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Abstract
The response of ventilation and of heart rate to hypoxia and hypercapnia was determined in eight young normal men age 22-30 yr and eight elderly men age 64-73. The elderly men were selected and carefully screened to eliminate the possibility of cardiopulmonary disease. All the subjects were born at low altitude and had no significant prior exposure to hypoxia. The ventilatory response to hypoxia was measured as the exponential slope constant. k, of regression lines relating the logarithm of incremental ventilation to PAo2 during isocapnic progressive hypoxia. The heart rate response to hypoxia was measured as the percentage change in heart rate between PAo2 = 100 and PAo2 = 40 mm Hg. The ventilatory response to hypercapnia was measured as the slope of regression lines relating ventilation to PAco2 during rebreathing with PAo2 > 200 mm Hg. The heart rate response to hypercapnia was measured as the percentage change in heart rate between control values at the start of the rebreathing test and PACO2 = 55 mm Hg.
Authors
Richard S. Kronenberg, Charles W. Drage
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Citation information
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Sleep-disordered Breathing in Children
CL Marcus |
American journal of respiratory and critical care medicine | 2001 |
|
Impact of age on breathing and resistive pressure in people with and without sleep apnea
HA Browne, L Adams, AK Simonds, MJ Morrell |
Journal of applied physiology | 2001 |
|
RESPIRATORY FUNCTION IN THE ELDERLY
M Zaugg, E Lucchinetti |
Anesthesiology Clinics of North America | 2000 |
|
Sleep disordered breathing in the elderly
JP Janssens, S Pautex, H Hilleret, JP Michel |
Aging clinical and experimental research | 2000 |
|
The Control of Breathing in Clinical Practice
B Caruana-Montaldo, K Gleeson, CW Zwillich |
Chest | 2000 |
|
Klinische Geriatrie
T Nikolaus, C Becker, P Oster, L Pientka, G Schlierf, W von Renteln-Kruse |
2000 | |
|
Selective potentiation of peripheral chemoreflex sensitivity in obstructive sleep apnea
K Narkiewicz, PJ van de Borne, CA Pesek, ME Dyken, N Montano, VK Somers |
Circulation | 1999 |
|
Management of Geriatric Patients
RC Harvey, RR Paddleford |
Veterinary Clinics of North America Small Animal Practice | 1999 |
|
Special Problems in the Elderly
RM Oskvig |
Chest | 1999 |
|
Human Obesity Is Characterized by a Selective Potentiation of Central Chemoreflex Sensitivity
K Narkiewicz, M Kato, CA Pesek, VK Somers |
Hypertension | 1999 |
|
HYPOVENTILATION SYNDROMES
S Krachman, GJ Criner |
Clinics in Chest Medicine | 1998 |
|
Determinants of the hypercapnic and hypoxic response in normal man
RJ van Klaveren, M Demedts |
Respiration Physiology | 1998 |
|
A mathematical and physiological evaluation of the different hypoxic response models in normal man
RJ van Klaveren, M Demedts |
Respiration Physiology | 1998 |
|
Effect of Age Upon Airway Obstruction and Reversibility in Adult Patients With Asthma
V Bellia, F Cibella, G Cuttitta, N Scichilone, G Mancuso, AM Vignola, G Bonsignore |
Chest | 1998 |
|
Geriatric Respiratory Medicine
ED Chan, CH Welsh |
Chest | 1998 |
|
Cardiovascular Biology of Purines
G Burnstock, JG Dobson, BT Liang, J Linden |
1998 | |
|
Respiratory Effort During Obstructive Sleep Apnea
J Krieger, E Sforza, A Boudewijns, M Zamagni, C Petiau |
Chest | 1997 |
|
