Citations to this article

Effect of Luminal Sodium Concentration on Bicarbonate Absorption in Rat Jejunum
Kenneth A. Hubel
Kenneth A. Hubel
Published December 1, 1973
Citation Information: J Clin Invest. 1973;52(12):3172-3179. https://doi.org/10.1172/JCI107517.
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Research Article

Effect of Luminal Sodium Concentration on Bicarbonate Absorption in Rat Jejunum

Abstract

An exchange of Na+ for H+ has been proposed to explain why jejunal Na+ absorption is influenced by luminal concentrations of H+ and HCO3-. We studied the influence of luminal Na+ concentration on net HCO3- absorption by perfusing rat jejunum in vivo. When Na+ was omitted from the perfusion fluid, HCO3- absorption diminished by a fixed amount over a range of initial HCO3- concentrations of 15 to 80 mM. This change was not caused by alterations in transmural PD or direction of water movement. Because the rate of HCO3- absorption decreased as the luminal HCO3- concentration lessened, Na+-dependent HCO3- absorption accounted for an increasing percent of total absorption as the luminal concentration of HCO3- diminished.

Authors

Kenneth A. Hubel

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Year: 2019 2013 2012 2008 2005 2001 1999 1990 1987 1984 1982 1980 1979 1978 1977 1976 Total
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Citations to this article (26)

Title and authors Publication Year
Expression, Localization, and Effect of High Salt Intake on Electroneutral Na+/HCO3– Cotransporter NBCn2 in Rat Small Intestine: Implication in Intestinal NaCl Absorption
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