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Citations to this article

A Collagen Defect in Homocystinuria
Andrew H. Kang, Robert L. Trelstad
Andrew H. Kang, Robert L. Trelstad
Published October 1, 1973
Citation Information: J Clin Invest. 1973;52(10):2571-2578. https://doi.org/10.1172/JCI107449.
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Research Article Article has an altmetric score of 1

A Collagen Defect in Homocystinuria

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Abstract

The biochemical mechanism accounting for the connective tissue abnormalities in homocystinuria was explored by examining the effects of various amino acids known to accumulate in the plasma of patients with this disease on cross-link formation in collagen. Neutral salt solutions of purified, rat skin collagen, rich in cross-link precursor aldehydes, were polymerized to native type fibrils by incubating at 37°C in the presence of homocysteine, homocystine, or methionine. After the polymerization was completed, each sample was examined for the formation of covalent intermolecular cross-links, assessed indirectly by solubility tests and directly by measuring the cross-link compounds after reduction with tritiated sodium borohydride and hydrolysis.

Authors

Andrew H. Kang, Robert L. Trelstad

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Total citations by year

Year: 2025 2023 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2002 2001 2000 1999 1998 1997 1996 1995 1993 1992 1990 1989 1988 1987 1985 1983 1982 1981 1980 1979 1978 1977 1976 1975 1974 1943 Total
Citations: 2 1 3 1 1 1 3 4 1 4 7 1 3 3 4 6 6 2 3 4 5 1 3 1 1 3 2 1 1 2 2 2 2 2 1 3 3 2 3 4 1 3 5 2 7 1 123
Citation information
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Citations to this article in year 2009 (4)

Title and authors Publication Year
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus
M Saito, K Marumo
Osteoporosis International 2009
Raloxifene ameliorates detrimental enzymatic and nonenzymatic collagen cross-links and bone strength in rabbits with hyperhomocysteinemia
M Saito, K Marumo, S Soshi, Y Kida, C Ushiku, A Shinohara
Osteoporosis International 2009
The relation of plasma homocysteine to radiographic knee osteoarthritis
M Fayfman, J Niu, YQ Zhang, DT Felson, B Sack, P Aliabadi, J Selhub, DJ Hunter
Osteoarthritis and Cartilage 2009

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