A direct neural role in the regulation of immunoreactive glucagon (IRG) secretion has been investigated during stimulation of mixed autonomic nerves to the pancreas in anesthetized dogs. The responses were evaluated by measurement of blood flow and hormone concentration in the venous effluent from the stimulated region of pancreas.
Errol B. Marliss, Lucien Girardier, Josiane Seydoux, Claes B. Wollheim, Yasunori Kanazawa, Lelio Orci, Albert E. Renold, Daniel Porte Jr.
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Title and authors | Publication | Year |
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Daniel Porte Jr., 13 August 1931-13 May 2023.
Kahn SE, Woods SC, Halter JB, Taborsky GJ, Schwartz MW |
Diabetes | 2024 |
Organ-specific sympathetic innervation defines visceral functions.
Wang T, Teng B, Yao DR, Gao W, Oka Y |
Nature | 2024 |
State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions
Lavin KM, Coen PM, Baptista LC, Bell MB, Drummer D, Harper SA, Lixandrão ME, McAdam JS, O\u2019Bryan SM, Ramos S, Roberts LM, Vega RB, Goodpaster BH, Bamman MM, Buford TW |
Comprehensive Physiology | 2022 |
Physiological Systems in Promoting Frailty
Perazza LR, Brown-Borg HM, Thompson LV |
Comprehensive Physiology | 2022 |
The elusive cephalic phase insulin response: triggers, mechanisms, and functions
Langhans W, Watts AG, Spector AC |
Physiological reviews | 2022 |
The sympathetic nervous system in the 21st Century: neuro-immune interactions in metabolic homeostasis and obesity
Martinez-Sanchez N, Sweeney O, Sidarta-Oliveira D, Caron A, Stanley SA, Domingos AI |
Neuron | 2022 |
Multi-omic Approaches to Identify Genetic Factors in Metabolic Syndrome
Clark KC, Kwitek AE |
Comprehensive Physiology | 2021 |
De la régulation nerveuse de l’insulino-sécrétion au rôle de l’insuline sur le cerveau. Les multiples travaux pionniers de Daniel Porte Jr. (1931–2020)
B Vialettes |
Médecine des Maladies Métaboliques | 2021 |
Glucagon-like Peptide-1: Actions and Influence on Pancreatic Hormone Function
Davis EM, Sandoval DA |
Comprehensive Physiology | 2020 |
Rebaudioside affords hepatoprotection ameliorating sugar sweetened beverage- induced nonalcoholic steatohepatitis
, J Bhattacharjee, RM Salazar-Gonzalez, S Park, A Jang, M Warren, R Merritt, S Michail, S Bouret, R Kohli |
Scientific Reports | 2020 |
Daniel Porte Jr.: A Leader in Our Understanding of the Role of Defective Insulin Secretion and Action in Obesity and Type 2 Diabetes
JP Palmer, SE Kahn, MW Schwartz, GJ Taborsky, SC Woods |
Diabetes care | 2020 |
Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice
BP Tooke, H Yu, JM Adams, GL Jones, T Sutton-Kennedy, L Mundada, NR Qi, MJ Low, KH Chhabra |
Molecular Metabolism | 2018 |
Endocrinology: Adult and Pediatric
M Gurnell, TJ Visser, P Beck-Peccoz, VK Chatterjee |
Endocrinology: Adult and Pediatric | 2016 |
Human Type 1 Diabetes Is Characterized by an Early, Marked, Sustained, and Islet-Selective Loss of Sympathetic Nerves
TO Mundinger, Q Mei, AK Foulis, CL Fligner, RL Hull, GJ Taborsky |
Diabetes | 2016 |
Endocrinology
C Napier, SH Pearce |
Endocrinology | 2016 |
Living without insulin: the role of leptin signaling in the hypothalamus
T Fujikawa, R Coppari |
Frontiers in neuroscience | 2015 |
Neural pathways that control the glucose counterregulatory response
AJ Verberne, A Sabetghadam, WS Korim |
Frontiers in neuroscience | 2014 |
Comprehensive Physiology
SN Cheuvront, RW Kenefick |
