Citations to this article

Histamine Release Induced by Human Leukocyte Lysates REABSORPTION OF PREVIOUSLY RELEASED HISTAMINE AFTER EXPOSURE TO CYCLIC AMP-ACTIVE AGENTS
Michael T. Kelly, Arthur White
Michael T. Kelly, Arthur White
Published August 1, 1973
Citation Information: J Clin Invest. 1973;52(8):1834-1840. https://doi.org/10.1172/JCI107365.
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Research Article

Histamine Release Induced by Human Leukocyte Lysates REABSORPTION OF PREVIOUSLY RELEASED HISTAMINE AFTER EXPOSURE TO CYCLIC AMP-ACTIVE AGENTS

Abstract

The role of cyclic AMP in histamine release induced by human leukocyte lysates was investigated. Leukocytes were incubated with leukocyte lysates prepared by ultrasonic disruption, and histamine was determined fluorimetrically. Several cyclic AMP-active agents had a marked inhibitory effect on histamine release. Theophylline and isoproterenol produced 50% inhibition at concentrations of less than 10-5 M. Prostaglandin E1 and dibutyryl cyclic AMP inhibited release by 50% at 7 × 10-8 M and 6 × 10-5 M concentrations, respectively. Histamine, which has recently been shown to increase leukocyte cyclic AMP, had a pronounced inhibitory effect on lysate-induced histamine release, producing 50% inhibition at a concentration of only 2.5 × 10-12 M.

Authors

Michael T. Kelly, Arthur White

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Total citations by year

Year: 2011 1982 1979 1978 1977 1975 1974 Total
Citations: 1 1 1 1 1 1 2 8
Citation information

Citations to this article (8)

Title and authors Publication Year
Annual Reports in Medicinal Chemistry
JJ Liu, TW Lee 		Annual Reports in Medicinal Chemistry Volume 46 2011
Effect of purine nucleotides and other compounds on the uptake of histamine and histidine
ES Assem 		Agents and Actions 1982
Polymorphonuclear leukocyte dysfunction in children with recurrent otitis media
GS Giebink, EL Mills, JS Huff, KL Cates, SK Juhn, PG Quie 		The Journal of Pediatrics 1979
Accumulation of histamine and cyclic nucleotides in lung tissue during chronic hypobaric hypoxia
N Völkel, E Kaukel, J Trautmann 		Lung 1978
Clinical conditions associated with defective polymorphonuclear leukocyte chemotaxis
PG Quie, KL Cates 		The American Journal of Pathology 1977
Histamine-an important mediator for the Euler-Liljestrand mechanism?
N Völkel, W Duschek, E Kaukel, W Beier, S Siemssen, V Sill 		Lung 1975
An Inhibitor of Histamine Release from Human Leukocytes
MT Kelly, A White 		Journal of Clinical Investigation 1974
DEFECT IN NEUTROPHIL GRANULOCYTE CHEMOTAXIS IN JOB'S SYNDROME OF RECURRENT "COLD" STAPHYLOCOCCAL ABSCESSES
HR Hill, PG Quie, HF Pabst, HD Ochs, RA Clark, SJ Klebanoff, RJ Wedgwood 		The Lancet 1974

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