Effects of Cycloheximide on the Response of Intestinal Mucosa to Cholera Enterotoxin

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Abstract

Prior studies have indicated that effects of cholera enterotoxin (CT) on the small intestine are delayed in onset and involve an interaction with adenyl cyclase in the mucosa. It has also been shown that the administration of cycloheximide to rabbits in doses which inhibit crypt cell mitoses (20 mg/kg), diminishes CT-induced fluid production in jejunal loops. These latter studies have been interpreted as indications that CT-related intestinal secretion is a crypt cell function and that it is mediated by a CT-induced protein.

Authors

Daniel V. Kimberg, Michael Field, Elaine Gershon, Robert T. Schooley, Antonia Henderson