Effect of High-Altitude Exposure in the Elderly: The Tenth Mountain Division Study
BD Levine, JH Zuckerman, CR deFilippi |
Circulation | 1997 |
|
Komplikationen in der Anästhesie
WF List, PM Osswald |
1997 | |
|
RESUSCITATION OF THE GERIATRIC PATIENT
DP Milzman, TC Rothenhaus |
Emergency Medicine Clinics of North America | 1996 |
|
Estimulación hipercápnica y respuesta ventilatoria en el síndrome de apnea obstructiva del sueño. Comparación de reinhalación y estado-estable
JG Campos, SC Gómez, JF Guerra, MA Armengol, FC Gil, JC Gómez |
Archivos de Bronconeumología | 1996 |
|
The Effects of Epidural Anesthesia on Ventilatory Response to Hypercapnia and Hypoxia in Elderly Patients:
S Sakura, Y Saito, Y Kosaka |
Anesthesia & Analgesia | 1996 |
|
Failure to Wean: Exploring the Influence of Age-related Pulmonary Changes
LF Thompson |
Critical Care Nursing Clinics of North America | 1996 |
|
ANATOMY AND PHYSIOLOGY OF THE AGING PROCESS
JB Dembo |
Oral and Maxillofacial Surgery Clinics of North America | 1996 |
|
Modeling and Control of Ventilation
SJ Semple, L Adams, BJ Whipp |
1995 | |
|
The Relationship of Hypercapnic Ventilatory Responses to Age, Gender and Athleticism:
SP McGurk, BA Blanksby, MJ Anderson |
Sports Medicine | 1995 |
|
Effects of lumbar puncture position on arterial blood gases
S Kohro, M Yamakage, T Kawamata, H Iwasaki, A Namiki |
Journal of Anesthesia | 1994 |
|
Post-anaesthetic complications
JM Desmonts |
Baillière's Clinical Anaesthesiology | 1994 |
|
Cardiovascular Responses to Postural Changes: Differences with Age for Women and Men
MA Frey, CM Tomaselli, WG Hoffler |
The Journal of Clinical Pharmacology | 1994 |
|
Estimation of severity of illness with APACHE II: age-related implications in cardiac arrest outcomes
RJ Beer, TA Teasdale, HF Ghusn, GE Taffet |
Resuscitation | 1994 |
|
CENTRAL CONTROL OF VENTILATION IN NEUROMUSCULAR DISEASE
DC Johnson, H Kazemi |
Clinics in Chest Medicine | 1994 |
|
Physiological Changes Due to Age: Implications for Respiratory Drug Therapy
JF Morris |
Drugs & Aging | 1994 |
|
Mechanisms of ventilatory periodicities
AI Pack, A Gottschalk |
Annals of Biomedical Engineering | 1993 |
|
Various intensities of leisure time physical activity in patients with coronary artery disease: Effects on cardiorespiratory fitness and progression of coronary atherosclerotic lesions
R Hambrecht, J Niebauer, C Marburger, M Grunze, B Kälberer, K Hauer, G Schlierf, W Kübler, G Schuler |
Journal of the American College of Cardiology | 1993 |
|
Hemodynamic effects of altitude exposure and oxygen administration in chronic obstructive pulmonary disease
BW Berg, TA Dillard, SS Derderian, KR Rajagopal |
The American Journal of Medicine | 1993 |
|
Gas exchange dynamics with sinusoidal work in young and elderly women
DA Cunningham, JE Himann, DH Paterson, JR Dickinson |
Respiration Physiology | 1993 |
|
Effect of Aging on Metabolic Respiratory Control in Sleeping Dogs
EA Phillipson, LF Kozar |
American journal of respiratory and critical care medicine | 1993 |
|
Effect of lumbar epidural anesthesia on ventilatory response to hypercapnia in young and elderly patients
S Sakura, Y Saito, Y Kosaka |
Journal of Clinical Anesthesia | 1993 |
|
Effects of Aging on Respiratory Load Compensation and Dyspnea Sensation
Y Akiyama, M Nishimura, S Kobayashi, M Yamamoto, K Miyamoto, Y Kawakami |
American journal of respiratory and critical care medicine | 1993 |
|
