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Citations to this article

Alteration of Bile Canalicular Enzymes in Cholestasis. A POSSIBLE CAUSE OF BILE SECRETORY FAILURE
Francis R. Simon, Irwin M. Arias
Francis R. Simon, Irwin M. Arias
Published April 1, 1973
Citation Information: J Clin Invest. 1973;52(4):765-775. https://doi.org/10.1172/JCI107239.
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Research Article

Alteration of Bile Canalicular Enzymes in Cholestasis. A POSSIBLE CAUSE OF BILE SECRETORY FAILURE

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Abstract

Bile secretory failure (cholestasis) may result from several possible mechanisms involved in bile secretion. We have examined the possibility that abnormalities in enzyme content, composition, and turnover of liver plasma membrane constituents are altered in cholestasis.

Authors

Francis R. Simon, Irwin M. Arias

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Total citations by year

Year: 2025 2014 2008 2007 2001 1997 1996 1995 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 1979 1978 1977 1976 1975 1974 1962 Total
Citations: 1 1 1 1 1 1 1 1 2 1 1 2 1 2 2 1 2 2 3 3 2 4 1 5 6 2 5 1 1 57
Citation information
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Citations to this article (57)

Title and authors Publication Year
Bile acids target an exposed cavity in the glucocorticoid receptor modulating receptor self-assembly, chromatin binding and transcriptional activity
Jiménez-Panizo A, Johnson TA, Wagh K, Alegre-Martí A, Novoa IM, Lafuente AL, Eckhard U, Rodríguez-Lumbreras LÁ, Hoang L, Stortz M, Abella M, Goldstein I, Valledor-Fernández A, Varticovski L, Arias I, Presman DM, Stavreva DA, Fernández-Recio J, Fuentes-Prior P, Hager GL, Estébanez-Perpiñá E
bioRxiv 2025
Immunomodulatory effects by oral contraceptives in normal and cholestatic female rats: Role of cytokines
E Fernández-Martínez, E Pérez-Soto, C González-Hernández, MI Ortiz, V Pérez-Álvarez, P Muriel, M Shibayama
International Immunopharmacology 2014
Perspective: Five decades of cholestasis research and the brave new world
IM Arias
Hepatology 2008
A Review of the Hepatotoxic Plant Lantana camara
OP Sharma, S Sharma, V Pattabhi, SB Mahato, PD Sharma
Critical Reviews in Toxicology 2007
Effects of docosahexaenoic acid on annular lipid fluidity of the rat bile canalicular plasma membrane
M Hashimoto, MS Hossain, T Shimada, H Yamasaki, Y Fujii, O Shido
Journal of lipid research 2001
Histological and biochemical changes induced by total bile duct ligation in the rat
S Hinz, H Franke, G Machnik, A Müller, R Dargel
Experimental and Toxicologic Pathology 1997
Hepatobiliary excretion of cysteinyl leukotrienes in three experimental models of acute hepatic injury
HM Omar, RA Sanders, JB Watkins
Inflammation Research 1996
Enhanced biliary excretion of canalicular membrane enzymes in estrogen-induced and obstructive cholestasis, and effects of different bile acids in the isolated perfused rat liver
L Accatino, C Figueroa, M Pizarro, N Solís
Journal of Hepatology 1995
Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver
R Bossard, B Stieger, B O'Neill, G Fricker, PJ Meier
Journal of Clinical Investigation 1993
Postcholestatic alkaline phosphatase activity after relief of bile duct obstruction in the rat
AM Wielandt, M Pizarro, N Solis, M Arrese, L Accatino
Hepatology 1993
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The Clinical Investigator 1992
Hepatotoxicity Induced by the Oriental Hornet (Vespa orientalis) Venom Sac Extract
MG Neuman, JS Ishay, M Waron, HJ Zimmerman, J Eshchar
Pharmacology & Toxicology 1991
Quantitative changes in acid phosphatase, alkaline phosphatase and 5‘-nucleotidase activity in rat liver after experimentally induced cholestasis
