Metabolism of Proinsulin, Insulin, and C-Peptide in the Rat

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Abstract

The renal extraction and excretion of bovine proinsulin, insulin, and C-peptide and the contribution of the kidney to their total metabolic clearance rate (MCR) were studied in the rat. Metabolic clearance rates were measured by the constant infusion technique and plasma and urine concentrations of each polypeptide were determined by radioimmunoassay.

Authors

Adrian I. Katz, Arthur H. Rubenstein