Bile secretory failure (cholestasis) may result from several possible mechanisms involved in bile secretion. We have examined the possibility that abnormalities in enzyme content, composition, and turnover of liver plasma membrane constituents are altered in cholestasis.
Francis R. Simon, Irwin M. Arias
Title and authors | Publication | Year |
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Bile acids target an exposed cavity in the glucocorticoid receptor modulating receptor self-assembly, chromatin binding and transcriptional activity
Jiménez-Panizo A, Johnson TA, Wagh K, Alegre-Martí A, Novoa IM, Lafuente AL, Eckhard U, Rodríguez-Lumbreras LÁ, Hoang L, Stortz M, Abella M, Goldstein I, Valledor-Fernández A, Varticovski L, Arias I, Presman DM, Stavreva DA, Fernández-Recio J, Fuentes-Prior P, Hager GL, Estébanez-Perpiñá E |
bioRxiv | 2025 |
Immunomodulatory effects by oral contraceptives in normal and cholestatic female rats: Role of cytokines
E Fernández-Martínez, E Pérez-Soto, C González-Hernández, MI Ortiz, V Pérez-Álvarez, P Muriel, M Shibayama |
International Immunopharmacology | 2014 |
Perspective: Five decades of cholestasis research and the brave new world
IM Arias |
Hepatology | 2008 |
A Review of the Hepatotoxic Plant Lantana camara
OP Sharma, S Sharma, V Pattabhi, SB Mahato, PD Sharma |
Critical Reviews in Toxicology | 2007 |
Effects of docosahexaenoic acid on annular lipid fluidity of the rat bile canalicular plasma membrane
M Hashimoto, MS Hossain, T Shimada, H Yamasaki, Y Fujii, O Shido |
Journal of lipid research | 2001 |
Histological and biochemical changes induced by total bile duct ligation in the rat
S Hinz, H Franke, G Machnik, A Müller, R Dargel |
Experimental and Toxicologic Pathology | 1997 |
Hepatobiliary excretion of cysteinyl leukotrienes in three experimental models of acute hepatic injury
HM Omar, RA Sanders, JB Watkins |
Inflammation Research | 1996 |
Enhanced biliary excretion of canalicular membrane enzymes in estrogen-induced and obstructive cholestasis, and effects of different bile acids in the isolated perfused rat liver
L Accatino, C Figueroa, M Pizarro, N Solís |
Journal of Hepatology | 1995 |
Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver
R Bossard, B Stieger, B O'Neill, G Fricker, PJ Meier |
Journal of Clinical Investigation | 1993 |
Postcholestatic alkaline phosphatase activity after relief of bile duct obstruction in the rat
AM Wielandt, M Pizarro, N Solis, M Arrese, L Accatino |
Hepatology | 1993 |
Alterations in bilirubin metabolism during extra- and intrahepatic cholestasis.
Basso D, Fabris C, Plebani M, Del Favero G, Muraca M, Vilei MT, Panozzo MP, Meggiato T, Fogar P, Burlina A |
The Clinical Investigator | 1992 |
Hepatotoxicity Induced by the Oriental Hornet (Vespa orientalis) Venom Sac Extract
MG Neuman, JS Ishay, M Waron, HJ Zimmerman, J Eshchar |
Pharmacology & Toxicology | 1991 |
Quantitative changes in acid phosphatase, alkaline phosphatase and 5‘-nucleotidase activity in rat liver after experimentally induced cholestasis
WM Frederiks, CJ Noorden, DC Aronson, F Marx, KS Bosch, GN Jonges, IM Vogels, J James |
Liver | 1990 |
S-Adenosyl-L-Methionine (SAMe)-Induced Amelioration of Intrahepatic Cholestasis of Pregnancy: Results of an Open Study
G Bonfirraro, O Chieffi, R Quinti, R Tedesco, C Grazie, M Bortolini |
Drug Investigation | 1990 |
Hepatic Transport of Organic Substances
E Petzinger, RK Kinne, H Sies |
1989 | |
Effect of different doses of S-adenosyl-L-methionine (SAMe) on nicotinic acid-induced hyperbilirubinaemia in Gilbert's syndrome
