Citations to this article

Calcium-Mobilizing Effect of Large Doses of 25-Hydroxycholecalciferol in Anephric Rats
Henriette Pavlovitch, … , Michele Garabedian, Sonia Balsan
Henriette Pavlovitch, … , Michele Garabedian, Sonia Balsan
Published October 1, 1973
Citation Information: J Clin Invest. 1973;52(10):2656-2659. https://doi.org/10.1172/JCI107458.
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Calcium-Mobilizing Effect of Large Doses of 25-Hydroxycholecalciferol in Anephric Rats

Abstract

The effect of high doses of 25-hydroxycholecalciferol on plasma calcium concentration was studied in rats receiving a low-calcium normal vitamin D diet. In bilaterally nephrectomized animals, as in sham-operated controls, 62.5 nmol of 25-hyroxycholecalciferol did not produce a rise of plasma calcium concentration. In contrast, the administration of 125 or 625 nmol, doses 1,000-5,000 times the minimal active dose in D-deficient rats, was followed in both groups of animals by a significant increase of plasma calcium concentration. Removal of either parathyroids alone or parathyroid and thyroid glands did not suppress this effect. These data suggest that when large doses are used in vivo, the renal conversion of 25-hydroxycholecalciferol to more polar metabolites is not an obligatory step for its calcium-mobilizing action. The present study does not elucidate, however, the exact mechanism(s) of this effect.

Authors

Henriette Pavlovitch, Michele Garabedian, Sonia Balsan

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Year: 2015 2013 2010 1988 1987 1983 1981 1980 1979 1978 1977 1976 1975 1974 Total
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Citations to this article (33)

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