Comprehensive Physiology | 2014 |
The search for the mechanism of early sympathetic islet neuropathy in autoimmune diabetes
GJ Taborsky, Q Mei, DJ Hackney, TO Mundinger |
Diabetes Obesity and Metabolism | 2014 |
The p75 Neurotrophin Receptor Is Required for the Major Loss of Sympathetic Nerves From Islets Under Autoimmune Attack
GJ Taborsky, Q Mei, KE Bornfeldt, DJ Hackney, TO Mundinger |
Diabetes | 2014 |
Comprehensive Physiology
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Islet organogenesis, angiogenesis and innervation
ME Cerf |
Cell Biology International | 2011 |
The Physiology of Glucagon
GJ Taborsky |
Journal of diabetes science and technology | 2010 |
Current Status of Islet Cell Replacement and Regeneration Therapy
PA Halban, MS German, SE Kahn, GC Weir |
The Journal of clinical endocrinology and metabolism | 2010 |
Loss of islet sympathetic nerves and impairment of glucagon secretion in the NOD mouse: relationship to invasive insulitis
GJ Taborsky, Q Mei, DJ Hackney, DP Figlewicz, R LeBoeuf, TO Mundinger |
Diabetologia | 2009 |
Pancreatic signals controlling food intake; insulin, glucagon and amylin
SC Woods, TA Lutz, N Geary, W Langhans |
Philosophical Transactions of the Royal Society B: Biological Sciences | 2006 |
Neurobiology of Food and Fluid Intake
EM Stricker, SC Woods |
2004 | |
Insulin sensitively controls the glucagon response to mild hypoglycemia in the dog
K Igawa, M Mugavero, M Shiota, DW Neal, AD Cherrington |
Diabetes | 2002 |
Fos expression in rat celiac ganglion: an index of the activation of postganglionic sympathetic nerves
Q Mei, TO Mundinger, D Kung, DG Baskin, GJ Taborsky |
American journal of physiology. Endocrinology and metabolism | 2001 |
Nutritional implications of the cephalic-phase reflexes: endocrine responses
K Teff |
Appetite | 2000 |
Pancreatic innervation is not essential for exercise-induced changes in glucagon and insulin or glucose kinetics
RH Coker, Y Koyama, DB Lacy, PE Williams, N Rhèaume, DH Wasserman |
American journal of physiology. Endocrinology and metabolism | 1999 |
Principles of Perinatal—Neonatal Metabolism
RM Cowett |
1998 | |
Pancreatic sympathetic nerves contribute to increased glucagon secretion during severe hypoglycemia in dogs
PJ Havel, TO Mundinger, GJ Taborsky |
American journal of physiology. Endocrinology and metabolism | 1996 |
Adrenoceptor antagonists, but not guanethidine, reduce glucopenia-induced glucagon secretion from perfused rat pancreas
K Ito, H Hirose, K Kido, K Koyama, H Maruyama, T Saruta |
Diabetes Research and Clinical Practice | 1995 |
Neural regulation of the endocrine pancreas
FC Brunicardi, DM Shavelle, DK Andersen |
International Journal of Gastrointestinal Cancer | 1995 |
Redundant parasympathetic and sympathoadrenal mediation of increased glucagon secretion during insulin-induced hypoglycemia in conscious rats
PJ Havel, SJ Parry, JS Stern, JO Akpan, RL Gingerich, GJ Taborsky, DL Curry |
Metabolism | 1994 |
Noradrenergic inhibition of canine gallbladder contraction and murine pancreatic secretion during stress by corticotropin-releasing factor
HJ Lenz, B Messmer, FG Zimmerman |
Journal of Clinical Investigation | 1992 |
Insulin and glucagon secretion in swimming mice: effects of adrenalectomy and chemical sympathectomy
S Karlsson, B Ahrén |
Journal of the Autonomic Nervous System | 1991 |
Principles of Perinatal-Neonatal Metabolism
RM Cowett |
1991 | |