S Gentile, M Persico, C Orlando, M Coltorti, CL Grazie, CD Padova |
Scandinavian Journal of Clinical & Laboratory Investigation | 1988 |
Ethinylestradiol administration selectively alters liver sinusoidal membrane lipid fluidity and protein composition
J Rosario, E Sutherland, L Zaccaro, FR Simon |
Biochemistry | 1988 |
Effect of colchicine and phalloidin on the distribution of three plasma membrane antigens in rat hepatocytes: Comparison with bile duct ligation
AM Durand-Schneider, M Maurice, M Dumont, G Feldmann |
Hepatology | 1987 |
Estrogen cholestasis
M Vore |
Gastroenterology | 1987 |
Effects of iron overload on bile secretion and hepatic porphyrin metabolism in ethinyl extradiol-treated rats
L Cantoni, CD Padova, M Rizzardini, DD Fiume, A Graziani, P Rovagnati, R Tritapepe |
Toxicology | 1986 |
Induction of plasma membrane alkaline phosphatase in rat liver
O Bachs, C Enrich, M Soriano, R Piñol, J Domingo |
Cell Biochemistry and Function | 1985 |
Selectively reduced biliary excretion of cholyldiglycylhistamine but not of cholytetraglycylhistamine in ethinyl estradioltreated rats
CO Mills, S Iqbal, E Elias |
Journal of Hepatology | 1985 |
Fluidity and Function of Hepatocyte Plasma Membranes
D Schachter |
Hepatology | 1984 |
A dietary regimen alters hepatocyte plasma membrane lipid fluidity and ameliorates ethinyl estradiol cholestasis in the rat
J Storch, D Schachter |
Biochimica et Biophysica Acta (BBA) - General Subjects | 1984 |
Estrogen-Induced Cholestasis: Clues to Pathogenesis and Treatment
AJ Schreiber, FR Simon |
Hepatology | 1983 |
Increased tight junction permeability: a possible mechanism of oestrogen cholestasis
E Elias, S Iqbal, S Knutton, A Hickey, R Coleman |
European Journal of Clinical Investigation | 1983 |
Similarities and Differences Between Models of Extrahepatic Biliary Obstruction and Complete Biliary Retention without Obstruction in the Rat
WG Hardison, RG Weiner, DE Hatoff, K Miyai |
Hepatology | 1983 |
Exercise in rats with liver injury induced by carbon tetrachloride or bile duct obstruction. Blood cholic acid and liver histology
V Simko, RE Kelley, HP Dincsoy, Z Gimmon, K Willmann |
Research in Experimental Medicine | 1982 |
Ultrastructural study of cholestasis induced by longterm treatment with estradiol valerate
H Robenek, J Rassat, V Grosser, H Themann |
Virchows Archiv B Cell Pathology Including Molecular Pathology | 1982 |
Intrahepatic cholestasis as a side-effect of drug therapy
G Feuer, MS Dhami |
Canadian family physician Médecin de famille canadien | 1982 |
In vitro effect of bile salts on rat liver plasma membrane, lipid fluidity, and ATPase activity
BF Scharschmidt, EB Keeffe, DA Vessey, NM Blankenship, RK Ockner |
Hepatology | 1981 |
Experimental hepatobiliary injury: Comparison ofin vivo drug elimination within vitro drug-metabolizing enzyme capacity in the rat
RA Willson, FE Hart, JT Hew |
Digestive Diseases and Sciences | 1981 |
A biochemical dissection of the functional polarity of the plasma membrane of the hepatocyte
WH Evans |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 1980 |
Mechanism of elevation of serum alkaline phosphatase activity in biliary obstruction: an experimental study
T Gotaro, I Yusei, K Makoto, O Hiroshi, O Toshitsugu |
Clinica Chimica Acta | 1980 |
Verhandlungen der Deutschen Gesellschaft für innere Medizin
B Schlegel |
1980 | |
Regulation of hepatic sodium plus potassium-activated adenosine triphosphatase activity by glucocorticoids in the rat
PB Miner, E Sutherland, FR Simon |
Gastroenterology | 1980 |
