This study was designed to determine the effect of in vivo hydrocortisone on subpopulations of lymphoid cells in normal humans. Subjects received a single intravenous dose of either 100 mg or 400 mg of hydrocortisone, and blood was drawn at hourly intervals for 6 h, and then again at 10 and 24 h after injection. Profound decreases in absolute numbers of circulating lymphocytes and monocytes occurred at 4-6 h after both 100 mg and 400 mg of hydrocortisone. Counts returned to normal by 24 h. The relative proportion of circulating thymus-derived lymphocytes as measured by the sheep red blood cell rosette assay decreased maximally by 4 h and returned to base line 24 h after hydrocortisone. There was a selective depletion of functional subpopulations of lymphocytes as represented by differential effects on in vitro stimulation with various mitogens and antigens. Phytohaemagglutinin response was relatively unaffected, while responses to concanavalin A were significantly diminished. Responses to pokeweed mitogen were unaffected by 100 mg of hydrocortisone, but greatly diminished by 400 mg of hydrocortisone. In vitro responses to the antigens streptokinase-streptodornase and tetanus toxoid were markedly diminished by in vivo hydrocortisone. Reconstitution of monocyte-depleted cultures with autologous monocytes partially corrected the diminished response to antigens. This transient selective depletion of monocytes and subsets of human lymphocytes by a single dose of hydrocortisone is most compatible with a redistribution of these cells out of the circulation into other body compartments.
Anthony S. Fauci, David C. Dale
Year: | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990 | 1989 | 1988 | 1987 | 1986 | 1985 | 1984 | 1983 | 1982 | 1981 | 1980 | 1979 | 1978 | 1977 | 1976 | 1975 | 1974 | 1969 | Total |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Citations: | 2 | 1 | 1 | 3 | 6 | 4 | 2 | 4 | 4 | 7 | 2 | 7 | 5 | 4 | 5 | 2 | 6 | 5 | 2 | 2 | 2 | 1 | 2 | 5 | 2 | 5 | 6 | 8 | 6 | 8 | 7 | 11 | 16 | 16 | 11 | 9 | 16 | 11 | 14 | 14 | 18 | 20 | 15 | 23 | 19 | 19 | 18 | 20 | 27 | 20 | 16 | 4 | 1 | 464 |
Title and authors | Publication | Year |
---|---|---|
The American Society for Clinical Investigation, the Spring Meetings and Growing Up in Academic Medicine: A Personal Perspective
Anthony S. Fauci |
Journal of Clinical Investigation | 2008 |
The use of leukocyte profiles to measure stress in vertebrates: a review for ecologists
AK Davis, DL Maney, JC Maerz |
Functional Ecology | 2008 |
Psychoneuroimmunology
F Tausk, I Elenkov, J Moynihan |
Dermatologic Therapy | 2008 |
Development of a swine model of secondary liver tumor from a genetically induced swine fibroblast cell line
R Abbas, SJ Adam, S Okadal, H Groar, J Anderson, J Sanabria |
HPB : the official journal of the International Hepato Pancreato Biliary Association | 2008 |
Enhancing versus Suppressive Effects of Stress on Immune Function: Implications for Immunoprotection versus Immunopathology
FS Dhabhar |
Allergy Asthma & Clinical Immunology | 2008 |