Insulin and glucagon secretion in swimming mice: Effects of autonomic receptor antagonism
S Karlsson, B Ahrén |
Metabolism | 1990 |
Mechanism of sympathetic neural regulation of insulin, somatostatin, and glucagon secretion
T Kurose, Y Seino, S Nishi, K Tsuji, T Taminato, K Tsuda, H Imura |
American journal of physiology. Endocrinology and metabolism | 1990 |
Pancreatic noradrenergic nerves are activated by neuroglucopenia but not by hypotension or hypoxia in the dog. Evidence for stress-specific and regionally selective activation of the sympathetic nervous system
PJ Havel, RC Veith, BE Dunning, GJ Taborsky |
Journal of Clinical Investigation | 1988 |
Effects of pancreatic noradrenaline infusion on basal and stimulated islet hormone secretion in the dog
B Ahrén, GJ Y. |
Acta Physiologica Scandinavica | 1988 |
Adrenergic control of the glucagon response to ammonia in the perfused rat pancreas
T Ichiba, A Tanaka, Y Ohta |
Diabetes Research and Clinical Practice | 1988 |
Insulin and glucagon secretion in rats: effects of calcitonin gene-related peptide
M Pettersson, B Ahrén |
Regulatory Peptides | 1988 |
Selective autonomic nervous control of thyroid hormone and calcitonin secretion during metabolic and cardiorespiratory activation by intracisternal thyrotropin-releasing hormone (TRH)
W Riedel, SL Burke |
Journal of the Autonomic Nervous System | 1988 |
Relative contributions of the nervous system and hormones to CNS-mediated hyperglycemia
A Iguchi, M Gotoh, H Matsunaga, A Yatomi, A Honmura, M Yanase, N Sakamoto |
American journal of physiology. Endocrinology and metabolism | 1988 |
Vagal regulation of insulin, glucagon, and somatostatin secretion in vitro in the rat
S Nishi, Y Seino, H Ishida, M Seno, T Taminato, H Sakurai, H Imura |
Journal of Clinical Investigation | 1987 |
Liver glycogen metabolism: An overview
G de Werve, B Jeanrenaud |
Diabetes / Metabolism Reviews | 1987 |
α1- and α2-adrenoceptor activation increases plasma glucagon levels in the mouse
G Skoglund, I Lundquist, B Ahrén |
European Journal of Pharmacology | 1987 |
Inhibition of 2-deoxy-glucose-induced glucagon secretion by muscarinic and α-adrenoceptor blockade in the mouse
S Karlsson, B Ahrén |
Diabetes Research and Clinical Practice | 1987 |
Halothane anesthesia does not suppress sympathetic activation produced by neuroglucopenia
PJ Havel, DE Flatness, JB Halter, JD Best, RC Veith, GJ Taborsky |
American journal of physiology. Endocrinology and metabolism | 1987 |
Role of autonomic nervous system in postprandial thermogenesis in dogs
P Diamond, J LeBlanc |
American journal of physiology. Endocrinology and metabolism | 1987 |
Clearance and action of insulin during general or epidural anaesthesia
J Magnússon, G Nybell-Lindahl, KG Tranberg |
Clinical Nutrition | 1986 |
Mechanism of central hyperglycemic effect of cholinergic agonists in fasted rats
A Iguchi, M Gotoh, H Matsunaga, A Yatomi, A Honmura, M Yanase, N Sakamoto |
American journal of physiology. Endocrinology and metabolism | 1986 |
Galanin: a novel pancreatic neuropeptide
BE Dunning, B Ahren, RC Veith, G Bottcher, F Sundler, GJ Taborsky |
American journal of physiology. Endocrinology and metabolism | 1986 |
Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion
B Ahrén, GJ Taborsky, D Porte |
Diabetologia | 1986 |
Endocrine Function in the Critically III
S Teich, S Sharpe, B Chernow |
1985 | |
Characteristics of the neuroendocrine responses to stimulation of the splanchnic nerves in bursts in the conscious calf
