Citations to this article

Periodic Hematopoiesis in Human Cyclic Neutropenia
D. Guerry IV, … , S. Perry, S. M. Wolff
D. Guerry IV, … , S. Perry, S. M. Wolff
Published December 1, 1973
Citation Information: J Clin Invest. 1973;52(12):3220-3230. https://doi.org/10.1172/JCI107522.
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Research Article

Periodic Hematopoiesis in Human Cyclic Neutropenia

Abstract

Human cyclic neutropenia is characterized by severe depression of blood neutrophil levels approximately every 21 days. To investigate the mechanism of cyclic neutropenia four patients were studied with daily complete blood counts, serial bone marrow examinations, marrow reserve testing, serum muramidase determinations, DF22P granulocytokinetic studies, and, in one patient, in vivo [3H]TdR labeling. Periodogram analysis of the serial blood counts in the latter patient and visual inspection of multiple cycles in the others revealed periodic fluctuations in the levels of blood neutrophils, monocytes, lymphocytes, reticulocytes, and platelets. Rhythmic changes in the morphologic and radioisotopic studies as well as the marrow reserve tests and muramidase measurements were consonant with a mechanism of periodic failure of marrow production rather than peripheral destruction. Human cyclic neutropenia is analogous to cyclic neutropenia in the grey collie dog and may be viewed as the consequence of cyclic hematopoiesis.