Anesthetic management for a palliative surgical procedure in a 72-year-old patient with tetralogy of Fallot
MC Mahoney, MP Hosking |
Journal of Cardiothoracic and Vascular Anesthesia | 1993 |
|
Immediate postoperative management
JA Hughes, E Major |
Baillière's Clinical Anaesthesiology | 1993 |
|
Acute Pulmonary Disease in the Aged
JM Williams, TC Evans |
Clinics in Geriatric Medicine | 1993 |
|
Ventilatory responses to exercise and carbon dioxide in elderly and younger humans
AK McConnell, ES Semple, CT Davies |
European Journal of Applied Physiology and Occupational Physiology | 1993 |
|
EVALUATION OF DYSPNEA IN THE ELDERLY PATIENT
GA Silvestri, DA Mahler |
Clinics in Chest Medicine | 1993 |
|
Physiological Changes Due to Age: Implications for Drug Therapy of Congestive Heart Failure
RJ Cody |
Drugs & Aging | 1993 |
|
Influence of intrathecal morphine and naloxone intervention on postoperative ventilatory regulation in elderly patients
A Johnson, M Bengtsson, K Söderlind, JB Löfström |
Acta Anaesthesiologica Scandinavica | 1992 |
|
Reduced subjective awareness of bronchoconstriction provoked by methacholine in elderly asthmatic and normal subjects as measured on a simple awareness scale
MJ Connolly, JJ Crowley, NB Charan, CP Nielson, RE Vestal |
Thorax | 1992 |
|
Hypoxic ventilatory response and carotid endarterectomy
RG Vanmaele, WA de Backer, MJ Willemen, PE van Schil, MG de Maeseneer, RF van Look, EJ Bosmans |
European Journal of Vascular Surgery | 1992 |
|
Cardiovascular response to acute hypoxia in double-muscled calves
H Amory, F Rollin, D Desmecht, A Linden, P Lekeux |
Research in Veterinary Science | 1992 |
|
Syncope in elderly patients: Why their risk is higher
JD Bonema, ME Maddens |
Postgraduate Medicine | 1992 |
|
Control of Breathing and Its Modeling Perspective
Y Honda, Y Miyamoto, K Konno, JG Widdicombe |
1992 | |
|
Anästhesiologie
A Doenicke, D Kettler, WF List, J Tarnow, D Thomson |
1992 | |
|
Changes in ventilatory response to hypoxia in the rat during growth and aging.
Fukuda Y |
1992 | |
|
Aging, fitness and muscular performance
S Fowlie |
Reviews in Clinical Gerontology | 1991 |
|
Ventilatory response to hypoxia in elderly humans
M Ahmed, GG Giesbrecht, C Serrette, D Georgopoulos, NR Anthonisen |
Respiration Physiology | 1991 |
|
Envejecimiento pulmonar
E Rodríguez, J Bugés, J Morera |
Archivos de Bronconeumología | 1991 |
|
Maintenance of ventilatory control by CO2 in the rat during growth and aging
Y Fukuda |
Pflügers Archiv - European Journal of Physiology | 1991 |
|
Respiratory function in the elderly and the effects of beta blockade
AE Tattersfield |
Cardiovascular Drugs and Therapy | 1991 |
|
Sleep and Health Risk
JH Peter, T Penzel, T Podszus, P von Wichert |
1991 | |
|
Geriatrie für die hausärztliche Praxis
GC Fischer |
1991 | |
|
Vieillissement et désaturation oxyhémoglobinée du sportif
J Masse-Biron, J Mercier, JP Cano, C Caillaud, F Anselme, C Préfaut |
Science & Sports | 1990 |
|
Effects of Aging on Diaphragm Contractile Function in Golden Hamsters
Y Zhang, SG Kelsen |
American journal of respiratory and critical care medicine | 1990 |
|
Effects of aging on phospholamban phosphorylation and calcium transport in rat cardiac sarcoplasmic reticulum
M Jiang, N Narayanan |
Mechanisms of Ageing and Development | 1990 |
|
Chemoreceptors and Chemoreceptor Reflexes
H Acker, A Trzebski, RG ORegan |
1990 | |
|
Comparative effects of almitrine and raubasine, singly and in combination, on electroencephalographic activity in young and old rats
