Citations to this article

Synthesis of Globin Chains in Sickle β-Thalassemia
Frances M. Gill, Elias Schwartz
Frances M. Gill, Elias Schwartz
Published March 1, 1973
Citation Information: J Clin Invest. 1973;52(3):709-714. https://doi.org/10.1172/JCI107232.
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Research Article

Synthesis of Globin Chains in Sickle β-Thalassemia

Abstract

In five patients with sickle β-thalassemia there was balanced α- and β-globin synthesis in the bone marrow and decreased total β-chain synthesis relative to that of α-chain in the peripheral blood. These findings are similar to those in patients with simple β-thalassemia trait. Despite a range of hemoglobin concentrations from 6.8 to 12.5 g/100 ml in the patients with sickle thalassemia, there was no evidence of a significant excess of α-chains in the red cells of the bone marrow which could contribute to the hemolysis and anemia.

Authors

Frances M. Gill, Elias Schwartz

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Year: 1986 1984 1982 1979 1978 1977 1976 1975 1974 1973 Total
Citations: 1 2 1 2 1 1 7 3 5 1 24
Citation information

Citations to this article (24)

Title and authors Publication Year
Bone marrow and peripheral blood globin chain synthesis in sickle cell beta zero thalassaemia
FF Costa, MA Zago 		Journal of medical genetics 1986
β Globin messenger RNA content of bone marrow erythroblasts in heterozygous β-thalassemia
EJ Benz, J Pritchard, D Hillman, J Glass, BG Forget 		American Journal of Hematology 1984
Sickle cell β-thalassaemia compared with sickle cell anaemia in Algeria
M Belhani, L Morle, J Godet, D Bachir, T Henni, F Zerhouni, A Bensenouci, P Colonna 		Scandinavian Journal of Haematology 1984
The interaction of α thalassaemia with heterozygous β thalassaemia
E Kanavakis, JS Wainscoat, WG Wood, DJ Weatherall, A Cao, M Furbetta, R Galanello, D Georgiou, T Sophocleous 		British Journal of Haematology 1982
Globin Synthesis in Bone Marrow Cells of Patients with Sickle Cell Anemia and β O -Thalassemia: Contamination of the β-Chain with Non-Globin Proteins
G Cividalli, H Kerem, EA Rachmilewitz 		Hemoglobin 1979
Globin chain synthesis in sickle beta-thalassaemic bone marrow and reticulocytes
S Ladas, G Chalevelakis, C Lyberatos, E Vaidakis, G Arapakis 		Journal of medical genetics 1979
Proteolytic activity in erythrocyte precursors
SM Hanash, DL Rucknagel 		Proceedings of the National Academy of Sciences 1978
The Interaction of B 0 -Thalassemia with Hemoglorin D Punjab: A Study of Globin Chain Synthesis in an Indian Family
SK Pallas, J Atwater, DG Norris 		Hemoglobin 1977
Heterozygous Beta Thalassaemia of Unusual Severity
S Friedman, S Özsoylu, R Luddy, E Schwartz 		British Journal of Haematology 1976
Variations in Globin Chain Synthesis in Hereditary Persistence of Fetal Haemoglobin
S Friedman, E Schwartz, E Ahern, V Ahern 		British Journal of Haematology 1976
Globin Synthesis in Normal Human Bone Marrow
G Chalevelakis, JB Clegg, DJ Weatherall 		British Journal of Haematology 1976
Hereditary persistence of foetal haemoglobin with β-chain synthesis in cis position (Gγ-β+-HPFH) in a negro family
S Friedman, E Schwartz 		Nature 1976
Sickle β-thalassemia: Identical twins differing in severity implicate nongenetic factors influencing course
SK Joishy, PF Griner, PT Rowley 		American Journal of Hematology 1976
Clinical, hematologic and biosynthetic studies in sickle cell-β°-thalassemia: A comparison with sickle cell anemia
MH Steinberg, BJ Dreiling 		American Journal of Hematology 1976
Sickle cell-β0 thalassemia variant with high hemoglobin F and mild clinical course
JR Shaeffer, JL Moake 		The American Journal of Medicine 1976
Globin synthesis in fractionated Normoblasts of beta-thalassemia heterozygotes
WG Wood, G Stamatoyannopoulos 		Journal of Clinical Investigation 1975
Imbalanced globin chain synthesis in heterozygous beta-thalassemic bone marrow
G Chalevelakis, JB Clegg, DJ Weatherall 		Proceedings of the National Academy of Sciences 1975
Cell Cycle and Cell Differentiation
J Reinert, H Holtzer 		1975
Globin Synthesis in the Jamaican Negro with Beta-Thalassaemia
S Friedman, E Schwartz, V Ahern, E Ahern 		British Journal of Haematology 1974
VARIATION IN ?/? SYNTHESIS RATIOS IN THALASSEMIA AND HEMOGLOBINOPATHIES
RF Rieder 		Annals of the New York Academy of Sciences 1974
THALASSEMIA IN BLACK AMERICANS
S Charache, CL Conley, TD Doeblin, M Bartalos 		Annals of the New York Academy of Sciences 1974
A NEW FORM OF ?-THALASSEMIA TRAIT
G Stamatoyannopoulos, T Papayannopoulou, R Woodson, D Heywood, S Kurachi 		Annals of the New York Academy of Sciences 1974
Inclusion-Body β-Thalassemia Trait: A Form of β Thalassemia Producing Clinical Manifestations in Simple Heterozygotes
G Stamatoyannopoulos, R Woodson, T Papayannopoulou, D Heywood, S Kurachi 		New England Journal of Medicine 1974
Free α-Globin Pool in Human Bone Marrow
FM Gill, E Schwartz 		Journal of Clinical Investigation 1973

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