Authors

D. Guerry IV, D. C. Dale, M. Omine, S. Perry, S. M. Wolff

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ORAL FINDINGS AND TREATMENT OF A PATIENT WITH CYCLIC NEUTROPENIA
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M Adimy, F Crauste 		Mathematical Modelling of Natural Phenomena 2012
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S Balamuralitharan, S Rajasekaran 		American Journal of Computational Mathematics 2012
A Model of Oscillatory Blood Cell Counts in Chronic Myelogenous Leukaemia
I Drobnjak, AC Fowler 		Bulletin of Mathematical Biology 2011
PERIODIC FEVER SYNDROMES AND OTHER INHERITED AUTOINFLAMMATORY DISEASES
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Multistability in an age-structured model of hematopoiesis: Cyclical neutropenia
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Hematopoietic Growth Factors in Oncology
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Hematopoietic Growth Factors in Oncology
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Hematopoietic Growth Factors in Oncology
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Hematopoietic Growth Factors in Oncology
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Hematopoietic Growth Factors in Oncology
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S Roy-Ghanta, JS Orange 		Clinical Reviews in Allergy & Immunology 2009
Dynamic hematological disease: a review
C Foley, MC Mackey 		Journal of Mathematical Biology 2008
Phagocyte dysfunction and inflammatory bowel disease
FZ Rahman, DJ Marks, BH Hayee, AM Smith, SL Bloom, AW Segal 		Inflammatory Bowel Diseases 2008
G-CSF treatment of canine cyclical neutropenia: A comprehensive mathematical model
C Colijn, C Foley, MC Mackey 		Experimental Hematology 2007
Cyclical mobilization and gated importation of thymocyte progenitors in the adult mouse: evidence for a thymus-bone marrow feedback loop
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I Drobnjak, AC Fowler, MC Mackey 		SIAM Journal on Applied Mathematics 2006
Cost-effective G-CSF therapy strategies for cyclical neutropenia: Mathematical modelling based hypotheses
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A mathematical model of hematopoiesis: II. Cyclical neutropenia
C Colijn, MC Mackey 		Journal of Theoretical Biology 2005
Update on childhood neutropenia: molecular and clinical advances
Y Dror, L Sung 		Hematology/Oncology Clinics of North America 2004
Bifurcations in a white-blood-cell production model
S Bernard, J Bélair, MC Mackey 		Comptes Rendus Biologies 2004
Systemic disease and periodontitis: manifestations of neutrophil dysfunction
DE Deas, SA Mackey, HT McDonnell 		Periodontology 2000 2003
Analysis of cell kinetics using a cell division marker: mathematical modeling of experimental data
S Bernard, L Pujo-Menjouet, MC Mackey 		Biophysical Journal 2003
Analysis of Cell Kinetics Using a Cell Division Marker: Mathematical Modeling of Experimental Data
S Bernard, L Pujo-Menjouet, MC Mackey 		Biophysical Journal 2003
Oscillations in cyclical neutropenia: new evidence based on mathematical modeling
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Cyclic neutropenia
DC Dale, AA Bolyard, A Aprikyan 		Seminars in Hematology 2002
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Clinical Implications of Mutations of Neutrophil Elastase in Congenital and Cyclic Neutropenia
DC Dale, WC Liles, D Garwicz, AG Aprikyan 		Journal of Pediatric Hematology/Oncology 2001
Cyclic Neutropenia: An Unusual Disorder of Granulopoiesis Effectively Treated with Recombinant Granulocyte Colony-Stimulating Factor
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Mutations in the neutrophil elastase gene in cyclic and congenital neutropenia
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R Lakshman, A Finn 		Journal of clinical pathology 2001
CYCLIC RED BLOOD CELL DESTRUCTION IN THALASSEMIA
U Giani, A Filosa 		Chronobiology International 2001
Impaired survival of bone marrow hematopoietic progenitor cells in cyclic neutropenia
AA Aprikyan, WC Liles, E Rodger, M Jonas, EY Chi, DC Dale 		Blood 2001
Hematopoietic dynamics in grey collies
C Haurie, R Person, DC Dale, MC Mackey 		Experimental Hematology 1999
Occurrence of periodic oscillations in the differential blood counts of congenital, idiopathic, and cyclical neutropenic patients before and during treatment with G-CSF
C Haurie, DC Dale, MC Mackey 		Experimental Hematology 1999
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U Heiden 		Medizinische Klinik 1998
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Mathematische Grundlagen der Medizin
U an der Heiden 		Medizinische Klinik 1998
Physiology and Pharmacology of Biological Rhythms
PH Redfern, B Lemmer 		1997
The effect of continuous G-CSF application in human cyclic neutropenia: a model analysis
S Schmitz, H Franke, HE Wichmann, V Diehl 		British Journal of Haematology 1995
Phagocytosis
EJ Brown 		BioEssays 1995
Reduced variance of bone-marrow transit time of granulopoiesis—a possible pathomechanism of human cyclic neutropenia
S Schmitz, H Franke, M Loeffler, HE Wichmann, V Diehl 		Cell Proliferation 1994
Cyclic Neutropenia: Natural History and Effects of Long-Term Treatment with Recombinant Human Granulocyte Colony-Stimulating Factor
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Self-Organization and Clinical Psychology
W Tschacher, G Schiepek, EJ Brunner 		1992
Fatal human cyclical neutropenia with unresolving tonsillitis and bilateral cervical abscesses
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Therapie innerer Krankheiten
G Riecker 		1991
Severe combined immune deficiency presenting with cyclic hematopoiesis
AK Junker, MC Poon, DI Hoar, PC Rogers 		Journal of Clinical Immunology 1991
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Abnormal responses of myeloid progenitor cells to granulocyte-macrophage colony-stimulating factor in human cyclic neutropenia
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Treatment of Cyclic Neutropenia with Granulocyte Colony-Stimulating Factor
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Cyclic neutropenia: A clinical review
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Oscillations in blood cells as a consequence of suppressed bone marrow cell production
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1/f-Like Scaling in Normal Neutrophil Dynamics: Implications for Hematologic Monitoring
AL Goldberger, K Kobalter, V Bhargava 		IEEE Transactions on Biomedical Engineering 1986
Cyclic neutropenia as a premalignant manifestation of acute lymphoblastic leukemia
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Adult-onset cyclic neutropenia is a benign neoplasm associated with clonal proliferation of large granular lymphocytes
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Canine cyclic hematopoiesis: Alterations in T lymphocyte subpopulations in peripheral blood, lymph nodes, and thymus of gray collie dogs
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Cyclical eosinophilia: a manifestation of periodic haemopoiesis?
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Increase in the haemolytic complement activity of dogs affected with cyclic haematopoiesis
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E Haus, DJ Lakatua, J Swoyer, L Sackett-Lundeen 		American Journal of Anatomy 1983
Cycling of peripheral blood and marrow lymphocytes in cyclic neutropenia
D Engelhard, KS Landreth, N Kapoor, PW Kincade, LE de Bault, A Theodore, RA Good 		Proceedings of the National Academy of Sciences 1983
Periodic neutropenia and monocytopenia
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DS Verma, G Spitzer, AR Zander, KA Dicke, KB McCredie 		Leukemia Research 1982
Oral manifestation in cyclic neutropenia
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T-lymphocyte cycling in human cyclic neutropenia: Effects of lithium in vitro and in vivo
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Effect of Oxymetholone on Human Cyclic Haematopoiesis
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Childhood Neutropenia
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Oscillations of Granulocytic and Megakaryocytic Progenitor Cell Populations in Cyclic Neutropenia in Man
N Jacobsen, HE Broxmeyer 		Scandinavian Journal of Haematology 1979
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RB Andrews, CD Dunn, J Jolly, JB Jones, RD Lange 		Scandinavian Journal of Haematology 1979
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D Bergsma 		Birth Defects Compendium 1979
The Child with Neutropenia
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Cell Kinetics in Human Cyclic Neutropenia
C Dresch, D Thevenieau, H Castro-Malaspina, A Faille 		Scandinavian Journal of Haematology 1977
Oscillation and Chaos in Physiological Control Systems
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Levamisole treatment of a child with severe aphthous stomatitis and neutropenia
H Verhaegen, JD Cree, WD Cock, J Brugmans 		Postgraduate medical journal 1976
Clinical uses of semi-solid bone marrow cultures
WA Robinson, OG Stonington 		Blut Zeitschrift für die Gesamte Blutforschung 1976
A mathematical model of neutrophil production and control in normal man
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WW Jedrzejczak 		Blut Zeitschrift für die Gesamte Blutforschung 1975
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JW Athens 		Clinics in Haematology 1975
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HJ Hoffman, D Guerry, DC Dale 		Journal of Interdisiplinary Cycle Research 1974

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