SR Bloom, AV Edwards |
The Journal of Physiology | 1984 |
Mechanisms of Gastrointestinal Motility and Secretion
A Bennett, G Velo |
1984 | |
The hypothalamus and blood glucose regulation
CA Benzo |
Life Sciences | 1983 |
Effects of adrenergic blockade on the release of insulin, glucagon and somatostatin from the pancreas in response to splanchnic nerve stimulation in cats
PO Andersson, J Holst, J Järhult |
Acta Physiologica Scandinavica | 1982 |
Plasma glucose and glucagon concentrations in the hibernating hedgehog
R Hoo-Paris, M Hamsany, BC Sutter, R Assan, J Boillot |
General and Comparative Endocrinology | 1982 |
Acute hypoglycemia in man: Neural control of pancreatic islet cell function
RJ Corrall, BM Frier |
Metabolism | 1981 |
Glucagon and the a Cell: Physiology and Pathophysiology(First of Two Parts)
RH Unger, L Orci |
New England Journal of Medicine | 1981 |
Comparison of glucagon responses to 2-deoxy-D-glucose and hypoglycemia in man
PL Werner, JW Benson, JB Brodsky, PM Hollander, CM Asplin, DG Johnson, JP Palmer |
American journal of physiology. Endocrinology and metabolism | 1980 |
Differential effect of isoproterenol on acute glucagon and insulin release in man
JP Palmer, J Halter, PL Werner |
Metabolism | 1979 |
Contemporary Metabolism
N Freinkel |
1979 | |
The role of the adrenergic innervation to the pancreatic islets in the control of insulin release during exercise in man
J Jrhult, J Holst |
Pflügers Archiv - European Journal of Physiology | 1979 |
Extrapancreatic Glucagon and Glucagonlike Immunoreactivity in Depancreatized Dogs A QUANTITATIVE ASSESSMENT OF SECRETION RATES AND ANATOMICAL DELINEATION OF SOURCES
WA Muller, L Girardier, J Seydoux, M Berger, AE Renold, M Vranic |
Journal of Clinical Investigation | 1978 |
Reflex adrenergic control of endocrine pancreas evoked by unloading of carotid baroreceptors in cats
J Järhult, JJ Holst |
Acta Physiologica Scandinavica | 1978 |
Glucagon and somatostatin
RH Unger |
Disease-a-Month | 1978 |
A Review of Hypersomolar Hyperglycemic Nonketotic Dehydration (HHND): Etiology, Pathophysiology and Prevention During Intravenous Hyperalimentation
MV Kaminski |
JPEN. Journal of parenteral and enteral nutrition | 1978 |
Ergot Alkaloids and Related Compounds
B Berde, HO Schild |
1978 | |
The Year in Endocrinology 1977
SH Ingbar |
1978 | |
The Year in Metabolism 1977
N Freinkel |
1978 | |
Catecholamines and the regulation of hormone secretion
JB Young, L Landsberg |
Clinics in Endocrinology and Metabolism | 1977 |
Proceedings of the 1976 Laurentian Hormone Conference
TE Andreoli, JA Schafer |
Proceedings of the 1976 Laurentian Hormone Conference | 1977 |
Glucagon response to hypoglycemia in sympathectomized man
JP Palmer, DP Henry, JW Benson, DG Johnson, JW Ensinck |
Journal of Clinical Investigation | 1976 |
The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog
AD Cherrington, JL Chiasson, JE Liljenquist, AS Jennings, U Keller, WW Lacy |
Journal of Clinical Investigation | 1976 |
Stimulatory and inhibitory effects of cyclic AMP on pancreatic glucagon release from monolayer cultures and the controlling role of calcium
CB Wollheim, B Blondel, AE Renold, GW Sharp |
Diabetologia | 1976 |
EFFECT OF EPIDURAL ANALGESIA ON THE GLYCOREGULATORY ENDOCRINE RESPONSE TO SURGERY
M Brandt, H Kehlet, C Binder, C Hagen, AS McNELLY |
Clinical Endocrinology | 1976 |
Glucagon responses to hypoglycemia in adrenalectomized man
