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Citations to this article

The Effect of In Vivo Hydrocortisone on Subpopulations of Human Lymphocytes
Anthony S. Fauci, David C. Dale
Anthony S. Fauci, David C. Dale
Published January 1, 1974
Citation Information: J Clin Invest. 1974;53(1):240-246. https://doi.org/10.1172/JCI107544.
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The Effect of In Vivo Hydrocortisone on Subpopulations of Human Lymphocytes

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Abstract

This study was designed to determine the effect of in vivo hydrocortisone on subpopulations of lymphoid cells in normal humans. Subjects received a single intravenous dose of either 100 mg or 400 mg of hydrocortisone, and blood was drawn at hourly intervals for 6 h, and then again at 10 and 24 h after injection. Profound decreases in absolute numbers of circulating lymphocytes and monocytes occurred at 4-6 h after both 100 mg and 400 mg of hydrocortisone. Counts returned to normal by 24 h. The relative proportion of circulating thymus-derived lymphocytes as measured by the sheep red blood cell rosette assay decreased maximally by 4 h and returned to base line 24 h after hydrocortisone. There was a selective depletion of functional subpopulations of lymphocytes as represented by differential effects on in vitro stimulation with various mitogens and antigens. Phytohaemagglutinin response was relatively unaffected, while responses to concanavalin A were significantly diminished. Responses to pokeweed mitogen were unaffected by 100 mg of hydrocortisone, but greatly diminished by 400 mg of hydrocortisone. In vitro responses to the antigens streptokinase-streptodornase and tetanus toxoid were markedly diminished by in vivo hydrocortisone. Reconstitution of monocyte-depleted cultures with autologous monocytes partially corrected the diminished response to antigens. This transient selective depletion of monocytes and subsets of human lymphocytes by a single dose of hydrocortisone is most compatible with a redistribution of these cells out of the circulation into other body compartments.

Authors

Anthony S. Fauci, David C. Dale

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Citations to this article in year 2008 (5)

Title and authors Publication Year
The American Society for Clinical Investigation, the Spring Meetings and Growing Up in Academic Medicine: A Personal Perspective
Anthony S. Fauci
Journal of Clinical Investigation 2008
The use of leukocyte profiles to measure stress in vertebrates: a review for ecologists
AK Davis, DL Maney, JC Maerz
Functional Ecology 2008
Psychoneuroimmunology
F Tausk, I Elenkov, J Moynihan
Dermatologic Therapy 2008
Development of a swine model of secondary liver tumor from a genetically induced swine fibroblast cell line
R Abbas, SJ Adam, S Okadal, H Groar, J Anderson, J Sanabria
HPB : the official journal of the International Hepato Pancreato Biliary Association 2008
Enhancing versus Suppressive Effects of Stress on Immune Function: Implications for Immunoprotection versus Immunopathology
FS Dhabhar
Allergy Asthma & Clinical Immunology 2008

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