical & Experimental Immunology | 1976 |
Structural determinants of the eosinophil: chemotactic activity of the acidic tetrapeptides of eosinophil chemotactic factor of anaphylaxis
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Journal of Experimental Medicine | 1976 |
A Chemotactic Receptor for VAL(ALA)-GLY-SER-GLU on Human Eosinophil Polymorphonuclear Leukocytes
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Immunological Investigations | 1976 |
Immunobiology of the Macrophage
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Immunobiology of the Macrophage | 1976 |
Molecular and Biological Aspects of the Acute Allergic Reaction
SG Johansson, K Strandberg, B Uvnäs |
1976 | |
The Reticuloendothelial System in Health and Disease
SM Reichard, MR Escobar, H Friedman |
1976 | |
H2O2 release from human granulocytes during phagocytosis. I. Documentation, quantitation, and some regulating factors
RK Root, J Metcalf, N Oshino, B Chance |
Journal of Clinical Investigation | 1975 |
The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes
RB Johnston, BB Keele, HP Misra, JE Lehmeyer, LS Webb, RL Baehner, KV RaJagopalan |
Journal of Clinical Investigation | 1975 |
Stimulation of human neutrophils by soluble and insoluble immunoglobulin aggregates. Secretion of granule constituents and increased oxidation of glucose
PM Henson, ZG Oades |
Journal of Clinical Investigation | 1975 |
Activation and control mechanisms of Hageman factor-dependent pathways of coagulation, fibrinolysis, and kinin generation and their contribution to the inflammatory response
AP Kaplan, KF Austen |
Journal of Allergy and Clinical Immunology | 1975 |
Polymorphonuclear leukocyte chemotaxis in the absence of oxygen
JH Kraal, EB Kenney |
Journal of Periodontal Research | 1975 |
LASMA AND CELL-DERIVED INHIBITORS OF HUMAN NEUTROPHIL CHEMOTAXIS
EJ Goetzl |
Annals of the New York Academy of Sciences | 1975 |
Modulation of human neutrophil polymorphonuclear leucocyte migration by human plasma alpha-globulin inhibitors and synthetic esterase inhibitors
EJ Goetzl |
Immunology | 1975 |
Stimulation of glucose oxidation in human polymorphonuclear leucocytes by C3-sepharose and soluble C
F Tedesco, S Trani, MR Soranzo, P Patriarca |
FEBS Letters | 1975 |
Leucocyte Chemotaxis: Physiological Considerations and Abnormalities
JI Gallin, SM Wolff |
Clinics in Haematology | 1975 |
Enhancement of Random Migration and Chemotactic Response of Human Leukocytes by Ascorbic Acid
EJ Goetzl, SI Wasserman, I Gigli, KF Austen |
Journal of Clinical Investigation | 1974 |
Modulation of the Random Migration of Human Platelets
FH Valone, KF Austen, EJ Goetzl |
Journal of Clinical Investigation | 1974 |
Effects of Corticosteroids on Human Monocyte Function
JJ Rinehart, SP Balcerzak, AL Sagone, AF LoBuglio |
Journal of Clinical Investigation | 1974 |
Leukotaxis and leukotactic disorders. A review
PA Ward |
The American Journal of Pathology | 1974 |