JW Ensinck, RM Walter, JP Palmer, RG Brodows, RG Campbell |
Metabolism | 1976 |
Central nervous system-mediated stimulation of glucagon secretion in the dog following 2-deoxyglucose
LA Frohman, K Nagai |
Metabolism | 1976 |
The Year in Metabolism 1975–1976
N Freinkel |
1976 | |
Eukaryotic Cell Function and Growth
JE Dumont, BL Brown, NJ Marshall |
1976 | |
Insulin and glucose as modulators of the amino acid-induced glucagon release in the isolated pancreas of alloxan and streptozotocin diabetic rats
AS Pagliara, SN Stillings, MW Haymond, BA Hover, FM Matschinsky |
Journal of Clinical Investigation | 1975 |
Estimation of pancreatic IRI output rate and its relation to glucose tolerance in normal anaesthetized dogs
U Fischer, H Hommel, HD Gottschling, P Heinke, E Jutzi |
Diabetologia | 1975 |
PORTAL AND CUBITAL SERUM INSULIN DURING ORAL, PORTAL AND CUBITAL GLUCOSE TOLERANCE TESTS
B Lund, A Schmidt, T Deckert |
Acta Medica Scandinavica | 1975 |
Exocrine pancreas: evidence for topographic partition of secretory function
F Malaisse-Lagae, M Ravazzola, P Robberecht, A Vandermeers, W Malaisse, L Orci |
Science | 1975 |
Minireviews of the Neurosciences from Life Sciences
M Hamon, J Glowinski |
Minireviews of the Neurosciences from Life Sciences | 1975 |
L-Dopa Stimulation of Glucagon Secretion in Man
EJ Rayfield, DT George, HL Eichner, TH Hsu |
New England Journal of Medicine | 1975 |
Diabetes mellitus · A
E Cerasi, P Dieterle, H Ege, A Englhardt, H Frerichs, W Gepts, A Hasselblatt, HR Henrichs, L Herberg, JJ Hoet, H Hungerland, K Jahnke, RJ Jarrett, G Jörgensen, KH Jørgensen, H Kasemir, H Keen, L Kerp, V Leclercq-Meyer, H Liebermeister, G Löffler, R Luft, WJ Malaisse, J Markussen, M Möllering, H Schadewaldt, J Schlichtkrull, K Schöffling, U Schwedes, PC Scriba, F Sundby, KH Usadel, L Weiss, H Zimmermann, K Oberdisse |
1975 | |
Adrenergic Modulation of Pancreatic Glucagon Secretion in Man
JE Gerich, M Langlois, C Noacco, V Schneider, PH Forsham |
Journal of Clinical Investigation | 1974 |
Glucose Modulation of Amino Acid-Induced Glucagon and Insulin Release in the Isolated Perfused Rat Pancreas
AS Pagliara, SN Stillings, B Hover, DM Martin, FM Matschinsky |
Journal of Clinical Investigation | 1974 |
The Effect of Adrenergic Blockade on the Glucagon Responses to Starvation and Hypoglycemia in Man
RM Walter, RJ Dudl, JP Palmer, JW Ensinck |
Journal of Clinical Investigation | 1974 |
Glucagon Secretion from the Perfused Rat Pancreas STUDIES WITH GLUCOSE AND CATECHOLAMINES
GC Weir, SD Knowlton, DB Martin |
Journal of Clinical Investigation | 1974 |
HYPERGLUCAGONÆMIA AFTER BURNS
DW Wilmore, JA Moylan, BA Pruitt, CA Lindsey, GR Faloona, RH Unger |
The Lancet | 1974 |
Alpha- and beta-cell interrelationships in health and disease
RH Unger |
Metabolism | 1974 |
The role of catecholamines and acetylcholine in the regulation of endocrine function
WF Ganong |
Life Sciences | 1974 |
The Neuroendocrine Design of the Gut
GM Makhlouf |
Gastroenterology | 1974 |
Acute Parathyroid Hormone Response to Epinephrine In Vivo
JA Fischer, JW Blum, U Binswanger |
Journal of Clinical Investigation | 1973 |
Fuels, Hormones, and Liver Metabolism at Term and during the Early Postnatal Period in the Rat
JR Girard, GS Cuendet, EB Marliss, A Kervran, M Rieutort, R Assan |
Journal of Clinical Investigation | 1973 |
Advances in Metabolic Disorders
G Aurbach, JT Potts |
Advances in Metabolic Disorders | 1964 |