Citations to this article

Mediation of Cytotoxic Effects of Streptococcal M Protein by Nontype-Specific Antibody in Human Sera
Edwin H. Beachey, Gene H. Stollerman
Edwin H. Beachey, Gene H. Stollerman
Published October 1, 1973
Citation Information: J Clin Invest. 1973;52(10):2563-2570. https://doi.org/10.1172/JCI107448.
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Mediation of Cytotoxic Effects of Streptococcal M Protein by Nontype-Specific Antibody in Human Sera

Abstract

The cytotoxic moiety(ies) in highly purified streptococcal M protein has been shown to be distinct from the type-specific M determinant. This nontype-specific M-associated determinant(s) (NTSM) causes humoral and cellular immunotoxic responses in man. NTSM is common to M protein prepared from all streptococcal serotypes studied so far. In this study, immunoabsorbents prepared by entrapping purified M proteins in polyacrylamide gel were employed to identify, separate, and purify antibodies directed against NTSM as well as against the type-specific M (TSM) determinants.

Authors

Edwin H. Beachey, Gene H. Stollerman

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Year: 2019 2003 2000 1999 1997 1996 1991 1990 1988 1984 1983 1982 1981 1979 1978 1977 1976 1975 1974 Total
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Citation information

Citations to this article (29)

Title and authors Publication Year
Molecular Mimicry, Autoimmunity, and Infection: The Cross-Reactive Antigens of Group A Streptococci and their Sequelae
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VA Fischetti, RP Novick, JJ Ferretti, DA Portnoy, M Braunstein, JI Rood 		2019
New Bacterial Vaccines
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Pathogenesis of group A streptococcal infections
MW Cunningham 		Clinical microbiology reviews 2000
Reactivity of Rheumatic Fever and Scarlet Fever Patients' Sera with Group A Streptococcal M Protein, Cardiac Myosin, and Cardiac Tropomyosin: a Retrospective Study
AD O'Brien, KF Jones, SS Whitehead, MW Cunningham, VA Fischetti 		Infection and immunity 2000
Stress Proteins
DS Latchman 		1999
Preferential recognition of human myocardial antigens by T lymphocytes from rheumatic heart disease patients
M El-Demellawy, R El-Ridi, NI Guirguis, MA Alim, A Kotby, M Kotb 		Infection and immunity 1997
Microorganisms and Autoimmune Diseases
H Friedman, NR Rose, M Bendinelli 		1996
Heat-Shock Proteins as Immunogenic Bacterial Antigens with the Potential to Induce and Regulate Autoimmune Arthritis
W Eden 		Immunological Reviews 1991
Rheumatogenic streptococci and autoimmunity
GH Stollerman 		Clinical Immunology and Immunopathology 1991
The Role of Micro-organisms in Non-infectious Diseases
RR de Vries, IR Cohen, JJ van Rood 		1990
Bacteria, Complement and the Phagocytic Cell
FC Cabello, C Pruzzo 		1988
Induction of human gamma interferon by structurally defined polypeptide fragments of group A streptococcal M protein
DA Weigent, EH Beachey, T Huff, JW Peterson, GJ Stanton, S Baron 		Infection and immunity 1984
Common protective antigens of group A streptococcal M proteins masked by fibrinogen
E Whitnack, JB Dale, EH Beachey 		Journal of Experimental Medicine 1984
Streptococcal rheumatic carditis
SK Unny, BL Middlebrooks 		Microbiological reviews 1983
Septicaemia: A Symposium Held in Stockholm, Sweden September 5–6, 1980
S Holm, A Lindberg, CE Nord, R Norrby 		Scandinavian Journal of Infectious Diseases 1982
Immunology of Human Infection
AJ Nahmias, RJ OReilly 		1981
Human immune response to immunization with a structurally defined polypeptide fragment of streptococcal M protein
EH Beachey, GH Stollerman, RH Johnson, I Ofek, AL Bisno 		Journal of Experimental Medicine 1979
Repeating covalent structure of streptococcal M protein
EH Beachey, JM Seyer, AH Kang 		Proceedings of the National Academy of Sciences 1978
Streptococcal M protein extracted by nonionic detergent. II. Analysis of the antibody response to the multiple antigenic determinants of the M-protein molecule
VA Fischetti 		Journal of Experimental Medicine 1977
Common (non-type-specific) antigens of group A streptococci
IM Lyampert, SG Shuratova, VV Akimova, VP Bukhova, VY Kolesnikova 		Infection and immunity 1977
Purification and properties of M protein extracted from group A streptococci with pepsin: covalent structure of the amino terminal region of type 24 M antigen
EH Beachey, GH Stollerman, EY Chiang, TM Chiang, JM Seyer, AH Kang 		Journal of Experimental Medicine 1977
Interaction of lipoteichoic acid of group A streptococci with human platelets
EH Beachey, TM Chiang, I Ofek, AH Kang 		Infection and immunity 1977
Antigenicity of the M proteins of group A hemolytic streptococci: further evidence for shared determinants among serotypes
MK Wittner 		Infection and immunity 1976
Characterization of a non-type-specific antigen(s) associated with group A streptococcal type 12 M protein
KL Vosti 		Infection and immunity 1975
The cell surface antigens of Streptococcus equi
ED Erickson, NL Norcross 		Canadian journal of comparative medicine. Revue canadienne de médecine comparée 1975
Evaluation of micro complement fixation tests for antibodies against group A streptococcal M and M-associated antigens in rabbit and human sera
EH Beachey, I Ofek, M Cunningham, A Bisno 		Applied microbiology 1974
Peptic Digestion of Streptococcal M Protein I. Effect of Digestion at Suboptimal pH upon the Biological and Immunochemical Properties of Purified M Protein Extracts
MW Cunningham, EH Beachey 		Infection and immunity 1974
Peptic Digestion of Streptococcal M Protein II. Extraction of M Antigen from Group A Streptococci With Pepsin
EH Beachey, GL Campbell, I Ofek 		Infection and immunity 1974

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