WM Frederiks, CJ Noorden, DC Aronson, F Marx, KS Bosch, GN Jonges, IM Vogels, J James
Liver 1990
S-Adenosyl-L-Methionine (SAMe)-Induced Amelioration of Intrahepatic Cholestasis of Pregnancy: Results of an Open Study
G Bonfirraro, O Chieffi, R Quinti, R Tedesco, C Grazie, M Bortolini
Drug Investigation 1990
Hepatic Transport of Organic Substances
E Petzinger, RK Kinne, H Sies
1989
Effect of different doses of S-adenosyl-L-methionine (SAMe) on nicotinic acid-induced hyperbilirubinaemia in Gilbert's syndrome
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Scandinavian Journal of Clinical & Laboratory Investigation 1988
Ethinylestradiol administration selectively alters liver sinusoidal membrane lipid fluidity and protein composition
J Rosario, E Sutherland, L Zaccaro, FR Simon
Biochemistry 1988
Effect of colchicine and phalloidin on the distribution of three plasma membrane antigens in rat hepatocytes: Comparison with bile duct ligation
AM Durand-Schneider, M Maurice, M Dumont, G Feldmann
Hepatology 1987
Estrogen cholestasis
M Vore
Gastroenterology 1987
Effects of iron overload on bile secretion and hepatic porphyrin metabolism in ethinyl extradiol-treated rats
L Cantoni, CD Padova, M Rizzardini, DD Fiume, A Graziani, P Rovagnati, R Tritapepe
Toxicology 1986
Induction of plasma membrane alkaline phosphatase in rat liver
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Cell Biochemistry and Function 1985
Selectively reduced biliary excretion of cholyldiglycylhistamine but not of cholytetraglycylhistamine in ethinyl estradioltreated rats
CO Mills, S Iqbal, E Elias
Journal of Hepatology 1985
Fluidity and Function of Hepatocyte Plasma Membranes
D Schachter
Hepatology 1984
A dietary regimen alters hepatocyte plasma membrane lipid fluidity and ameliorates ethinyl estradiol cholestasis in the rat
J Storch, D Schachter
Biochimica et Biophysica Acta (BBA) - General Subjects 1984
Estrogen-Induced Cholestasis: Clues to Pathogenesis and Treatment
AJ Schreiber, FR Simon
Hepatology 1983
Increased tight junction permeability: a possible mechanism of oestrogen cholestasis
E Elias, S Iqbal, S Knutton, A Hickey, R Coleman
European Journal of Clinical Investigation 1983
Similarities and Differences Between Models of Extrahepatic Biliary Obstruction and Complete Biliary Retention without Obstruction in the Rat
WG Hardison, RG Weiner, DE Hatoff, K Miyai
Hepatology 1983
Exercise in rats with liver injury induced by carbon tetrachloride or bile duct obstruction. Blood cholic acid and liver histology
V Simko, RE Kelley, HP Dincsoy, Z Gimmon, K Willmann
Research in Experimental Medicine 1982
Ultrastructural study of cholestasis induced by longterm treatment with estradiol valerate
H Robenek, J Rassat, V Grosser, H Themann
Virchows Archiv B Cell Pathology Including Molecular Pathology 1982
Intrahepatic cholestasis as a side-effect of drug therapy
G Feuer, MS Dhami
Canadian family physician Médecin de famille canadien 1982
In vitro effect of bile salts on rat liver plasma membrane, lipid fluidity, and ATPase activity
BF Scharschmidt, EB Keeffe, DA Vessey, NM Blankenship, RK Ockner
Hepatology 1981
Experimental hepatobiliary injury: Comparison ofin vivo drug elimination within vitro drug-metabolizing enzyme capacity in the rat
RA Willson, FE Hart, JT Hew
Digestive Diseases and Sciences 1981
A biochemical dissection of the functional polarity of the plasma membrane of the hepatocyte
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Biochimica et Biophysica Acta (BBA) - Biomembranes 1980
Mechanism of elevation of serum alkaline phosphatase activity in biliary obstruction: an experimental study
T Gotaro, I Yusei, K Makoto, O Hiroshi, O Toshitsugu
Clinica Chimica Acta 1980
Verhandlungen der Deutschen Gesellschaft für innere Medizin
B Schlegel
1980