C Sebban, B Tesolin, B Coulomb, P Berthaux |
Experimental Gerontology | 1989 |
|
Anesthetic Considerations for the Geriatric Patient
RR Paddleford |
Veterinary Clinics of North America Small Animal Practice | 1989 |
|
Cardiovascular function during sleep apnoeas
ED Vlachogianni |
Postgraduate medical journal | 1989 |
|
Ventilatory and heart rate responses to hypoxia and hypercapnia in patients with diabetes mellitus
M Nishimura, K Miyamoto, A Suzuki, H Yamamoto, M Tsuji, F Kishi, Y Kawakami |
Thorax | 1989 |
|
Modeling and Parameter Estimation in Respiratory Control
MC Khoo |
1989 | |
|
Ventilatory responses to hypercapnia during tetracaine spinal anesthesia
RA Steinbrook, GP Topulos, M Concepcion |
Journal of Clinical Anesthesia | 1988 |
|
Sex Differences in Awake Ventilatory Drive and Abnormal Breathing during Sleep in Eucapnic Obesity
F Kunitomo, H Kimura, K Tatsumi, T Kuriyama, S Watanabe, Y Honda |
Chest | 1988 |
|
Aging of the lung: Pulmonary disease in the elderly
RC Young, DL Borden, RE Rachal |
AGE | 1987 |
|
Perioperative Care in Cancer Surgery
JC Johnson |
Clinics in Geriatric Medicine | 1987 |
|
Preanesthetic Assessment 1
EA Frost |
1987 | |
|
Changes in Control of Ventilation, Awake and Asleep, in the Elderly
AI Pack, RP Millman |
Journal of the American Geriatrics Society | 1986 |
|
Homeostatic Fragility in the Elderly
N Stern, ML Tuck |
Cardiology Clinics | 1986 |
|
The Aging Lung
DA Mahler, RA Rosiello, J Loke |
Clinics in Geriatric Medicine | 1986 |
|
Ventilatory Control During Sleep in the Elderly
PL Smith, ER Rleecker |
Clinics in Geriatric Medicine | 1986 |
|
Contemporary Geriatric Medicine
SR Gambert |
1986 | |
|
Strategies in Gynecologic Surgery
HJ Buchsbaum, LA Walton |
1986 | |
|
Respiratory Considerations in the Elderly Surgical Patient
SJ Allen |
1986 | |
|
Outpatient Anesthesia in the Geriatric Patient
JA Felts |
1986 | |
|
Systemic changes in the elderly patient and their anaesthetic implications
H Desmeules, L Foumier, PR Tremblay |
Canadian Anaesthetists’ Society Journal | 1985 |
|
Pulmonary Function and Ventilatory Response to Chemical Stimuli in Familial Myopathy
TR Weng, GE Schultz, CH Chang, MA Nigro |
Chest | 1985 |
|
The Aging Respiratory System
PE Krumpe, RJ Knudson, G Parsons, K Reiser |
Clinics in Geriatric Medicine | 1985 |
|
Physiology of Aging
RA Kenney |
Clinics in Geriatric Medicine | 1985 |
|
Organfunktion und Stoffwechsel in der perioperativen Phase
K Reinhart, K Eyrich |
1985 | |
|
Sleep and Control of Heart Rate
CF George, MH Kryger |
Clinics in Chest Medicine | 1985 |
|
Effects of age on the adrenergic cardiac neuroeffector junction
PB Goldberg, MS Kreider, J Roberts |
Life Sciences | 1984 |
|
Awake Abnormalities of Control of Breathing and of the Upper Airway
M Littner, E Young, D McGinty, E Beahm, W Riege, J Sowers |
Chest | 1984 |
|
High Altitude and Man
JB West, S Lahiri |
1984 | |
|
Breakdown in Human Adaptation to ‘Stress’
RE Ballieux, JF Fielding, A LAbbate |
1984 | |
|
Geriatrics 3
D Platt |
1984 | |
|
Clinical Tests of Respiratory Function
GJ Gibson |
1984 | |
|
Age-dependent differences in the positive inotropic effect of phenylephrine on rat isolated atria
H Hashimoto, M Nakashima, N Sugino |
British Journal of Pharmacology | 1983 |
|
The Medical Evaluation and Management of the Elderly Surgical Patient
JC Johnson |
Journal of the American Geriatrics Society | 1983 |