The effects of common bile duct ligation upon the rat liver β-adrenergic receptor-adenylate cyclase system
PH Schmelck, MC Billon, A Munnich, P Geynet, D Houssin, J Hanoune |
FEBS Letters | 1979 |
The influence of various bile salts and some cholephilic dyes on Na+, K+- and Mg2+-activated ATPase of rat liver in relation to cholestatic effects
DK Meijer, RJ Vonk, JG Weitering |
Toxicology and Applied Pharmacology | 1978 |
Reversal by triton WR-1339 of ethynyloestradiol-induced hepatic cholesterol esterification
RA Davis, R Showalter, F Kern |
Biochemical Journal | 1978 |
Evidence for microfilament involvement in norethandrolone-induced intrahepatic cholestasis
MJ Phillips, M Oda, K Funatsu |
The American Journal of Pathology | 1978 |
Alterations of hepatic Na+,K+-atpase and bile flow by estrogen: effects on liver surface membrane lipid structure and function
RA Davis, F Kern, R Showalter, E Sutherland, M Sinensky, FR Simon |
Proceedings of the National Academy of Sciences | 1978 |
Uneven distribution of enzymatic alterations on the liver cell surface in experimental extrahepatic cholestasis of rat
G Toda, M Kako, H Oka, T Oda, Y Ikeda |
Experimental and Molecular Pathology | 1978 |
Relationship between bile flow and Na+, K+-adenosinetriphosphatase in liver plasma membranes enriched in bile canaliculi
J Reichen, G Paumgartner |
Journal of Clinical Investigation | 1977 |
Membranous localization and properties of ATPase of rat liver lysosomes
DL Schneider |
The Journal of Membrane Biology | 1977 |
Hepatic accumulation, metabolism and biliary excretion of sulfobromophthalein by rainbow trout (Salmo gairdneri)
WH Gingerich, LJ Weber, RE Larson |
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology | 1977 |
A clinical pharmacologist's view of drug hepatotoxicity
CA Dujovne |
Pharmacological Research Communications | 1977 |
Cholestatic steroid hormones inhibit taurocholate uptake into isolated rat hepatocytes
LR Schwarz, M Schwenk, E Pfaff, H Greim |
Biochemical Pharmacology | 1977 |
Increased Sulfation and Decreased 7α-Hydroxylation of Deoxycholic Acid in Ethinyl Estradiol-Induced Cholestasis in Rats
RT Jensen, RA Davis, F Kern |
Gastroenterology | 1977 |
Role of membranes in bile formation. Comparison of the composition of bile and a liver bile-canalicular plasma-membrane subfraction
WH Evans, T Kremmmer, JG Culvenor |
Biochemical Journal | 1976 |
The bile canalicular network in vitro
MJ Phillips, M Oda, E Mak, V Edwards, I Yousef, MM Fisher |
Journal of Ultrastructure Research | 1976 |
Properties of (Na+ + K+)-activated ATPase in rat liver plasma membranes enriched with bile canaliculi
JL Boyer, D Reno |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 1975 |
Subfractionation of rat liver plasma membrane
G Toda, H Oka, T Oda, Y Ikeda |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 1975 |
α-Naphthyl-isothiocyanate-induced cholestasis in the rat: studies of liver plasma membrane enzymes
PJ Hertzog, PS Bhathal, PR Dorling, RN Page |
Pathology | 1975 |
Isolation and partial characterization of a bile canalicular plasma membrane fraction from normal and regenerating rat liver
AE Sirica, PJ Goldblatt, JF McKelvy |
The Journal of biological chemistry | 1975 |
Electron microscopic cytochemical characterization of bile canaliculi and bile ductsin vitro
M Oda, MJ Phillips |
Virchows Archiv B Cell Pathology | 1975 |
Über die aktivitätserhöhung der unspezifisch lipoproteidgebundenen alkalischen phosphatase im menschlichen serum
N Husen, U Gerlach |
Clinica Chimica Acta | 1974 |
Jaundice
S Sherlock |
British medical journal | 1962 |