Regulation of hepatic sodium plus potassium-activated adenosine triphosphatase activity by glucocorticoids in the rat
PB Miner, E Sutherland, FR Simon
Gastroenterology 1980
The effects of common bile duct ligation upon the rat liver β-adrenergic receptor-adenylate cyclase system
PH Schmelck, MC Billon, A Munnich, P Geynet, D Houssin, J Hanoune
FEBS Letters 1979
The influence of various bile salts and some cholephilic dyes on Na+, K+- and Mg2+-activated ATPase of rat liver in relation to cholestatic effects
DK Meijer, RJ Vonk, JG Weitering
Toxicology and Applied Pharmacology 1978
Reversal by triton WR-1339 of ethynyloestradiol-induced hepatic cholesterol esterification
RA Davis, R Showalter, F Kern
Biochemical Journal 1978
Evidence for microfilament involvement in norethandrolone-induced intrahepatic cholestasis
MJ Phillips, M Oda, K Funatsu
The American Journal of Pathology 1978
Alterations of hepatic Na+,K+-atpase and bile flow by estrogen: effects on liver surface membrane lipid structure and function
RA Davis, F Kern, R Showalter, E Sutherland, M Sinensky, FR Simon
Proceedings of the National Academy of Sciences 1978
Uneven distribution of enzymatic alterations on the liver cell surface in experimental extrahepatic cholestasis of rat
G Toda, M Kako, H Oka, T Oda, Y Ikeda
Experimental and Molecular Pathology 1978
Relationship between bile flow and Na+, K+-adenosinetriphosphatase in liver plasma membranes enriched in bile canaliculi
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Journal of Clinical Investigation 1977
Membranous localization and properties of ATPase of rat liver lysosomes
DL Schneider
The Journal of Membrane Biology 1977
Hepatic accumulation, metabolism and biliary excretion of sulfobromophthalein by rainbow trout (Salmo gairdneri)
WH Gingerich, LJ Weber, RE Larson
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 1977
A clinical pharmacologist's view of drug hepatotoxicity
CA Dujovne
Pharmacological Research Communications 1977
Cholestatic steroid hormones inhibit taurocholate uptake into isolated rat hepatocytes
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Biochemical Pharmacology 1977
Increased Sulfation and Decreased 7α-Hydroxylation of Deoxycholic Acid in Ethinyl Estradiol-Induced Cholestasis in Rats
RT Jensen, RA Davis, F Kern
Gastroenterology 1977
Role of membranes in bile formation. Comparison of the composition of bile and a liver bile-canalicular plasma-membrane subfraction
WH Evans, T Kremmmer, JG Culvenor
Biochemical Journal 1976
The bile canalicular network in vitro
MJ Phillips, M Oda, E Mak, V Edwards, I Yousef, MM Fisher
Journal of Ultrastructure Research 1976
Properties of (Na+ + K+)-activated ATPase in rat liver plasma membranes enriched with bile canaliculi
JL Boyer, D Reno
Biochimica et Biophysica Acta (BBA) - Biomembranes 1975
Subfractionation of rat liver plasma membrane
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Biochimica et Biophysica Acta (BBA) - Biomembranes 1975
α-Naphthyl-isothiocyanate-induced cholestasis in the rat: studies of liver plasma membrane enzymes
PJ Hertzog, PS Bhathal, PR Dorling, RN Page
Pathology 1975
Isolation and partial characterization of a bile canalicular plasma membrane fraction from normal and regenerating rat liver
AE Sirica, PJ Goldblatt, JF McKelvy
The Journal of biological chemistry 1975
Electron microscopic cytochemical characterization of bile canaliculi and bile ductsin vitro
M Oda, MJ Phillips
Virchows Archiv B Cell Pathology 1975
Über die aktivitätserhöhung der unspezifisch lipoproteidgebundenen alkalischen phosphatase im menschlichen serum
N Husen, U Gerlach
Clinica Chimica Acta 1974
Jaundice
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British medical journal 1962

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