|
Aging and the Respiratory System
RD Brandstetter, H Kazemi |
Medical Clinics of North America | 1983 |
|
Sleep related breathing disorders in older men: A search for underlying mechanisms
D McGinty, M Littner, E Beahm, E Ruiz-Primo, E Young, J Sowers |
Neurobiology of Aging | 1982 |
|
Assessment and management of acute asthma in the elderly: a comparison with younger asthmatics
IS Petheram, DA Jones, JV Collins |
Postgraduate medical journal | 1982 |
|
Psychological and physiological effects of physical conditioning on the elderly
JA Blumenthal, DD Schocken, TL Needels, P Hindle |
Journal of Psychosomatic Research | 1982 |
|
Chemical Regulation of Respiration
LL Hedemark, RS Kronenberg |
Chest | 1982 |
|
Hemodynamics Following Normovolemic Hemodilution in Elderly Patients
B Rosberg, K Wulff |
Acta Anaesthesiologica Scandinavica | 1981 |
|
Attenuated Responses to CO2 and Hypoxia in Parents of Threatened Sudden Infant Death Syndrome Infants
TM Berman, M Bartlett, HD Westgate, KR Steiner, RS Kronenberg |
Chest | 1981 |
|
Comparison between developmental and senescent changes in enzyme activities linked to energy metabolism in rat heart
J Vitorica, J Cano, J Satrústegui, A Machado |
Mechanisms of Ageing and Development | 1981 |
|
EVALUATION OF RESPIRATORY CONTROL
ML Ata, RV LourenÇO |
Clinics in Chest Medicine | 1980 |
|
The physiopathology of respiration in neurosurgical patients
EA Frost |
Journal of Neurosurgery | 1979 |
|
Effects of hypercapnia and inspiratory flow-resistive loading on respiratory activity in chronic airways obstruction
MD Altose, WC McCauley, SG Kelsen, NS Cherniack |
Journal of Clinical Investigation | 1977 |
|
Effects of Hypermetabolism on Ventilation and Chemosensitivity
CW Zwillich, SA Sahn, JV Weil |
Journal of Clinical Investigation | 1977 |
|
Hypoxic ventilatory response in subjects with normal and high oxygen affinity hemoglobins
RP Hebbel, RS Kronenberg, JW Eaton |
Journal of Clinical Investigation | 1977 |
|
Acute respiratory failure and obesity with normal ventilatory response to carbon dioxide and absent hypoxic ventilatory drive
RS Kronenberg, CW Drage, JE Stevenson |
The American Journal of Medicine | 1977 |
|
Regulation of Respiration
AJ Berger, RA Mitchell, JW Severinghaus |
New England Journal of Medicine | 1977 |
|
Idiopathic scoliosis. Gas exchange and the age dependence of arterial blood gases
ER Kafer |
Journal of Clinical Investigation | 1976 |
|
Plasma noradrenaline increases with age
MG Ziegler, CR Lake, IJ Kopin |
Nature | 1976 |
|
Measurement of the Ventilatory Response to Hypoxia
J Severinghaus, G Ozanne, Y Massuda |
Chest | 1976 |
|
Assessment of Ventilatory Response to Hypoxia Methods and Interpretation
JV Weil, CW Zwillich |
Chest | 1976 |
|
Pulmonary Management of the Urologic Patient
TW Feeley, JJ Skillman |
The Urologic clinics of North America | 1976 |
|
Idiopathic scoliosis. Mechanical properties of the respiratory system and the ventilatory response to carbon dioxide
ER Kafer |
Journal of Clinical Investigation | 1975 |
|
Abnormal breathing patterns
NS Cherniack, AP Fishman |
Disease-a-Month | 1975 |
|
Diminished inotropic response of aged myocardium to catecholamines
EG Lakatta, G Gerstenblith, CS Angell, NW Shock, ML Weisfeldt |
Circulation research | 1975 |
|
Tissue Sensitivity to Drugs in Disease States
DT Lowenthal |
Medical Clinics of North America | 1974 |
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