Advertisement
Research Article Free access | 10.1172/JCI107316
Department of Hematology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C. 20012
National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510
Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut
Veterans Administration Hospital, Newington, Connecticut 06111
Find articles by Rickles, F. in: JCI | PubMed | Google Scholar
Department of Hematology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C. 20012
National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510
Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut
Veterans Administration Hospital, Newington, Connecticut 06111
Find articles by Hardin, J. in: JCI | PubMed | Google Scholar
Department of Hematology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C. 20012
National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510
Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut
Veterans Administration Hospital, Newington, Connecticut 06111
Find articles by Pitlick, F. in: JCI | PubMed | Google Scholar
Department of Hematology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C. 20012
National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510
Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut
Veterans Administration Hospital, Newington, Connecticut 06111
Find articles by Hoyer, L. in: JCI | PubMed | Google Scholar
Department of Hematology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C. 20012
National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510
Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut
Veterans Administration Hospital, Newington, Connecticut 06111
Find articles by Conrad, M. in: JCI | PubMed | Google Scholar
Published June 1, 1973 - More info
The procoagulant material of lymphocytes has been characterized as tissue factor. Lymphocytes stimulated with phytohemagglutinin or the purified protein derivative of the tubercle bacillus developed procoagulant activity with incubation in tissue culture. While this material corrected the prolonged clotting time of factor VIII (AHF) deficient plasma, we have shown, utilizing a sensitive radioimmunoassay, that no AHF antigen was present in the cell cultures. Further, we have demonstrated this material to be tissue factor by coagulation techniques and immunological cross-reactivity. The published data regarding factor VIII synthesis is reviewed in light of these observations and comments are made regarding the role of the lymphocyte procoagulant.